Stem-Loop I of the Tembusu Virus 3′-Untranslated Region Is Responsible for Viral Host-Specific Adaptation and the Pathogenicity of the Virus in Mice by Li Mao, Yu He, Zhen Wu, Xiaoli Wang, Jiaqi Guo, Senzhao Zhang, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Sai Mao, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Qun Gao, Di Sun, Anchun Cheng, Shun Chen

“…Compared with rMM 1775, rMM-CQ3′UTR (recombinant MM 1775 virus carrying the 3′UTR of CQW1) exhibited enhanced proliferation in vitro, with peak titers increasing by 5-fold in duck embryonic fibroblast (DEF) cells or 12-fold in baby hamster kidney (BHK-21) cells; however, the neurovirulence of rMM-CQ3′UTR was attenuated in 14-day-old Kunming mice via intracranial injection, with slower weight loss, lower mortality, and reduced viral loads. …”
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Population structure and antimicrobial resistance patterns of Salmonella Typhi and Paratyphi A amid a phased municipal vaccination campaign in Navi Mumbai, India by Kesia Esther da Silva, Kashmira Date, Nilma Hirani, Christopher LeBoa, Niniya Jayaprasad, Priyanka Borhade, Joshua Warren, Rahul Shimpi, Seth A. Hoffman, Matthew Mikoleit, Pankaj Bhatnagar, Yanjia Cao, Pradeep Haldar, Pauline Harvey, Chenhua Zhang, Savita Daruwalla, Dhanya Dharmapalan, Jeetendra Gavhane, Shrikrishna Joshi, Rajesh Rai, Varsha Rathod, Keertana Shetty, Divyalatha S. Warrier, Shalini Yadav, Debjit Chakraborty, Sunil Bahl, Arun Katkar, Abhishek Kunwar, Vijay Yewale, Shanta Dutta, Stephen P. Luby, Jason R. Andrews

“…Most isolates were non-susceptible to fluoroquinolones, with nearly 20% containing ≥3 quinolone resistance-determining region mutations. Two H58 isolates carried an IncX3 plasmid containing blaSHV-12, associated with ceftriaxone resistance, suggesting that the ceftriaxone-resistant isolates from India independently evolved on multiple occasions. …”
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Phytochemistry and Biological Activities of Essential Oils from Six Aromatic Medicinal Plants with Cosmetic Properties by Atika Ailli, Nadia Handaq, Hanane Touijer, Aman Allah Gourich, Aziz Drioiche, Khalid Zibouh, Brahim Eddamsyry, Fadoua El Makhoukhi, Aicha Mouradi, Yousef A. Bin Jardan, Mohammed Bourhia, Abdelhakim Elomri, Touriya Zair

“…The analysis of the chemical composition carried out by GC-MS showed the presence of 30 to 35 compounds and represent between 99.97% and 100% of the total composition of EOs, with a variation in the chemical composition detected at the level of the majority compounds between these species. …”
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The Effects of Telmisartan and Its Combinations on Office Blood Pressure: Results of Prospective Observational Study TAINA by O. D. Ostroumova, A. I. Kochetkov, F. T. Ageev, G. S. Anikin, E. Kh. Akhmetzyanova, E. I. Bezuglova, A. B. Bekoeva, N. Yu. Borovkova, N. G. Vinogradova, E. V. Gorbunova, A. A. Goryacheva, E. S. Zhugrova, O. A. Kislyak, S. M. Klyashev, V. P. Kuzmin, A. A. Lipchenko, G. V. Matyushin, E. A. Mikhailova, V. A. Nevzorova, A. G. Obrezan, T. A. Petrichko, M. M. Petrova, A. N. Reider, A. N. Repin, V. I. Sadovoy, N. P. Sanina, A. E. Skripchenko, R. I. Stryuk, I. V. Faiyance, L. A. Khaisheva, N. R. Khasanov, R. A. Khokhlov, E. E. Tsareva, A. L. Cherkashina, I. I. Shaposhnik, I. A. Shelestova, R. N. Shepel, E. V. Shikh, D. A. Yakhontov

