Genome-wide analysis of the FOXA1 transcriptional regulatory network identifies super enhancer associated LncRNAs in tamoxifen resistance by Xiulei Zhang, Qian Zhang, Guangzhi Liu

“…Through analyzing the FOXA1 ChIP-seq data in tamoxifen sensitive MCF7 and tamoxifen resistant MCF7/TamR cells, we show that the FOXA1 chromatin occupancy is enhanced in both the promoter and enhancer regions, and the recruitment events may be E2 dependent in both MCF7 and MCF7/TamR cells. …”
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Tunnel anisotropic magnetoresistance in magnetic tunnel junctions using FeAlSi by S. Akamatsu, T. Nakano, Muftah Al-Mahdawi, W. Yupeng, M. Tsunoda, Y. Ando, M. Oogane

“…We also investigated tunnel anisotropic magneto-resistance (TAMR) and clearly observed a TAMR peak similar to Fe/MgO/Fe MTJs, where the TAMR ratio of FeAlSi/MgO/CoFeB MTJs was 1.0% comparable to 1.1% in Fe/MgO/Fe MTJs. …”
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Bridging the diversity gap: Analytical and study design considerations for improving the accuracy of trans-ancestry genetic prediction by Ozvan Bocher, Arthur Gilly, Young-Chan Park, Eleftheria Zeggini, Andrew P. Morris

“…In contrast, trans-ancestry meta-regression (TAMR) builds ancestry-aware PGS that account for more complex trans-ancestry architectures. …”
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Integrated computational and experimental analysis of non-neuronal cell molecular mechanisms contributing to Alzheimer's disease progression by Lee, Meelim Jasmine

“…Overall, this work provides a computational framework for rational selection of mouse models and presents preliminary data towards our hypothesis that TAMR ligands preferentially binding Mer could modulate absolute and relative TAMR abundance to bias microglia towards a therapeutically beneficial, phagocytic state. …”
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Targeting c-Jun inhibits fatty acid oxidation to overcome tamoxifen resistance in estrogen receptor-positive breast cancer by Cen Jiang, Youzhi Zhu, Huaying Chen, Junyu Lin, Ruiwang Xie, Weiwei Li, Jiajie Xue, Ling Chen, Xiangjin Chen, Sunwang Xu

“…Herein, we show that fatty acid oxidation (FAO) was activated in tamoxifen-resistant (TamR) ER-positive BC cells by performing bioinformatic and functional studies. …”
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Favipiravir, an antiviral drug, in combination with tamoxifen exerts synergistic effect in tamoxifen-resistant breast cancer cells via hTERT inhibition by Sally A. Fahim, Yehia A. ElZohairy, Rehab I. Moustafa

“…Our findings suggest that the TAM/FAV combination exhibits synergistic effects against TAMR-1 human breast cancer cells by targeting hTERT.…”
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IGF-1 Stimulates Glycolytic ATP Production in MCF-7L Cells by Bhumika Rajoria, Xihong Zhang, Douglas Yee

“…MCF-7L cells express both IGF-1R and IR, while tamoxifen-resistant MCF-7L (MCF-7L TamR) cells have downregulated IGF-1R with unchanged IR levels. …”
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Modulation of BAG-1 Expression Alters the Sensitivity of Breast Cancer Cells to Tamoxifen by Hong Liu, Su Lu, Lin Gu, Yongchang Gao, Tong Wang, Jing Zhao, Jianyu Rao, Jun Chen, Xishan Hao, Shou-Ching Tang

“…Results: Our results showed that the TAM-resistant MCF-7 (TAMR/MCF-7) cells expressed higher level of BAG-1 than that of the MCF-7 cells. …”
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Autophagy Triggers Tamoxifen Resistance in Human Breast Cancer Cells by Preventing Drug-Induced Lysosomal Damage by Chiara Actis, Giuliana Muzio, Riccardo Autelli

“…MCF7-TamR cells overexpress messenger RNAs (mRNAs) for metallothionein 2A and ferritin heavy chain, and they are re-sensitized to Tam by inhibition of autophagy. …”
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Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells by Barkovskaya, A, Seip, K, Prasmickaite, L, Mills, IG, Moestue, SA, Itkonen, HM

“…In this study, we probed the importance of O-GlcNAc transferase (OGT) activity for the survival of tamoxifen-sensitive (TamS) and tamoxifen-resistant (TamR) breast cancer cells. Tamoxifen is an antagonist of estrogen receptor (ERα), a transcription factor expressed in over 50% of breast cancers. …”

Evaluation of Some Fruit Quality of Date Palm Cv. “Medjoul” Grown Under Al Bahria and El-Dakhla Oases Conditions by Essam Madboly, Emad Ashmawy, Samia Hosny, Mona Samouny

