New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop by Maria A. Telpoukhovskaia, Thomas J. Murdy, Olivia J. Marola, Kevin Charland, Michael MacLean, Tain Luquez, Alexandra M. Lish, Sarah Neuner, Amy Dunn, Kristen D. Onos, Jesse Wiley, Derek Archer, Matthew J. Huentelman, Matthias Arnold, Vilas Menon, Alison Goate, Linda J. Van Eldik, Paul R. Territo, Gareth R. Howell, Gregory W. Carter, Kristen M. S. O'Connell, Catherine C. Kaczorowski, the 2022 JAX CADR Workshop

“…Abstract INTRODUCTION In September 2022, The Jackson Laboratory Center for Alzheimer's and Dementia Research (JAX CADR) hosted a workshop with leading researchers in the Alzheimer's disease and related dementias (ADRD) field. …”
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FusorSV: an algorithm for optimally combining data from multiple structural variation detection methods by Timothy Becker, Wan-Ping Lee, Joseph Leone, Qihui Zhu, Chengsheng Zhang, Silvia Liu, Jack Sargent, Kritika Shanker, Adam Mil-homens, Eliza Cerveira, Mallory Ryan, Jane Cha, Fabio C. P. Navarro, Timur Galeev, Mark Gerstein, Ryan E. Mills, Dong-Guk Shin, Charles Lee, Ankit Malhotra

“…FusorSV is available at https://github.com/TheJacksonLaboratory/SVE.…”
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Genetically diverse mouse platform to xenograft cancer cells by Jennifer K. Sargent, Mark A. Warner, Benjamin E. Low, William H. Schott, Todd Hoffert, David Coleman, Xing Yi Woo, Todd Sheridan, Sonia Erattupuzha, Philipp P. Henrich, Vivek M. Philip, Jeffrey H. Chuang, Michael V. Wiles, Muneer G. Hasham

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Sexual-dimorphism in human immune system aging by Eladio J. Márquez, Cheng-han Chung, Radu Marches, Robert J. Rossi, Djamel Nehar-Belaid, Alper Eroglu, David J. Mellert, George A. Kuchel, Jacques Banchereau, Duygu Ucar

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Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells by Joshy George, Asli Uyar, Kira Young, Lauren Kuffler, Kaiden Waldron-Francis, Eladio Marquez, Duygu Ucar, Jennifer J. Trowbridge

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Graph embedding and unsupervised learning predict genomic sub-compartments from HiC chromatin interaction data by Haitham Ashoor, Xiaowen Chen, Wojciech Rosikiewicz, Jiahui Wang, Albert Cheng, Ping Wang, Yijun Ruan, Sheng Li

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Protein coding variation in the J:ARC and J:DO outbred laboratory mouse stocks provides a molecular basis for distinct research applications by Belinda K Cornes, Carolyn Paisie, Emily Swanzey, Peter D Fields, Andrew Schile, Kelly Brackett, Laura G Reinholdt, Anuj Srivastava

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The Mouse Models of Human Cancer database (MMHCdb) by Dale A. Begley, Debra M. Krupke, John P. Sundberg, Emily L. Jocoy, Joel E. Richardson, Steven B. Neuhauser, Carol J. Bult

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Animals, quality and the pursuit of relevance by Karen L. Svenson, Stephen D. Krasinski, Michael Ellis, Nadia Rosenthal, Edison T. Liu, Kenneth H. Fasman

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Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leukemia by Ping Wang, Zhonghui Tang, Byoungkoo Lee, Jacqueline Jufen Zhu, Liuyang Cai, Przemyslaw Szalaj, Simon Zhongyuan Tian, Meizhen Zheng, Dariusz Plewczynski, Xiaoan Ruan, Edison T. Liu, Chia-Lin Wei, Yijun Ruan

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High-throughput deconvolution of 3D organoid dynamics at cellular resolution for cancer pharmacology with Cellos by Patience Mukashyaka, Pooja Kumar, David J. Mellert, Shadae Nicholas, Javad Noorbakhsh, Mattia Brugiolo, Elise T. Courtois, Olga Anczukow, Edison T. Liu, Jeffrey H. Chuang

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1208 Differential reliance on glucose oxidation by activated autoreactive B cells provides a novel target of therapeutic intervention by Peter E Lipsky, Derry C Roopenian, Amrie C Grammer, John J Wilson, Jian Wei, Andrea R Daamen, John D Sears, Elaine Bechtel, Colleen L Mayberry, Grace A Stafford, Chih-Hao Chang

Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation by Shubham Khetan, Susan Kales, Romy Kursawe, Alexandria Jillette, Jacob C. Ulirsch, Steven K. Reilly, Duygu Ucar, Ryan Tewhey, Michael L. Stitzel

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Transposable element-mediated rearrangements are prevalent in human genomes by Parithi Balachandran, Isha A. Walawalkar, Jacob I. Flores, Jacob N. Dayton, Peter A. Audano, Christine R. Beck

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CRISPR-mediated multiplexed live cell imaging of nonrepetitive genomic loci with one guide RNA per locus by Patricia A. Clow, Menghan Du, Nathaniel Jillette, Aziz Taghbalout, Jacqueline J. Zhu, Albert W. Cheng

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AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data by Asa Thibodeau, Alper Eroglu, Christopher S. McGinnis, Nathan Lawlor, Djamel Nehar-Belaid, Romy Kursawe, Radu Marches, Daniel N. Conrad, George A. Kuchel, Zev J. Gartner, Jacques Banchereau, Michael L. Stitzel, A. Ercument Cicek, Duygu Ucar

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Multiplex immunofluorescence-guided laser capture microdissection for spatial transcriptomics of metastatic melanoma tissues by Jan Martinek, Te-Chia Wu, Lili Sun, Jianan Lin, Kyung In Kim, Florentina Marches, Paul Robson, Joshy George, Karolina Palucka

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Behavioral phenotypes revealed during reversal learning are linked with novel genetic loci in diversity outbred mice by Jared R. Bagley, Lauren S. Bailey, Leona H. Gagnon, Hao He, Vivek M. Philip, Laura G. Reinholdt, Lisa M. Tarantino, Elissa J. Chesler, James D. Jentsch

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CRISPR artificial splicing factors by Menghan Du, Nathaniel Jillette, Jacqueline Jufen Zhu, Sheng Li, Albert Wu Cheng

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Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways by Aziz Taghbalout, Menghan Du, Nathaniel Jillette, Wojciech Rosikiewicz, Abhijit Rath, Christopher D. Heinen, Sheng Li, Albert W. Cheng

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