Stereotactic body radiotherapy as a viable treatment on extracranial oligometastases in melanoma patients: a retrospective multicentric study by Victorine Trentesaux, Sophie Maiezza, Emilie Bogart, Marie-Cécile Le Deley, Emmanuel Meyer, Ludovic Vanquin, David Pasquier, David Pasquier, Laurent Mortier, Laurent Mortier, Xavier Mirabel

“…Future randomized studies are needed to establish the role of SBRT in therapeutic approaches for patients with oligometastatic melanoma.…”
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Multiparametric Magnetic Resonance Imaging and Metabolic Characterization of Patient-Derived Xenograft Models of Clear Cell Renal Cell Carcinoma by Joao Piraquive Agudelo, Deepti Upadhyay, Dalin Zhang, Hongjuan Zhao, Rosalie Nolley, Jinny Sun, Shubhangi Agarwal, Robert A. Bok, Daniel B. Vigneron, James D. Brooks, John Kurhanewicz, Donna M. Peehl, Renuka Sriram

“…Dysregulated metabolism is a key feature of clear cell renal cell carcinoma (ccRCC) and authentic preclinical models are needed to evaluate novel imaging and therapeutic approaches targeting metabolism. We characterized 5 PDX from high-grade or metastatic ccRCC by multiparametric magnetic resonance imaging (MRI) and steady state metabolic profiling and flux analysis. …”
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A porcine large animal model of radiofrequency ablation-induced left bundle branch block by Felix Wiedmann, Felix Wiedmann, Felix Wiedmann, Max Jamros, Valerie Herlt, Amelie Paasche, Amelie Paasche, Manuel Kraft, Manuel Kraft, Moritz Beck, Merten Prüser, Merten Prüser, Merten Prüser, Atilla Erkal, Maren Harder, Marcin Zaradzki, Jasmin Soethoff, Matthias Karck, Norbert Frey, Norbert Frey, Norbert Frey, Constanze Schmidt, Constanze Schmidt, Constanze Schmidt

“…This study aimed to establish a translational model of LBBB to enhance our understanding of its pathophysiology and improve therapeutic approaches.MethodsFourteen male pigs underwent radiofrequency catheter ablation of the proximal LBB under fluoroscopy and ECG guidance. …”
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Divergent Responses of Hydrophilic CdSe and CdSe@CdS Core–Shell Nanocrystals in Apoptosis and In Vitro Cancer Cell Imaging: A Comparative Analysis by Kishan Das, Neelima Bhatt, Ajith Manayil Parambil, Kajal Kumari, Raj Kumar, Kamla Rawat, Paulraj Rajamani, Himadri B. Bohidar, Ahmed Nadeem, Saravanan Muthupandian, Ramovatar Meena

“…The application of core–shell nanocrystals offers significant potential in increasing diagnostic and therapeutic approaches for cancer research in apoptosis and in vitro cancer cell imaging. …”
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Should We Keep Walking along the Trail for Pancreatic Cancer Treatment? Revisiting TNF-Related Apoptosis-Inducing Ligand for Anticancer Therapy by Anna-Laura Kretz, Silvia von Karstedt, Andreas Hillenbrand, Doris Henne-Bruns, Uwe Knippschild, Anna Trauzold, Johannes Lemke

“…Consequently, novel therapeutic approaches are urgently needed. Many hopes for cancer treatment have been placed in the death ligand tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) since it was reported to induce apoptosis selectively in tumor cells in vitro and in vivo. …”
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In Silico Evaluation of the Potential Association of the Pathogenic Mutations of Alpha Synuclein Protein with Induction of Synucleinopathies by Mohamed E. Elnageeb, Imadeldin Elfaki, Khalid M. Adam, Elsadig Mohamed Ahmed, Elkhalifa M. Elkhalifa, Hytham A. Abuagla, Abubakr Ali Elamin Mohamed Ahmed, Elshazali Widaa Ali, Elmoiz Idris Eltieb, Ali M. Edris

“…After being verified these findings can be used in genetic testing for the early diagnosis of PD, the evaluation of the risk factors, and therapeutic approaches.…”
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Fibroblast growth factor 7 alleviates myocardial infarction by improving oxidative stress via PI3Kα/AKT-mediated regulation of Nrf2 and HXK2 by Lin Mei, Yunjie Chen, Peng Chen, Huinan Chen, Shengqu He, Cheng Jin, Yang Wang, Zhicheng Hu, Wanqian Li, Litai Jin, Weitao Cong, Xu Wang, Xueqiang Guan