“…The study was a non-intervention, prospective, multicenter, comparative, observational, epidemiological program, which was carried out in Russian medical institutions. The total patient population in which the prescribed therapy was administered included 1933 people (758 men and 1175 women, mean age 57.0-59.3 years). …”
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Effect of breathing intervention in patients with COVID and healthcare workers by Manjari Rain, Goverdhan Dutt Puri, Aashish Bhalla, Pramod Avti, Balachundhar Subramaniam, Vipin Kaushal, Vinod Srivastava, Pranay Mahajan, Mini Singh, Navin Pandey, Pankaj Malhotra, Sonu Goel, Krishan Kumar, Naresh Sachdeva, Kalyan Maity, Kalyan Maity, Prashant Verma, Prashant Verma, Nishant Dixit, Sheetal Jindal Gupta, Sheetal Jindal Gupta, Priya Mehra, Priya Mehra, Pooja Nadholta, Radhika Khosla, Shweta Ahuja, Akshay Anand, Akshay Anand, Akshay Anand

“…Pre-post estimation of neuropsychological parameters (nine questionnaires) and heart rate variability (HRV) were carried out. The paired t-test or Wilcoxon rank test was applied for pre-post comparison and the Student's t-test or Mann–Whitney U test was used for group comparison. …”
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Case report: Identification of facioscapulohumeral muscular dystrophy 1 in two siblings with normal phenotypic parents using optical genome mapping by Jieni Jiang, Jieni Jiang, Jieni Jiang, Xiaotang Cai, Xiaotang Cai, Haibo Qu, Haibo Qu, Qiang Yao, Qiang Yao, Tiantian He, Tiantian He, Tiantian He, Mei Yang, Mei Yang, Mei Yang, Hui Zhou, Hui Zhou, Xuemei Zhang, Xuemei Zhang, Xuemei Zhang

“…The proband's father, who was found to be normal after a neurological examination, also carried the 4qA allele with eight D4Z4 repeat units. …”
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A systematic review and meta-analysis of digital application use in clinical research in pain medicine by Ashish Shetty, Gayathri Delanerolle, Yutian Zeng, Yutian Zeng, Jian Qing Shi, Jian Qing Shi, Rawan Ebrahim, Joanna Pang, Dharani Hapangama, Martin Sillem, Suchith Shetty, Balakrishnan Shetty, Martin Hirsch, Martin Hirsch, Vanessa Raymont, Kingshuk Majumder, Sam Chong, Sam Chong, William Goodison, Rebecca O’Hara, Louise Hull, Nicola Pluchino, Naresh Shetty, Sohier Elneil, Sohier Elneil, Tacson Fernandez, Tacson Fernandez, Robert M. Brownstone, Peter Phiri, Peter Phiri

“…Out of the 84 studies that were initially identified, 38 were included in the systematic review.Data extraction and synthesisThe AMSTAR guidelines were used to assess data quality. This assessment was carried out by 3 reviewers. The data were pooled using a random-effects model.Main outcome(s) and measure(s)Before data collection began, the primary outcome was to report on the standard mean difference of digital application usage for chronic pain conditions. …”
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Practice of continuing care with Traditional Chinese Medicine nursing for patients after surgical treatment of mixed hemorrhoids in the specialized outpatient clinic (基于专病门诊的混合痔术后患... by Qin Shasha (秦沙沙), E Haiyan (鄂海燕), WEI Yongchun (魏永春), PENG Yujie (彭雨洁), TANG Ling (唐玲), LI Ye (李野), WANG Yali (王亚丽), DONG Yuxia (董玉霞)

“…Patients in the control group received routing telephone follow-up and health education after discharged form hospital, and those in the observation group were given continuing care with Traditional Chinese Medicine nursing in the specialized outpatient clinic, and a three-step integrated management of follow-up was carried out. The occurrence of postoperative complications was assessed, and patient satisfaction was evaluated by using a self-made questionnaire. …”
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Radiation doses to the population of the Russian Federation in 2020 by A. N. Barkovsky, Ruslan R. Akhmatdinov, Rustam R. Akhmatdinov, N. К. Baryshkov, A. M. Biblin, A. A. Bratilova, V. Е. Zhuravleva, T. A. Kormanovskaya, S. I. Kuvshinnikov, A. G. Sivenkov, O. E. Tutelyan, A. G. Tsovyanov

