Trehalose Attenuates Oxidative Stress and Endoplasmic Reticulum Stress-Mediated Apoptosis in IPEC-J2 Cells Subjected to Heat Stress by Fan Mo, Xu Zhou, Mengting Yang, Leyi Chen, Zhining Tang, Chong Wang, Yanjun Cui

“…This study was carried out to investigate the effects of trehalose (Tre) on antioxidant capacity, endoplasmic reticulum stress (ERS) response and apoptosis of heat-stressed intestinal porcine epithelial cells (IPEC-J2). …”
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Real-world effectiveness of voxilaprevir/velpatasvir/sofosbuvir in patients following DAA failure by Christiana Graf, Roberta D’Ambrosio, Elisabetta Degasperi, Stefania Paolucci, Jordi Llaneras, Johannes Vermehren, Georg Dultz, Kai-Henrik Peiffer, Fabian Finkelmeier, Eva Herrmann, Stefan Zeuzem, Maria Buti, Pietro Lampertico, Julia Dietz, Christoph Sarrazin

“…Most patients were infected with HCV genotype 1 (56%) and 3 (32%). 86% of patients carried resistance-associated substitutions in the NS3, NS5A or NS5B regions. …”
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A modified LC-MS/MS method for the detection of whole blood tacrolimus and its clinical value in Chinese kidney transplant patients by Ke-Wei Yu, Bing-Ling Li, Ying-Shi Yuan, Jia-Min Liao, Wei-Kang Li, Heng Dong, Pei-Feng Ke, Xing Jin, Lu Chen, Jing-Jing Zhao, Heng Wang, Shun-Wang Cao, Wei-Ye Chen, Xian-Zhang Huang, Bei-Bei Zhao, Chun-Min Kang

“…In this way, the instrument throughput is also improved and realizing the detection of 2 samples within 3.5 min and carried out a shorter analyzing time for each sample of 1.75 min. …”
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A TNFR2-Specific TNF Fusion Protein With Improved In Vivo Activity by Juan Gamboa Vargas, Juan Gamboa Vargas, Jennifer Wagner, Haroon Shaikh, Haroon Shaikh, Isabell Lang, Juliane Medler, Mohamed Anany, Mohamed Anany, Tim Steinfatt, Josefina Peña Mosca, Josefina Peña Mosca, Stephanie Haack, Julia Dahlhoff, Maike Büttner-Herold, Carolin Graf, Estibaliz Arellano Viera, Hermann Einsele, Harald Wajant, Andreas Beilhack, Andreas Beilhack

“…With the aim to improve the in vivo availability of TNFR2-specific TNF fusion proteins, we used here the neonatal Fc receptor (FcRn)-interacting IgG1 molecule as an oligomerizing building block and generated a new TNFR2 agonist with improved serum retention and superior in vivo activity.MethodsSingle-chain encoded murine TNF80 trimers (sc(mu)TNF80) were fused to the C-terminus of an in mice irrelevant IgG1 molecule carrying the N297A mutation which avoids/minimizes interaction with Fcγ-receptors (FcγRs). …”
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Estado nutricional y marcadores de estrés oxidativo en trabajadores agrícolas, Arroyo Naranjo, 2019 / Nutritional status and oxidative stress markers in agricultural workers from t... by Luana Argote Ravelo, Lucía Fariñas Rodríguez, Judith Pupo Balboa, Gladys Rabelo Padua, Amarilis Pandolfi Blanco, Giselle Lemus Molina, María del Carmen Batlles Almodóvar, Elen García Silva, Waldo Jacobo Díaz Piñera, Julieta Nodarse Silva

“…Methods: A descriptive and cross-sectional study was carried out with a sample of 68 workers obtained by random sampling and classified, according to body mass index, in three groups: normal weight, overweight and obese. …”
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Consenso sobre el diagnóstico y el tratamiento de la alergia a las proteínas de la leche de vaca de la Sociedad Latinoamericana de Gastroenterología, Hepatología y Nutrición by M.C. Toca, M.B. Morais, R. Vázquez-Frias, D.J. Becker-Cuevas, C.G. Boggio-Marzet, L. Delgado-Carbajal, M.M. Higuera-Carrillo, L. Ladino, S. Marchisone, G.C. Messere, G.J. Ortiz, L.R. Ortiz-Paranza, C. Ortiz-Piedrahita, J.P. Riveros-López, P.C. Sosa, N.C. Villalobos-Palencia

