957 The ATR-inhibitor ceralasertib modulates the tumor microenvironment and improves the effect of anti-PDL1 by activating type I IFN pathway by Dmitry Gabrilovich, Simon Barry, Mark Cobbold, Sehmus Tohumeken, Kathy Mulgrew, Marta Milo, Emilio Sanseviero, Devon Taylor, Mimi Mai, Ali Mostafa, Serge Fuchs

Targeting HIV/SIV infection of CD4+ T follicular helper (Tfh) Cells: BCL6 inhibition represses HIV infection CD4+ T cells and reduces germinal center hyperplasia in rhesus macaque by Y. Cai, M. Abdel-Mohsen, M. Watkins, F. Xue, Y. AI, H. Cheng, C. Midkiff, C. Tomescu, X. Wang, X. Alvarez, R. Veazey, L. Montaner

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DNA vaccination protects mice against Zika virus-induced damage to the testes by Bryan D. Griffin, Kar Muthumani, Bryce M. Warner, Anna Majer, Mable Hagan, Jonathan Audet, Derek R. Stein, Charlene Ranadheera, Trina Racine, Marc-Antoine De La Vega, Jocelyne Piret, Stephanie Kucas, Kaylie N. Tran, Kathy L. Frost, Christine De Graff, Geoff Soule, Leanne Scharikow, Jennifer Scott, Gordon McTavish, Valerie Smid, Young K. Park, Joel N. Maslow, Niranjan Y. Sardesai, J. Joseph Kim, Xiao-jian Yao, Alexander Bello, Robbin Lindsay, Guy Boivin, Stephanie A. Booth, Darwyn Kobasa, Carissa Embury-Hyatt, David Safronetz, David B. Weiner, Gary P. Kobinger

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Preclinical platforms to study therapeutic efficacy of human γδ T cells by Lingling Ou, Huaishan Wang, Hui Huang, Zhiyan Zhou, Qiang Lin, Yeye Guo, Tara Mitchell, Alexander C. Huang, Giorgos Karakousis, Lynn Schuchter, Ravi Amaravadi, Wei Guo, Joseph Salvino, Meenhard Herlyn, Xiaowei Xu

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Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation by Hyungsoo Kim, Dennie T. Frederick, Mitchell P. Levesque, Zachary A. Cooper, Yongmei Feng, Clemens Krepler, Laurence Brill, Yardena Samuels, Nicholas K. Hayward, Ally Perlina, Adriano Piris, Tongwu Zhang, Ruth Halaban, Meenhard M. Herlyn, Kevin M. Brown, Jennifer A. Wargo, Reinhard Dummer, Keith T. Flaherty, Ze’ev A. Ronai

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“We are looking at the future right now”: community acceptability of a home-based viral load test device in the context of HIV cure-related research with analytical treatment inter... by Karine Dubé, John Kanazawa, Christopher Roebuck, Steven Johnson, William B. Carter, Lynda Dee, Beth Peterson, Kenneth M. Lynn, Linden Lalley-Chareczko, Emily Hiserodt, Sukyung Kim, Daniel Rosenbloom, Brad R. Evans, Melanie Anderson, Daria J. Hazuda, Lisa Shipley, Kevin Bateman, Bonnie J. Howell, Karam Mounzer, Pablo Tebas, Luis J. Montaner

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CD32+ CD4+ T Cells are HIV transcriptionally active rather than a resting reservoir by M. Abdel-Mohsen, C. Tomescu, S. Vadrevu, A. Spivak, L. Kuri-Cervantes, G. Wu, K. Cox, S. Vemula, M. Fair, K. Lynn, M.J. Buzon, J. Martinez-Picado, M. Betts, V. Planelles, K. Mounzer, B. Howell, D. Hazuda, P. Tebas, L.J. Montaner

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Mutated processes predict immune checkpoint inhibitor therapy benefit in metastatic melanoma by Andrew Patterson, Noam Auslander

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PARP1 as an Epigenetic Modulator: Implications for the Regulation of Host-Viral Dynamics by Asher A. Sobotka, Italo Tempera