“…The authors have analyzed the data contained in the forms of state statistical observation No. 1-DOZ, No. 2-DOZ, No. 3-DOZ and No. 4-DOZ for 2020 submitted by the organizations and territories, the state sanitary and epidemiological supervision of which was carried out by Rospotrebnadzor and Federal Medical Biological Agency of Russia. …”
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Consenso de la Asociación Mexicana de Gastroenterología sobre el diagnóstico y tratamiento de pancreatitis aguda en niñas, niños y adolescentes by R. Vázquez-Frias, Y. Rivera-Suazo, A.K. Aguayo-Elorriaga, J.E. Alfaro-Bolaños, G.A. Argüello-Arévalo, J.F. Cadena-León, J.A. Chávez-Sáenz, A. Consuelo-Sánchez, E.V. Cruz-Romero, D. Espinosa-Saavedra, M.X. Espriu-Ramírez, J. Flores-Calderón, B. González-Ortiz, V. Hernández-Rosiles, K.R. Ignorosa-Arellano, C.M. Jaramillo-Esparza, F.R. Lozano-Hernández, A. Larrosa-Haro, U. Leal-Quiroga, J.A. Macias-Flores, B.A. Martínez-Leo, A. Martínez-Vázquez, N.M.J. Mendoza-Tavera, S. Pacheco-Sotelo, M. Reyes-Apodaca, C.A. Sánchez-Ramírez, C.A. Sifuentes-Vela, M. Sosa-Arce, F.E. Zárate-Mondragón

“…Despite the ever-increasing evidence regarding the management of AP in children and adults, therapeutic actions that could potentially affect having a poor prognosis in those patients, especially in the pediatric population, continue to be carried out. Therefore, the Asociación Mexicana de Gastroenterología convened a group of 24 expert pediatric gastroenterologists from different institutions and areas of Mexico, as well as 2 pediatric nutritionists and 2 specialists in pediatric surgery, to discuss different aspects of the epidemiology, diagnosis, and treatment of AP and RAP in the pediatric population. …”
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Investigating miR-9 as a mediator in laryngeal cancer health disparities by Christina Gobin, Samuel Inkabi, Chayil C. Lattimore, Tongjun Gu, James N. Menefee, Mayrangela Rodriguez, Heather Kates, Christopher Fields, Tengfei Bian, Natalie Silver, Chengguo Xing, Clayton Yates, Clayton Yates, Clayton Yates, Rolf Renne, Mingyi Xie, Kristianna M. Fredenburg

“…BackgroundFor several decades, Black patients have carried a higher burden of laryngeal cancer among all races. …”
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Capillary leak syndrome following COVID-19 vaccination: Data from the European pharmacovigilance database Eudravigilance by Rosanna Ruggiero, Rosanna Ruggiero, Nunzia Balzano, Nunzia Balzano, Raffaella Di Napoli, Raffaella Di Napoli, Annamaria Mascolo, Annamaria Mascolo, Pasquale Maria Berrino, Concetta Rafaniello, Concetta Rafaniello, Liberata Sportiello, Liberata Sportiello, Francesco Rossi, Francesco Rossi, Annalisa Capuano, Annalisa Capuano