“…Unfortunately, effective therapeutic approaches are lacking. Fibroblast growth factor 7 (FGF7) is proved with respect to its proliferative effects and high expression level during embryonic heart development. …”
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Proteomics based identification of KDM5 histone demethylases associated with cardiovascular diseaseResearch in context by Marika Mokou, Julie Klein, Manousos Makridakis, Vasiliki Bitsika, Jean-Loup Bascands, Jean Sebastien Saulnier-Blache, William Mullen, Michael Sacherer, Jerome Zoidakis, Burkert Pieske, Harald Mischak, Maria G. Roubelakis, Joost P. Schanstra, Antonia Vlahou

“…Background: The increased prevalence of cardiovascular disease (CVD) indicates a demand for novel therapeutic approaches. Proteome analysis of vascular tissues from animal models and humans with CVD could lead to the identification of novel druggable targets. …”
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Prevalence and Spectrum of <i>BRCA</i> Germline Variants in Central Italian High Risk or Familial Breast/Ovarian Cancer Patients: A Monocentric Study by Jennifer Foglietta, Vienna Ludovini, Fortunato Bianconi, Lorenza Pistola, Maria Sole Reda, Antonella Al-Refaie, Francesca Romana Tofanetti, Annamaria Mosconi, Elisa Minenza, Paola Anastasi, Carmen Molica, Fabrizio Stracci, Fausto Roila

“…Recently, data has shown that identification of <i>BRCA</i> variants has an immediate impact not only in cancer prevention but also in targeted therapeutic approaches. This prospective observational study characterized the overall germline <i>BRCA</i> variant and variant of uncertain significance (VUS) frequency and spectrum in individuals affected by breast (BC) or ovarian cancer (OC) and in healthy individuals at risk by sequencing the entire <i>BRCA</i> genes. …”
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Progranulin in Musculoskeletal Inflammatory and Degenerative Disorders, Focus on Rheumatoid Arthritis, Lupus and Intervertebral Disc Disease: A Systematic Review by María González-Rodríguez, Djedjiga Ait Edjoudi, Alfonso Cordero Barreal, Clara Ruiz-Fernández, Mariam Farrag, Beatriz González-Rodríguez, Francisca Lago, Maurizio Capuozzo, Miguel Angel Gonzalez-Gay, Antonio Mera Varela, Jesús Pino, Yousof Farrag, Oreste Gualillo

“…On the other hand, serum levels were directly correlated with SLE disease activity index, suggesting an important role of PGRN as a player in the progression of inflammatory diseases and a therapeutical approach for the recovery. This review has some limitations due to the small number of studies in this regard; therefore, we highlight the importance and the necessity of further investigation. …”
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Significance of flavonoids targeting PI3K/Akt/HIF-1α signaling pathway in therapy-resistant cancer cells – A potential contribution to the predictive, preventive, and personalized... by Alena Mazurakova, Lenka Koklesova, Sandra Hurta Csizmár, Marek Samec, Aranka Brockmueller, Miroslava Šudomová, Kamil Biringer, Erik Kudela, Martin Pec, Samson Mathews Samuel, Monika Kassayova, Sherif T.S. Hassan, Karel Smejkal, Mehdi Shakibaei, Dietrich Büsselberg, Luciano Saso, Peter Kubatka, Olga Golubnitschaja

“…Background: Cancer management faces multiple obstacles, including resistance to current therapeutic approaches. In the face of challenging microenvironments, cancer cells adapt metabolically to maintain their supply of energy and precursor molecules for biosynthesis and thus sustain rapid proliferation and tumor growth. …”
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Circadian Pattern of Acute Myocardial Infarction and Atrial Fibrillation in a Mediterranean Country: A study in Diabetic Patients by Stylianos Daios, Christos Savopoulos, Ilias Kanellos, Christos Argyrios Goudis, Ifigeneia Nakou, Stergiani Petalloti, Nicolas Hadjidimitriou, Dimitrios Pilalas, Antonios Ziakas, Georgia Kaiafa

“…More studies are needed to elucidate the circadian pattern of AMI and AF in diabetic patients to contribute to the development of new therapeutic approaches in this setting.…”
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CXCL13 contributes to chronic pain of a mouse model of CRPS-I via CXCR5-mediated NF-κB activation and pro-inflammatory cytokine production in spinal cord dorsal horn by Jie Wang, Chengyu Yin, Yushuang Pan, Yunqin Yang, Wei Li, Huadong Ni, Boyu Liu, Huimin Nie, Ruoyao Xu, Huina Wei, Yunwen Zhang, Yuanyuan Li, Qimiao Hu, Yan Tai, Xiaomei Shao, Jianqiao Fang, Boyi Liu

