Differential regulation of gene expression pathways with dexamethasone and ACTH after early life seizures by Jeffrey L. Brabec, Mohamed Ouardouz, J. Matthew Mahoney, Rod C. Scott, Amanda E. Hernan

Get full text

Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo by Daniel M. Virga, Stevie Hamilton, Bertha Osei, Abigail Morgan, Parker Kneis, Emiliano Zamponi, Natalie J. Park, Victoria L. Hewitt, David Zhang, Kevin C. Gonzalez, Fiona M. Russell, D. Grahame Hardie, Julien Prudent, Erik Bloss, Attila Losonczy, Franck Polleux, Tommy L. Lewis

Get full text

Robustness of single-cell RNA-seq for identifying differentially expressed genes by Yong Liu, Jing Huang, Rajan Pandey, Pengyuan Liu, Bhavika Therani, Qiongzi Qiu, Sridhar Rao, Aron M. Geurts, Allen W. Cowley, Andrew S. Greene, Mingyu Liang

Get full text

Anthropogenic events and responses to environmental stress are shaping the genomes of Ethiopian indigenous goats by Shumuye Belay, Gurja Belay, Helen Nigussie, Abulgasim M. Ahbara, Abdulfatai Tijjani, Tadelle Dessie, Getinet M. Tarekegn, Han Jian-Lin, Siobhan Mor, Helina S. Woldekiros, Keith Dobney, Ophelie Lebrasseur, Olivier Hanotte, Joram M. Mwacharo

Get full text

Co-option of endogenous retroviruses through genetic escape from TRIM28 repression by Rocio Enriquez-Gasca, Poppy A. Gould, Hale Tunbak, Lucia Conde, Javier Herrero, Alexandra Chittka, Christine R. Beck, Robert Gifford, Helen M. Rowe

Get full text

Single-tube Ptprc SNP genotyping of JAXBoy (CD45.1) and C57BL/6J (CD45.2) mice by endpoint PCR and gel electrophoresis by Claire E. Ryan, Thomas R. Salvetti, Ilana R. Baum, Brandon A. Figueroa, Brittany E. LeBere, Michael O. Alberti

“…Historically, this was accomplished using bone marrow from C57BL/6 (Ptprcb/CD45.2/Ly5.2) and congenic B6.SJL-PtprcaPepcb/Boy (Ptprca/CD45.1/Ly5.1) mice. Recently, the Jackson Laboratory directly CRISPR-engineered the Ptprca allele in C57BL/6J mice. …”
Get full text

Identifying susceptibility genes for essential hypertension by transcriptome-wide association study by Lu-jie Huang, Qiao-xia Zhang, Robert K. Valenzuela, Jia-chen Xu, Fang Yan, Jie Ma

Get full text

Sarcopenia and adipose tissue evaluation by artificial intelligence predicts the overall survival after TAVI by Matej Pekař, Otakar Jiravský, Jan Novák, Piotr Branny, Jakub Balušík, Daniel Daniš, Jan Hečko, Marek Kantor, Robert Prosecky, Lubomir Blaha, Radek Neuwirth

Get full text

Sex-specific role of myostatin signaling in neonatal muscle growth, denervation atrophy, and neuromuscular contractures by Marianne E Emmert, Parul Aggarwal, Kritton Shay-Winkler, Se-Jin Lee, Qingnian Goh, Roger Cornwall

Get full text

The origin of genetic diversity of indigenous cockfighting chickens of Pakistan by analyzing the mtDNA by Sajid Mahmood, Mian Sayed Khan, Zaib Ullah, Raman Akinyanju Lawal, Olivier Hanotte

Get full text

An evaluation of GPT models for phenotype concept recognition by Tudor Groza, Harry Caufield, Dylan Gration, Gareth Baynam, Melissa A. Haendel, Peter N. Robinson, Christopher J. Mungall, Justin T. Reese

Get full text

miR‐181a/b downregulation exerts a protective action on mitochondrial disease models by Alessia Indrieri, Sabrina Carrella, Alessia Romano, Alessandra Spaziano, Elena Marrocco, Erika Fernandez‐Vizarra, Sara Barbato, Mariateresa Pizzo, Yulia Ezhova, Francesca M Golia, Ludovica Ciampi, Roberta Tammaro, Jorge Henao‐Mejia, Adam Williams, Richard A Flavell, Elvira De Leonibus, Massimo Zeviani, Enrico M Surace, Sandro Banfi, Brunella Franco

