Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation by Cláudia Caldeira, Carolina Cunha, Ana R. Vaz, Ana R. Vaz, Ana S. Falcão, Andreia Barateiro, Elsa Seixas, Adelaide Fernandes, Adelaide Fernandes, Dora Brites, Dora Brites

“…Reduced phagocytosis may derive from increased CD33 expression, reduced triggering receptor expressed on myeloid cells 2 (TREM2) and milk fat globule-EGF factor 8 protein (MFG-E8) levels, which were mainly observed in 16 DIV cells. …”
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A novel predictive strategy for the incidence of postoperative neurocognitive dysfunction in elderly patients with mild cognitive impairment by Yueying Liang, Xi Xin, Hongyan Wang, Wei Hua, Yi Wu, Xinyi Wang, Ping Li, Tong Zhou, Haiyun Wang

“…Preoperative levels of amyloidβ-40 (Aβ-40), Aβ-42, total tau protein (T-tau), phosphorylated tau protein (P-tau), and triggering receptors on myeloid cells-2 (TREM2) were investigated. SctO2 was monitored intraoperatively.Results: Aβ-42 had the strongest significant correlation with preoperative MoCA score. …”
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Translocator protein (TSPO) genotype does not change cerebrospinal fluid levels of glial activation, axonal and synaptic damage markers in early Alzheimer’s disease by Dominique Gouilly, Agathe Vrillon, Elsa Bertrand, Marie Goubeaud, Hélène Catala, Johanne Germain, Nadéra Ainaoui, Marie Rafiq, Leonor Nogueira, François Mouton-Liger, Mélanie Planton, Anne-Sophie Salabert, Anne Hitzel, Déborah Méligne, Laurence Jasse, Benjamine Sarton, Stein Silva, Béatrice Lemesle, Patrice Péran, Pierre Payoux, Claire Thalamas, Claire Paquet, Jérémie Pariente

“…Method: We performed a trans-sectional study in early AD to compare cerebrospinal-fluid levels of GFAP, YKL-40, sTREM2, IL-6, IL-10, NfL and neurogranin between TSPO genetic subgroups. …”
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Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages by Suzanne A.E. van Wouw, Marlene van den Berg, Maroua El Ouraoui, Amber Meurs, Jenina Kingma, Roelof Ottenhoff, Melanie Loix, Marten A. Hoeksema, Koen Prange, Gerard Pasterkamp, Jerome J.A. Hendriks, Jeroen F.J. Bogie, Jan B. van Klinken, Frederic M. Vaz, Aldo Jongejan, Menno P.J. de Winther, Noam Zelcer

“…We demonstrate that TMEM86a is a direct transcriptional target of LXR in macrophages and microglia and that it is highly expressed in TREM2+/lipid-associated macrophages in human atherosclerotic plaques, where its expression positively correlates with other LXR-regulated genes. …”
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Heterogeneity in intrahepatic macrophage populations and druggable target expression in patients with steatotic liver disease-related fibrosis by Omar A. Saldarriaga, Timothy G. Wanninger, Esteban Arroyave, Joseph Gosnell, Santhoshi Krishnan, Morgan Oneka, Daniel Bao, Daniel E. Millian, Michael L. Kueht, Akshata Moghe, Jingjing Jiao, Jessica I. Sanchez, Heidi Spratt, Laura Beretta, Arvind Rao, Jared K. Burks, Heather L. Stevenson

“…Results: Several genes known to be pro-fibrotic (e.g. CD206, TREM2, CD163, and ARG1) showed either no significant differences or significantly decreased with advanced fibrosis. …”
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Data-driven CSF biomarker profiling: imaging and clinical outcomes in a cohort at risk of Alzheimer’s disease by Georgette Argiris, Muge Akinci, Cleofé Peña-Gómez, Eleni Palpatzis, Marina Garcia-Prat, Mahnaz Shekari, Kaj Blennow, Henrik Zetterberg, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Nicholas J. Ashton, Thomas K. Karikari, Ann Brinkmalm-Westman, Juan Lantero-Rodriguez, Karine Fauria, Gonzalo Sánchez-Benavides, Oriol Grau-Rivera, Marc Suárez-Calvet, Eider M. Arenaza-Urquijo, for the ALFA study

