TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia by Amit Jairaman, Amanda McQuade, Alberto Granzotto, You Jung Kang, Jean Paul Chadarevian, Sunil Gandhi, Ian Parker, Ian Smith, Hansang Cho, Stefano L Sensi, Shivashankar Othy, Mathew Blurton-Jones, Michael D Cahalan

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TREM2, Driving the Microglial Polarization, Has a TLR4 Sensitivity Profile After Subarachnoid Hemorrhage by Yangchun Hu, Chao Li, Xiaojian Wang, Weiwei Chen, Yu Qian, Xingliang Dai

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Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model by Li Zhong, Ying Xu, Rengong Zhuo, Tingting Wang, Kai Wang, Ruizhi Huang, Daxin Wang, Yue Gao, Yifei Zhu, Xuan Sheng, Kai Chen, Na Wang, Lin Zhu, Dan Can, Yuka Marten, Mitsuru Shinohara, Chia-Chen Liu, Dan Du, Hao Sun, Lei Wen, Huaxi Xu, Guojun Bu, Xiao-Fen Chen

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Serum sTREM2: A Potential Biomarker for Mild Cognitive Impairment in Patients With Obstructive Sleep Apnea by Xu Jiahuan, Zou Ying, Jin Hongyu, Wei Zhijing, Guan Shibo, Deng Chengyue, Fu Liangyu, Liu Fan, Wang Wei

“…Multivariate linear regression was used to analyze the factors influencing sTREM2, and the receiver operating characteristic curve was used to assess the predictive value of serum sTREM2 for mild cognitive impairment in patients with OSA.ResultsPatients with OSA had higher serum sTREM2 levels than the controls. …”
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Galectin-3 as TREM2 upstream factor contributes to lung ischemia-reperfusion injury by regulating macrophage polarization by Hao Liu, Lu Zhang, Zhen Liu, Jinyuan Lin, Xiaojing He, Siyi Wu, Yi Qin, Chen Zhao, Youyuan Guo, Fei Lin

“…In addition, we observed colocalization of Gal3 and TREM2 in macrophages, inhibition of Gal3 could recover the downregulation of TREM2 induced by LIRI while promoting TREM2 expression could attenuate lung injury in LIRI. …”
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Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer’s disease by Xingyu Zhang, Li Tang, Jiaolong Yang, Lanxia Meng, Jiehui Chen, Lingyan Zhou, Jiangyu Wang, Min Xiong, Zhentao Zhang

“…The proteolytic shedding of TREM2 results in the release of soluble TREM2 (sTREM2), which is increased in the cerebrospinal fluid of patients with Alzheimer’s disease (AD). …”
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Trem-2 Promotes Emergence of Restorative Macrophages and Endothelial Cells During Recovery From Hepatic Tissue Damage by Inês Coelho, Nádia Duarte, André Barros, Maria Paula Macedo, Maria Paula Macedo, Maria Paula Macedo, Carlos Penha-Gonçalves, Carlos Penha-Gonçalves

“…Trem-2 gene ablation led to a delayed re-population of Kupffer cells correlating with deterred resolution of hepatic damage following acute and chronic injury. …”
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Paeonol enhances macrophage phagocytic function by modulating lipid metabolism through the P53-TREM2 axis by Jifei Miao, Jifei Miao, Xiaoming Liu, Yuanpin Liao, Yiwen Li, Yingyan Kuang, Juanxia Zheng, Zigang Li, Jiao Lan

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Association between air pollution and CSF sTREM2 in cognitively normal older adults: The CABLE study by Meng Li, Ya‐Hui Ma, Yan Fu, Jia‐Yao Liu, He‐Ying Hu, Yong‐Li Zhao, Liang‐Yu Huang, Lan Tan

