Comparative highlights on MERS-CoV, SARS-CoV-1, SARS-CoV-2, and NEO-CoV by Rajat Goyal, Rupesh Gautam, Hitesh Chopra, Ankit Kumar Dubey, Rajeev K. Singla, Rehab A. Rayan, Mohammad Amjad Kamal

“…In this review article, we will discuss the comparative highlights of SARS-CoV-1, MERS-CoV, SARS-CoV-2, and Neo-CoV, concerning their structural features, morphological characteristics, sources of virus origin and their evolutionary transitions, infection mechanism, computational study approaches, pathogenesis and their severity towards several diseases, possible therapeutic approaches, and preventive measures.…”
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Clenching the Strings of Bruxism Etiopathogenesis: Association Analyses on Genetics and Environmental Risk Factors in a Deeply Characterized Italian Cohort by Alessandro Pecori, Valentina Luppieri, Aurora Santin, Beatrice Spedicati, Stefania Zampieri, Milena Cadenaro, Giorgia Girotto, Maria Pina Concas

“…Overall, this work provided a deeper understanding of bruxism etiopathogenesis with the long-term perspective of developing personalized therapeutic approaches for improving affected individuals’ quality of life.…”
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Novel Insights into Diagnosis, Biology and Treatment of Primary Diffuse Leptomeningeal Melanomatosis by Alicia Baumgartner, Natalia Stepien, Lisa Mayr, Sibylle Madlener, Christian Dorfer, Maria T. Schmook, Tatjana Traub-Weidinger, Daniela Lötsch-Gojo, Dominik Kirchhofer, Dominik Reisinger, Cora Hedrich, Saleha Arshad, Stefan Irschik, Heidrun Boztug, Gernot Engstler, Marie Bernkopf, Fikret Rifatbegovic, Christoph Höller, Irene Slavc, Walter Berger, Leonhard Müllauer, Christine Haberler, Amedeo A. Azizi, Andreas Peyrl, Johannes Gojo

“…Mortality remains substantial despite diverse therapeutic approaches with a median overall survival of 4 months from diagnosis. …”
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Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT): Patient Characteristics, Treatment, and Outcome—A Systematic Review by Francis S. P. L. Wens, Caroline C. C. Hulsker, Marta Fiocco, József Zsiros, Stephanie E. Smetsers, Ronald R. de Krijger, Alida F. W. van der Steeg, Ronald P. Zweemer, Inge O. Baas, Eva Maria Roes, Leendert H. J. Looijenga, Cornelis G. Gerestein, Annelies M. C. Mavinkurve-Groothuis

“…A great diversity in the diagnostic work-up and therapeutic approaches was reported. The chemotherapy regimens were very diverse, all containing a platinum-based (cisplatin or carboplatin) backbone. …”
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Baseline levels of miR-223-3p correlate with the effectiveness of electroconvulsive therapy in patients with major depression by Lalit Kaurani, Matthias Besse, Isabel Methfessel, Aditi Methi, Jiayin Zhou, Ranjit Pradhan, Susanne Burkhardt, Laura Kranaster, Alexander Sartorius, Ute Habel, Michael Grözinger, Andre Fischer, Jens Wiltfang, David Zilles-Wegner

“…Abstract There is a strong medical need to develop suitable biomarkers to improve the diagnosis and treatment of depression, particularly in predicting response to certain therapeutic approaches such as electroconvulsive therapy (ECT). …”
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Emerging Trends in AI and Radiomics for Bladder, Kidney, and Prostate Cancer: A Critical Review by Georgios Feretzakis, Patrick Juliebø-Jones, Arman Tsaturyan, Tarik Emre Sener, Vassilios S. Verykios, Dimitrios Karapiperis, Themistoklis Bellos, Stamatios Katsimperis, Panagiotis Angelopoulos, Ioannis Varkarakis, Andreas Skolarikos, Bhaskar Somani, Lazaros Tzelves

“…The integration of radiogenomics offers a comprehensive view of disease biology, leading to tailored therapeutic approaches. Prostate cancer diagnosis and management have also seen substantial benefits from these technologies. …”
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Characteristics and Prognosis of a Contemporary Cohort with Myocardial Infarction with Non-Obstructed Coronary Arteries (MINOCA) Presenting Different Patterns of Late Gadolinium En... by Valentina Bucciarelli, Francesco Bianco, Alessia Di Francesco, Piergiusto Vitulli, Annaclara Biasi, Martina Primavera, Sara Belleggia, Giuseppe Ciliberti, Federico Guerra, Jelena Seferovic, Antonio Dello Russo, Sabina Gallina

