The association of Plk1 with the astrin–kinastrin complex promotes formation and maintenance of a metaphase plate by Geraghty, Z, Barnard, C, Pelin, U, Gruneberg, U

“…Errors in mitotic chromosome segregation can lead to DNA damage and aneuploidy, both hallmarks of cancer. To achieve synchronous error-free segregation, mitotic chromosomes must align at the metaphase plate with stable amphitelic attachments to microtubules emanating from opposing spindle poles. …”

Roles of Rho-associated kinase in lung cancer review by Zakaria, Muhammad Asyaari, Rajab, Nor Fadilah, Eng, Wee Chua, Selvarajah, Gayathri Thevi, Masre, Siti Fathiah

“…The present review also suggests the use of ROCK as a potential target for the development of lung cancer therapies, as ROCK inhibition can reduce multiple hallmarks of cancer, particularly by decreasing cancer cell migration, which is an initial step of metastasis.…”

FOXP3+ regulatory T cells and the immune escape in solid tumours by Yiran Qiu, Yiran Qiu, Shouyu Ke, Shouyu Ke, Jieqiong Chen, Zhizhen Qin, Wenle Zhang, Yaqin Yuan, Dehua Meng, Gang Zhao, Gang Zhao, Kejin Wu, Bin Li, Bin Li, Bin Li, Dan Li, Dan Li

“…Our comprehension of the interplay between FOXP3+ Treg cells and key hallmarks of cancer may provide new insights into the development of next-generation engineered T cell-based immune treatments for solid tumours.…”
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Molecular Crosstalk between Chromatin Remodeling and Tumor Microenvironment in Multiple Myeloma by Chandraditya Chakraborty, Srimoyee Mukherjee

“…Modulation of tumor microenvironment is one of the hallmarks of cancer biology, including MM, which affects the myeloma genomic architecture and disease progression subtly through chromatin modifications. …”
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Overcoming Radiation Resistance in Gliomas by Targeting Metabolism and DNA Repair Pathways by Wei Meng, Joshua D. Palmer, Michael Siedow, Saikh Jaharul Haque, Arnab Chakravarti

“…Metabolic reprogramming is one of the hallmarks of cancer cells, as well as one of the oldest fields in cancer biology research. …”
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Deciphering Genomic Heterogeneity and the Internal Composition of Tumour Activities through a Hierarchical Factorisation Model by José Carbonell-Caballero, Antonio López-Quílez, David Conesa, Joaquín Dopazo

“…We envision that this kind of approaches will be essential to better understand the hallmarks of cancer.…”
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Multifunctional Role of Astrocyte Elevated Gene-1 (AEG-1) in Cancer: Focus on Drug Resistance by Debashri Manna, Devanand Sarkar

“…The oncogene Astrocyte elevated gene-1/Metadherin (AEG-1/MTDH) is overexpressed in a diverse array of cancers, and its overexpression promotes all the hallmarks of cancer, such as proliferation, invasion, metastasis, angiogenesis and chemoresistance. …”
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Implication of microRNAs in Carcinogenesis with Emphasis on Hematological Malignancies and Clinical Translation by Zsuzsanna Gaál

“…MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs, that are involved in the multistep process of carcinogenesis, contributing to all established hallmarks of cancer. In this review, implications of miRNAs in hematological malignancies and their clinical utilization fields are discussed. …”
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Metabolomics and the Multi-Omics View of Cancer by David Wishart

“…Thanks to metabolomics, these multi-omics feedback loops are now much more evident and their roles in explaining the hallmarks of cancer are much better understood. Importantly, this more holistic, multi-omics view portrays cancer as a disease that is much more preventable, easier to understand, and potentially, far more treatable.…”
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Protein cargo in extracellular vesicles as the key mediator in the progression of cancer by Klára Hánělová, Martina Raudenská, Michal Masařík, Jan Balvan

