APLASIA DE MEDULA ÓSSEA HEPATITE B-RELACIONADA: RELATO DE CASO by MT Souza, IA Campinas, LP Menezes, RO Coelho, BB Cal, ME Pelicer, BB Arnold, LO Cantadori, RD Gaiolla, L Niero-Melo

“…Embora o quadro clínico de entrada tenha sido frustro, o exame sorológico levou ao diagnóstico de AMOAH por VHB, com pronta demanda para tratamento (Tenofovir e Suporte Transfusional). Discussão: AA é entidade rara, com incidência estimada entre 1 - 6 casos/milhão/ano, podendo ser congênita ou adquirida, sem preferência entre sexos, com acometimento bimodal entre adulto jovem e idosos. …”
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Maternal ART throughout gestation prevents caudate volume reductions in neonates who are HIV exposed but uninfected by Abdulmumin Ibrahim, Abdulmumin Ibrahim, Fleur L. Warton, Fleur L. Warton, Samantha Fry, Mark F. Cotton, Sandra W. Jacobson, Sandra W. Jacobson, Joseph L. Jacobson, Joseph L. Jacobson, Christopher D. Molteno, Francesca Little, Andre J. W. van der Kouwe, Andre J. W. van der Kouwe, Andre J. W. van der Kouwe, Barbara Laughton, Ernesta M. Meintjes, Ernesta M. Meintjes, Ernesta M. Meintjes, Martha J. Holmes, Martha J. Holmes

“…Mothers with HIV received standard care fixed drug combination ART (Tenofovir/Efavirenz/Emtricitabine). Infants were imaged unsedated on a 3T Skyra (Siemens, Erlangen, Germany) at mean GA equivalent of 41.5 (± 1.0) weeks. …”
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Single oral dose for HIV pre or post-exposure prophylaxis: user desirability and biological efficacy in macaques by Ivana Massud, Susan Ruone, Maria Zlotorzynska, Richard Haaland, Patrick Mills, Mian-er Cong, Kristen Kelley, Ryan Johnson, Angela Holder, Chuong Dinh, George Khalil, Yi Pan, Colleen F. Kelley, Travis Sanchez, Walid Heneine, J. Gerardo García-Lerma

“…We investigated willingness to use a single oral pill before or after sex among men who have sex with men (MSM) and assessed the biological efficacy of a potent antiretroviral combination containing elvitegravir (EVG), emtricitabine (FTC), and tenofovir alafenamide (TAF). Methods: Data on willingness to use single-dose PrEP or PEP were obtained from the 2017 cycle of the American Men's Internet Survey (AMIS), an annual online behavioral surveillance survey of MSM in the United States. …”
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Implementation and outcomes of dolutegravir-based first-line antiretroviral therapy for people with HIV in South Africa: a retrospective cohort study by Dorward, J, Sookrajh, Y, Khubone, T, van der Molen, J, Govender, R, Phakathi, S, Lewis, L, Bottomley, C, Maraj, M, Lessells, RJ, Naidoo, K, Butler, CC, Van Heerden, R, Garrett, N

“…The median age was 38 years (IQR 32–45), and the median time on ART was 3·9 years (2·0–6·4) years, with most people receiving efavirenz (178 624 [98·7%] people) and tenofovir (178 148 [98·4%]). By Feb 28, 2022, 121 174 (67·0%) of 180 956 people had transitioned to first-line dolutegravir at a median of 283 days (IQR 203–526). …”

Optimizing bone health in people living with HIV: insights from a network meta-analysis of randomized controlled trialsResearch in context by Jui-Chien Wang, Sun-Mei Chung, Po-Ting Wu, Yu-Kang Tu, Pei-Chun Lai, Ta-Wei Tai, Chih-Hsing Wu, Yin-Fan Chang, Fa-Chuan Kuan, Kai-Lan Hsu, Ching-Ju Fang, Chia-Wen Li, Po-Lin Chen, Chien-An Shih

“…Both HIV infection and long-term antiretroviral therapy (ART), particularly tenofovir disoproxil fumarate (TDF), are associated with early-onset osteoporosis. …”
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Plasma Viral Load of 200 Copies/mL is a Suitable Threshold to Define Viral Suppression and HIV Drug Resistance Testing in Low- and Middle-Income Countries: Evidence From a Facility... by Collins Ambe Chenwi MD, MSc, Rachel Audrey Nayang Mundo MSc, Alex Durand Nka MSc, PhD, Ezechiel Ngoufack Jagni Semengue MSc, PhD, Grâce Angong Beloumou MSc, Aude Christelle Ka’e MSc, PhD, Willy Leroi Togna Pabo MSc, Désiré Takou MSc, Aissatou Abba MSc, Sandrine Claire Djupsa MSc, Evariste Molimbou MSc, Naomi-karell Etame MSc, Aurelie Minelle Kengni Ngueko MSc, David Kob Same MD, MPH, Jolle Nounouce Bouba Pamen MSc, PhD, Aristide Stephane Abah Abah MD, MPH, Serge Clotaire Billong MD, Rogers Ajeh Awoh MPH, PhD, Gregory Edie Halle-Ekane MD, Giulia Cappelli MSc, PhD, Anne-Esther Njom-Nlend MD, Anne-Cecile ZK Bissek MD, Elvis Temfack MD, PhD, Maria Mercedes Santoro MSc, PhD, Francesca Ceccherini-Silberstein MSc, PhD, Vittorio Colizzi MD, PhD, Jean Kaseya MD, MPH, Nicaise Ndembi MSc, PhD, Alexis Ndjolo MD, Carlo Federico Perno MD, PhD, Joseph Fokam MSc, PhD, PGD

“…We evaluated sequencing success rates (SSR) at LLV, described HIVDR profiles and adequacy with potential efficacy of tenofovir-lamivudine-dolutegravir (TLD). Methods A cross-sectional study was conducted among individuals with LLV at the Chantal BIYA International Reference Centre, Yaoundé, Cameroon from January 2020 through August 2021. …”
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BREATHER (PENTA 16) short-cycle therapy (SCT) (5 days on/2 days off) in young people with chronic human immunodeficiency virus infection: an open, randomised, parallel-group Phase... by Karina Butler, Jamie Inshaw, Deborah Ford, Sarah Bernays, Karen Scott, Julia Kenny, Nigel Klein, Anna Turkova, Lynda Harper, Eleni Nastouli, Sara Paparini, Rahela Choudhury, Tim Rhodes, Abdel Babiker, Diana Gibb, on behalf of the PENTA team

“…Further trials of SCT in settings with infrequent VL monitoring and with other antiretroviral drugs such as tenofovir alafenamide, which has a long intracellular half-life, and/or dolutegravir, which has a higher barrier to resistance, are planned. …”
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Human immunodeficiency virus prevention and testing strategies among men who have sex with men in the UK: the PANTHEON research programme including the SELPHI RCT by Janey Sewell, T Charles Witzel, David Dunn, Fiona Lampe, Fiona Burns, Peter Weatherburn, Sheena McCormack, Leanne McCabe, Alec Miners, Valentina Cambiano, Roger Pebody, Roy Trevelion, Nadia Hanum, Andrew Phillips, Alison Rodger

“…Modelling suggested that provision of oral tenofovir/emtricitabine pre-exposure prophylaxis increased human immunodeficiency virus testing, with anti-retroviral therapy initiation at diagnosis, and reductions in the level of condom-less sex, that each played an important role in decreasing human immunodeficiency virus incidence among men who have sex with men, and that the current human immunodeficiency virus incidence would have been double what it is if any one of them had not occurred. …”
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