Elicitation of immune responses against Nipah virus by an engineered synthetic DNA vaccine by Hyeree Choi, Sagar B. Kudchodkar, Ziyang Xu, Michelle Ho, Peng Xiao, Stephanie Ramos, Laurent Humeau, David B. Weiner, Kar Muthumani

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Synthetic DNA delivery by electroporation promotes robust in vivo sulfation of broadly neutralizing anti-HIV immunoadhesin eCD4-IgResearch in context by Ziyang Xu, Megan C. Wise, Hyeree Choi, Alfredo Perales-Puchalt, Ami Patel, Edgar Tello-Ruiz, Jacqueline D. Chu, Kar Muthumani, David B. Weiner

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Decitabine disrupts EBV genomic epiallele DNA methylation patterns around CTCF binding sites to increase chromatin accessibility and lytic transcription in gastric cancer by Sarah Preston-Alp, Lisa Beatrice Caruso, Chenhe Su, Kelsey Keith, Samantha S. Soldan, Davide Maestri, Jozef Madzo, Andrew Kossenkov, Giorgia Napoletani, Benjamin Gewurz, Paul M. Lieberman, Italo Tempera

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Pre-clinical modeling of cutaneous melanoma by Vito W. Rebecca, Rajasekharan Somasundaram, Meenhard Herlyn

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SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase by Hengrui Zhu, Shancheng Ren, Benjamin G. Bitler, Katherine M. Aird, Zhigang Tu, Emmanuel Skordalakes, Yasheng Zhu, Jun Yan, Yinghao Sun, Rugang Zhang

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DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections by Sarah T. C. Elliott, Nicole L. Kallewaard, Ebony Benjamin, Leslie Wachter-Rosati, Josephine M. McAuliffe, Ami Patel, Trevor R. F. Smith, Katherine Schultheis, Daniel H. Park, Seleeke Flingai, Megan C. Wise, Janess Mendoza, Stephanie Ramos, Kate E. Broderick, Jian Yan, Laurent M. Humeau, Niranjan Y. Sardesai, Kar Muthumani, Qing Zhu, David B. Weiner

“…A team of researchers led by Sarah Elliott and David Weiner of The Wistar Institute of Anatomy and Biology, Philadelphia, developed potent plasmid-based constructs that, once injected, entered hosts’ cells and utilized cellular machinery to encode antibodies protective against a range of influenza A and B subtypes. …”
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TERRA G-quadruplex RNA interaction with TRF2 GAR domain is required for telomere integrity by Yang Mei, Zhong Deng, Olga Vladimirova, Nitish Gulve, F. Brad Johnson, William C. Drosopoulos, Carl L. Schildkraut, Paul M. Lieberman

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Siglec-9 Restrains Antibody-Dependent Natural Killer Cell Cytotoxicity against SARS-CoV-2 by Pratima Saini, Opeyemi S. Adeniji, Devivasha Bordoloi, Jennifer Kinslow, Jeff Martinson, Danielle M. Parent, Kai Ying Hong, Jane Koshy, Abhijeet J. Kulkarni, Netanel F. Zilberstein, Robert A. Balk, James N. Moy, Leila B. Giron, Russell P. Tracy, Ali Keshavarzian, Kar Muthumani, Alan Landay, David B. Weiner, Mohamed Abdel-Mohsen

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Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment by Weili Ma, Maria Cecília Oliveira-Nunes, Ke Xu, Andrew Kossenkov, Benjamin C. Reiner, Richard C. Crist, James Hayden, Qing Chen

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Persistent HIV reservoir suppression by (-)-hopeaphenol, a plant-derived stilbenoid by I. Tietjen, Z. Haq, M. Naidu, J. Rivera-Ortiz, Y. Cai, K. Beattie, T. Rali, Z. Brumme, L. Montaner, R. Davis

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Pathological mobilization and activities of dendritic cells in tumor-bearing hosts: challenges and opportunities for immunotherapy of cancer by Amelia J Tesone, Nikolaos eSvoronos, Nikolaos eSvoronos, Michael J Allegrezza, Michael J Allegrezza, Jose eConejo-Garcia

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Antimelanoma CTL recognizes peptides derived from an ORF transcribed from the antisense strand of the 3′ untranslated region of TRIT1 by Rolf K Swoboda, Rajasekharan Somasundaram, Laura Caputo-Gross, Francesco M Marincola, Paul Robbins, Meenhard Herlyn, Dorothee Herlyn

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Oxidation of cholesterol by rat liver mitochondria: effect of dietary fat by David Kritchevsky, Ruth R. Kolman, Michael W. Whitehouse, Martha C. Cottrell, Ezra Staple

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Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge by Ebony N. Gary, Nicholas J. Tursi, Nicholas J. Tursi, Bryce M. Warner, Gina Cuismano, Gina Cuismano, Jennifer Connors, Jennifer Connors, Elizabeth M. Parzych, Bryan D. Griffin, Matthew R. Bell, Matthew R. Bell, Ali R. Ali, Drew Frase, Casey E. Hojecki, Gabriela A. Canziani, Irwin Chaiken, Toshitha Kannan, Estella Moffat, Carissa Embury-Hyatt, Sarah K. Wooton, Andrew Kossenkov, Andrew Kossenkov, Ami Patel, Darwyn Kobasa, Darwyn Kobasa, Michele A. Kutzler, Michele A. Kutzler, Elias K. Haddad, Elias K. Haddad, David B. Weiner

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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser by Keerthana Gnanapradeepan, Julia I-Ju Leu, Subhasree Basu, Thibaut Barnoud, Madeline Good, Joyce V Lee, William J Quinn, Che-Pei Kung, Rexford Ahima, Joseph A Baur, Kathryn E Wellen, Qin Liu, Zachary T Schug, Donna L George, Maureen E Murphy

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Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infections by Pratima Saini, Opeyemi S. Adeniji, Mohamed Abdel-Mohsen

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The Telomeric Response to Viral Infection by Zhuo Wang, Zhong Deng, Steve Tutton, Paul M. Lieberman

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Phorbol esters isolated from Croton megalobotrys reverse HIV latency ex vivo by I. Tietjen, K. Richard, D. Williams, J. Rivera-Ortiz, Y. Cai, A. Pagliuzza, N. Chomont, R. Andersen, L. Montaner, K. Andrae-Marobela

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Targeting cellular senescence to combat cancer and ageing by Chen Wang, Xue Hao, Rugang Zhang

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Tmem119 expression is downregulated in a subset of brain metastasis-associated microglia by Weili Ma, Jack Oswald, Angela Rios Angulo, Qing Chen

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