“…CSF Aβ42, Aβ40, p-tau181, p-tau217, p-tau231, NfL, neurogranin, sTREM2, YKL40, GFAP, S100, α-Synuclein, SYT1, and SNAP25 were measured. …”
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Pyroptosis-related signatures predict immune characteristics and prognosis in IPF by Yijun He, Tingting Yao, Yan Zhang, Lingzhi Long, Guoliang Jiang, Xiangyu Zhang, Xin Lv, Yuanyuan Han, Xiaoyun Cheng, Mengyu Li, Mao Jiang, Zhangzhe Peng, Lijian Tao, Jie Meng

“…We constructed a prognostic model that included eight PRGs (CLEC5A, TREM2, MMP1, IRF2, SEZ6L2, ADORA3, NOS2, USP24) by LASSO Cox regression and validated it in the Leuven cohort. …”
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Decoding the inflammatory signature of the major depressive episode: insights from peripheral immunophenotyping in active and remitted condition, a case–control study by Federico Manuel Daray, Leandro Nicolás Grendas, Ángeles Romina Arena, Vera Tifner, Romina Isabel Álvarez Casiani, Alejandro Olaviaga, Luciana Carla Chiapella, Gustavo Vázquez, Melina Bianca Penna, Fernando Hunter, Cintia Romina Prokopez, Eugenio Antonio Carrera Silva, Andrea Emilse Errasti

“…Additionally, patients showed increased plasma levels of sTREM2 (p = 0.0089). These changes are more likely state markers, indicating the presence of an ongoing inflammatory response during an active MDE. …”
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CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline by Frances Evans, Daniela Alí-Ruiz, Natalia Rego, María Luciana Negro-Demontel, Natalia Lago, Fabio Andrés Cawen, Bruno Pannunzio, Paula Sanchez-Molina, Laura Reyes, Andrea Paolino, Jorge Rodríguez-Duarte, Valentina Pérez-Torrado, Almudena Chicote-González, Celia Quijano, Inés Marmisolle, Ana Paula Mulet, Geraldine Schlapp, María Noel Meikle, Mariana Bresque, Martina Crispo, Eduardo Savio, Cristina Malagelada, Carlos Escande, Hugo Peluffo

“…Summary: Emerging evidence suggests that immune receptors may participate in many aging-related processes such as energy metabolism, inflammation, and cognitive decline. CD300f, a TREM2-like lipid-sensing immune receptor, is an exceptional receptor as it integrates activating and inhibitory cell-signaling pathways that modulate inflammation, efferocytosis, and microglial metabolic fitness. …”
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Effects of IL-34 on Macrophage Immunological Profile in Response to Alzheimer's-Related Aβ42 Assemblies by Leah R. Zuroff, Leah R. Zuroff, Tania Torbati, Tania Torbati, Tania Torbati, Nadav J. Hart, Nadav J. Hart, Dieu-Trang Fuchs, Julia Sheyn, Altan Rentsendorj, Yosef Koronyo, Eric Y. Hayden, David B. Teplow, Keith L. Black, Maya Koronyo-Hamaoui, Maya Koronyo-Hamaoui

“…Similarly, IL-34 macrophages expressed lower levels of proteins involved in both Aβ uptake (triggering receptor expressed on myeloid cells 2, TREM2) as well as Aβ-degradation (matrix metallopeptidase 9, MMP-9). …”
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siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell GrowthSummary by Shane P. Duggan, Catherine Garry, Fiona M. Behan, Sinead Phipps, Hiromi Kudo, Murat Kirca, Abdul Zaheer, Sarah McGarrigle, John V. Reynolds, Robert Goldin, Steve E. Kalloger, David F. Schaeffer, Aideen Long, Jessica Strid, Dermot Kelleher

“…Over-representation of immune pathway–associated genes supporting EAC cell growth included leukemia inhibitory factor, complement component 1, q subcomponent A chain (C1QA), and triggering receptor expressed on myeloid cells 2 (TREM2), which were validated further as targets sharing downstream signaling pathways through genomic and pathologic studies. …”
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Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice by Xiaoye Ma, Dmitry Prokopenko, Ni Wang, Tomonori Aikawa, Younjung Choi, Can Zhang, Dan Lei, Yingxue Ren, Keiji Kawatani, Skylar C. Starling, Ralph B. Perkerson, Bhaskar Roy, Astrid C. Quintero, Tammee M. Parsons, Yining Pan, Zonghua Li, Minghui Wang, Hanmei Bao, Xianlin Han, Guojun Bu, Rudolph E. Tanzi, Takahisa Kanekiyo