Get full text

Helicobacter pylori-infected C57BL/6 mice with different gastrointestinal microbiota have contrasting gastric pathology, microbial and host immune responses by Ge, Zhongming, Sheh, Alexander, Feng, Yan, Muthupalani, Sureshkumar, Ge, Lili, Wang, Chuanwu, Kurnick, Susanna, Mannion, Anthony, Whary, Mark T, Fox, James G

“…C57BL/6 (B6) mice from Taconic Sciences (Tac) and the Jackson Laboratory (Jax) were infected with H. pylori PMSS1 (Hp) for 16 week; there was no significant difference in the gastric histologic activity index between Hp infected Tac and Jax B6. …”
Get full text
Get full text
Get full text

Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2rγnull mice treated with alogliptin by Jurczyk A, diIorio P, Brostowin D, Leehy L, Yang C, Urano F, Harlan DM, Shultz LD, Greiner DL, Bortell R

“…Agata Jurczyk,1 Philip diIorio,1 Dean Brostowin,1 Linda Leehy,1 Chaoxing Yang,1 Fumihiko Urano,2 David M Harlan,3 Leonard D Shultz,4 Dale L Greiner,1 Rita Bortell1 1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, 2Department of Medicine, Washington University School of Medicine, St Louis, MO, 3Department of Medicine, University of Massachusetts Medical School, Worcester, MA, 4The Jackson Laboratory, Bar Harbor, ME, USA Purpose: Dipeptidyl-peptidase-4 (DPP-4) inhibitors are known to increase insulin secretion and beta cell proliferation in rodents. …”
Get full text

FOS Rescues Neuronal Differentiation of Sox2-Deleted Neural Stem Cells by Genome-Wide Regulation of Common SOX2 and AP1(FOS-JUN) Target Genes by Miriam Pagin, Mattias Pernebrink, Mattia Pitasi, Federica Malighetti, Chew-Yee Ngan, Sergio Ottolenghi, Giulio Pavesi, Claudio Cantù, Silvia K. Nicolis

Get full text

Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics by Nigel G. Kooreman, Patricia E. de Almeida, Jonathan P. Stack, Raman V. Nelakanti, Sebastian Diecke, Ning-Yi Shao, Rutger-Jan Swijnenburg, Veronica Sanchez-Freire, Elena Matsa, Chun Liu, Andrew J. Connolly, Jaap F. Hamming, Paul H.A. Quax, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Joseph C. Wu

Get full text

The Environmental Conditions, Treatments, and Exposures Ontology (ECTO): connecting toxicology and exposure to human health and beyond by Lauren E. Chan, Anne E. Thessen, William D. Duncan, Nicolas Matentzoglu, Charles Schmitt, Cynthia J. Grondin, Nicole Vasilevsky, Julie A. McMurry, Peter N. Robinson, Christopher J. Mungall, Melissa A. Haendel

Get full text

Short-chain fatty acid valerate reduces voluntary alcohol intake in male mice by Suresh C. Bokoliya, Jordan Russell, Yair Dorsett, Hunter A. Panier, Vijender Singh, Lauren Daddi, Hanshu Yuan, Liv R. Dedon, Zhongmao Liu, Yuqi Zhou, Zefang Min, Jessica R. Barson, Jonathan Covault, Jason A. Bubier, Yanjiao Zhou

Get full text

Improvement of variant reclassification in genetic neurodevelopmental conditions by Michelle Kowanda, Rebecca Sheedy Smith, Jamie Lundy, Catherine Kentros, Elisheva Kleinman, Lauren Kasparson Walsh, Gerhard Schratt, Cora M. Taylor, Wendy K. Chung

Get full text

GLI1 regulates a novel neuropilin‐2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation by Hira Lal Goel, Bryan Pursell, Cheng Chang, Leslie M. Shaw, Junhao Mao, Karl Simin, Prashant Kumar, Craig W. Vander Kooi, Leonard D. Shultz, Dale L. Greiner, Jens Henrik Norum, Rune Toftgard, Charlotte Kuperwasser, Arthur M. Mercurio

Get full text