A methodology for identifying flexible design opportunities by Wilds, Jennifer M

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Increasing the robustness of networked systems by Kandula, Srikanth

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Pheochromocytoma-induced cardiomyopathy : a model of synergistic effects of multifactorial tumor secretions by Mobine, Hector R

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Transcriptional role of cyclin D1 in development revealed by a “genetic-proteomic” screen by Bienvenu, Frederic, Jirawatnotai, Siwanon, Elias, Joshua E., Meyer, Clifford A., Mizeracka, Karolina, Marson, Alexander, Frampton, Garrett M., Cole, Megan F., Odom, Duncan, Odajima, Junko, Geng, Yan, Zagozdzon, Agnieszka, Jecrois, Marie, Young, Richard A., Liu, X. Shirley, Cepko, Constance L., Gygi, Steven P., Sicinski, Piotr

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Paxillin-dependent control of tumor angiogenesis by German, Alexandra Elisa

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Disembodied, dehumanised but safe and feasible: the social-spatial flow of a pandemic OSCE by Brown, Craig, MacLeod, Anna, Hawick, Lorraine, Cleland, Jennifer

“…Each change had material and social ‘knock on’ effects. We identified three main interrelated orderings: Substituting technologies for bodies: Disembodied and dehumanised but feasible; Flow through space: Architectural affordances and one-way traffic; Barriers to flow: Time and technology. …”
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Functional roles of HMGA2 in human embryonic stem cells and human tumor cells by Li, Ou

“…The non-histone chromatin-associated factor high-mobility group protein A2 (HMGA2) has been studied mostly in the mouse where its function seems critical for embryonic cell growth and adipocytic cell differentiation, leading to a pygmy phenotype with greatly reduced fat tissue in homozygous knock out mice. We showed that among the major HMG proteins, HMGA2 was highly expressed in two hESC lines. …”
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Engineering escherichia coli for nanoparticle synthesis and targeting of colon cancer by Pasula, Rupali Reddy

“…Here, we report the first attempt to employ a synthetic biology approach to engineer the bacterium Escherichia coli to increase the iron loading in Archaeoglobus fulgidus Ferritin (AfFtn) by co-expressing an iron influx protein (FeoB) and knocking out an iron efflux protein (fieF). We exploit the natural iron storage function of ferritin to sequester iron and store it in the internal cavity to produce iron nanoparticles. …”
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Improving ethanol tolerance of Escherichia coli by rewiring Its global regulator cAMP receptor protein (CRP) by Chong, Huiqing, Huang, Lei, Yeow, Jianwei, Wang, Ivy, Zhang, Hongfang, Song, Hao, Jiang, Rongrong

“…Based on the RT-PCR results, entA, marA or bhsA was knocked out in iE2 and the resulting strains became more sensitive towards ethanol.…”
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EFEK PEMAPARAN DELTAMETHRIN PADA BROILER TERHADAP AKTIVITAS ENZIM ALANIN AMINOTRANSFERASE, ASPARTAT AMINOTRANSFERASE, GAMBARAN HISTOPATOLOGI HEPAR DAN FEED CONVERTION RATIO by , NEMAY ANGGADEWI NDAONG, , Dr. drh. Agustina Dwi Wijayanti, MP.

“…Deltamethrin is a synthetic broad-spectrum insecticide pyretroid, which is used as a organochlorine and organophospat substitute in pest control programs in poultry, cattle, pigs, and dogs, has had a knock-down effect on the target organism and the low bioaccumulation in the environment. …”

Phospholemman phosphorylation regulates vascular tone, blood pressure, and hypertension in mice and humans by Boguslavskyi, A, Tokar, S, Prysyazhna, O, Rudyk, O, Sanchez-Tatay, D, Lemmey, HAL, Dora, KA, Garland, CJ, Warren, HR, Doney, A, Palmer, CNA, Caulfield, MJ, Vlachaki Walker, J, Howie, J, Fuller, W, Shattock, MJ

