Wilson Disease: Intersecting DNA Methylation and Histone Acetylation Regulation of Gene Expression in a Mouse Model of Hepatic Copper AccumulationSummary by Gaurav V. Sarode, Kari Neier, Noreene M. Shibata, Yuanjun Shen, Dmitry A. Goncharov, Elena A. Goncharova, Tagreed A. Mazi, Nikhil Joshi, Matthew L. Settles, Janine M. LaSalle, Valentina Medici

“…Prior methylome investigations in human WD liver and blood and in the Jackson Laboratory (Bar Harbor, ME) C3He-Atp7btx-j/J (tx-j) WD mouse model revealed an epigenetic signature of WD, including changes in histone deacetylase (HDAC) 5. …”
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Chemotherapy-induced oral mucositis is associated with detrimental bacterial dysbiosis by Bo-Young Hong, Takanori Sobue, Linda Choquette, Amanda K. Dupuy, Angela Thompson, Joseph A. Burleson, Andrew L. Salner, Peter K. Schauer, Pujan Joshi, Evan Fox, Dong-Guk Shin, George M. Weinstock, Linda D. Strausbaugh, Anna Dongari-Bagtzoglou, Douglas E. Peterson, Patricia I. Diaz

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Targeted RNAseq assay incorporating unique molecular identifiers for improved quantification of gene expression signatures and transcribed mutation fraction in fixed tumor samples by Chunxiao Fu, Michal Marczyk, Michael Samuels, Alexander J. Trevarton, Jiaxin Qu, Rosanna Lau, Lili Du, Todd Pappas, Bruno V. Sinn, Rebekah E. Gould, Lajos Pusztai, Christos Hatzis, W. Fraser Symmans

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MSIsensor-pro: Fast, Accurate, and Matched-normal-sample-free Detection of Microsatellite Instability by Peng Jia, Xiaofei Yang, Li Guo, Bowen Liu, Jiadong Lin, Hao Liang, Jianyong Sun, Chengsheng Zhang, Kai Ye

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Effects of Probiotics on Colitis-Induced Exacerbation of Alzheimer’s Disease in <i>App^NL-G-F</i> Mice by Bijayani Sahu, Lauren M. Johnson, Mona Sohrabi, Anastasia A. Usatii, Rachel M. J. Craig, Joshua B. Kaelberer, Sathiya Priya Chandrasekaran, Harpreet Kaur, Suba Nookala, Colin K. Combs

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Author Correction: Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma by Yige Wu, Nadezhda V. Terekhanova, Wagma Caravan, Nataly Naser Al Deen, Preet Lal, Siqi Chen, Chia-Kuei Mo, Song Cao, Yize Li, Alla Karpova, Ruiyang Liu, Yanyan Zhao, Andrew Shinkle, Ilya Strunilin, Cody Weimholt, Kazuhito Sato, Lijun Yao, Mamatha Serasanambati, Xiaolu Yang, Matthew Wyczalkowski, Houxiang Zhu, Daniel Cui Zhou, Reyka G. Jayasinghe, Daniel Mendez, Michael C. Wendl, David Clark, Chelsea Newton, Yijun Ruan, Melissa A. Reimers, Russell K. Pachynski, Chris Kinsinger, Scott Jewell, Daniel W. Chan, Hui Zhang, Aadel A. Chaudhuri, Milan G. Chheda, Benjamin D. Humphreys, Mehdi Mesri, Henry Rodriguez, James J. Hsieh, Li Ding, Feng Chen

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α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes by Marcela Brissova, Rachana Haliyur, Diane Saunders, Shristi Shrestha, Chunhua Dai, David M. Blodgett, Rita Bottino, Martha Campbell-Thompson, Radhika Aramandla, Gregory Poffenberger, Jill Lindner, Fong Cheng Pan, Matthias G. von Herrath, Dale L. Greiner, Leonard D. Shultz, May Sanyoura, Louis H. Philipson, Mark Atkinson, David M. Harlan, Shawn E. Levy, Nripesh Prasad, Roland Stein, Alvin C. Powers

