Recalculation of 23 mouse HDL QTL datasets improves accuracy and allows for better candidate gene analysis by Cheryl Ackert-Bicknell, Beverly Paigen, Ron Korstanje

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Deep learning modeling m6A deposition reveals the importance of downstream cis-element sequences by Zhiyuan Luo, Jiacheng Zhang, Jingyi Fei, Shengdong Ke

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Editorial: Genetic basis of tolerance induction defects underlying the development of autoimmune pathologies by Jeremy J. Racine, Laurence Morel, Yi-Guang Chen, David V. Serreze

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Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging by Adelaida R. Palla, Keren I. Hilgendorf, Ann V. Yang, Jaclyn P. Kerr, Aaron C. Hinken, Janos Demeter, Peggy Kraft, Nancie A. Mooney, Nora Yucel, David M. Burns, Yu Xin Wang, Peter K. Jackson, Helen M. Blau

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GOPHER: Generator Of Probes for capture Hi-C Experiments at high Resolution by Peter Hansen, Salaheddine Ali, Hannah Blau, Daniel Danis, Jochen Hecht, Uwe Kornak, Darío G. Lupiáñez, Stefan Mundlos, Robin Steinhaus, Peter N. Robinson

“…Source code and a precompiled executable can be downloaded from the GOPHER GitHub page at https://github.com/TheJacksonLaboratory/Gopher.…”
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Transcriptional profiling predicts running promotes cerebrovascular remodeling in young but not midlife mice by Kate E. Foley, Hongtian Stanley Yang, Leah C. Graham, Gareth R. Howell

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Young infants display heterogeneous serological responses and extensive but reversible transcriptional changes following initial immunizations by Nima Nouri, Raquel Giacomelli Cao, Eleonora Bunsow, Djamel Nehar-Belaid, Radu Marches, Zhaohui Xu, Bennett Smith, Santtu Heinonen, Sara Mertz, Amy Leber, Gaby Smits, Fiona van der Klis, Asunción Mejías, Jacques Banchereau, Virginia Pascual, Octavio Ramilo

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Discovery of a Role for Rab3b in Habituation and Cocaine Induced Locomotor Activation in Mice Using Heterogeneous Functional Genomic Analysis by Jason A. Bubier, Vivek M. Philip, Price E. Dickson, Price E. Dickson, Guy Mittleman, Elissa J. Chesler

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3D‐Epigenomic Regulation of Gene Transcription in Hepatocellular Carcinoma by Yuliang Feng, Ping Wang, Liuyang Cai, Meixiao Zhan, Fan He, Jiahui Wang, Yong Li, Eva Gega, Wei Zhang, Wei Zhao, Yongjie Xin, Xudong Chen, Yijun Ruan, Ligong Lu

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Metabolism of 25-hydroxycholesterol in mammalian cell cultures. Side-chain scission to pregnenolone in mouse L929 fibroblasts. by F R Taylor, A A Kandutsch

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Rapid replacement by non-vaccine pneumococcal serotypes may mitigate the impact of the pneumococcal conjugate vaccine on nasopharyngeal bacterial ecology by Brenda Kwambana-Adams, Blake Hanson, Archibald Worwui, Schadrac Agbla, Ebenezer Foster-Nyarko, Fatima Ceesay, Chinelo Ebruke, Uzochukwu Egere, Yanjiao Zhou, Maze Ndukum, Erica Sodergren, Michael Barer, Richard Adegbola, George Weinstock, Martin Antonio

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Model organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD by Adrian L. Oblak, Stefania Forner, Paul R. Territo, Michael Sasner, Gregory W. Carter, Gareth R. Howell, Stacey J. Sukoff‐Rizzo, Benjamin A. Logsdon, Lara M. Mangravite, Ali Mortazavi, David Baglietto‐Vargas, Kim N. Green, Grant R. MacGregor, Marcelo A. Wood, Andrea J. Tenner, Frank M. LaFerla, Bruce T. Lamb, and The MODEL‐AD, Consortium

“…MODEL‐AD is a collaboration among Indiana University (IU); The Jackson Laboratory (JAX); University of Pittsburgh School of Medicine (Pitt); Sage BioNetworks (Sage); and the University of California, Irvine (UCI) that will generate new AD modeling processes and pipelines, data resources, research results, standardized protocols, and models that will be shared through JAX's and Sage's proven dissemination pipelines with the National Institute on Aging–supported AD Centers, academic and medical research centers, research institutions, and the pharmaceutical industry worldwide.…”
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Development of a Novel Orthotopic Gastric Cancer Mouse Model by Wonyoung Kang, Leigh Maher, Michael Michaud, Seong-Woo Bae, Seongyeong Kim, Hye Seung Lee, Seock-Ah Im, Han-Kwang Yang, Charles Lee