“…Tumour-derived exosomes (TDEs) participate in many important molecular pathways and affect various hallmarks of cancer, including fibroblasts activation, modification of the tumour microenvironment (TME), modulation of immune responses, angiogenesis promotion, setting the pre-metastatic niche, enhancing metastatic potential, and affecting therapy sensitivity and resistance. …”
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MicroRNAs and Metabolism: Revisiting the Warburg Effect with Emphasis on Epigenetic Background and Clinical Applications by Zsuzsanna Gaál

“…Since the well-known hallmarks of cancer were described by Hanahan and Weinberg, fundamental advances of molecular genomic technologies resulted in the discovery of novel puzzle pieces in the multistep pathogenesis of cancer. …”
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Biological Therapy with Complementary and Alternative Medicine in Innocuous Integrative Oncology: A Case of Cervical Cancer by Elvin Peter Chizenga, Heidi Abrahamse

“…This review therefore presents innocuous therapeutic regimes by means of CAM and integrative medicine approaches that can specifically target the hallmarks of cancer, using the case of cervical cancer.…”
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Epigenetic Drugs for Cancer and microRNAs: A Focus on Histone Deacetylase Inhibitors by Pierre Autin, Christophe Blanquart, Delphine Fradin

“…Over recent decades, it has become clear that epigenetic abnormalities are involved in the hallmarks of cancer. Histone modifications, such as acetylation, play a crucial role in cancer development and progression, by regulating gene expression, such as for oncogenes or tumor suppressor genes. …”
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The Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer by Martina Giuppi, Anna La Salvia, Jessica Evangelista, Michele Ghidini

“…Angiogenesis is one of the hallmarks of cancer with a fundamental role in GC growth and progression. …”
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Mucin1 and Mucin16: Therapeutic Targets for Cancer Therapy by Dong-Hee Lee, Seunghyun Choi, Yoon Park, Hyung-seung Jin

“…In this review, we discuss the biological roles of the transmembrane mucins MUC1 and MUC16 in the context of hallmarks of cancer and current efforts to develop MUC1- and MUC16-targeted therapies.…”
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Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy by Liang Yan, Yanlian Tan, Guo Chen, Jun Fan, Jun Zhang

“…Immune escape is one of the hallmarks of cancer. While metabolic reprogramming provides survival advantage to tumor cancer cells, accumulating data also suggest such metabolic rewiring directly affects the activation, differentiation and function of immune cells, particularly in the tumor microenvironment. …”
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The potential role of reprogrammed glucose metabolism: an emerging actionable codependent target in thyroid cancer by Sai-li Duan, Min Wu, Zhe-Jia Zhang, Shi Chang

“…Altered energy metabolism is one of the hallmarks of cancer and a well-documented feature in thyroid cancer. …”
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Gas6/Axl Signaling Pathway in the Tumor Immune Microenvironment by Mai Tanaka, Dietmar W. Siemann

“…This review focuses on the role of the Gas6/Axl signaling pathway in promoting the immunosuppressive tumor microenvironment, as immune evasion is considered one of the hallmarks of cancer. The review discusses the structure and activation of the Gas6/Axl signaling pathway, GAS6 and AXL expression patterns in the tumor microenvironment, mechanisms of Axl-mediated tumor immune response, and the role of Gas6/Axl signaling in immune cell recruitment.…”
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The Mediterranean Diet as a Source of Natural Compounds: Does It Represent a Protective Choice against Cancer? by Giuseppina Augimeri, Daniela Bonofiglio

“…The beneficial effects elicited by the MD pattern on cancer are due to the high contents of bioactive compounds contained in many foods of MD, which protect cells by oxidative and inflammatory processes and inhibit carcinogenesis by targeting the various hallmarks of cancer with different mechanisms of action. …”
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Iron Metabolism in Cancer and Senescence: A Cellular Perspective by Elvira Crescenzi, Antonio Leonardi, Francesco Pacifico

“…Alterations in iron metabolism are considered hallmarks of cancer and drivers of aggressive behaviors, such as uncontrolled proliferation, resistance to apoptosis, enhanced metastatic ability, increased cell plasticity and stemness. …”
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