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Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D by Ana Viñuela, Arushi Varshney, Martijn van de Bunt, Rashmi B. Prasad, Olof Asplund, Amanda Bennett, Michael Boehnke, Andrew A. Brown, Michael R. Erdos, João Fadista, Ola Hansson, Gad Hatem, Cédric Howald, Apoorva K. Iyengar, Paul Johnson, Ulrika Krus, Patrick E. MacDonald, Anubha Mahajan, Jocelyn E. Manning Fox, Narisu Narisu, Vibe Nylander, Peter Orchard, Nikolay Oskolkov, Nikolaos I. Panousis, Anthony Payne, Michael L. Stitzel, Swarooparani Vadlamudi, Ryan Welch, Francis S. Collins, Karen L. Mohlke, Anna L. Gloyn, Laura J. Scott, Emmanouil T. Dermitzakis, Leif Groop, Stephen C. J. Parker, Mark I. McCarthy

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miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells by Clarice X. Lim, Bernett Lee, Olivia Geiger, Christina Passegger, Michaela Beitzinger, Johann Romberger, Anika Stracke, Christoph Högenauer, Anton Stift, Heribert Stoiber, Michael Poidinger, Armin Zebisch, Gunter Meister, Adam Williams, Richard A. Flavell, Jorge Henao-Mejia, Herbert Strobl

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Author Correction: Interaction between the microbiome and TP53 in human lung cancer by K. Leigh Greathouse, James R. White, Ashely J. Vargas, Valery V. Bliskovsky, Jessica A. Beck, Natalia von Muhlinen, Eric C. Polley, Elise D. Bowman, Mohammed A. Khan, Ana I. Robles, Tomer Cooks, Bríd M. Ryan, Noah Padgett, Amiran H. Dzutsev, Giorgio Trinchieri, Marbin A. Pineda, Sven Bilke, Paul S. Meltzer, Alexis N. Hokenstad, Tricia M. Stickrod, Marina R. Walther-Antonio, Joshua P. Earl, Joshua C. Mell, Jaroslaw E. Krol, Sergey V. Balashov, Archana S. Bhat, Garth D. Ehrlich, Alex Valm, Clayton Deming, Sean Conlan, Julia Oh, Julie A. Segre, Curtis C. Harris

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Acetate Promotes T Cell Effector Function during Glucose Restriction by Jing Qiu, Matteo Villa, David E. Sanin, Michael D. Buck, David O’Sullivan, Reagan Ching, Mai Matsushita, Katarzyna M. Grzes, Frances Winkler, Chih-Hao Chang, Jonathan D. Curtis, Ryan L. Kyle, Nikki Van Teijlingen Bakker, Mauro Corrado, Fabian Haessler, Francesca Alfei, Joy Edwards-Hicks, Leonard B. Maggi, Jr., Dietmar Zehn, Takeshi Egawa, Bertram Bengsch, Ramon I. Klein Geltink, Thomas Jenuwein, Edward J. Pearce, Erika L. Pearce

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A-Kinase Anchor Protein 1 deficiency causes mitochondrial dysfunction in mouse model of hyperoxia induced acute lung injury by Ramani Soundararajan, Helena Hernández-Cuervo, Helena Hernández-Cuervo, Timothy M Stearns, Anthony J Griswold, Sahebgowda Sidramagowda Patil, Jutaro Fukumoto, Venkata Ramireddy Narala, Lakshmi Galam, Richard Lockey, Narasaiah Kolliputi, Narasaiah Kolliputi

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Preclinical rationale for entinostat in embryonal rhabdomyosarcoma by Narendra Bharathy, Noah E. Berlow, Eric Wang, Jinu Abraham, Teagan P. Settelmeyer, Jody E. Hooper, Matthew N. Svalina, Zia Bajwa, Martin W. Goros, Brian S. Hernandez, Johannes E. Wolff, Ranadip Pal, Angela M. Davies, Arya Ashok, Darnell Bushby, Maria Mancini, Christopher Noakes, Neal C. Goodwin, Peter Ordentlich, James Keck, Douglas S. Hawkins, Erin R. Rudzinski, Atiya Mansoor, Theodore J. Perkins, Christopher R. Vakoc, Joel E. Michalek, Charles Keller

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Design of a targeted blood transcriptional panel for monitoring immunological changes accompanying pregnancy by Tobias Brummaier, Tobias Brummaier, Tobias Brummaier, Darawan Rinchai, Darawan Rinchai, Mohammed Toufiq, Mohammed Y. Karim, Tanwir Habib, Tanwir Habib, Jürg Utzinger, Jürg Utzinger, Daniel H. Paris, Daniel H. Paris, Rose McGready, Rose McGready, Alexandra K. Marr, Tomoshige Kino, Annalisa Terranegra, Souhaila Al Khodor, Damien Chaussabel, Damien Chaussabel, Basirudeen Syed Ahamed Kabeer

