NOX Dependent ROS Generation and Cell Metabolism by Tiziana Pecchillo Cimmino, Rosario Ammendola, Fabio Cattaneo, Gabriella Esposito

“…Notably, altered redox balance and deregulated redox signaling are recognized hallmarks of cancer and are involved in malignant progression and resistance to drugs treatment. …”
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Glycolysis-related lncRNA TMEM105 upregulates LDHA to facilitate breast cancer liver metastasis via sponging miR-1208 by Jinzhu Han, Xuyi Chen, Jianlong Wang, Bin Liu

“…Abstract Increased glycolysis is one of the key metabolic hallmarks of cancer cells. However, the roles of lncRNAs in energy metabolism and cancer metastasis remain unclear. …”
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New insights into the roles of peroxiredoxins in cancer by Yan Liu, Pu Wang, Weina Hu, Da Chen

“…Oxidative stress is one of the hallmarks of cancer. Tumorigenesis and progression are accompanied by elevated reactive oxygen species (ROS) levels and adaptive elevation of antioxidant expression levels. …”
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Extracellular Vesicle-Mediated Mitochondrial Reprogramming in Cancer by Roger Carles-Fontana, Nigel Heaton, Elena Palma, Shirin E. Khorsandi

“…Altered metabolism is a defining hallmark of cancer. Metabolic adaptations are often linked to a reprogramming of the mitochondria due to the importance of these organelles in energy production and biosynthesis. …”
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HPV16E1 downregulation altered the cell characteristics involved in cervical cancer development by Thanayod Sasivimolrattana, Arkom Chaiwongkot, Parvapan Bhattarakosol

“…Various cell functions associated with the hallmarks of cancer, including cell viability, colony formation, invasion, and anchorage-independent cell growth, were altered when HPV16E1 was downregulated. …”
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Pleiotropic Roles of Atrial Natriuretic Peptide in Anti-Inflammation and Anti-Cancer Activity by Huafeng Fu, Jian Zhang, Qinbo Cai, Yulong He, Dongjie Yang

“…Therefore, ANPs act on several hallmarks of cancer, such as inflammation, angiogenesis, sustained tumor growth, and metastasis. …”
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The fuel and engine: The roles of reprogrammed metabolism in metastasis of primary liver cancer by Wen-Wei Zhu, Ming Lu, Xiang-Yu Wang, Xu Zhou, Chao Gao, Lun-Xiu Qin

“…Metastasis and metabolism reprogramming are two major hallmarks of cancer. In the initiation and progression of cancer, tumor cells are known to undergo fundamental metabolic changes to sustain their development and progression. …”
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Bioactive Compounds: Multi-Targeting Silver Bullets for Preventing and Treating Breast Cancer by Nethaji Muniraj, Sumit Siddharth, Dipali Sharma

“…Cancer cells outsmart normal cells and evade apoptosis and it is one of the major hallmarks of cancer. The cardinal quest for anti-cancer drug discovery (bioactive or synthetic compounds) is to be able to re-induce the so called “programmed cell death” in cancer cells. …”
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Targeting Human Papillomavirus-Associated Cancer by Oncoprotein-Specific Recombinant Antibodies by Maria Gabriella Donà, Paola Di Bonito, Maria Vincenza Chiantore, Carla Amici, Luisa Accardi

“…Here, we describe the main biological activities of the HPV16 E6, E7, and E5 oncoproteins, which are involved in the subversion of important regulatory pathways directly associated with all known hallmarks of cancer. We then review the state of art of the recombinant antibodies targeted to HPV oncoproteins developed so far in different formats, and outline their mechanisms of action. …”
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Adipocyte-derived extracellular vesicles: bridging the communications between obesity and tumor microenvironment by Chuan Zhou, Yu-Qian Huang, Ming-Xu Da, Wei-Lin Jin, Feng-Hai Zhou

“…ADEVs are strongly associated with hallmarks of cancer (proliferation and resistance to cell death, angiogenesis, invasion, metastasis, immunological response) and may be useful as biomarkers and antitumor therapy strategy. …”
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Endothelin-1 and Its Role in Cancer and Potential Therapeutic Opportunities by Madeline Harrison, Dmitry Zinovkin, Md Zahidul Islam Pranjol

