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290261
Stem-Loop I of the Tembusu Virus 3′-Untranslated Region Is Responsible for Viral Host-Specific Adaptation and the Pathogenicity of the Virus in Mice
Published 2022-10-01“…Compared with rMM 1775, rMM-CQ3′UTR (recombinant MM 1775 virus carrying the 3′UTR of CQW1) exhibited enhanced proliferation in vitro, with peak titers increasing by 5-fold in duck embryonic fibroblast (DEF) cells or 12-fold in baby hamster kidney (BHK-21) cells; however, the neurovirulence of rMM-CQ3′UTR was attenuated in 14-day-old Kunming mice via intracranial injection, with slower weight loss, lower mortality, and reduced viral loads. …”
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290262
Population structure and antimicrobial resistance patterns of Salmonella Typhi and Paratyphi A amid a phased municipal vaccination campaign in Navi Mumbai, India
Published 2023-08-01“…Most isolates were non-susceptible to fluoroquinolones, with nearly 20% containing ≥3 quinolone resistance-determining region mutations. Two H58 isolates carried an IncX3 plasmid containing blaSHV-12, associated with ceftriaxone resistance, suggesting that the ceftriaxone-resistant isolates from India independently evolved on multiple occasions. …”
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290263
Phytochemistry and Biological Activities of Essential Oils from Six Aromatic Medicinal Plants with Cosmetic Properties
Published 2023-04-01“…The analysis of the chemical composition carried out by GC-MS showed the presence of 30 to 35 compounds and represent between 99.97% and 100% of the total composition of EOs, with a variation in the chemical composition detected at the level of the majority compounds between these species. …”
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290264
The Effects of Telmisartan and Its Combinations on Office Blood Pressure: Results of Prospective Observational Study TAINA
Published 2020-05-01“…The study was a non-intervention, prospective, multicenter, comparative, observational, epidemiological program, which was carried out in Russian medical institutions. The total patient population in which the prescribed therapy was administered included 1933 people (758 men and 1175 women, mean age 57.0-59.3 years). …”
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290265
Effect of breathing intervention in patients with COVID and healthcare workers
Published 2022-09-01“…Pre-post estimation of neuropsychological parameters (nine questionnaires) and heart rate variability (HRV) were carried out. The paired t-test or Wilcoxon rank test was applied for pre-post comparison and the Student's t-test or Mann–Whitney U test was used for group comparison. …”
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290266
Case report: Identification of facioscapulohumeral muscular dystrophy 1 in two siblings with normal phenotypic parents using optical genome mapping
Published 2024-02-01“…The proband's father, who was found to be normal after a neurological examination, also carried the 4qA allele with eight D4Z4 repeat units. …”
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290267
A systematic review and meta-analysis of digital application use in clinical research in pain medicine
Published 2022-11-01“…Out of the 84 studies that were initially identified, 38 were included in the systematic review.Data extraction and synthesisThe AMSTAR guidelines were used to assess data quality. This assessment was carried out by 3 reviewers. The data were pooled using a random-effects model.Main outcome(s) and measure(s)Before data collection began, the primary outcome was to report on the standard mean difference of digital application usage for chronic pain conditions. …”
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290268
Practice of continuing care with Traditional Chinese Medicine nursing for patients after surgical treatment of mixed hemorrhoids in the specialized outpatient clinic (基于专病门诊的混合痔术后患...
Published 2022-01-01“…Patients in the control group received routing telephone follow-up and health education after discharged form hospital, and those in the observation group were given continuing care with Traditional Chinese Medicine nursing in the specialized outpatient clinic, and a three-step integrated management of follow-up was carried out. The occurrence of postoperative complications was assessed, and patient satisfaction was evaluated by using a self-made questionnaire. …”
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290269
Radiation doses to the population of the Russian Federation in 2020
Published 2021-12-01“…The authors have analyzed the data contained in the forms of state statistical observation No. 1-DOZ, No. 2-DOZ, No. 3-DOZ and No. 4-DOZ for 2020 submitted by the organizations and territories, the state sanitary and epidemiological supervision of which was carried out by Rospotrebnadzor and Federal Medical Biological Agency of Russia. …”
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290270
Consenso de la Asociación Mexicana de Gastroenterología sobre el diagnóstico y tratamiento de pancreatitis aguda en niñas, niños y adolescentes
Published 2023-07-01“…Despite the ever-increasing evidence regarding the management of AP in children and adults, therapeutic actions that could potentially affect having a poor prognosis in those patients, especially in the pediatric population, continue to be carried out. Therefore, the Asociación Mexicana de Gastroenterología convened a group of 24 expert pediatric gastroenterologists from different institutions and areas of Mexico, as well as 2 pediatric nutritionists and 2 specialists in pediatric surgery, to discuss different aspects of the epidemiology, diagnosis, and treatment of AP and RAP in the pediatric population. …”
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290271
Investigating miR-9 as a mediator in laryngeal cancer health disparities
Published 2023-04-01“…BackgroundFor several decades, Black patients have carried a higher burden of laryngeal cancer among all races. …”
