Study on pyroptosis-related genes Casp8, Gsdmd and Trem2 in mice with cerebral infarction by Shunli Liang, Linsheng Xu, Xilin Xin, Rongbo Zhang, You Wu

“…We selected Trem2 for subsequent functional analysis. OGD treatment of BV2 cell in vitro significantly upregulated the expressions of Trem2. …”
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TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target by Rui-Yang Li, Qi Qin, Han-Chen Yang, Ying-Ying Wang, Ying-Xin Mi, Yun-Si Yin, Meng Wang, Chao-Ji Yu, Yi Tang

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Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Impairs Host Defense in Experimental Melioidosis. by Tassili A F Weehuizen, Tijmen J Hommes, Jacqueline M Lankelma, Hanna K de Jong, Joris J T H Roelofs, Alex F de Vos, Marco Colonna, Tom van der Poll, W Joost Wiersinga

“…Triggering receptor expressed on myeloid cells (TREM) -1 and TREM-2 are key regulators of the inflammatory response that are involved in the clearance of invading pathogens. …”
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The Protective Role of TREM2 in the Heterogenous Population of Macrophages during Post-Myocardial Infarction Inflammation by Sang Hyun Kim, Kwan Yong Lee, Kiyuk Chang

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Myeloid Trem2 Dynamically Regulates the Induction and Resolution of Hepatic Ischemia-Reperfusion Injury Inflammation by Sheng Han, Xiangdong Li, Nan Xia, Yu Zhang, Wenjie Yu, Jie Li, Chenyu Jiao, Ziyi Wang, Liyong Pu

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Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup by Ione O. C. Woollacott, Jennifer M. Nicholas, Amanda Heslegrave, Carolin Heller, Martha S. Foiani, Katrina M. Dick, Lucy L. Russell, Ross W. Paterson, Ashvini Keshavan, Nick C. Fox, Jason D. Warren, Jonathan M. Schott, Henrik Zetterberg, Jonathan D. Rohrer

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Author Correction: TREM2 has a significant, gender-specific, effect on human obesity by Tzila Reich, Orit Adato, Naomi Schneid Kofman, Ariel Feiglin, Ron Unger

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Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region by Kai Schlepckow, Kathryn M Monroe, Gernot Kleinberger, Ludovico Cantuti‐Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner, Alice Sülzen, Brigitte Nuscher, Heike Hampel, Xianyuan Xiang, Regina Feederle, Sabina Tahirovic, Joshua I Park, Rachel Prorok, Cathal Mahon, Chun‐Chi Liang, Ju Shi, Do Jin Kim, Hanna Sabelström, Fen Huang, Gilbert Di Paolo, Mikael Simons, Joseph W Lewcock, Christian Haass

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Author Correction: Modulation of microglial phenotypes by dexmedetomidine through TREM2 reduces neuroinflammation in heatstroke by Ping Li, Tingting Shen, Xue Luo, Ju Yang, Zhen Luo, Yulong Tan, Genlin He, Zeze Wang, Xueting Yu, Ying Wang, Xuesen Yang

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Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities by Hailan Yao, Hailan Yao, Kyle Coppola, Kyle Coppola, Jonas Elias Schweig, Jonas Elias Schweig, Fiona Crawford, Fiona Crawford, Michael Mullan, Michael Mullan, Daniel Paris, Daniel Paris

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TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury by Wei Wei, Lin Zhang, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Zhongnan Hao, Stefan T. Gerner, Sabine Huber, Martin Juenemann, Marius Butz, Hagen B. Huttner, Mathias Bähr, Dirk Fitzner, Feng Jia, Thorsten R. Doeppner

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Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model by Li Zhong, Ying Xu, Rengong Zhuo, Tingting Wang, Kai Wang, Ruizhi Huang, Daxin Wang, Yue Gao, Yifei Zhu, Xuan Sheng, Kai Chen, Na Wang, Lin Zhu, Dan Can, Yuka Marten, Mitsuru Shinohara, Chia-Chen Liu, Dan Du, Hao Sun, Lei Wen, Huaxi Xu, Guojun Bu, Xiao-Fen Chen