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The landscape of BRAF transcript and protein variants in human cancer by Andrea Marranci, Zhijie Jiang, Marianna Vitiello, Elena Guzzolino, Laura Comelli, Samanta Sarti, Simone Lubrano, Cinzia Franchin, Ileabett Echevarría-Vargas, Andrea Tuccoli, Alberto Mercatanti, Monica Evangelista, Paolo Sportoletti, Giorgio Cozza, Ettore Luzi, Enrico Capobianco, Jessie Villanueva, Giorgio Arrigoni, Giovanni Signore, Silvia Rocchiccioli, Letizia Pitto, Nicholas Tsinoremas, Laura Poliseno

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Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth by Anna Han, Dzmitry Mukha, Vivian Chua, Timothy J. Purwin, Manoela Tiago, Bhavik Modasia, Usman Baqai, Jenna L. Aumiller, Nelisa Bechtel, Emily Hunter, Meggie Danielson, Mizue Terai, Philip B. Wedegaertner, Takami Sato, Solange Landreville, Michael A. Davies, Stefan Kurtenbach, J. William Harbour, Zachary T. Schug, Andrew E. Aplin

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Glycolysis downregulation is a hallmark of HIV‐1 latency and sensitizes infected cells to oxidative stress by Iart Luca Shytaj, Francesco Andrea Procopio, Mohammad Tarek, Irene Carlon‐Andres, Hsin‐Yao Tang, Aaron R Goldman, MohamedHusen Munshi, Virender Kumar Pal, Mattia Forcato, Sheetal Sreeram, Konstantin Leskov, Fengchun Ye, Bojana Lucic, Nicolly Cruz, Lishomwa C Ndhlovu, Silvio Bicciato, Sergi Padilla‐Parra, Ricardo Sobhie Diaz, Amit Singh, Marina Lusic, Jonathan Karn, David Alvarez‐Carbonell, Andrea Savarino

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New Rabies Vaccines for Use in Humans by Hildegund C. J. Ertl

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Tackling Antimicrobial Resistance in the Shadow of COVID-19 by Ami Patel

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Tumor-B-cell interactions promote isotype switching to an immunosuppressive IgG4 antibody response through upregulation of IL-10 in triple negative breast cancers by Nicole J. Toney, Lynn M. Opdenaker, Kader Cicek, Lisa Frerichs, Christopher Ryan Kennington, Samuel Oberly, Holly Archinal, Rajasekharan Somasundaram, Jennifer Sims-Mourtada

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<i>Pparγ1</i> Facilitates ErbB2-Mammary Adenocarcinoma in Mice by Xuanmao Jiao, Lifeng Tian, Zhao Zhang, Joanna Balcerek, Andrew V. Kossenkov, Mathew C. Casimiro, Chenguang Wang, Yichuan Liu, Adam Ertel, Raymond E. Soccio, Eric R. Chen, Qin Liu, Anthony W. Ashton, Wei Tong, Richard G. Pestell

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Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche by Ting-Lin B. Yang, Qijun Chen, Jennifer T. Deng, Geetha Jagannathan, John W. Tobias, David C. Schultz, Shan Wang, Christopher J. Lengner, Anil K. Rustgi, John P. Lynch, F. Brad Johnson

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The Critical Role of PARPs in Regulating Innate Immune Responses by Huifang Zhu, Yan-Dong Tang, Guoqing Zhan, Chenhe Su, Chunfu Zheng

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Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming by Raquel Buj, Chi-Wei Chen, Erika S. Dahl, Kelly E. Leon, Rostislav Kuskovsky, Natella Maglakelidze, Maithili Navaratnarajah, Gao Zhang, Mary T. Doan, Helen Jiang, Michael Zaleski, Lydia Kutzler, Holly Lacko, Yiling Lu, Gordon B. Mills, Raghavendra Gowda, Gavin P. Robertson, Joshua I. Warrick, Meenhard Herlyn, Yuka Imamura, Scot R. Kimball, David J. DeGraff, Nathaniel W. Snyder, Katherine M. Aird

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Circulating brain-derived extracellular vesicles expressing neuroinflammatory markers are associated with HIV-related neurocognitive impairment by Erika G. Marques de Menezes, Erika G. Marques de Menezes, Jocelyn S. Liu, Scott A. Bowler, Leila B. Giron, Michelle L. D’Antoni, Cecilia M. Shikuma, Mohamed Abdel-Mohsen, Lishomwa C. Ndhlovu, Lishomwa C. Ndhlovu, Lishomwa C. Ndhlovu, Philip J. Norris, Philip J. Norris, Philip J. Norris

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