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290272
Capillary leak syndrome following COVID-19 vaccination: Data from the European pharmacovigilance database Eudravigilance
Published 2022-09-01“…Our pharmacovigilance study aims to evaluate the CLS onset following receipt of COVID-19 mRNA vaccines (mRNA-1273 and BNT162b2) compared to viral vector vaccines (Ad26.COV2-S and ChAdOx1-SARS-COV-2). We carried a cross-sectional study using all Individual Case Safety Reports (ICSRs) reporting a COVID-19 vaccine as suspected drug and CLS as AEFI, which were collected in the pharmacovigilance database EudraVigilance from January 1st, 2021, to January 14th, 2022. …”
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290273
Non‐invasive diagnosis and surveillance of bladder cancer with driver and passenger DNA methylation in a prospective cohort study
Published 2022-08-01“…BLCA‐specific DNAm signature discovery was carried out with genome‐wide bisulfite sequencing in 32 tumour tissues and 12 normal urine samples. …”
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290274
In- silico evaluation of bioactive compounds from selected medicinal plants from Southern Nigeria against hepatitis C virus genotype 1 RNA-directed RNA polymerase
Published 2023-11-01“…The collection of plant parts and phytochemical screening via gas chromatography-mass spectrophotometer (GC–MS) were carried out. Resulting bioactive compounds and a control HCV drug, remdesivir, were screened for ADMET properties using the pkCSM online prediction tool, while molecular docking was performed using AutoDockTool 1.5.6 and the resulting interactions visualised in 2-Dimension using Discovery Studio 2022 Client. …”
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290275
Sustained viral response and relapse after discontinuation of oral antiviral drugs in HBeAg-positive patients with chronic hepatitis B infection
Published 2022-11-01“…During the follow-up, the antiviral treatment information of the patients was collected, and the follow-up observation was carried out every 3 months since the enrollment. We monitored the virological indexes, liver and kidney function, serology and liver imaging during follow-up. …”
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290276
Clinical outcomes after vena cava thrombectomy for renal cell carcinoma with venous extension – institutional experience
Published 2023-01-01“…METHODS: Retrospective analysis of a single-center consecutive serie of patients with RCC and IVC tumor thrombi treated with surgery in our department between 2012 and 2021 was carried out. Demographic data, diagnostic and procedural characteristics, clinical outcomes and survival analysis were examined. …”
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290277
Effects of remnant cholesterol on the efficacy of genotype-guided dual antiplatelet in CYP2C19 loss-of -function carriers with minor stroke or transient ischaemic attack: a post-ho...
Published 2024-01-01“…Methods: This post-hoc study used data from the CHANCE-2 trial, which was a randomised, double-blind, placebo-controlled trial of 6412 patients (aged >40 years) enrolled from 202 hospitals in China, between Sept 23, 2019, and March 22, 2021, who carried CYP2C19 loss-of-function alleles and had either an acute minor stroke or high-risk transient ischaemic attack (TIA), and could start treatment within 24 h of symptom onset. …”
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290278
Measurement report: On the difference in aerosol hygroscopicity between high and low relative humidity conditions in the North China Plain
Published 2022-04-01“…Using <span class="inline-formula">O:C</span>-dependent hygroscopic parameters of secondary organic compounds (<span class="inline-formula"><i>κ</i><sub>SOA</sub></span>), closure analysis between the HTDMA-measured <span class="inline-formula"><i>κ</i></span> and the ACSM-derived <span class="inline-formula"><i>κ</i></span> was carried out. The results showed that <span class="inline-formula"><i>κ</i><sub>SOA</sub></span> under the LRH episode was less sensitive to the changes in organic oxidation level, while <span class="inline-formula"><i>κ</i><sub>SOA</sub></span> under HRH had a relatively stronger dependency on the organic <span class="inline-formula">O:C</span> ratio. …”
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290279
Isolation and Characterization of Three Pseudomonas aeruginosa Viruses with Therapeutic Potential
Published 2023-06-01“…Following full-genome sequencing, we found that phage PA_LZ01 contained a genome of 65,367 bp in size and harbored 90 predicted open reading frames (ORFs), phage PA_LZ02 contained a genome of 57,243 bp in size and harbored 75 predicted ORFs, and phage PA_LZ03 contained a genome of 57,367 bp in size and carried 77 predicted ORFs. Further comparative analysis showed that phage PA_LZ01 belonged to the genus Pbunavirus genus, phage PA_LZ02 belonged to the genus Pamexvirus, and phage PA_LZ03 belonged to the family Mesyanzhinovviridae. …”
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290280
Four missense genetic variants in CUBN are associated with higher levels of eGFR in non-diabetes but not in diabetes mellitus or its subtypes: A genetic association study in Europe...
Published 2023-02-01“…Furthermore, we sought to deepen our understanding of these variants in a range of single- and aggregate- variant analyses of other kidney-related traits in individuals with and without diabetes mellitus.MethodsWe carried out a genetic association-based linear regression analysis between four CUBN missense variants (rs141640975, rs144360241, rs45551835, rs1801239) and eGFRcreatinine (ml/min/1.73 m2, CKD-EPIcreatinine(2012), natural log-transformed) in populations with T1D (n ~ 3,588) or T2D (n ~ 31,155) from multiple European studies and in individuals without diabetes from UK Biobank (UKBB, n ~ 370,061) with replication in deCODE (n = 127,090). …”
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