“…Our work suggests that targeting CXCL13/CXCR5 pathway may lead to novel therapeutic approaches for CRPS-I.…”
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The tight junction protein claudin 6 is a potential target for patient-individualized treatment in esophageal and gastric adenocarcinoma and is associated with poor prognosis by Adrian Georg Simon, Su Ir Lyu, Mark Laible, Stefan Wöll, Özlem Türeci, Uğur Şahin, Hakan Alakus, Luca Fahrig, Thomas Zander, Reinhard Buettner, Christiane Josephine Bruns, Wolfgang Schroeder, Florian Gebauer, Alexander Quaas

“…Abstract Background The prognosis of esophageal adenocarcinoma (EAC) and gastric adenocarcinoma (GAC) remains poor, and new therapeutic approaches are urgently needed. Claudin 6 (CLDN6) is an oncofetal antigen that is largely absent in healthy tissues and upregulated in several cancers, making it a promising therapeutical target. …”
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Development of innate immune memory by non-immune cells during Staphylococcus aureus infection depends on reactive oxygen species by Emmanuel Chaumond, Sandrine Peron, Nathalie Daniel, Yann Le Gouar, Éric Guédon, David L. Williams, Yves Le Loir, Gwénaël Jan, Nadia Berkova

“…Our findings may help the development of alternative therapeutic approaches for the prevention of S. aureus infection. …”
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RNA binding proteins PTBP1 and HNRNPL regulate CFTR mRNA decay by Amna Siddiqui, Arpit Saxena, Joshua Echols, Viktoria Havasi, Lianwu Fu, Kim M. Keeling

“…This suggests that PTBP1 and/or HNRNPL may represent potential therapeutic targets to increase CFTR mRNA abundance and enhance responses to CFTR modulators and other therapeutic approaches in PwCF.…”
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RETRACTED ARTICLE: Gamma-radiated immunosuppressed tumor xenograft mice can be a new ideal model in cancer research by Hamid Khodayari, Saeed Khodayari, Solmaz Khalighfard, Arash Tahmasebifar, Mahboubeh Tajaldini, Amirhoushang Poorkhani, Hassan Nikoueinejad, Gholam Ali Hamidi, Hassan Nosrati, Mohammad Reza Kalhori, Ali Mohammad Alizadeh

“…Abstract Tumor xenograft models can create a high capacity to study human tumors and discover efficient therapeutic approaches. Here, we aimed to develop the gamma-radiated immunosuppressed (GIS) mice as a new kind of tumor xenograft model for biomedical studies. …”
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METTL3-mediated m6A RNA methylation induces the differentiation of lung resident mesenchymal stem cells into myofibroblasts via the miR-21/PTEN pathway by Yi Lu, Zeyu Liu, Yunjiao Zhang, Xiuhua Wu, Wei Bian, Shan Shan, Danrong Yang, Tao Ren

“…Targeting METTL3-mediated m6A RNA methylation and its downstream targets may present innovative therapeutic approaches for the prevention and treatment of PF.…”
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Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies by Alessandra Marrella, Alessandra Dondero, Maurizio Aiello, Beatrice Casu, Daniel Olive, Stefano Regis, Cristina Bottino, Cristina Bottino, Daniela Pende, Raffaella Meazza, Guido Caluori, Guido Caluori, Roberta Castriconi, Roberta Castriconi, Silvia Scaglione, Silvia Scaglione

“…Thus, based on our results, 3D alginate-based hydrogels might represent a clinical-relevant cell culture platform where to test the efficacy of personalized therapeutic approaches aimed to optimize the current and innovative immune based therapies in a very systematic and reliable way.…”
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The Nutraceutical Genistein-Lycopene Combination Improves Bone Damage Induced by Glucocorticoids by Stimulating the Osteoblast Formation Process by Federica Mannino, Tommaso D’Angelo, Giovanni Pallio, Antonio Ieni, Igor Pirrotta, Domenico Antonio Giorgi, Alessandro Scarfone, Silvio Mazziotti, Christian Booz, Alessandra Bitto, Francesco Squadrito, Natasha Irrera

“…Chronic glucocorticoid (GC) therapy is the most common cause of iatrogenic osteoporosis and represents an important risk factor for osteoporosis and bone fractures. New therapeutic approaches are required in order to treat osteoporosis and reduce the side effects related to the use of anti-osteoporotic drugs. …”
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