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Low Peripheral T Follicular Helper Cells in Perinatally HIV-Infected Children Correlate With Advancing HIV Disease by Bret McCarty, Mussa Mwamzuka, Fatma Marshed, Matthew Generoso, Patricia Alvarez, Tiina Ilmet, Adam Kravietz, Aabid Ahmed, William Borkowsky, Derya Unutmaz, Alka Khaitan, Alka Khaitan

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Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes by Kendall Higgins, Bret A. Moore, Zorana Berberovic, Hibret A. Adissu, Mohammad Eskandarian, Ann M. Flenniken, Andy Shao, Denise M. Imai, Dave Clary, Louise Lanoue, Susan Newbigging, Lauryl M. J. Nutter, David J. Adams, Fatima Bosch, Robert E. Braun, Steve D. M. Brown, Mary E. Dickinson, Michael Dobbie, Paul Flicek, Xiang Gao, Sanjeev Galande, Anne Grobler, Jason D. Heaney, Yann Herault, Martin Hrabe de Angelis, Hsian-Jean Genie Chin, Fabio Mammano, Chuan Qin, Toshihiko Shiroishi, Radislav Sedlacek, J.-K. Seong, Ying Xu, The IMPC Consortium, K. C. Kent Lloyd, Colin McKerlie, Ala Moshiri

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Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment by Hua Sun, Song Cao, R. Jay Mashl, Chia-Kuei Mo, Simone Zaccaria, Michael C. Wendl, Sherri R. Davies, Matthew H. Bailey, Tina M. Primeau, Jeremy Hoog, Jacqueline L. Mudd, Dennis A. Dean, Rajesh Patidar, Li Chen, Matthew A. Wyczalkowski, Reyka G. Jayasinghe, Fernanda Martins Rodrigues, Nadezhda V. Terekhanova, Yize Li, Kian-Huat Lim, Andrea Wang-Gillam, Brian A. Van Tine, Cynthia X. Ma, Rebecca Aft, Katherine C. Fuh, Julie K. Schwarz, Jose P. Zevallos, Sidharth V. Puram, John F. Dipersio, The NCI PDXNet Consortium, Brandi Davis-Dusenbery, Matthew J. Ellis, Michael T. Lewis, Michael A. Davies, Meenhard Herlyn, Bingliang Fang, Jack A. Roth, Alana L. Welm, Bryan E. Welm, Funda Meric-Bernstam, Feng Chen, Ryan C. Fields, Shunqiang Li, Ramaswamy Govindan, James H. Doroshow, Jeffrey A. Moscow, Yvonne A. Evrard, Jeffrey H. Chuang, Benjamin J. Raphael, Li Ding

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An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1 by David S Lorberbaum, Andrea I Ramos, Kevin A Peterson, Brandon S Carpenter, David S Parker, Sandip De, Lauren E Hillers, Victoria M Blake, Yuichi Nishi, Matthew R McFarlane, Ason CY Chiang, Judith A Kassis, Benjamin L Allen, Andrew P McMahon, Scott Barolo

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At-home blood collection and stabilization in high temperature climates using homeRNA by Lauren G. Brown, Amanda J. Haack, Amanda J. Haack, Dakota S. Kennedy, Karen N. Adams, Jennifer E. Stolarczuk, Meg G. Takezawa, Erwin Berthier, Sanitta Thongpang, Sanitta Thongpang, Fang Yun Lim, Damien Chaussabel, Damien Chaussabel, Mathieu Garand, Mathieu Garand, Ashleigh B. Theberge, Ashleigh B. Theberge

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A Static Analysis of <italic>Wnt</italic>/<italic>&#x03B2;</italic>-Catenin and <italic>Wnt</italic>/<italic>Ca</italic>^2&#x002B; Biological Regulatory Networks for ARVC... by Nazia Azim, Nadeem Iqbal, Jamil Ahmad, Mukhtaj Khan, Amnah Siddiqa, Javaria Ashraf, Abbas Khan, Dong-Qing Wei

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