“…No significant evidence supported NO2 related to CSF sTREM2. For potentially causal associations with accumulated AD pathologies, the total effects of PM2.5 on CSF amyloid‐related protein (CSF Aβ42 and p‐tau/Aβ42) were partly mediated by CSF sTREM2, with proportions of 14.22% and 47.15%, respectively. …”
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The ratio of urinary TREM-1/TREM-2 mRNA expression in chronic kidney disease and renal fibrosis by Yuhan Cao, Yuwei Wang, Nana Peng, Jie Xiao, Sufen Wang, Cong Fu

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INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model by Akihiro Iguchi, Sho Takatori, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Genta Ito, Haruaki Sato, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C. Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita

“…Summary: The genetic associations of TREM2 loss-of-function variants with Alzheimer disease (AD) indicate the protective roles of microglia in AD pathogenesis. …”
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A high cerebrospinal fluid soluble TREM2 level is associated with slow clinical progression of Alzheimer's disease by Trine Holt Edwin, Kristi Henjum, Lars N.G. Nilsson, Leiv Otto Watne, Karin Persson, Rannveig Sakshaug Eldholm, Ingvild Saltvedt, Nathalie Bodd Halaas, Geir Selbæk, Knut Engedal, Bjørn Heine Strand, Anne‐Brita Knapskog

Subjects: “…soluble triggering receptor expressed on myeloid cells 2 (sTREM2)…”
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Association between Cerebrospinal Fluid Soluble <i>TREM2</i>, Alzheimer’s Disease and Other Neurodegenerative Diseases by Wenchuan Zhou, Yutong Zhou, Jing Li

Subjects: “…soluble <i>TREM2</i>…”
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TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy by Shane M. Bemiller, Tyler J. McCray, Kevin Allan, Shane V. Formica, Guixiang Xu, Gina Wilson, Olga N. Kokiko-Cochran, Samuel D. Crish, Cristian A. Lasagna-Reeves, Richard M. Ransohoff, Gary E. Landreth, Bruce T. Lamb

Subjects: “…TREM2…”
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Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration by Nicolai Franzmeier, M. Suárez-Calvet, Lukas Frontzkowski, Annah Moore, Timothy J. Hohman, Estrella Morenas-Rodriguez, Brigitte Nuscher, Leslie Shaw, John Q. Trojanowski, Martin Dichgans, Gernot Kleinberger, Christian Haass, Michael Ewers, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)

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Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2) by Li Zhong, Zongqi Wang, Daxin Wang, Zhe Wang, Yuka A. Martens, Linbei Wu, Ying Xu, Kai Wang, Jianguo Li, Ruizhi Huang, Dan Can, Huaxi Xu, Guojun Bu, Xiao-Fen Chen

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TREM2‐IGF1 Mediated Glucometabolic Enhancement Underlies Microglial Neuroprotective Properties During Ischemic Stroke by Sheng Yang, Chuan Qin, Man Chen, Yun‐Hui Chu, Yue Tang, Luo‐Qi Zhou, Hang Zhang, Ming‐Hao Dong, Xiao‐Wei Pang, Lian Chen, Long‐Jun Wu, Dai‐Shi Tian, Wei Wang

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Trem2 deficiency impairs recovery and phagocytosis and dysregulates myeloid gene expression during virus-induced demyelination by Mihyun Hwang, Carine Savarin, Jihye Kim, Jennifer Powers, Natasha Towne, Hyunsuk Oh, Cornelia C. Bergmann

Subjects: “…TREM2…”
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Functional insight into LOAD-associated microglial response genes by Lauren A. Jonas, Tanya Jain, Yue-Ming Li

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Microglial TREM2 Mitigates Inflammatory Responses and Neuronal Apoptosis in Angiotensin II-Induced Hypertension in Middle-Aged Mice by Xiaotian Xu, Xiaotian Xu, Lin Du, Jianxiong Jiang, Ming Yang, Zhaoxia Wang, Yingge Wang, Tieyu Tang, Xuetao Fu, Jiukuan Hao

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