Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation by Guliang Yang, Haiyan Zhong, Xinxin Xia, Zhiwen Qi, Chengzhang Wang, Shiming Li

Subjects: Get full text

Partial volume correction in longitudinal tau PET studies: is it really needed? by Alejandro Costoya-Sánchez, Alexis Moscoso, Tomás Sobrino, Álvaro Ruibal, Michel J. Grothe, Michael Schöll, Jesús Silva-Rodríguez, Pablo Aguiar

Subjects: Get full text

GS-DTA: integrating graph and sequence models for predicting drug-target binding affinity by Junwei Luo, Ziguang Zhu, Zhenhan Xu, Chuanle Xiao, Jingjing Wei, Jiquan Shen

Subjects: “…Drug-target binding affinity…”
Get full text

FingerDTA: A Fingerprint-Embedding Framework for Drug-Target Binding Affinity Prediction by Xuekai Zhu, Juan Liu, Jian Zhang, Zhihui Yang, Feng Yang, Xiaolei Zhang

Subjects: “…drug-target binding affinity…”
Get full text

Highly sensitive detection of antibody nonspecific interactions using flow cytometry by Emily K. Makowski, Lina Wu, Alec A. Desai, Peter M. Tessier

Subjects: Get full text

Impact of spill-in counts from off-target regions on [18F]Flortaucipir PET quantification by Francisco J. López-González, Alejandro Costoya-Sánchez, José Paredes-Pacheco, Alexis Moscoso, Jesús Silva-Rodríguez, Pablo Aguiar

Subjects: Get full text

Sex differences in off-target binding using tau positron emission tomography by Ruben Smith, Olof Strandberg, Antoine Leuzy, Tobey J. Betthauser, Sterling C. Johnson, Joana B. Pereira, Oskar Hansson

Subjects: Get full text

GLiDe: a web-based genome-scale CRISPRi sgRNA design tool for prokaryotes by Tongjun Xiang, Huibao Feng, Xin-hui Xing, Chong Zhang

Subjects: Get full text

HLA-E Binding Peptide as a Potential Therapeutic Candidate for High-Risk Multiple Myeloma by Ying Yang, Zhuogang Liu, Hongtao Wang, Guojun Zhang

Subjects: Get full text

Biological representation of chemicals using latent target interaction profile by Mohamed Ayed, Hansaim Lim, Lei Xie

Subjects: Get full text

A brief review of protein–ligand interaction prediction by Lingling Zhao, Yan Zhu, Junjie Wang, Naifeng Wen, Chunyu Wang, Liang Cheng

Subjects: Get full text

Genome-wide Cas9 binding specificity in Saccharomyces cerevisiae by Zachary J. Waldrip, Piroon Jenjaroenpun, Oktawia DeYoung, Intawat Nookaew, Sean D. Taverna, Kevin D. Raney, Alan J. Tackett

Subjects: Get full text

Polypharmacology of Berberine Based on Multi-Target Binding Motifs by Ming Chu, Ming Chu, Xi Chen, Jing Wang, Likai Guo, Likai Guo, Qianqian Wang, Qianqian Wang, Zirui Gao, Jiarui Kang, Mingbo Zhang, Jinqiu Feng, Jinqiu Feng, Qi Guo, Binghua Li, Binghua Li, Chengrui Zhang, Chengrui Zhang, Xueyuan Guo, Xueyuan Guo, Zhengyun Chu, Yuedan Wang, Yuedan Wang

Subjects: Get full text

Drug-target binding affinity prediction using message passing neural network and self supervised learning by Leiming Xia, Lei Xu, Shourun Pan, Dongjiang Niu, Beiyi Zhang, Zhen Li

Subjects: “…Drug-target binding affinity…”
Get full text

Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson’s case by Marta Marquié, Eline E. Verwer, Avery C. Meltzer, Sally Ji Who Kim, Cinthya Agüero, Jose Gonzalez, Sara J. Makaretz, Michael Siao Tick Chong, Prianca Ramanan, Ana C. Amaral, Marc D. Normandin, Charles R. Vanderburg, Stephen N. Gomperts, Keith A. Johnson, Matthew P. Frosch, Teresa Gómez-Isla

Subjects: Get full text

SubMDTA: drug target affinity prediction based on substructure extraction and multi-scale features by Shourun Pan, Leiming Xia, Lei Xu, Zhen Li

Subjects: “…Drug–target binding affinity…”
Get full text

MTAF–DTA: multi-type attention fusion network for drug–target affinity prediction by Jinghong Sun, Han Wang, Jia Mi, Jing Wan, Jingyang Gao

Subjects: “…Drug–target binding affinity…”
Get full text

Off-target binding of an anti-amyloid beta monoclonal antibody to platelet factor 4 causes acute and chronic toxicity in cynomolgus monkeys by Lise I. Loberg, Meha Chhaya, Alexander Ibraghimov, Edit Tarcsa, Andreas Striebinger, Andreas Popp, Lili Huang, Frank Oellien, Stefan Barghorn

Subjects: Get full text

Calmodulin mutations affecting Gly114 impair binding to the NaV1.5 IQ-domain by Malene Brohus, Ana-Octavia Busuioc, Reinhard Wimmer, Mette Nyegaard, Michael Toft Overgaard

Subjects: Get full text

Improving Identification of Drug-Target Binding Sites Based on Structures of Targets Using Residual Graph Transformer Network by Shuang-Qing Lv, Xin Zeng, Guang-Peng Su, Wen-Feng Du, Yi Li, Meng-Liang Wen

Subjects: “…drug-target binding sites…”
Get full text