“…Among the MINOCA patients, CMR can identify patients at higher risk who require more aggressive therapeutic approached and strict follow-up.…”
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Standardizing an Experimental Murine Model of Extraparenchymal Neurocysticercosis That Immunologically Resembles Human Infection by Alejandro Espinosa-Cerón, Alejandro Méndez, Juan Hernández-Aceves, Juan C. Juárez-González, Nelly Villalobos, Marisela Hernández, Georgina Díaz, Paola Soto, Luis Concha, Iván N. Pérez-Osorio, Juan J. Ortiz-Retana, Raúl J. Bobes, Robert M. Parkhouse, P. T. Hamamoto Filho, Gladis Fragoso, Edda Sciutto

“…Methods: An experimental murine model of EXP-NCC, as an adequate model to evaluate new therapeutic approaches, and the parameters that support it are described. …”
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Hypoxia and Microvascular Alterations Are Early Predictors of IDH-Mutated Anaplastic Glioma Recurrence by Andreas Stadlbauer, Stefan Oberndorfer, Gertraud Heinz, Max Zimmermann, Thomas M. Kinfe, Arnd Doerfler, Michael Buchfelder, Natalia Kremenevski, Franz Marhold

“…Hence, increased knowledge about pathophysiological precursors of AG recurrence is urgently needed in order to develop precise diagnostic monitoring and tailored therapeutic approaches. In this study, 142 physiological magnetic resonance imaging (phyMRI) follow-up examinations in 60 AG patients after standard therapy were evaluated and magnetic resonance imaging (MRI) biomarker maps for microvascular architecture and perfusion, neovascularization activity, oxygen metabolism, and hypoxia calculated. …”
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Extracellular vesicles as potential biomarkers for diagnosis and recurrence detection of hepatocellular carcinoma by Mazen A. Juratli, Nicola S. Pollmann, Elsie Oppermann, Annika Mohr, Dhruvajyoti Roy, Andreas Schnitzbauer, Sabine Michalik, Thomas Vogl, Nikolas H. Stoecklein, Philipp Houben, Shadi Katou, Felix Becker, Jens Peter Hoelzen, Andreas Andreou, Andreas Pascher, Wolf O. Bechstein, Benjamin Struecker

“…This finding of our pilot study suggests EVs could play a role as potential targets for the development of diagnostic and therapeutic approaches for the early and non-invasive detection of HCC recurrence. …”
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Comparison of Exosomes Derived from Non- and Gamma-Irradiated Melanoma Cancer Cells as a Potential Antigenic and Immunogenic Source for Dendritic Cell-Based Immunotherapeutic Vacci... by Woo Sik Kim, DaeSeong Choi, Ji Min Park, Ha-Yeon Song, Ho Seong Seo, Dong-Eun Lee, Eui-Baek Byun

“…Therefore, an improved understanding of the immunological interventions that stress-induced tumor exosomes have may provide novel therapeutic approaches and more effective vaccine designs. …”
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Epidemiology and Management of ST‐Segment–Elevation Myocardial Infarction in Patients With COVID‐19: A Report From the American Heart Association COVID‐19 Cardiovascular Disease Re... by Ankeet S. Bhatt, Anubodh S. Varshney, Erica L. Goodrich, Jingyi Gong, Curtis Ginder, Balimkiz C. Senman, Matthew Johnson, Kayleigh Butler, Ann E. Woolley, James A. de Lemos, David A. Morrow, Erin A. Bohula

“…We sought to determine the incidence, diagnostic and therapeutic approaches, and outcomes in STEMI patients hospitalized for COVID‐19. …”
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Liposomal Glutathione Supplementation Mitigates Extrapulmonary Tuberculosis in the Liver and Spleen by Kayvan Sasaninia, Melissa Kelley, Arbi Abnousian, James Owens, SonYeol Yoon, Abrianna Beever, Nala Kachour, Aram Yegiazaryan, Afsal Kolloli, Ranjeet Kumar, Santhamani Ramasamy, Selvakumar Subbian, Vishwanath Venketaraman

“…The rise of multidrug resistance in M. tb alongside the hepatotoxicity associated with antibiotics presents challenges in managing and treating tuberculosis (TB), thereby prompting a need for new therapeutic approaches. Administration of liposomal glutathione (L-GSH) has previously been shown to lower oxidative stress, enhance a granulomatous response, and reduce the burden of M. tb in the lungs of M. tb-infected mice. …”
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Treatment Options for Hepatitis A and E: A Non-Systematic Review by Filippo Gabrielli, Francesco Alberti, Cristina Russo, Carmela Cursaro, Hajrie Seferi, Marzia Margotti, Pietro Andreone