“…Our pharmacovigilance study aims to evaluate the CLS onset following receipt of COVID-19 mRNA vaccines (mRNA-1273 and BNT162b2) compared to viral vector vaccines (Ad26.COV2-S and ChAdOx1-SARS-COV-2). We carried a cross-sectional study using all Individual Case Safety Reports (ICSRs) reporting a COVID-19 vaccine as suspected drug and CLS as AEFI, which were collected in the pharmacovigilance database EudraVigilance from January 1st, 2021, to January 14th, 2022. …”
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Non‐invasive diagnosis and surveillance of bladder cancer with driver and passenger DNA methylation in a prospective cohort study by Yu Xiao, Lingao Ju, Kaiyu Qian, Wan Jin, Gang Wang, Yan Zhao, Wei Jiang, Nan Liu, Kai Wu, Minsheng Peng, Rui Cao, Sheng Li, Hongjie Shi, Yan Gong, Hang Zheng, Tongzu Liu, Yongwen Luo, Haoli Ma, Luyuan Chang, Gang Li, Xinyue Cao, Ye Tian, Zilin Xu, Zhonghua Yang, Liuying Shan, Zhongqiang Guo, Dongai Yao, Xianlong Zhou, Xintong Chen, Zicheng Guo, Dongmei Liu, Song Xu, Chundong Ji, Fang Yu, Xin Hong, Jun Luo, Hong Cao, Yi Zhang, Xinghuan Wang

“…BLCA‐specific DNAm signature discovery was carried out with genome‐wide bisulfite sequencing in 32 tumour tissues and 12 normal urine samples. …”
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In- silico evaluation of bioactive compounds from selected medicinal plants from Southern Nigeria against hepatitis C virus genotype 1 RNA-directed RNA polymerase by Clement I. Mboto, Uwem O. Edet, Elizabeth N. Mbim, Wilfred O. Ndifon, Eno E. Ebenso, Henry O. Egharevba, Uwem E. George, Francisca O. Nwaokorie, Samuel.I. Udo

“…The collection of plant parts and phytochemical screening via gas chromatography-mass spectrophotometer (GC–MS) were carried out. Resulting bioactive compounds and a control HCV drug, remdesivir, were screened for ADMET properties using the pkCSM online prediction tool, while molecular docking was performed using AutoDockTool 1.5.6 and the resulting interactions visualised in 2-Dimension using Discovery Studio 2022 Client. …”
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Sustained viral response and relapse after discontinuation of oral antiviral drugs in HBeAg-positive patients with chronic hepatitis B infection by Fangfang Sun, Fangfang Sun, Zhenhua Li, Leiping Hu, Wen Deng, Tingting Jiang, Shiyu Wang, Xiaoyue Bi, Huihui Lu, Huihui Lu, Liu Yang, Yanjie Lin, Zhan Zeng, Ge Shen, Ruyu Liu, Min Chang, Shuling Wu, Yuanjiao Gao, Hongxiao Hao, Mengjiao Xu, Xiaoxue Chen, Lu Zhang, Yao Lu, Jianping Dong, Yao Xie, Yao Xie, Minghui Li, Minghui Li

“…During the follow-up, the antiviral treatment information of the patients was collected, and the follow-up observation was carried out every 3 months since the enrollment. We monitored the virological indexes, liver and kidney function, serology and liver imaging during follow-up. …”
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Clinical outcomes after vena cava thrombectomy for renal cell carcinoma with venous extension – institutional experience by Fábio Pais, José Aragão de Morais, Ana Quintas, Rita Soares Ferreira, Joana Catarino, Ricardo Correia, Rita Bento, Rita Garcia, Frederico Bastos Gonçalves, Maria Emília Ferreira

“…METHODS: Retrospective analysis of a single-center consecutive serie of patients with RCC and IVC tumor thrombi treated with surgery in our department between 2012 and 2021 was carried out. Demographic data, diagnostic and procedural characteristics, clinical outcomes and survival analysis were examined. …”
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Effects of remnant cholesterol on the efficacy of genotype-guided dual antiplatelet in CYP2C19 loss-of -function carriers with minor stroke or transient ischaemic attack: a post-ho... by Anxin Wang, Xue Tian, Xuewei Xie, Hao Li, Jing Jing, Jinxi Lin, Yilong Wang, Xingquan Zhao, Zixiao Li, Liping Liu, Yongjun Wang, Xia Meng