“…A search of the medical literature was carried out to support the information presented in each module and 28 statements were then selected. …”
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Shedding Light on the Role of Na,K-ATPase as a Phosphatase during Matrix-Vesicle-Mediated Mineralization by Heitor Gobbi Sebinelli, Luiz Henrique Silva Andrilli, Bruno Zoccaratto Favarin, Marcos Aantonio Eufrasio Cruz, Maytê Bolean, Michele Fiore, Carolina Chieffo, David Magne, Andrea Magrini, Ana Paula Ramos, José Luis Millán, Saida Mebarek, Rene Buchet, Massimo Bottini, Pietro Ciancaglini

“…It was hypothesized that the loss of Na/K asymmetry in MVs could be caused by a complete depletion of ATP inside MVs, impairing the maintenance of symmetry by NKA. Our study carried out on NKA-liposomes confirmed that NKA could contribute to mineral formation inside MVs, which might complement the known action of PHOSPHO1 in the MV lumen.…”
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Prescripción de ejercicio en pacientes con cirrosis: recomendaciones para la atención clínica by R.U. Macías-Rodríguez, A. Ruiz-Margáin, B.M. Román-Calleja, E. Moreno-Tavarez, L. Weber-Sangri, M.F. González-Arellano, G. Fernández-del-Rivero, K. Ramírez-Soto

“…Even though some studies have reported an acute, exercise-induced increase in the hepatic venous pressure gradient (HVPG), the opposite (a decrease in the HVPG) has been shown by recent data after an exercise program carried out for >14 weeks. In addition to that benefit, improvement has been described in the metabolic profile, quality of life, muscle mass, cardiopulmonary function, and nutritional status. …”
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Feasibility, acceptability and practicality of transcranial stimulation in obsessive compulsive symptoms (FEATSOCS): A randomised controlled crossover trial by Naomi A. Fineberg, Eduardo Cinosi, Megan V.A. Smith, Amanda D. Busby, David Wellsted, Nathan T.M. Huneke, Kabir Garg, Ibrahim H. Aslan, Arun Enara, Matthew Garner, Robert Gordon, Natalie Hall, Daniel Meron, Trevor W. Robbins, Solange Wyatt, Luca Pellegrini, David S. Baldwin

“…Each course comprised four 20-min 2 mA stimulations, delivered over two consecutive days, separated by a ‘washout’ period of at least four weeks. Assessments were carried out by raters who were blind to stimulation-type. …”
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Terahertz Rotational Spectroscopy of Greenhouse Gases Using Long Interaction Path-Lengths by Arnaud Cuisset, Francis Hindle, Gaël Mouret, Robin Bocquet, Jonas Bruckhuisen, Jean Decker, Anastasiia Pienkina, Cédric Bray, Éric Fertein, Vincent Boudon

“…To illustrate, new measurements on CH<inline-formula><math display="inline"><semantics><msub><mrow></mrow><mn>4</mn></msub></semantics></math></inline-formula> and CF<inline-formula><math display="inline"><semantics><msub><mrow></mrow><mn>4</mn></msub></semantics></math></inline-formula> have been carried out. For CH<inline-formula><math display="inline"><semantics><msub><mrow></mrow><mn>4</mn></msub></semantics></math></inline-formula>, pure rotational transitions, recorded by cw-THz photomixing up to 2.6 THz in a White type cell adjusted to 20 m, have allowed to update the methane line list of atmospheric databases. …”
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Spatial modeling, risk mapping, change detection, and outbreak trend analysis of coronavirus (COVID-19) in Iran (days between February 19 and June 14, 2020) by Hamid Reza Pourghasemi, Soheila Pouyan, Bahram Heidari, Zakariya Farajzadeh, Seyed Rashid Fallah Shamsi, Sedigheh Babaei, Rasoul Khosravi, Mohammad Etemadi, Gholamabbas Ghanbarian, Ahmad Farhadi, Roja Safaeian, Zahra Heidari, Mohammad Hassan Tarazkar, John P. Tiefenbacher, Amir Azmi, Faezeh Sadeghian

“…Methods: This is the first comprehensive study of COVID-19 in Iran; and it carries out spatial modeling, risk mapping, change detection, and outbreak trend analysis of the disease spread. …”
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Digging into the NGS Information from a Large-Scale South European Population with Metastatic/Unresectable Pancreatic Ductal Adenocarcinoma: A Real-World Genomic Depiction by Dimitrios C. Ziogas, Eirini Papadopoulou, Helen Gogas, Stratigoula Sakellariou, Evangellos Felekouras, Charalampos Theocharopoulos, Dimitra T. Stefanou, Maria Theochari, Ioannis Boukovinas, Dimitris Matthaios, Anna Koumarianou, Eleni Zairi, Michalis Liontos, Konstantinos Koutsoukos, Vasiliki Metaxa-Mariatou, George Kapetsis, Angeliki Meintani, Georgios N. Tsaousis, George Nasioulas

