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Farnesiferol C Exerts Antiproliferative Effects on Hepatocellular Carcinoma HepG2 Cells by Instigating ROS-Dependent Apoptotic Pathway
Published 2022-08-01“…In the present study, the authors tested the hypothesis that Far-C-instigated oxidative stress resulted in anti-proliferation and apoptosis instigation within human liver cancer HepG2 cells. …”
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Two de novo GluN2B mutations affect multiple NMDAR-functions and instigate severe pediatric encephalopathy
Published 2021-07-01“…We employ protein-stability measures to explain why current (and future) LBD mutations in GluN2B primarily instigate Loss-of-Function.…”
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“My children do not deserve it”: Understanding how epiphanies instigate support-seeking practices among veteran families living with PTSD in Denmark
Published 2022-12-01“…Aided by Denzin’s notion of epiphany, we locate and report on the occurrence of four types of epiphanies that instigate help-seeking. The epiphanies reveal details about parents’ experiences of the effect of PTSD on family life, as well as their needs and responses to struggles of parenting and children’s distress. …”
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Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium.
Published 2015-11-01“…Our findings indicate Ctnnb1 gene dose exerts tissue-specific differences in Apc mutation-instigated tumorigenesis. Differential expression of selected β-catenin/TCF-regulated genes, such as Myc, likely underlies context-dependent effects of Ctnnb1 gene dosage in tumorigenesis.…”
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ATRAGEREA MINORILOR LA ACTIVITATE CRIMINALĂ: MODALITATE NORMATIVĂ DE EXPRIMARE A FAPTEI PREJUDICIABILE CONSEMNATE LA ART.208 CP RM
Published 2015-11-01Subjects: “…attracting, criminal activity, instigation, minor, adult person…”
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ATRAGEREA MINORILOR LA ACTIVITATE CRIMINALĂ SAU DETERMINAREA LOR LA SĂVÂRŞIREA UNOR FAPTE IMORALE (art.208 CP RM) vs PRINCIPIUL NEADMITERII TRAGERII LA RĂSPUNDERE PENALĂ DE DOUĂ OR...
Published 2016-03-01Subjects: “…attracting, criminal activity, instigation, minor, adult person…”
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Propylthiouracil, Perchlorate, and Thyroid-Stimulating Hormone Modulate High Concentrations of Iodide Instigated Mitochondrial Superoxide Production in the Thyroids of Metallothionein I/II Knockout Mice
Published 2016-03-01“…Our aim is to investigate the effects of propylthiouracil (PTU), a thyroid peroxidase inhibitor, perchlorate (KClO4), a competitive inhibitor of iodide transport, and thyroid stimulating hormone (TSH) on mitochondrial superoxide production instigated by high concentrations of iodide in the thyroids of MT-I/II knockout (MT-I/II KO) mice.MethodsEight-week-old 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J (MT-I/II KO) mice and background-matched wild type (WT) mice were used.ResultsBy using a mitochondrial superoxide indicator (MitoSOX Red), lactate dehydrogenase (LDH) release, and methyl thiazolyl tetrazolium (MTT) assay, we demonstrated that the decreased relative viability and increased LDH release and mitochondrial superoxide production induced by potassium iodide (100 µM) can be relieved by 300 µM PTU, 30 µM KClO4, or 10 U/L TSH in the thyroid cell suspensions of both MT-I/II KO and WT mice (P<0.05). …”
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Selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo
Published 2024-03-01“…We conclude that selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin positive endothelial cells instigates diffuse large B-cell lymphoma via upregulation of BCL6 stability. …”
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