“…Methods: This post-hoc study used data from the CHANCE-2 trial, which was a randomised, double-blind, placebo-controlled trial of 6412 patients (aged >40 years) enrolled from 202 hospitals in China, between Sept 23, 2019, and March 22, 2021, who carried CYP2C19 loss-of-function alleles and had either an acute minor stroke or high-risk transient ischaemic attack (TIA), and could start treatment within 24 h of symptom onset. …”
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Measurement report: On the difference in aerosol hygroscopicity between high and low relative humidity conditions in the North China Plain by J. Shi, J. Shi, J. Hong, J. Hong, N. Ma, N. Ma, Q. Luo, Q. Luo, Y. He, Y. He, H. Xu, H. Tan, H. Tan, Q. Wang, Q. Wang, J. Tao, J. Tao, Y. Zhou, Y. Zhou, S. Han, S. Han, L. Peng, L. Peng, L. Xie, L. Xie, G. Zhou, W. Xu, Y. Sun, Y. Sun, Y. Sun, Y. Cheng, H. Su

“…Using <span class="inline-formula">O:C</span>-dependent hygroscopic parameters of secondary organic compounds (<span class="inline-formula"><i>κ</i>_SOA</span>), closure analysis between the HTDMA-measured <span class="inline-formula"><i>κ</i></span> and the ACSM-derived <span class="inline-formula"><i>κ</i></span> was carried out. The results showed that <span class="inline-formula"><i>κ</i>_SOA</span> under the LRH episode was less sensitive to the changes in organic oxidation level, while <span class="inline-formula"><i>κ</i>_SOA</span> under HRH had a relatively stronger dependency on the organic <span class="inline-formula">O:C</span> ratio. …”
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Isolation and Characterization of Three Pseudomonas aeruginosa Viruses with Therapeutic Potential by Xiao Wang, Jingjing Tang, Wen Dang, Zhen Xie, Fuhua Zhang, Xinwei Hao, Sihuai Sun, Xuan Liu, Yi Luo, Mengyuan Li, Yanchao Gu, Yao Wang, Qiwei Chen, Xihui Shen, Lei Xu

“…Following full-genome sequencing, we found that phage PA_LZ01 contained a genome of 65,367 bp in size and harbored 90 predicted open reading frames (ORFs), phage PA_LZ02 contained a genome of 57,243 bp in size and harbored 75 predicted ORFs, and phage PA_LZ03 contained a genome of 57,367 bp in size and carried 77 predicted ORFs. Further comparative analysis showed that phage PA_LZ01 belonged to the genus Pbunavirus genus, phage PA_LZ02 belonged to the genus Pamexvirus, and phage PA_LZ03 belonged to the family Mesyanzhinovviridae. …”
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Four missense genetic variants in CUBN are associated with higher levels of eGFR in non-diabetes but not in diabetes mellitus or its subtypes: A genetic association study in Europe... by Nicoline Uglebjerg, Fariba Ahmadizar, Fariba Ahmadizar, Dina M. Aly, Marisa Cañadas-Garre, Marisa Cañadas-Garre, Marisa Cañadas-Garre, Claire Hill, Annemieke Naber, Asmundur Oddsson, Sunny S. Singh, Laura Smyth, David-Alexandre Trégouët, Layal Chaker, Layal Chaker, Mohsen Ghanbari, Valgerdur Steinthorsdottir, Emma Ahlqvist, Samy Hadjadj, Mandy Van Hoek, Maryam Kavousi, Amy Jayne McKnight, Eric J. Sijbrands, Kari Stefansson, Kari Stefansson, Matias Simons, Peter Rossing, Peter Rossing, Tarunveer S. Ahluwalia, Tarunveer S. Ahluwalia

“…Furthermore, we sought to deepen our understanding of these variants in a range of single- and aggregate- variant analyses of other kidney-related traits in individuals with and without diabetes mellitus.MethodsWe carried out a genetic association-based linear regression analysis between four CUBN missense variants (rs141640975, rs144360241, rs45551835, rs1801239) and eGFRcreatinine (ml/min/1.73 m2, CKD-EPIcreatinine(2012), natural log-transformed) in populations with T1D (n ~ 3,588) or T2D (n ~ 31,155) from multiple European studies and in individuals without diabetes from UK Biobank (UKBB, n ~ 370,061) with replication in deCODE (n = 127,090). …”
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