“…In addition, we observed that ABCA7-A696S substitution disturbs the induction of proinflammatory cytokines interleukin 1β and interferon γ in the brains of 5xFAD mice, although some disease-associated microglia gene expression, including Trem2 and Tyrobp, are upregulated. Lipidomics also detected higher total lysophosphatidylethanolamine levels in the brains of 5xFAD mice with ABCA7-A696S substitution than controls. …”
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Xixin Decoction’s novel mechanism for alleviating Alzheimer’s disease cognitive dysfunction by modulating amyloid-β transport across the blood–brain barrier to reduce neuroinflamma... by Chaokai Yang, Enlong Zhao, Hu Zhang, Liqi Duan, Xinyue Han, Hongli Ding, Yan Cheng, Dengkun Wang, Dengkun Wang, Dengkun Wang, Xiaojing Lei, Xiaojing Lei, Xiaojing Lei, Yongchang Diwu, Yongchang Diwu, Yongchang Diwu

“…Additionally, XXD upregulated the expression of TREM2, downregulated IBA1, TLR1, TLR2, and CMPK2 expression, and reduced the levels of pro-inflammatory factors NLRP3, NF-κB p65, COX-2, TNF-α, and IL-1β in the hippocampal tissues.ConclusionXXD may exert its effects by regulating the P-gp/ECS axis, the RAGE/LRP1 receptor system, and the expression of MRP2 and Mfsd2a proteins, thereby modulating the transport function of the BBB to expedite the clearance of Aβ, reduce cerebral Aβ accumulation, and consequently inhibit the activation of microglia induced by Aβ aggregation. …”
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Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape by Isabel Reinisch, Helene Michenthaler, Alba Sulaj, Elisabeth Moyschewitz, Jelena Krstic, Markus Galhuber, Ruonan Xu, Zina Riahi, Tongtong Wang, Nemanja Vujic, Melina Amor, Riccardo Zenezini Chiozzi, Martin Wabitsch, Dagmar Kolb, Anastasia Georgiadi, Lisa Glawitsch, Ellen Heitzer, Tim J. Schulz, Michael Schupp, Wenfei Sun, Hua Dong, Adhideb Ghosh, Anne Hoffmann, Dagmar Kratky, Laura C. Hinte, Ferdinand von Meyenn, Albert J. R. Heck, Matthias Blüher, Stephan Herzig, Christian Wolfrum, Andreas Prokesch

“…Finally, in cohorts of obese/diabetic patients, we describe a p53 polymorphism that links to efficacy of a fasting-mimicking diet and that the expression of p53 and TREM2 in AT negatively correlates with maintaining weight loss after bariatric surgery. …”
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Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension by Oleksandr Petrenko, Philipp Königshofer, Ksenia Brusilovskaya, Benedikt S. Hofer, Katharina Bareiner, Benedikt Simbrunner, Frank Jühling, Thomas F. Baumert, Joachim Lupberger, Michael Trauner, Stefan G. Kauschke, Larissa Pfisterer, Eric Simon, André F. Rendeiro, Laura P.M.H. de Rooij, Philipp Schwabl, Thomas Reiberger

“…These candidate biomarkers (e.g., Tcf4, Mmp7, Trem2, Spp1, Scube1, Islr) were validated in RNA sequencing datasets of patients with cirrhosis and portal hypertension, and those cured from hepatitis C infection. …”
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Mode of administration influences plasma levels of active Centella asiatica compounds in 5xFAD mice while markers of neuroinflammation remain unaltered by Alex B. Speers, Alex B. Speers, Kirsten M. Wright, Kirsten M. Wright, Mikah S. Brandes, Mikah S. Brandes, Nareg Kedjejian, Nareg Kedjejian, Donald G. Matthews, Maya Caruso, Christopher J. Harris, Seiji Koike, Seiji Koike, Thuan Nguyen, Thuan Nguyen, Joseph F. Quinn, Joseph F. Quinn, Joseph F. Quinn, Amala Soumyanath, Amala Soumyanath, Nora E. Gray, Nora E. Gray