“…ET-1 has been found to potentiate hallmarks of cancer progression such as cell proliferation, invasion and metastasis, as well as angiogenesis. …”
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Onco-Preventive and Chemo-Protective Effects of Apple Bioactive Compounds by Linda Nezbedova, Tony McGhie, Mark Christensen, Julian Heyes, Noha Ahmed Nasef, Sunali Mehta

“…Finally, we report on the latest findings from in vitro and in vivo studies highlighting some of the key molecular mechanisms targeted by apple phytochemicals in relation to inhibiting multiple ‘hallmarks of cancer’ that are important in the progression of cancer.…”
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The blood proteome of imminent lung cancer diagnosis by The Lung Cancer Cohort Consortium (LC3)

“…We map the 36 proteins to the hallmarks of cancer and find that activation of invasion and metastasis, proliferative signaling, tumor-promoting inflammation, and angiogenesis are most frequently implicated.…”
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Keep Calm and Carry on with Extra Centrosomes by Batuhan Mert Kalkan, Selahattin Can Ozcan, Nicholas J. Quintyne, Samantha L. Reed, Ceyda Acilan

“…Aberrations in the centrosome number and structure can readily be detected at all stages of tumor progression and are considered hallmarks of cancer. Centrosome anomalies are closely linked to chromosome instability and, therefore, are proposed to be one of the driving events of tumor formation and progression. …”
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Can the Mitochondrial Metabolic Theory Explain Better the Origin and Management of Cancer than Can the Somatic Mutation Theory? by Thomas N. Seyfried, Christos Chinopoulos

“…Evidence is reviewed showing that the mitochondrial metabolic theory (MMT) can better account for the hallmarks of cancer than can the SMT. Proliferating cancer cells cannot survive or grow without carbons and nitrogen for the synthesis of metabolites and ATP (Adenosine Triphosphate). …”
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Metabolic Oscillations and Glycolytic Phenotypes of Cancer Cells by Takashi Amemiya, Kenichi Shibata, Tomohiko Yamaguchi

“…The glycolytic phenotype is one of the hallmarks of cancer cells and is considered to be one of the crucial features of malignant cancers. …”
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Bilayer Forming Phospholipids as Targets for Cancer Therapy by Celine Stoica, Adilson Kleber Ferreira, Kayleigh Hannan, Marica Bakovic

“…Altered phosphatidylcholine and phosphatidylethanolamine membrane content, phospholipid metabolite levels, and fatty acid profiles are frequently identified as hallmarks of cancer development and progression. This review summarizes the research on how phospholipid metabolism changes over oncogenic transformation, and how phospholipid profiling can differentiate between human cancer and healthy tissues, with a focus on colorectal cancer, breast cancer, and non-small cell lung cancer. …”
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The Rb tumor suppressor regulates epithelial cell migration and polarity by Parisi, Tiziana, Balsamo, Michele, Gertler, Frank, Lees, Jacqueline

“…Altered cell polarity and migration are hallmarks of cancer and metastases. Here we show that inactivation of the retinoblastoma gene (Rb) tumor suppressor causes defects in tissue closure that reflect the inability of Rb null epithelial cells to efficiently migrate and polarize. …”
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Regulation of telomerase expression by Hox gene family transcriptional factors by Ng, Joscelyn Jun Quan

“…In recent years, cancer has been the leading cause of death in Singapore. One of the hallmarks of cancer cells is its limitless potential to replicate. …”
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The c-Myc/AKT1/TBX3 axis is important to target in the treatment of embryonal rhabdomyosarcoma by Sims, D, Maranyane, HM, Damerell, V, Govender, D, Isaacs, AW, Peres, J, Prince, S

“…To this end, rhabdomyosarcoma cell culture models in which TBX3 was either stably knocked down or overexpressed were established and the impact on key hallmarks of cancer were examined using growth curves, soft agar and scratch motility assays, as well as tumour-forming ability in nude mice. …”