“…<i>BRCA1/2</i> variants with on-label indications were detected in 2%, and 87.50% carried a variant associated with off-label treatment (<i>KRAS</i>, <i>ERBB2</i>, <i>STK11</i>, or HRR-genes), while 3.5% of the alterations had unknown/preliminary-studied actionability (<i>TP53/CDKN2A</i>). …”
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Chemical Composition and Biological Properties of Two <i>Jatropha</i> Species: Different Parts and Different Extraction Methods by Gokhan Zengin, Mohamad Fawzi Mahomoodally, Kouadio Ibrahime Sinan, Gunes Ak, Ouattara Katinan Etienne, Jugreet B. Sharmeen, Luigi Brunetti, Sheila Leone, Simonetta Cristina Di Simone, Lucia Recinella, Annalisa Chiavaroli, Luigi Menghini, Giustino Orlando, József Jekő, Zoltán Cziáky, Claudio Ferrante

“…Finally, a bioinformatics analysis was carried out with the aim to unravel the putative mechanisms consistent with both metabolomic fingerprints and pharmacological effects. …”
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The Responses of Leaf Litter Calcium, Magnesium, and Manganese Dynamics to Simulated Nitrogen Deposition and Reduced Precipitation Vary with Different Decomposition Stages by Shixing Zhou, Gang Yan, Junxi Hu, Xiong Liu, Xingcheng Zou, Liehua Tie, Rongze Yuan, Yudie Yang, Lin Xiao, Xinglei Cui, Lihua Tu, Jiaming Lai, Anjiu Zhao, Congde Huang

“…Thus, to better understand Ca, Mg, and Mn dynamics during leaf litter decomposition in the scenario of increasing N deposition and decreasing precipitation, we carried out a two-year field litterbag experiment in a natural evergreen broad-leaved forest in the central area of the rainy area of Western China. …”
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The Asociación Mexicana de Gastroenterología consensus on the diagnosis and treatment of acute pancreatitis in children and adolescents by R. Vázquez-Frias, Y. Rivera-Suazo, A.K. Aguayo-Elorriaga, J.E. Alfaro-Bolaños, G.A. Argüello-Arévalo, J.F. Cadena-León, J.A. Chávez-Sáenz, A. Consuelo-Sánchez, E.V. Cruz-Romero, D. Espinosa-Saavedra, M.X. Espriu-Ramírez, J. Flores-Calderón, B. González-Ortiz, V. Hernández-Rosiles, K.R. Ignorosa-Arellano, C.M. Jaramillo-Esparza, F.R. Lozano-Hernández, A. Larrosa-Haro, U. Leal-Quiroga, J.A. Macias-Flores, B.A. Martínez-Leo, A. Martínez-Vázquez, N.M.J. Mendoza-Tavera, S. Pacheco-Sotelo, M. Reyes-Apodaca, C.A. Sánchez-Ramírez, C.A. Sifuentes-Vela, M. Sosa-Arce, F.E. Zárate-Mondragón

“…Despite the ever-increasing evidence regarding the management of AP in children and adults, therapeutic actions that could potentially affect having a poor prognosis in those patients, especially in the pediatric population, continue to be carried out. Therefore, the Asociación Mexicana de Gastroenterología convened a group of 24 expert pediatric gastroenterologists from different institutions and areas of Mexico, as well as 2 pediatric nutritionists and 2 specialists in pediatric surgery, to discuss different aspects of the epidemiology, diagnosis, and treatment of AP and RAP in the pediatric population. …”
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Tibetan medicine Jiuwei Qingpeng San could inhibit influenza A virus induced lung injury via regulating the expression of IFN-γ and its signaling pathway by Liu Wei, Li Chufang, Song Jian, Li Jintao, Liang Liren, Cai Kaiyin, Wang Yinong, Chen Weiwu, Chen Lvyi, Hou Hongping, Mingji Cuomu, Zhong Nanshan

