PP 2.12 – 00153 eCD4-Ig-DNA Decreased HIV Reservoir and Delayed Viral Rebound Through Fc Mediated Functions in BLT Humanized Mice by Z. Yuan, M. Purwar, S. Adeniji, Z. Xu, G. Zu, C. Hart, A. Kulkarni, M. Abdel-Mohsen, D. Weiner, L. Montaner

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Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence by Bo Zhao, Pingyu Liu, Takeshi Fukumoto, Timothy Nacarelli, Nail Fatkhutdinov, Shuai Wu, Jianhuang Lin, Katherine M. Aird, Hsin-Yao Tang, Qin Liu, David W. Speicher, Rugang Zhang

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A deep learning approach reveals unexplored landscape of viral expression in cancer by Abdurrahman Elbasir, Ying Ye, Daniel E. Schäffer, Xue Hao, Jayamanna Wickramasinghe, Konstantinos Tsingas, Paul M. Lieberman, Qi Long, Quaid Morris, Rugang Zhang, Alejandro A. Schäffer, Noam Auslander

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Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer by Jianhuang Lin, Heng Liu, Takeshi Fukumoto, Joseph Zundell, Qingqing Yan, Chih-Hang Anthony Tang, Shuai Wu, Wei Zhou, Dajiang Guo, Sergey Karakashev, Chih-Chi Andrew Hu, Kavitha Sarma, Andrew V. Kossenkov, Rugang Zhang

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Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence by Katherine M. Aird, Gao Zhang, Hua Li, Zhigang Tu, Benjamin G. Bitler, Azat Garipov, Hong Wu, Zhi Wei, Stephan N. Wagner, Meenhard Herlyn, Rugang Zhang

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DAXX-ATRX regulation of p53 chromatin binding and DNA damage response by Nitish Gulve, Chenhe Su, Zhong Deng, Samantha S. Soldan, Olga Vladimirova, Jayamanna Wickramasinghe, Hongwu Zheng, Andrew V. Kossenkov, Paul. M. Lieberman

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DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2 by Elizabeth M. Parzych, Jianqiu Du, Ali R. Ali, Katherine Schultheis, Drew Frase, Trevor R. F. Smith, Jiayan Cui, Neethu Chokkalingam, Nicholas J. Tursi, Viviane M. Andrade, Bryce M. Warner, Ebony N. Gary, Yue Li, Jihae Choi, Jillian Eisenhauer, Igor Maricic, Abhijeet Kulkarni, Jacqueline D. Chu, Gabrielle Villafana, Kim Rosenthal, Kuishu Ren, Joseph R. Francica, Sarah K. Wootton, Pablo Tebas, Darwyn Kobasa, Kate E. Broderick, Jean D. Boyer, Mark T. Esser, Jesper Pallesen, Dan W. Kulp, Ami Patel, David B. Weiner

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Author Correction: African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin by Kumar Sachin Singh, Julia I-Ju Leu, Thibaut Barnoud, Prashanthi Vonteddu, Keerthana Gnanapradeepan, Cindy Lin, Qin Liu, James C. Barton, Andrew V. Kossenkov, Donna L. George, Maureen E. Murphy, Farokh Dotiwala

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Erratum for Adeniji et al., “COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions” by Opeyemi S. Adeniji, Leila B. Giron, Mansi Purwar, Netanel F. Zilberstein, Abhijeet J. Kulkarni, Maliha W. Shaikh, Robert A. Balk, James N. Moy, Christopher B. Forsyth, Qin Liu, Harsh Dweep, Andrew Kossenkov, David B. Weiner, Ali Keshavarzian, Alan Landay, Mohamed Abdel-Mohsen

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COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions by Opeyemi S. Adeniji, Leila B. Giron, Mansi Purwar, Netanel F. Zilberstein, Abhijeet J. Kulkarni, Maliha W. Shaikh, Robert A. Balk, James N. Moy, Christopher B. Forsyth, Qin Liu, Harsh Dweep, Andrew Kossenkov, David B. Weiner, Ali Keshavarzian, Alan Landay, Mohamed Abdel-Mohsen

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ARID1A promotes genomic stability through protecting telomere cohesion by Bo Zhao, Jianhuang Lin, Lijie Rong, Shuai Wu, Zhong Deng, Nail Fatkhutdinov, Joseph Zundell, Takeshi Fukumoto, Qin Liu, Andrew Kossenkov, Stephanie Jean, Mark G. Cadungog, Mark E. Borowsky, Ronny Drapkin, Paul M. Lieberman, Cory T. Abate-Shen, Rugang Zhang