“…Medjoul fruits required 289 -291 days, mean Temp. 27.2 C ̊, 25.0 C ̊ and humidity 46.0%, 47.0 % to reach tamr stage under El Wahat Al-Baharia and required 267-272 days, mean Temp. 29.1 C ̊, 26.4 C ̊ and humidity 37.2%, 42.3% to reach tamr stage under El-Dakhla region. …”
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Dependency of Tamoxifen Sensitive and Resistant ER⁺ Breast Cancer Cells on Semaphorin 3C (SEMA3C) for Growth by Satyam Bhasin, Christopher Dusek, James W. Peacock, Artem Cherkasov, Yuzhuo Wang, Martin Gleave, Christopher J. Ong

“…Moreover, the analysis of tamoxifen resistant (TamR) cell models (TamC3 and TamR3) showed that SEMA3C levels remain high despite treatment with tamoxifen. …”
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Formulation, Characterization and Cytotoxicity Effects of Novel Thymoquinone-PLGA-PF68 Nanoparticles by Nurul Shahfiza Noor, Noor Haida Mohd Kaus, Myron R. Szewczuk, Shahrul Bariyah Sahul Hamid

“…Cytotoxicity activity showed that tamoxifen-resistant (TamR) MCF-7 breast cancer cells required a higher concentration of TQ-PLGA-PF68 nanoparticles than the parental MCF-7 cells to achieve IC₅₀ (<i>p</i> < 0.05). …”
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Tamoxifen Activates Transcription Factor EB and Triggers Protective Autophagy in Breast Cancer Cells by Inducing Lysosomal Calcium Release: A Gateway to the Onset of Endocrine Resi... by Cecilia Boretto, Chiara Actis, Pawan Faris, Francesca Cordero, Marco Beccuti, Giulio Ferrero, Giuliana Muzio, Francesco Moccia, Riccardo Autelli

“…TFEB was overexpressed and prominently nuclear in Tam-resistant MCF7 cells (MCF7-TamR) compared with their parental counterpart, and this was not dependent on alterations of its nucleo-cytoplasmic shuttling. …”
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Co-delivery of Doxorubicin and PSC 833 (Valspodar) by Stealth Nanoliposomes for Efficient Overcoming of Multidrug Resistance by Elmira Bajelan, Azadeh Haeri, Amir Masoud Vali, Seyed Nasser Ostad, Simin Dadashzadeh

“…In DOX-resistant T47D/TAMR-6 cells, dual-agent stealth liposomes showed significantly greater cytotoxicity (P < 0.05) than free DOX and liposomal DOX plus free PSC 833 treatments. …”
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Antioxidant Capacity and Phenolic and Sugar Profiles of Date Fruits Extracts from Six Different Algerian Cultivars as Influenced by Ripening Stages and Extraction Systems by Malika Tassoult, Djamel Edine Kati, María África Fernández-Prior, Alejandra Bermúdez-Oria, Juan Fernandez-Bolanos, Guillermo Rodríguez-Gutiérrez

“…Uronic acids were mostly detected at the tamr stage (4.02–8.82 mg gallic acid equivalent/100 mg dried weight). …”
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FoxO3a Inhibits Tamoxifen-Resistant Breast Cancer Progression by Inducing Integrin α5 Expression by Elena Ricci, Mariarosa Fava, Pietro Rizza, Michele Pellegrino, Daniela Bonofiglio, Ivan Casaburi, Marilena Lanzino, Cinzia Giordano, Rosalinda Bruno, Rosa Sirianni, Ines Barone, Diego Sisci, Catia Morelli

“…Here, the role of the Forkhead box class O (FoxO)3a transcription factor in tumor progression has been evaluated in tamoxifen-resistant BC cells (TamR), expressing lower levels of FoxO3a compared to sensitive ones. …”
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GDNF-RET signaling and EGR1 form a positive feedback loop that promotes tamoxifen resistance via cyclin D1 by Brooke A. Marks, Ilissa M. Pipia, Chinatsu Mukai, Sachi Horibata, Edward J. Rice, Charles G. Danko, Scott A. Coonrod

“…Methods To gain a better understanding of the GDNF-RET-EGR1 resistance mechanism, we studied the GDNF-EGR1 positive feedback loop and the role of GDNF and EGR1 in endocrine resistance by modulating their transcription levels using CRISPR-dCAS9 in tamoxifen sensitive (TamS) and tamoxifen resistant (TamR) MCF-7 cells. Additionally, we performed kinetic studies using recombinant GDNF (rGDNF) treatment of TamS cells. …”
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Improving Engineering Properties of Soil for Highways Purposes by Halloysite Nanotubes by Mukheef Itimad A., Jawad Ibtehaj T., Al–Kremy Abdul Rudha I. A.

“…The soil that was utilized for this study was collected from Ayn al-Tamr in Karbala City, southwest of Iraq, having an average gypsum of 30% and was designated as (SP) by (USCS). …”
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Evidence for asymmetric rotation of spins in antiferromagnetic exchange-spring by Y Y Wang, C Song, G Y Wang, F Zeng, F Pan

“…Moreover, the observed tunneling anisotropic magnetoresistance (TAMR) in AFM-based junctions based on this asymmetric rotation provides an electrical approach to monitoring the dynamic twist of the AFM spins. …”
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