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11961
Comparison of the efficacy of schema-based couple therapy and McKay\'s cognitive approach on controlling emotions and conflict resolution styles inconflicting couples
Published 2022-08-01“…Background: Current statistics show that cognitive couple therapy and schema therapy have an effect on controlling emotions and conflict resolution styles in couples with marital conflict.The existence of several studies on the effectiveness of McKay cognitive couple therapy and schema therapy on reducing marital conflicts, the above differences led to the present study to compare the effectiveness of these two therapeutic approaches. Aims: The aim of this study was to compare the effectiveness of McKay's cognitive couple therapy and schema therapy on controlling emotions and conflict resolution styles in couples with marital conflict in Qom. …”
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11962
Mechanisms of Resistance to Immunotherapy in Hepatocellular Carcinoma
Published 2023-11-01“…Herein we describe a selection of resistance mechanisms that have been involved in impairing response to ICI and propose potential therapeutic approaches to overcome resistance.Keywords: immune checkpoint inhibitors, liver cancer, recurrence, tumor microenvironment…”
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11963
Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma
Published 2019-06-01“…Several researchers have analyzed the alterations of the methionine cycle associated with liver disease to clarify the pathogenesis of human hepatocellular carcinoma (HCC) and improve the preventive and the therapeutic approaches to this tumor. Different alterations of the methionine cycle leading to a decrease of S-adenosylmethionine (SAM) occur in hepatitis, liver steatosis, liver cirrhosis, and HCC. …”
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11964
2566 Personalized models of distal airway epithelial-stromal unit in COPD
Published 2018-06-01“…Patient-specific models of distal airway epithelial-stromal cross-talk established in this study can be used to identify candidate pathways that mediate disease-relevant airway remodeling and potentially utilized as pre-clinical platforms for developing personalized therapeutic approaches to suppress the progression of distal airway remodeling in chronic lung diseases, including COPD.…”
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11965
Top caregiver concerns in Rett syndrome and related disorders: data from the US natural history study
Published 2023-10-01“…Abstract Objective Recent advances in the understanding of neurodevelopmental disorders such as Rett syndrome (RTT) have enabled the discovery of novel therapeutic approaches that require formal clinical evaluation of efficacy. …”
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11966
Outpatient geriatric health care in the German federal state of Mecklenburg-Western Pomerania: a population-based spatial analysis of claims data
Published 2024-04-01“…Holistic and coordinated therapeutic approaches addressing those needs maintain the independence of elderly patients and avoid adverse effects. …”
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11967
Identification of diagnostic genes and vital microRNAs involved in rheumatoid arthritis: based on data mining and experimental verification
Published 2021-05-01“…Conclusion Our study reveals diagnostic genes and vital microRNAs highly related to RA, which could help improve our understanding of the molecular mechanisms underlying the disorder and provide theoretical support for the future exploration of innovative therapeutic approaches.…”
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11968
Binaural acoustic stimulation in patients with Parkinson’s disease
Published 2023-05-01“…Moreover, the positive effects of CAS underline the general positive potential for improvement of motor function by acoustically supported therapeutic approaches. However, more studies are needed to fully characterize the clinical relevance of BBS and to further optimize its ameliorating effects.…”
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11969
Hemoptysis caused by Parvimonas micra: case report and literature review
Published 2024-02-01“…The absence of a consensus on the diagnostic and therapeutic approaches to P. micra exacerbates the complexity of addressing associated conditions. …”
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11970
Psychosocial Needs of Gynecological Cancer Survivors: Mixed Methods Study
Published 2022-09-01“…Survivors of gynecological cancer have unique needs, such as those related to a genetic predisposition to future cancers, impact of cancer on sexual health, the advanced stage at which many are diagnosed, and the influx of new therapeutic approaches. ObjectiveThis study aimed to present a unique methodology to leverage large amounts of data from internet-based platforms for mixed methods analysis. …”
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11971
The effect of varicella-zoster virus reactivation on the long-term outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation
Published 2023-10-01“…Conclusion This is the first study to show that VZV reactivation following allo-HSCT is an independent predictor for lower relapse rates and improved OS, providing novel therapeutic approaches to improve patients’ long-term survival following allo-HSCT.…”
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11972
Stroke isquémico en pacientes jóvenes: un desafío diagnóstico Ischemic stroke in young adults: a challenging diagnosis
Published 2011-06-01“…To highlight the important role of neuroimaging in the diagnosis, prognosis, and therapeutical approach of these patients. Materials and Methods. 30 young adult patients between the ages of 15 and 45 with diagnosis of acute ischemic stroke were retrospectively studied. …”
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11973
Patient-specific identification of genome-wide DNA-methylation differences between intracranial and extracranial melanoma metastases
Published 2023-01-01“…Our analysis contributes to an in-depth characterization of DNA-methylation differences between patient-matched intra- and extracranial melanoma metastases and may provide a basis for future experimental studies to identify targets for new therapeutic approaches.…”
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11974
Genetic synergy between Acinetobacter baumannii undecaprenyl phosphate biosynthesis and the Mla system impacts cell envelope and antimicrobial resistance
Published 2024-03-01“…Therefore, novel therapeutic approaches are urgently needed. We report that a defective undecaprenyl pyrophosphate synthase (UppS) paired with a perturbed Mla system leads to synthetically sick cells that are more susceptible to clinically relevant antibiotics and show reduced virulence in a lung infection model. …”
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11975
Construction of luciferase-expressing Neospora caninum and drug screening
Published 2024-03-01“…Due to the limited effectiveness of currently available drugs, there is an urgent need for new therapeutic approaches to control neosporosis. Luciferase-based assays are potentially powerful tools in the search for antiprotozoal compounds, permitting the development of faster and more automated assays. …”
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11976
Alterations in the Gut Fungal Community in a Mouse Model of Huntington’s Disease
Published 2022-04-01“…This study highlights the potential role of gut fungi in HD and may facilitate the development of novel therapeutic approaches.…”
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11977
Literature Review of the Effect of Ankle-Foot Orthosis on Gait Parameters After Stroke
Published 2017-07-01“…Ankle-Foot Orthoses (AFOs) is one of the most common therapeutic approaches to control foot drop among stroke patients. …”
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11978
Effectiveness of Combinational Treatments for Alzheimer’s Disease with Human Neural Stem Cells and Microglial Cells Over-Expressing Functional Genes
Published 2023-05-01“…Since AD therapy using acetylcholinesterase (AChE) inhibitors are only palliative for memory deficits without reversing disease progress, there is a need for effective therapies, and cell-based therapeutic approaches should fulfil this requirement. We established F3.ChAT human neural stem cells (NSCs) encoding the choline acetyltransferase (ChAT) gene, an ACh-synthesizing enzyme, HMO6.NEP human microglial cells encoding the neprilysin (NEP) gene, an Aβ-degrading enzyme, and HMO6.SRA cells encoding the scavenger receptor A (SRA) gene, an Aβ-uptaking receptor. …”
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11979
Prognostic factors associated with early recurrence following liver resection for colorectal liver metastases: a systematic review and meta-analysis
Published 2024-04-01“…Additionally, it is essential to undertake well-designed prospective investigations to examine additional prognostic factors and develop salvage therapeutic approaches for ER of CRLM.…”
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11980
Triple-Negative Breast Cancer: Clinical Characteristics, Prognostic Features, and Long-Term Outcome: A Comparative Study
Published 2012-01-01“…Background: Because of the reported poor prognosis and absence of effective and specific therapeutic approaches, triple-negative breast cancer (TNBC) tumors have remained as an important area of investigations for clinicians and researchers. …”
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