Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis by Yoshiaki Ito, Tokio Matsuzaki, Fumiaki Ayabe, Sho Mokuda, Ryota Kurimoto, Takahide Matsushima, Yusuke Tabata, Maiko Inotsume, Hiroki Tsutsumi, Lin Liu, Masahiro Shinohara, Yoko Tanaka, Ryo Nakamichi, Keiichiro Nishida, Martin K. Lotz, Hiroshi Asahara

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Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket by Pierrick Craveur, Anna T. Gres, Karen A. Kirby, Dandan Liu, John A. Hammond, Yisong Deng, Stefano Forli, David S. Goodsell, James R. Williamson, Stefan G. Sarafianos, Arthur J. Olson

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Microbial Metabolite 3-Indolepropionic Acid Mediates Immunosuppression by Carlos Guijas, Lucy E. Horton, Linh Hoang, Xavier Domingo-Almenara, Elizabeth M. Billings, Brian C. Ware, Brian Sullivan, Gary Siuzdak

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Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ by Zahra Heidari, Ian M. Chrisman, Michelle D. Nemetchek, Scott J. Novick, Anne-Laure Blayo, Trey Patton, Desiree E. Mendes, Philippe Diaz, Theodore M. Kamenecka, Patrick R. Griffin, Travis S. Hughes

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Genetic control of active neural circuits by Leon Reijmers, Leon Reijmers, Mark Mayford, Mark Mayford

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Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements by William H. Hudson, Ian Mitchelle S. de Vera, Jerome C. Nwachukwu, Emily R. Weikum, Austin G. Herbst, Qin Yang, David L. Bain, Kendall W. Nettles, Douglas J. Kojetin, Eric A. Ortlund

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Nitrogenous Derivatives of Phosphorus and the Origins of Life: Plausible Prebiotic Phosphorylating Agents in Water by Megha Karki, Clémentine Gibard, Subhendu Bhowmik, Ramanarayanan Krishnamurthy

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A chemically contiguous hapten approach for a heroin–fentanyl vaccine by Yoshihiro Natori, Candy S. Hwang, Lucy Lin, Lauren C. Smith, Bin Zhou, Kim D. Janda

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FRET-based reporters for the direct visualization of abscisic acid concentration changes and distribution in Arabidopsis by Rainer Waadt, Kenichi Hitomi, Noriyuki Nishimura, Chiharu Hitomi, Stephen R Adams, Elizabeth D Getzoff, Julian I Schroeder

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Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer by Shangwei Zhong, Ji-Hak Jeong, Changhao Huang, Xueyan Chen, Shohreh Iravani Dickinson, Jasreman Dhillon, Li Yang, Jun-Li Luo

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Molecular Deconvolution Platform to Establish Disease Mechanisms by Surveying GPCR Signaling by Ikuo Masuho, Sreenivas Chavali, Brian S. Muntean, Nickolas K. Skamangas, Kristina Simonyan, Dipak N. Patil, Grant M. Kramer, Laurie Ozelius, M. Madan Babu, Kirill A. Martemyanov

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ERCC1/XPF Is Important for Repair of DNA Double-Strand Breaks Containing Secondary Structures by Shibo Li, Hongyan Lu, Zi Wang, Qing Hu, Hongjun Wang, Rong Xiang, Takuya Chiba, Xiaohua Wu

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Fisetin is a senotherapeutic that extends health and lifespanResearch in Context by Matthew J. Yousefzadeh, Yi Zhu, Sara J. McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I. Melos, Tamar Pirtskhalava, Christina L. Inman, Collin McGuckian, Erin A. Wade, Jonathon I. Kato, Diego Grassi, Mark Wentworth, Christin E. Burd, Edgar A. Arriaga, Warren L. Ladiges, Tamara Tchkonia, James L. Kirkland, Paul D. Robbins, Laura J. Niedernhofer

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Complex I inhibition in the visual pathway induces disorganization of the node of Ranvier by Mathieu Marella, Gaurav Patki, Akemi Matsuno-Yagi, Takao Yagi

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Impact of Elevated Brain IL-6 in Transgenic Mice on the Behavioral and Neurochemical Consequences of Chronic Alcohol Exposure by Donna L. Gruol, Delilah Calderon, Salvador Huitron-Resendiz, Chelsea Cates-Gatto, Amanda J. Roberts

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Participation of macrophages in atherosclerotic lesion morphology in LDLr−/− mice by Natalie K. Schiller, Audrey S. Black, Gary P. Bradshaw, David J. Bonnet, Linda K. Curtiss

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Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor-deficient mice by Marion M. Marsh, V. Robert Walker, Linda K. Curtiss, Carole L. Banka

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Individual and Collective Contributions of Chaperoning and Degradation to Protein Homeostasis in E. coli by Younhee Cho, Xin Zhang, Kristine Faye R. Pobre, Yu Liu, David L. Powers, Jeffery W. Kelly, Lila M. Gierasch, Evan T. Powers

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PAZ6 cells constitute a representative model for human brown pre-adipocytes by Melissa eKazantzis, Virginia eTakahashi, Jessica eHinkle, Smitha eKota, Vladimir eZilberfarb, Vladimir eZilberfarb, Vladimir eZilberfarb, Tarik eIssad, Tarik eIssad, Tarik eIssad, Mouaadh eAbdelkarim, Lotfi eChouchane, Arthur Donny eStrosberg, Arthur Donny eStrosberg, Arthur Donny eStrosberg

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Melanocortin-3 receptors in the limbic system mediate feeding-related motivational responses during weight loss by Maria Mavrikaki, Clemence Girardet, Andras Kern, Alicia Faruzzi Brantley, Courtney A. Miller, Heather Macarthur, Daniel L. Marks, Andrew A. Butler

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