“…Gene expression of inflammatory mediators (IL-6, TNFα, IL-1β, TREM2, AIF1, CX3CR1, CX3CL1, CD36, C3AR1, RAGE, CCR6, CD3E) was measured in the deep grey matter.ResultsCAW decreased cortical Aβ plaque burden in female 5xFAD mice administered CAW in the drinking water but had no effect on Aβ plaques in other treatment groups. …”
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Immunological alterations in patients with current and lifetime suicide ideation and attempts: Examining the relationship with depressive symptoms by Leandro Nicolás Grendas, Eugenio Antonio Carrera Silva, Romina Isabel Álvarez Casiani, Alejandro Olaviaga, Josefina Robetto, Ángeles Romina Arena, Vera Tifner, Luciana Carla Chiapella, Marcelo Fisichella, Melina Bianca Penna, Fernando Hunter, Cintia Romina Prokopez, Andrea Emilse Errasti, Federico Manuel Daray

“…The plasmainflammatory status was marked by higher levels of soluble Triggering receptor expressed on myeloid cells 2 (sTREM2) in patients with lifetime SI/SA compared to HC. …”
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Single-cell Atlas reveals core function of CPVL/MSR1 expressing macrophages in the prognosis of triple-negative breast cancer by Xinan Wang, Xinan Wang, Xinan Wang, Xinan Wang, Li Lin, Xue Zhang, Minghui Zhang, Minghui Zhang, Minghui Zhang, Minghui Zhang, Zhuo Sun, Zhuo Sun, Zhuo Sun, Zhuo Sun, Yichen Yang, Yichen Yang, Yichen Yang, Yichen Yang, Xiuna Zhang, Yonghui Yuan, Yong Zhang, Hao Chen, Ti Wen, Ti Wen, Ti Wen, Ti Wen

“…Moreover, cytokines including IL-18, IFNγR1, CCL20, and CCL2, along with complement-related gene like TREM2 and complement component CFD, may participate in the process of CPVL or MSR1 regulating macrophage polarization. …”
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Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice by Adrian L. Oblak, Adrian L. Oblak, Adrian L. Oblak, Kevin P. Kotredes, Ravi S. Pandey, Ravi S. Pandey, Alaina M. Reagan, Cynthia Ingraham, Cynthia Ingraham, Bridget Perkins, Bridget Perkins, Christopher Lloyd, Christopher Lloyd, Deborah Baker, Deborah Baker, Peter B. Lin, Peter B. Lin, Disha M. Soni, Disha M. Soni, Andy P. Tsai, Andy P. Tsai, Scott A. Persohn, Scott A. Persohn, Amanda A. Bedwell, Amanda A. Bedwell, Kierra Eldridge, Kierra Eldridge, Rachael Speedy, Rachael Speedy, Jill A. Meyer, Jill A. Meyer, Johnathan S. Peters, Johnathan S. Peters, Lucas L. Figueiredo, Lucas L. Figueiredo, Michael Sasner, Paul R. Territo, Paul R. Territo, Paul R. Territo, Stacey J. Sukoff Rizzo, Gregory W. Carter, Bruce T. Lamb, Bruce T. Lamb, Bruce T. Lamb, Gareth R. Howell

“…These included a combined risk model with APOE4 and a variant in triggering receptor expressed on myeloid cells 2 (Trem2R47H). We have termed this model, LOAD1. Additional variants including the M28L variant in phospholipase C Gamma 2 (Plcg2M28L) and the 677C > T variant in methylenetetrahydrofolate reductase (Mthfr677C >T) were engineered by CRISPR onto LOAD1 to generate LOAD1.Plcg2M28L and LOAD1.Mthfr677C >T. …”
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Intratumoral CD103+CD8+ T cells predict response to neoadjuvant chemoimmunotherapy in advanced head and neck squamous cell carcinoma by Siqi Ren, Tianjun Lan, Fan Wu, Suling Chen, Xue Jiang, Chuying Huo, Zitian Li, Shule Xie, Donghui Wu, Ruixin Wang, Yanyan Li, Lin Qiu, Guoxin Huang, Shurui Li, Xiaojuan Wang, Meifeng Cen, Tingting Cai, Zhaoyu Lin, Jinsong Li, Bowen Li

“…Mechanistically, targeting the triggering receptor expressed on myeloid cells 2‐positive (TREM2+) macrophages might enhance the population of CD103+CD8+ TILs and facilitate antitumor immunity during NACI treatment. …”
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