Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease by Mehdi Eshraghi, Pabalu P. Karunadharma, Juliana Blin, Neelam Shahani, Emiliano P. Ricci, Audrey Michel, Nicolai T. Urban, Nicole Galli, Manish Sharma, Uri Nimrod Ramírez-Jarquín, Katie Florescu, Jennifer Hernandez, Srinivasa Subramaniam

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Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms by Gregory M Solis, Rozina Kardakaris, Elizabeth R Valentine, Liron Bar-Peled, Alice L Chen, Megan M Blewett, Mark A McCormick, James R Williamson, Brian Kennedy, Benjamin F Cravatt, Michael Petrascheck

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A small molecule UPR modulator for diabetes identified by high throughput screening by Valeria Marrocco, Tuan Tran, Siying Zhu, Seung Hyuk Choi, Ana M. Gamo, Sijia Li, Qiangwei Fu, Marta Diez Cunado, Jason Roland, Mitch Hull, Van Nguyen-Tran, Sean Joseph, Arnab K. Chatterjee, Nikki Rogers, Matthew S. Tremblay, Weijun Shen

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Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model by James E. Voss, Raiees Andrabi, Laura E. McCoy, Natalia de Val, Roberta P. Fuller, Terrence Messmer, Ching-Yao Su, Devin Sok, Salar N. Khan, Fernando Garces, Laura K. Pritchard, Richard T. Wyatt, Andrew B. Ward, Max Crispin, Ian A. Wilson, Dennis R. Burton

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1205 Treatment of Lupus-prone BXSB Mice with a Modulatable CAR T cell System Targeting CD19 by Travis S Young, Argyrios N Theofilopoulos, Hua Huang, Sophie Viaud, Dwight H Kono, Ivo Rimann, Parker Mace, Rosana Gonzalez-Quintial, Eduardo Laborda, Hannah Mora

Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response” by Julia A. Jones, Na Wei, Haissi Cui, Yi Shi, Guangsen Fu, Navin Rauniyar, Ryan Shapiro, Yosuke Morodomi, Nadine Berenst, Calin Dan Dumitru, Sachiko Kanaji, John R. Yates, III, Taisuke Kanaji, Xiang-Lei Yang

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Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles by Sonu Kumar, Xiaohe Lin, Timothy Ngo, Benjamin Shapero, Cindy Sou, Joel D. Allen, Jeffrey Copps, Lei Zhang, Gabriel Ozorowski, Linling He, Max Crispin, Andrew B. Ward, Ian A. Wilson, Jiang Zhu

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A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation by Andreu Viader, Daisuke Ogasawara, Christopher M Joslyn, Manuel Sanchez-Alavez, Simone Mori, William Nguyen, Bruno Conti, Benjamin F Cravatt

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Transcriptome analyses of adult mouse brain reveal enrichment of lncRNAs in specific brain regions and neuronal populations by Beena Mary Kadakkuzha, Xin-An eLiu, Jennifer eMccrate, Gautam eShankar, Valerio eRizzo, Alina eAfinogenova, Brandon eYoung, Mohammad eFallahi, Anthony eCarvalloza, Bindu eRaveendra, Sathyanarayanan ePuthanveettil

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Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer by Jeong Hyun Lee, Catherine Nakao, Michael Appel, Amber Le, Elise Landais, Oleksandr Kalyuzhniy, Xiaozhen Hu, Alessia Liguori, Tina-Marie Mullen, Bettina Groschel, Robert K. Abbott, Devin Sok, William R. Schief, Shane Crotty

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Identification of new transmembrane proteins concentrated at the nuclear envelope using organellar proteomics of mesenchymal cells by Li-Chun Cheng, Sabyasachi Baboo, Cory Lindsay, Liza Brusman, Salvador Martinez-Bartolomé, Olga Tapia, Xi Zhang, John R. Yates, Larry Gerace

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Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy by Zhongying Mo, Xiaobei Zhao, Huaqing Liu, Qinghua Hu, Xu-Qiao Chen, Jessica Pham, Na Wei, Ze Liu, Jiadong Zhou, Robert W. Burgess, Samuel L. Pfaff, C. Thomas Caskey, Chengbiao Wu, Ge Bai, Xiang-Lei Yang

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Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection by Gregory M. Martin, Jonathan L. Torres, Tossapol Pholcharee, David Oyen, Yevel Flores-Garcia, Grace Gibson, Re’em Moskovitz, Nathan Beutler, Diana D. Jung, Jeffrey Copps, Wen-Hsin Lee, Gonzalo Gonzalez-Paez, Daniel Emerling, Randall S. MacGill, Emily Locke, C. Richter King, Fidel Zavala, Ian A. Wilson, Andrew B. Ward

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Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network by Jerome C Nwachukwu, Sathish Srinivasan, Nelson E Bruno, Alexander A Parent, Travis S Hughes, Julie A Pollock, Olsi Gjyshi, Valerie Cavett, Jason Nowak, Ruben D Garcia-Ordonez, René Houtman, Patrick R Griffin, Douglas J Kojetin, John A Katzenellenbogen, Michael D Conkright, Kendall W Nettles

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A combined quantitative mass spectrometry and electron microscopy analysis of ribosomal 30S subunit assembly in E. coli by Dipali G Sashital, Candacia A Greeman, Dmitry Lyumkis, Clinton S Potter, Bridget Carragher, James R Williamson

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Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling by Zhi-Xiang Xu, Ji-Wei Tan, Haifei Xu, Cassandra J. Hill, Olga Ostrovskaya, Kirill A. Martemyanov, Baoji Xu

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Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates by Alex R. Nanna, Xiuling Li, Even Walseng, Lee Pedzisa, Rebecca S. Goydel, David Hymel, Terrence R. Burke Jr., William R. Roush, Christoph Rader

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Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription by Yongchuan Zhu, Min Huang, Eric Bushong, Sebastien Phan, Marco Uytiepo, Elizabeth Beutter, Daniel Boemer, Kristin Tsui, Mark Ellisman, Anton Maximov

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Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response by Shridhar Bale, Lifei Yang, Mehrdad Alirezaei, Richard Wilson, Takayuki Ota, Esmeralda D. Doyle, Christopher A. Cottrell, Javier Guenaga, Karen Tran, Wenjuan Li, Leonidas Stamatatos, Leonidas Stamatatos, David Nemazee, Andrew B. Ward, Andrew B. Ward, Andrew B. Ward, Richard T. Wyatt, Richard T. Wyatt, Richard T. Wyatt

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846 Myeloid reprogramming by JAK inhibition enhances checkpoint blockade immunotherapy by Veronika Bachanova, Jaroslav Zak, Isaraphorn Pratumchai, Brett S Marro, Kristi L Marquardt, Michael BA Oldstone, Judith A Varner, John R Teijaro