Comparison of the efficacy of schema-based couple therapy and McKay\'s cognitive approach on controlling emotions and conflict resolution styles inconflicting couples by Maliheh Fadaei moghadam, Hasan Khoshakhlagh, Hasan Rezaei Jamalooei

“…Background: Current statistics show that cognitive couple therapy and schema therapy have an effect on controlling emotions and conflict resolution styles in couples with marital conflict.The existence of several studies on the effectiveness of McKay cognitive couple therapy and schema therapy on reducing marital conflicts, the above differences led to the present study to compare the effectiveness of these two therapeutic approaches. Aims: The aim of this study was to compare the effectiveness of McKay's cognitive couple therapy and schema therapy on controlling emotions and conflict resolution styles in couples with marital conflict in Qom. …”
Get full text

Mechanisms of Resistance to Immunotherapy in Hepatocellular Carcinoma by Manfredi GF, Celsa C, John C, Jones C, Acuti N, Scheiner B, Fulgenzi CAM, Korolewicz J, Pinter M, Gennari A, Mauri FA, Pirisi M, Minisini R, Vincenzi F, Burlone M, Rigamonti C, Donadon M, Cabibbo G, D'Alessio A, Pinato DJ

“…Herein we describe a selection of resistance mechanisms that have been involved in impairing response to ICI and propose potential therapeutic approaches to overcome resistance.Keywords: immune checkpoint inhibitors, liver cancer, recurrence, tumor microenvironment…”
Get full text

Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma by Rosa M. Pascale, Graziella Peitta, Maria M. Simile, Francesco Feo

“…Several researchers have analyzed the alterations of the methionine cycle associated with liver disease to clarify the pathogenesis of human hepatocellular carcinoma (HCC) and improve the preventive and the therapeutic approaches to this tumor. Different alterations of the methionine cycle leading to a decrease of S-adenosylmethionine (SAM) occur in hepatitis, liver steatosis, liver cirrhosis, and HCC. …”
Get full text

2566 Personalized models of distal airway epithelial-stromal unit in COPD by Seyed B. Mahjour, Kazunori Gomi, Busub Lee, Olivier Elemento, Scott Randell, Renat Shaykhiev

“…Patient-specific models of distal airway epithelial-stromal cross-talk established in this study can be used to identify candidate pathways that mediate disease-relevant airway remodeling and potentially utilized as pre-clinical platforms for developing personalized therapeutic approaches to suppress the progression of distal airway remodeling in chronic lung diseases, including COPD.…”
Get full text

Top caregiver concerns in Rett syndrome and related disorders: data from the US natural history study by Jeffrey L. Neul, Timothy A. Benke, Eric D. Marsh, Bernhard Suter, Lori Silveira, Cary Fu, Sarika U. Peters, Alan K. Percy, for the Rett syndrome Natural History Study Group

“…Abstract Objective Recent advances in the understanding of neurodevelopmental disorders such as Rett syndrome (RTT) have enabled the discovery of novel therapeutic approaches that require formal clinical evaluation of efficacy. …”
Get full text

Outpatient geriatric health care in the German federal state of Mecklenburg-Western Pomerania: a population-based spatial analysis of claims data by Nils Pfeuffer, Franziska Radicke, Maren Leiz, Kilson Moon, Wolfgang Hoffmann, Neeltje van den Berg

“…Holistic and coordinated therapeutic approaches addressing those needs maintain the independence of elderly patients and avoid adverse effects. …”
Get full text

Identification of diagnostic genes and vital microRNAs involved in rheumatoid arthritis: based on data mining and experimental verification by Conglin Ren, Mingshuang Li, Yang Zheng, Fengqing Wu, Weibin Du, Renfu Quan

“…Conclusion Our study reveals diagnostic genes and vital microRNAs highly related to RA, which could help improve our understanding of the molecular mechanisms underlying the disorder and provide theoretical support for the future exploration of innovative therapeutic approaches.…”
Get full text

Binaural acoustic stimulation in patients with Parkinson’s disease by Alexander Calvano, Lars Timmermann, Lars Timmermann, Philipp Alexander Loehrer, Philipp Alexander Loehrer, Carina Renate Oehrn, Carina Renate Oehrn, Immo Weber

“…Moreover, the positive effects of CAS underline the general positive potential for improvement of motor function by acoustically supported therapeutic approaches. However, more studies are needed to fully characterize the clinical relevance of BBS and to further optimize its ameliorating effects.…”
Get full text

