Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice by Martina Soldemo, Monika Àdori, Julian M. Stark, Yu Feng, Karen Tran, Richard Wilson, Lifei Yang, Javier Guenaga, Richard T. Wyatt, Gunilla B. Karlsson Hedestam

Get full text

PPARG Post-translational Modifications Regulate Bone Formation and Bone Resorption by L.A. Stechschulte, P.J. Czernik, Z.C. Rotter, F.N. Tausif, C.A. Corzo, D.P. Marciano, A. Asteian, J. Zheng, J.B. Bruning, T.M. Kamenecka, C.J. Rosen, P.R. Griffin, B. Lecka-Czernik

Get full text

AAV vectors engineered to target insulin receptor greatly enhance intramuscular gene delivery by Cody B. Jackson, Audrey S. Richard, Amrita Ojha, Kimberly A. Conkright, Jeffrey M. Trimarchi, Charles C. Bailey, Michael D. Alpert, Mark A. Kay, Michael Farzan, Hyeryun Choe

Get full text

Discovery of PLD4 modulators by high-throughput screening and kinetic analysis by Jinny Claire Lee, Ryan J. Shirey, Lewis D. Turner, Hyeri Park, Luke L. Lairson, Kim D. Janda

Get full text

The HIV-1 Envelope Glycoprotein C3/V4 Region Defines a Prevalent Neutralization Epitope following Immunization by Lin Lei, Yuhe R. Yang, Karen Tran, Yimeng Wang, Chi-I Chiang, Gabriel Ozorowski, Yongli Xiao, Andrew B. Ward, Richard T. Wyatt, Yuxing Li

Get full text

Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease by Supriya Swarnkar, Youjun Chen, William M. Pryor, Neelam Shahani, Damon T. Page, Srinivasa Subramaniam

Get full text

Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex by Francisco Javier Pavón, Ilham Y. Polis, David G. Stouffer, Benjamin F. Cravatt, Marisa Roberto, Rémi Martin-Fardon, Fernando Rodríguez de Fonseca, Loren H. Parsons, Antonia Serrano

Get full text

Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging by Aditi U. Gurkar, Andria R. Robinson, Yuxiang Cui, Xuesen Li, Shailaja K. Allani, Amanda Webster, Mariya Muravia, Mohammad Fallahi, Herbert Weissbach, Paul D. Robbins, Yinsheng Wang, Eric E. Kelley, Claudette M. St. Croix, Laura J. Niedernhofer, Matthew S. Gill

Get full text

Real-time assembly of ribonucleoprotein complexes on nascent RNA transcripts by Olivier Duss, Galina A. Stepanyuk, Annette Grot, Seán E. O’Leary, Joseph D. Puglisi, James R. Williamson

Get full text

Cell-based glycan arrays for probing glycan–glycan binding protein interactions by Jennie Grace Briard, Hao Jiang, Kelley W. Moremen, Matthew Scott Macauley, Peng Wu

Get full text

Progress in Anti-Mammarenavirus Drug Development by Yu-Jin Kim, Victor Venturini, Juan C. de la Torre

Get full text

Unconventional mechanism and selectivity of the Pd-catalyzed C–H bond lactonization in aromatic carboxylic acid by Li-Ping Xu, Shaoqun Qian, Zhe Zhuang, Jin-Quan Yu, Djamaladdin G. Musaev

Get full text

Mechanistic Insights into Two-Phase Radical C–H Arylations by Ryan D. Baxter, Yong Liang, Xin Hong, Timothy A. Brown, Richard N. Zare, K. N. Houk, Phil S. Baran, Donna G. Blackmond

Get full text

Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10 by Wang-Yong Yang, Rui Gao, Mark Southern, Partha S. Sarkar, Matthew D. Disney

Get full text

Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites by Jeffrey L. Pitman, David J. Bonnet, Linda K. Curtiss, Nicholas Gekakis

Get full text

Improved Cell-Penetrating Zinc-Finger Nuclease Proteins for Precision Genome Engineering by Jia Liu, Thomas Gaj, Mark C Wallen, Carlos F Barbas, III

Get full text

Reciprocal synapses between mushroom body and dopamine neurons form a positive feedback loop required for learning by Isaac Cervantes-Sandoval, Anna Phan, Molee Chakraborty, Ronald L Davis

Get full text

Transcriptional responses of skeletal stem/progenitor cells to hindlimb unloading and recovery correlate with localized but not systemic multi-systems impacts by Cori N. Booker, Christopher L. Haga, Siddaraju V. Boregowda, Jacqueline Strivelli, Donald G. Phinney

Get full text

Wikidata as a knowledge graph for the life sciences by Andra Waagmeester, Gregory Stupp, Sebastian Burgstaller-Muehlbacher, Benjamin M Good, Malachi Griffith, Obi L Griffith, Kristina Hanspers, Henning Hermjakob, Toby S Hudson, Kevin Hybiske, Sarah M Keating, Magnus Manske, Michael Mayers, Daniel Mietchen, Elvira Mitraka, Alexander R Pico, Timothy Putman, Anders Riutta, Nuria Queralt-Rosinach, Lynn M Schriml, Thomas Shafee, Denise Slenter, Ralf Stephan, Katherine Thornton, Ginger Tsueng, Roger Tu, Sabah Ul-Hasan, Egon Willighagen, Chunlei Wu, Andrew I Su

Get full text

Illuminating spatial pharmacology with in situ drug imaging by Zhengyuan Pang, Li Ye

Get full text