“…However, several therapeutic approaches have been attempted: for HAV infection, corticosteroid therapy has shown outcome improvement, and molecules, such as AZD 1480, zinc chloride and heme oxygenase-1, have demonstrated a reduction in viral replication in vitro. …”
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OncoPan^®: An NGS-Based Screening Methodology to Identify Molecular Markers for Therapy and Risk Assessment in Pancreatic Ductal Adenocarcinoma by Maria Grazia Tibiletti, Ileana Carnevali, Valeria Pensotti, Anna Maria Chiaravalli, Sofia Facchi, Sara Volorio, Frederique Mariette, Paolo Mariani, Stefano Fortuzzi, Marco Alessandro Pierotti, Fausto Sessa

“…Whole genome sequencing provides a wide description of genomic events involved in pancreatic carcinogenesis and identifies putative biomarkers for new therapeutic approaches. However, currently, there are no approved treatments targeting driver mutations in PDAC that could produce clinical benefit for PDAC patients. …”
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Antimicrobial and anti-inflammatory activity of Cystatin C on human gingival fibroblast incubated with Porphyromonas gingivalis by Blanca Esther Blancas-Luciano, Ingeborg Becker-Fauser, Jaime Zamora-Chimal, José Delgado-Domínguez, Adriana Ruíz-Remigio, Elba Rosa Leyva-Huerta, Javier Portilla-Robertson, Ana María Fernández-Presas

“…Knowledge on the antimicrobial and immunomodulatory properties of cystatin C could aid in the design of new therapeutic approaches to facilitate the elimination of this bacterium to improve the treatment of periodontal disease.…”
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β-Catenin Signaling Evokes Hair Follicle Senescence by Accelerating the Differentiation of Hair Follicle Mesenchymal Progenitors by Jimin Han, Jimin Han, Jimin Han, Kaijun Lin, Huiqin Choo, Jia He, Xusheng Wang, Yaojiong Wu, Yaojiong Wu, Xiaodong Chen

“…Therefore, our study reveals that the regulation of β-catenin signaling in hfDSCs may potentially become an important subject for future exploration in development of clinically effective therapies for hair loss treatment and an excellent model for revealing new therapeutic approaches to reverse aging or retarding the development of alopecia.…”
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Plasmin Triggers a Switch-Like Decrease in Thrombospondin-Dependent Activation of TGF-β1 by Venkatraman, Lakshmi, Chia, Ser-Mien, Narmada, Balakrishnan Chakrapani, White, Jacob K., Bhowmick, Sourav S., Tucker-Kellogg, Lisa, Yu, Hanry, Dewey, C. Forbes, So, Peter T. C.

“…This switch suggests an explanation for the unexpected effects of the plasminogen activation system on TGF-β1 in fibrotic diseases in vivo, as well as novel prognostic and therapeutic approaches for diseases with TGF-β dysregulation.…”
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IL-21/23 axis modulates inflammatory cytokines and RANKL expression in RA CD4+ T cells via p-Akt1 signaling by Gargee Bhattacharya, Gargee Bhattacharya, Soumya Sengupta, Soumya Sengupta, Rohila Jha, Rohila Jha, Shubham K. Shaw, Shubham K. Shaw, Gajendra M. Jogdand, Prakash K. Barik, Prasanta Padhan, Jyoti R. Parida, Satish Devadas, Satish Devadas

“…Subsequent dissection of the signaling pathway found p-Akt1 as the key phosphoprotein downstream of both IL-21 and IL-23, capable of increasing inflammatory cytokines and RANKL production.DiscussionOur findings unequivocally identify IL-21/23 axis in RA CD4+ T cells as a key regulator dictating two critical processes i.e. exaggerated inflammation and higher RANKL expression and provide critical targets in their downstream signalling for therapeutic approaches.…”
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Circulating extracellular vesicles provide valuable protein, but not DNA, biomarkers in metastatic breast cancer by Mercedes Tkach, Caroline Hego, Marc Michel, Lauren Darrigues, Jean‐Yves Pierga, François‐Clément Bidard, Clotilde Théry, Charlotte Proudhon

“…These non‐invasive biomarkers represent a promising tool for cancer diagnosis and real‐time monitoring of treatment efficacy and these results will impact the development of therapeutic approaches using EVs as targets or biomarkers of cancer.…”
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