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Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model by Ami Patel, Jewell N. Walters, Emma L. Reuschel, Katherine Schultheis, Elizabeth Parzych, Ebony N. Gary, Igor Maricic, Mansi Purwar, Zeena Eblimit, Susanne N. Walker, Diana Guimet, Pratik Bhojnagarwala, Opeyemi S. Adeniji, Arthur Doan, Ziyang Xu, Dustin Elwood, Sophia M. Reeder, Laurent Pessaint, Kevin Y. Kim, Anthony Cook, Neethu Chokkalingam, Brad Finneyfrock, Edgar Tello-Ruiz, Alan Dodson, Jihae Choi, Alison Generotti, John Harrison, Nicholas J. Tursi, Viviane M. Andrade, Yaya Dia, Faraz I. Zaidi, Hanne Andersen, Mohamed Abdel-Mohsen, Mark G. Lewis, Kar Muthumani, J. Joseph Kim, Daniel W. Kulp, Laurent M. Humeau, Stephanie J. Ramos, Trevor R.F. Smith, David B. Weiner, Kate E. Broderick

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Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity by Xue Zhang, Shishir M. Pant, Cecily C. Ritch, Hsin-Yao Tang, Hongguang Shao, Harsh Dweep, Yao-Yu Gong, Rebekah Brooks, Patricia Brafford, Adam J. Wolpaw, Yool Lee, Ashani Weeraratna, Amita Sehgal, Meenhard Herlyn, Andrew Kossenkov, David Speicher, Peter K. Sorger, Sandro Santagata, Chi V. Dang

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African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin by Kumar Sachin Singh, Julia I-Ju Leu, Thibaut Barnoud, Prashanthi Vonteddu, Keerthana Gnanapradeepan, Cindy Lin, Qin Liu, James C. Barton, Andrew V. Kossenkov, Donna L. George, Maureen E. Murphy, Farokh Dotiwala

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Structural and functional analysis of the human POT1-TPP1 telomeric complex by Cory Rice, Prashanth Krishna Shastrula, Andrew V. Kossenkov, Robert Hills, Duncan M. Baird, Louise C. Showe, Tzanko Doukov, Susan Janicki, Emmanuel Skordalakes

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CTCF driven TERRA transcription facilitates completion of telomere DNA replication by Kate Beishline, Olga Vladimirova, Stephen Tutton, Zhuo Wang, Zhong Deng, Paul M. Lieberman

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Engineered antibody cytokine chimera synergizes with DNA-launched nanoparticle vaccines to potentiate melanoma suppression in vivo by Nicholas J. Tursi, Nicholas J. Tursi, Ziyang Xu, Ziyang Xu, Michaela Helble, Michaela Helble, Susanne Walker, Kevin Liaw, Neethu Chokkalingam, Toshitha Kannan, Yuanhan Wu, Edgar Tello-Ruiz, Daniel H. Park, Xizhou Zhu, Megan C. Wise, Trevor R. F. Smith, Sonali Majumdar, Andrew Kossenkov, Daniel W. Kulp, David B. Weiner

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DNA immunotherapy targeting BARF1 induces potent anti-tumor responses against Epstein-Barr-virus-associated carcinomas by Xizhou Zhu, Alfredo Perales-Puchalt, Krzysztof Wojtak, Ziyang Xu, Kun Yun, Pratik S. Bhojnagarwala, Devivasha Bordoloi, Daniel H. Park, Kevin Liaw, Mamadou A. Bah, Paul M. Lieberman, Ebony N. Gary, Ami Patel, David B. Weiner

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Multivalent in vivo delivery of DNA-encoded bispecific T cell engagers effectively controls heterogeneous GBM tumors and mitigates immune escape by Daniel H. Park, Kevin Liaw, Pratik Bhojnagarwala, Xizhou Zhu, Jihae Choi, Ali R. Ali, Devivasha Bordoloi, Ebony N. Gary, Ryan P. O’Connell, Abhijeet Kulkarni, Diana Guimet, Trevor Smith, Alfredo Perales-Puchalt, Ami Patel, David B. Weiner

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1101 Activation of myeloid cells suppresses metastatic ovarian cancer via tumoricidal neutrophils and IL-27-secreting macrophages by Nan Zhang, Toshitha Kannan, Andrew Kossenkov, Taito Miyamoto, Brennah Murphy, Bryan Manning, Daniel Claiborne, Rugang Zhang