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Developmental constraint through negative pleiotropy in the zygomatic arch by Christopher J. Percival, Rebecca Green, Charles C. Roseman, Daniel M. Gatti, Judith L. Morgan, Stephen A. Murray, Leah Rae Donahue, Jessica M. Mayeux, K. Michael Pollard, Kunjie Hua, Daniel Pomp, Ralph Marcucio, Benedikt Hallgrímsson

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Whole genome analysis for 163 gRNAs in Cas9-edited mice reveals minimal off-target activity by Kevin A. Peterson, Sam Khalouei, Nour Hanafi, Joshua A. Wood, Denise G. Lanza, Lauri G. Lintott, Brandon J. Willis, John R. Seavitt, Robert E. Braun, Mary E. Dickinson, Jacqueline K. White, K. C. Kent Lloyd, Jason D. Heaney, Stephen A. Murray, Arun Ramani, Lauryl M. J. Nutter

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Untangling HDL quantitative trait loci on mouse chromosome 5 and identifying Scarb1 and Acads as the underlying genes by Zhiguang Su, Magalie S. Leduc, Ron Korstanje, Beverly Paigen

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Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts by Bret A. Moore, Brian C. Leonard, Lionel Sebbag, Sydney G. Edwards, Ann Cooper, Denise M. Imai, Ewan Straiton, Luis Santos, Christopher Reilly, Stephen M. Griffey, Lynette Bower, David Clary, Jeremy Mason, Michel J. Roux, Hamid Meziane, Yann Herault, International Mouse Phenotyping Consortium, Colin McKerlie, Ann M. Flenniken, Lauryl M. J. Nutter, Zorana Berberovic, Celeste Owen, Susan Newbigging, Hibret Adissu, Mohammed Eskandarian, Chih-Wei Hsu, Sowmya Kalaga, Uchechukwu Udensi, Chinwe Asomugha, Ritu Bohat, Juan J. Gallegos, John R. Seavitt, Jason D. Heaney, Arthur L. Beaudet, Mary E. Dickinson, Monica J. Justice, Vivek Philip, Vivek Kumar, Karen L. Svenson, Robert E. Braun, Sara Wells, Heather Cater, Michelle Stewart, Sharon Clementson-Mobbs, Russell Joynson, Xiang Gao, Tomohiro Suzuki, Shigeharu Wakana, Damian Smedley, J. K. Seong, Glauco Tocchini-Valentini, Mark Moore, Colin Fletcher, Natasha Karp, Ramiro Ramirez-Solis, Jacqueline K. White, Martin Hrabe de Angelis, Wolfgang Wurst, Sara M. Thomasy, Paul Flicek, Helen Parkinson, Steve D. M. Brown, Terrence F. Meehan, Patsy M. Nishina, Stephen A. Murray, Mark P. Krebs, Ann-Marie Mallon, K. C. Kent Lloyd, Christopher J. Murphy, Ala Moshiri

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Editorial: Long Non-coding RNAs and Immunity by Grace J. Kwon, Grace J. Kwon, Jorge Henao-Mejia, Jorge Henao-Mejia, Jorge Henao-Mejia, Adam Williams, Adam Williams

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Widespread perturbation of ETS factor binding sites in cancer by Sebastian Carrasco Pro, Heather Hook, David Bray, Daniel Berenzy, Devlin Moyer, Meimei Yin, Adam Thomas Labadorf, Ryan Tewhey, Trevor Siggers, Juan Ignacio Fuxman Bass

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Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction by Lukas S. Tombor, David John, Simone F. Glaser, Guillermo Luxán, Elvira Forte, Milena Furtado, Nadia Rosenthal, Nina Baumgarten, Marcel H. Schulz, Janina Wittig, Eva-Maria Rogg, Yosif Manavski, Ariane Fischer, Marion Muhly-Reinholz, Kathrin Klee, Mario Looso, Carmen Selignow, Till Acker, Sofia-Iris Bibli, Ingrid Fleming, Ralph Patrick, Richard P. Harvey, Wesley T. Abplanalp, Stefanie Dimmeler

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