Impaired inflammatory resolution with severe SARS-CoV-2 infection in leptin knock out obese hamster by Ren-Di Jiang, Yun-Zhe Luo, Hao-Feng Lin, Xiao-Shuang Zheng, Wen-Tao Zeng, Mei-Qin Liu, Hao-Hao Deng, Qi Wang, Ya-Na Lai, Ying Chen, Zi-Shuo Guo, Ya Zeng, Qian-Chun Gong, Chen Qiu, Mei Dong, Xi Wang, Zi-Yi Wang, Li-Na Ji, Pan-Pan Hou, Qian Li, Xu-Rui Shen, Bei Li, Yun Gao, Ai-Hua Zhang, Ting-Ting Jiang, Ai-Min Shi, Peng Zhou, Xin-Hua Lin, Zi-Qing Deng, Jian-Min Li, Zheng-Li Shi

“…Using single-cell transcriptomics on lung tissues pre- and post-infection, we found that monocyte-derived alveolar macrophages (MD-AM) play a key role in lung hyper-inflammation, including two unique MD-AM cell fate branches specific to Leptin−/− hamsters. Notably, reduced Trem2-dependent efferocytosis pathways in Leptin−/− hamsters indicated weakened inflammation resolution, consistent with the scRNA-seq data from patients with obesity. …”
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CD137 agonism enhances anti-PD1 induced activation of expanded CD8+ T cell clones in a neoadjuvant pancreatic cancer clinical trial by Janelle M. Montagne, Jacob T. Mitchell, Joseph A. Tandurella, Eric S. Christenson, Ludmila V. Danilova, Atul Deshpande, Melanie Loth, Dimitrios N. Sidiropoulos, Emily Davis-Marcisak, Daniel R. Bergman, Qingfeng Zhu, Hao Wang, Luciane T. Kagohara, Logan L. Engle, Benjamin F. Green, Alexander V. Favorov, Won Jin Ho, Su Jin Lim, Rui Zhang, Pan Li, Jessica Gai, Guanglan Mo, Sarah Mitchell, Rulin Wang, Ajay Vaghasia, Wenpin Hou, Yao Xu, Jacquelyn W. Zimmerman, Jennifer H. Elisseeff, Srinivasan Yegnasubramanian, Robert A. Anders, Elizabeth M. Jaffee, Lei Zheng, Elana J. Fertig

“…Addition of CD137 agonist increased abundance of clonally expanded CD8+ T cells and increased immunosuppressive TREM2 signaling in tumor associated macrophages (TAMs), identified by comparison of ligand-receptor networks, corresponding to changes in metabolism and ECM interactions. …”
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