“…A replication competent PR8 carrying Gaussia luciferase (PR8-Luci) was further utilized to infect BEAS-2B cells to determine the inhibitory activity of virus replication by detection of the intensity of bioluminescence that correlates with viral load. …”
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Use of Radiology, D-Dimer, and Mean Platelet Volume Combination as a Prognostic Marker in Hospitalized Coronavirus Disease-19 Patients by Nagihan Durmus Kocak, Ozlem Oruc, Sibel Boga, Cem Acar, Murat Kavas, Selma Aydogan Eroglu, Baran Gundogus, Ozlem Sogukpinar, Sumeyye Bekir, Aysem Askim Oztin Guven, Makbule Ozlem Akbay, Sibel Arinc, Dildar Duman, Huriye Berk Takir, Feride Yaman, Fatma Ozbaki, Esin Sonkaya, Esra Usta Bulbul, Dilem Anil Tokyay, Lale Dagyildizi, Ulku Aka Akturk, Selahattin Oztas, Dilek Ernam, Gokay Gungor, Nalan Adiguzel, Tekin Yildiz, Ozlem Yazicioglu Mocin, Hakan Gunen, Reyhan Yildiz, Tulin Sevim, Tulay Torun

“…Receiver operator curve (ROC) analyzes were carried out to assess the efficacy of D-dimer and MPV parameters as prognostic markers.ResultsBetween the mentioned dates, 575 of 1,564 patients were found to be compatible with COVID-19, and the number of patients who were included in the study was 306. …”
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Preliminary Assessment and Verification of the Langley Plots Calibration of the Sun Photometer at Mt Foyeding Observatory, Beijing by Yu Zheng, Huizheng Che, Ke Gui, Xiangao Xia, Hujia Zhao, Lei Li, Lei Zhang, Xinglu Zhang, Hengheng Zhao, Yuanxin Liang, Hong Wang, Yaqiang Wang, Xiaoye Zhang

“…We explored whether the Langley plot calibration is practicable for this mountainous site by analyzing the aerosol climatology and carrying out a case study. Then, the aerosol optical depth (AOD) results were verified under the reference of AERONET AOD. …”
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Association of High‐Sensitivity Troponin T and I Blood Concentrations With All‐Cause Mortality and Cardiovascular Outcome in Stable Patients—Results From the INTERCATH Cohort by Benjamin Bay, Alina Goßling, Christopher M. Blaum, Friederike Kroeger, Luise Koppe, Thiess Lorenz, Lukas Koester, Peter Clemmensen, Dirk Westermann, Paulus Kirchhof, Stefan Blankenberg, Tanja Zeller, Moritz Seiffert, Christoph Waldeyer, Fabian J. Brunner

“…To investigate the association of hsTnT and hsTnI with outcome, a multivariable analysis adjusting for classical cardiovascular risk factors, low‐density lipoprotein cholesterol, estimated glomerular filtration rate, hs‐CRP (high‐sensitivity C‐reactive protein), NT‐proBNP (N‐terminal pro–brain natriuretic peptide), and Gensini score was carried out. Of 1829 patients, 27.9% were women, and the mean age was 68.6±10.9 years. …”
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Robotic Versus Laparoscopic Gastrectomy for Gastric Cancer: A Mega Meta-Analysis by Shantanu Baral, Shantanu Baral, Shantanu Baral, Mubeen Hussein Arawker, Mubeen Hussein Arawker, Qiannan Sun, Qiannan Sun, Qiannan Sun, Mingrui Jiang, Mingrui Jiang, Mingrui Jiang, Liuhua Wang, Liuhua Wang, Liuhua Wang, Yong Wang, Yong Wang, Yong Wang, Muhammad Ali, Muhammad Ali, Muhammad Ali, Daorong Wang, Daorong Wang, Daorong Wang, Daorong Wang

“…To systematically assess the safety and effectiveness of robotic gastrectomy for gastric cancer, we carried out a systematic review and meta-analysis on short-term and long-term outcomes of robotic gastrectomy.MethodsIn order to find relevant studies on the efficacy and safety of robotic gastrectomy (RG) and laparoscopic gastrectomy (LG) in the treatment of gastric cancer, numerous medical databases including PubMed, Medline, Cochrane Library, Embase, Google Scholar, and China Journal Full-text Database (CNKI) were consulted, and Chinese and English studies on the efficacy and safety of RG and LG in the treatment of gastric cancer published from 2012 to 2022 were screened according to inclusion and exclusion criteria, and a meta-analysis was conducted using RevMan 5.4 software.ResultsThe meta-analysis inlcuded 48 literatures, with 20,151 gastric cancer patients, including 6,175 in the RG group and 13,976 in the LG group, respectively. …”
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