“…TREM2 is a genetic risk factor for Alzheimer’s disease, and soluble TREM2 (sTREM2) in the CSF correlates with AD progression. …”
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TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway by Rong Li, Jing Zhang, Qiong Wang, Meng Cheng, Bin Lin

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Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages by Rui Sun, Chao Lei, Zhishan Xu, Xuemei Gu, Liu Huang, Liang Chen, Yi Tan, Min Peng, Kavitha Yaddanapudi, Leah Siskind, Maiying Kong, Robert Mitchell, Jun Yan, Zhongbin Deng

“…Metabolite ceramide leads to reprogramming of macrophages toward immune suppressive TREM2+ tumor associated macrophages, which promote CD8 T cells exhaustion.…”
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The immunoregulatory effect of the TREM2-agonist Sulfavant A in human allogeneic mixed lymphocyte reaction by Giusi Barra, Carmela Gallo, Dalila Carbone, Marcello Ziaco, Mario Dell’Isola, Mario Affuso, Emiliano Manzo, Genoveffa Nuzzo, Laura Fioretto, Giuliana D’Ippolito, Raffaele De Palma, Angelo Fontana, Angelo Fontana

“…The molecule triggers TREM2-related maturation of dendritic cells (DCs) and has shown promising adjuvant activity in a cancer vaccine model.Methodsthe immunomodulatory activity of SULF A is tested in an allogeneic mixed lymphocyte reaction (MLR) assay based on monocyte-derived dendritic cells and naïve T lymphocytes from human donors. …”
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Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain by Szykowska, A, Chen, Y, Smith, TB, Preger, C, Yang, J, Qian, D, Mukhopadhyay, SM, Wigren, E, Neame, SJ, Gräslund, S, Persson, H, Atkinson, PJ, Di Daniel, E, Mead, E, Wang, J, Davis, JB, Burgess-Brown, NA, Bullock, AN

“…Mutations in TREM2, a receptor expressed by microglia in the brain, are associated with an increased risk of neurodegeneration, including Alzheimer's disease. …”

Triggering Receptor Expressed on Myeloid Cells 2 Mediates the Involvement of M2-Type Macrophages in Pulmonary Tuberculosis Infection by Shang X, Maimaiti N, Fan J, Wang L, Wang Y, Sun H, Lv J, Zhang X, Wang J, Ma X

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Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2hi macrophages in infarcted hearts by Seung-Hyun Jung, Byung-Hee Hwang, Sun Shin, Eun-Hye Park, Sin-Hee Park, Chan Woo Kim, Eunmin Kim, Eunho Choo, Ik Jun Choi, Filip K. Swirski, Kiyuk Chang, Yeun-Jun Chung

“…Here, using single cell and spatial transcriptomics in a MI-HF mouse model, the authors show that macrophages expressing Trem2 are found within the infarcts and this could be a useful biomarker.…”
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CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline by Marc Suárez‐Calvet, Anja Capell, Miguel Ángel Araque Caballero, Estrella Morenas‐Rodríguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters, Martin N Rossor, John M Ringman, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, the Dominantly Inherited Alzheimer Network, the Alzheimer's Disease Neuroimaging Initiative

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TREM2 deficiency inhibits microglial activation and aggravates demyelinating injury in neuromyelitis optica spectrum disorder by Yun-Fan You, Man Chen, Yue Tang, Wen-Xiang Yu, Xiao-Wei Pang, Yun-Hui Chu, Hang Zhang, Ke Shang, Gang Deng, Luo-Qi Zhou, Sheng Yang, Wei Wang, Jun Xiao, Dai-Shi Tian, Chuan Qin

Subjects: “…TREM2…”
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