An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain by Nicholas C. Wu, Meng Yuan, Hejun Liu, Chang-Chun D. Lee, Xueyong Zhu, Sandhya Bangaru, Jonathan L. Torres, Tom G. Caniels, Philip J.M. Brouwer, Marit J. van Gils, Rogier W. Sanders, Andrew B. Ward, Ian A. Wilson

Get full text

HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity by Jie Zheng, Chen Wang, Mi Ra Chang, Swapnil C. Devarkar, Brandon Schweibenz, Gogce C. Crynen, Ruben D. Garcia-Ordonez, Bruce D. Pascal, Scott J. Novick, Smita S. Patel, Joseph Marcotrigiano, Patrick R. Griffin

Get full text

eCD4-Ig promotes ADCC activity of sera from HIV-1-infected patients by M.E. Davis-Gardner, M.R. Gardner, B. Alfant, M. Farzan

Get full text

Schema Playground: a tool for authoring, extending, and using metadata schemas to improve FAIRness of biomedical data by Marco A. Cano, Ginger Tsueng, Xinghua Zhou, Jiwen Xin, Laura D. Hughes, Julia L. Mullen, Andrew I. Su, Chunlei Wu

Get full text

Activation of Methotrexate Prodrugs by Enzyme/Monoclonal Antibody Conjugates by Vitols K. S., Haenseler E., Montejano Y., Baer T., Huennekens F. M.

Get full text

IMPACT OF CHRONIC ETHANOL EXPOSURE ON INHIBITORY MODULATION OF CRF1-EXPRESSING NEURONS IN THE MOUSE VENTRAL BED NUCLEUS OF THE STRIA TERMINALIS by Paula Cristina Bianchi, Angela Snyder, Amanda Roberts, Valentina Vozella, Fabio Cruz, Marisa Roberto

Get full text

TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits by Juan Ji An, Clint E. Kinney, Ji-Wei Tan, Guey-Ying Liao, Eric J. Kremer, Baoji Xu

Get full text

Protocol for analyzing antibody responses to glycoprotein antigens using electron-microscopy-based polyclonal epitope mapping by Hannah L. Turner, Abigail M. Jackson, Sara T. Richey, Leigh M. Sewall, Aleksandar Antanasijevic, Lars Hangartner, Andrew B. Ward

Get full text

Imbalanced unfolded protein response signaling contributes to 1-deoxysphingolipid retinal toxicity by Jessica D. Rosarda, Sarah Giles, Sarah Harkins-Perry, Elizabeth A. Mills, Martin Friedlander, R. Luke Wiseman, Kevin T. Eade

Get full text

High throughput screening for compounds to the orphan nuclear receptor NR2F6 by Emery Smith, Sean Campbell, Adrianna N. Wilson, Justin Shumate, Pierre Baillargeon, Louis Scampavia, Theodore M. Kamenecka, Timothy P. Spicer, Laura A. Solt

Get full text

A reverse translational study of PPAR-α agonist efficacy in human and rodent models relevant to alcohol use disorder by Barbara J. Mason, David Estey, Amanda Roberts, Giordano de Guglielmo, Olivier George, John Light, Mike Stoolmiller, Susan Quello, Michael Skinner, Farhad Shadan, Adnan Begovic, Mark C. Kyle, R. Adron Harris

Get full text

Strain Prioritization and Genome Mining for Enediyne Natural Products by Xiaohui Yan, Huiming Ge, Tingting Huang, Hindra, Dong Yang, Qihui Teng, Ivana Crnovčić, Xiuling Li, Jeffrey D. Rudolf, Jeremy R. Lohman, Yannick Gansemans, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Filip Van Nieuwerburgh, Christoph Rader, Yanwen Duan, Ben Shen

Get full text

Recombinant Expression and Stapling of a Novel Long-Acting GLP-1R Peptide Agonist by Sam Lear, Hyosuk Seo, Candy Lee, Lei Lei, Zaid Amso, David Huang, Huafei Zou, Zhihong Zhou, Vân T. B. Nguyen-Tran, Weijun Shen

Get full text

Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine candidates by Yi-Nan Zhang, Jennifer Paynter, Aleksandar Antanasijevic, Joel D. Allen, Mor Eldad, Yi-Zong Lee, Jeffrey Copps, Maddy L. Newby, Linling He, Deborah Chavez, Pat Frost, Anna Goodroe, John Dutton, Robert Lanford, Christopher Chen, Ian A. Wilson, Max Crispin, Andrew B. Ward, Jiang Zhu

Get full text

Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization by Colin Havenar-Daughton, Diane G. Carnathan, Archana V. Boopathy, Amit A. Upadhyay, Ben Murrell, Samantha M. Reiss, Chiamaka A. Enemuo, Etse H. Gebru, Yury Choe, Pallavi Dhadvai, Federico Viviano, Kirti Kaushik, Jinal N. Bhiman, Bryan Briney, Dennis R. Burton, Steven E. Bosinger, William R. Schief, Darrell J. Irvine, Guido Silvestri, Shane Crotty

Get full text

Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration by Thomas Venables, Ann V. Griffith, Alice DeAraujo, Howard T. Petrie

Get full text

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization by Stephanie J Papp, Anne-Laure Huber, Sabine D Jordan, Anna Kriebs, Madelena Nguyen, James J Moresco, John R Yates III, Katja A Lamia

Get full text

OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels by Swetha E Murthy, Adrienne E Dubin, Tess Whitwam, Sebastian Jojoa-Cruz, Stuart M Cahalan, Seyed Ali Reza Mousavi, Andrew B Ward, Ardem Patapoutian

Get full text

Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function by Jihuan Chen, Valerie Chen, Tomoya Kawamura, Ivy Hoang, Yang Yang, Ashley Tess Wong, Ryan McBride, Vez Repunte-Canonigo, Glenn L. Millhauser, Pietro Paolo Sanna

Get full text

A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates by Ivy Phung, Kristen A. Rodrigues, Ester Marina-Zárate, Laura Maiorino, Bapi Pahar, Wen-Hsin Lee, Mariane Melo, Amitinder Kaur, Carolina Allers, Marissa Fahlberg, Brooke F. Grasperge, Jason P. Dufour, Faith Schiro, Pyone P. Aye, Paul G. Lopez, Jonathan L. Torres, Gabriel Ozorowski, Saman Eskandarzadeh, Michael Kubitz, Erik Georgeson, Bettina Groschel, Rebecca Nedellec, Michael Bick, Katarzyna Kaczmarek Michaels, Hongmei Gao, Xiaoying Shen, Diane G. Carnathan, Guido Silvestri, David C. Montefiori, Andrew B. Ward, Lars Hangartner, Ronald S. Veazey, Dennis R. Burton, William R. Schief, Darrell J. Irvine, Shane Crotty

Get full text