“…<p><strong>Methods:</strong></p> In mouse studies, phospholemman knock-in mice (PLM3SA; phospholemman [FXYD1] in which the 3 phosphorylation sites on serines 63, 68, and 69 are mutated to alanines), in which phospholemman is rendered unphosphorylatable, were used to assess the role of phospholemman phosphorylation in vitro in aortic and mesenteric vessels using wire myography and membrane potential measurements. …”

Chronic estrogen deficiency causes gastroparesis by altering neuronal nitric oxide synthase function. by Ravella, K, Al-Hendy, A, Sharan, C, Hale, AB, Channon, K, Srinivasan, S, Gangula, P

“…AIMS: The purpose of this study was to investigate whether reduced levels of estradiol-17β (E2) down-regulates tetrahydrobiopterin (BH4, a cofactor for nNOS dimerization and enzyme activity) biosynthesis and therefore nNOS mediated gastric motility would be impaired in a mouse model of chronic estrogen deficiency, follicle stimulating hormone receptor knock-out female mice (FORKO). METHODS: In-bred 12-week-old female FORKO mice were obtained from our FORKO breeding colony. …”

Altered cortisol metabolism in individuals with HNF1A-MODY by Juszczak, A, Gilligan, LC, Hughes, BA, McCarthy, M, Tomlinson, J, Owen, K

“…Data from hepatocytes derived from&nbsp;<em>Hnf1a&nbsp;</em>knock‐out mice demonstrated dysregulation of 11&beta;‐hydroxysteroid dehydrogenase type 1 (11&beta;‐HSD1), which regulates glucocorticoid availability and action in target tissues, together with 11&beta;‐HSD2 and steroid A‐ring reductases, 5&alpha;‐ and 5&beta;‐reductase. …”

Alcohol fuels for spark-ignition engines: performance, efficiency and emissions effects at mid to high blend rates for binary mixtures and pure components by Turner, J, Lewis, A, Akehurst, S, Brace, C, Verhelst, S, Vancoillie, J, Sileghem, L, Leach, F, Edwards, P

“…Additionally, pure alcohols are tested in two of the engines, in order to show the maximum response that can be expected in terms of knock limit and efficiency as a result of the beneficial properties of the two alcohols investigated. …”

Intracellular delivery of radioimmunoconjugates that target the cancer testis antigen, NY-ESO-1 by Chu, H

“…Cytotoxicity was inversely proportional to specific activity and the concentration of cells exposed to 111In-DTPA-anti-NY-ESO-1-TAT-PT. siRNA knock down of NY-ESO-1 resulted in partial reversal of 111In-DTPA-anti-NY-ESO-1-TAT-PT associated cytotoxicity. …”

Understanding the role of microglia in the pathogenesis of amyotrophic lateral sclerosis by Vahsen, BF

“…Mimicking C9ORF72 haploinsufficiency through C9orf72 knock-out in mice led to a pro-inflammatory microglial state, but whether this phenotype is replicated in human C9ORF72-ALS microglia and if they contribute to motor neuron death in C9ORF72-ALS is currently unknown. …”

Understanding the role of islet development in type 2 diabetes susceptibility by Pérez Alcántara, MC

“…</p> <p>One of these candidate genes, PROX1, was functionally tested in islet development in the laboratory, aiming to modulate its expression using CRISPR activation, interference, and knock-out. PROX1 was successfully upregulated in the undifferentiated hiPSC system using CRISPRa. …”

Monolayers of cationic surfactants at the air-water and oil-water interfaces by Knock, M

The role of adenosine A2A receptor signalling in cardiac fibrosis by Stockenhuber, A, Ashrafian, H, Watkins, H

“…Crossbreeding of actin E99K and A2AR knock-out (KO) mice resulted in a significant reduction of myocardial collagen content and fibrosis in E99K heterozygous A2AR KO animals compared to E99K heterozygous A2AR wild-type (WT) animals.…”

Hypoxic regulation of chromatin and gene transcription by Kindrick, JD

“…After blocking the HIF transcriptional pathway by HIF-1β knock-out, the global induction of histone methylation persisted across the genome. …”