Hemoptysis caused by Parvimonas micra: case report and literature review by Axue Shao, Axue Shao, Qingqing He, Qingqing He, Xin Jiao, Xin Jiao, Jianbo Liu, Jianbo Liu

“…The absence of a consensus on the diagnostic and therapeutic approaches to P. micra exacerbates the complexity of addressing associated conditions. …”
Get full text

Psychosocial Needs of Gynecological Cancer Survivors: Mixed Methods Study by Elizabeth J Adams, David Tallman, Marcy L Haynam, Larissa Nekhlyudov, Maryam B Lustberg

“…Survivors of gynecological cancer have unique needs, such as those related to a genetic predisposition to future cancers, impact of cancer on sexual health, the advanced stage at which many are diagnosed, and the influx of new therapeutic approaches. ObjectiveThis study aimed to present a unique methodology to leverage large amounts of data from internet-based platforms for mixed methods analysis. …”
Get full text

The effect of varicella-zoster virus reactivation on the long-term outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation by Ping Li, Jingxia Li, Haoyuan Huang, Xiongnong Chen, Yue Lin, Ganlin He, Duorong Xu

“…Conclusion This is the first study to show that VZV reactivation following allo-HSCT is an independent predictor for lower relapse rates and improved OS, providing novel therapeutic approaches to improve patients’ long-term survival following allo-HSCT.…”
Get full text

Stroke isquémico en pacientes jóvenes: un desafío diagnóstico Ischemic stroke in young adults: a challenging diagnosis by María Belén Nallino, Adriana Ojeda, Ana María Uriarte

“…To highlight the important role of neuroimaging in the diagnosis, prognosis, and therapeutical approach of these patients. Materials and Methods. 30 young adult patients between the ages of 15 and 45 with diagnosis of acute ischemic stroke were retrospectively studied. …”
Get full text

Patient-specific identification of genome-wide DNA-methylation differences between intracranial and extracranial melanoma metastases by Theresa Kraft, Konrad Grützmann, Matthias Meinhardt, Friedegund Meier, Dana Westphal, Michael Seifert

“…Our analysis contributes to an in-depth characterization of DNA-methylation differences between patient-matched intra- and extracranial melanoma metastases and may provide a basis for future experimental studies to identify targets for new therapeutic approaches.…”
Get full text

Genetic synergy between Acinetobacter baumannii undecaprenyl phosphate biosynthesis and the Mla system impacts cell envelope and antimicrobial resistance by Hannah R. Noel, Sowmya Keerthi, Xiaomei Ren, Jonathan D. Winkelman, Jerry M. Troutman, Lauren D. Palmer

“…Therefore, novel therapeutic approaches are urgently needed. We report that a defective undecaprenyl pyrophosphate synthase (UppS) paired with a perturbed Mla system leads to synthetically sick cells that are more susceptible to clinically relevant antibiotics and show reduced virulence in a lung infection model. …”
Get full text

Construction of luciferase-expressing Neospora caninum and drug screening by Fei Wang, Yangfei Xue, Yanqun Pei, Meng Yin, Zhepeng Sun, Zihui Zhou, Jing Liu, Qun Liu

“…Due to the limited effectiveness of currently available drugs, there is an urgent need for new therapeutic approaches to control neosporosis. Luciferase-based assays are potentially powerful tools in the search for antiprotozoal compounds, permitting the development of faster and more automated assays. …”
Get full text

Alterations in the Gut Fungal Community in a Mouse Model of Huntington’s Disease by Geraldine Kong, Kim-Anh Lê Cao, Anthony J. Hannan

“…This study highlights the potential role of gut fungi in HD and may facilitate the development of novel therapeutic approaches.…”
Get full text

Literature Review of the Effect of Ankle-Foot Orthosis on Gait Parameters After Stroke by Elnaz Esfandiari, Mokhtar Arazpour, Hassan Saeedi, Amir Ahmadi

“…Ankle-Foot Orthoses (AFOs) is one of the most common therapeutic approaches to control foot drop among stroke patients. …”
Get full text

Effectiveness of Combinational Treatments for Alzheimer’s Disease with Human Neural Stem Cells and Microglial Cells Over-Expressing Functional Genes by Young-Hwan Ban, Dongsun Park, Ehn-Kyoung Choi, Tae Myoung Kim, Seong Soo Joo, Yun-Bae Kim

“…Since AD therapy using acetylcholinesterase (AChE) inhibitors are only palliative for memory deficits without reversing disease progress, there is a need for effective therapies, and cell-based therapeutic approaches should fulfil this requirement. We established F3.ChAT human neural stem cells (NSCs) encoding the choline acetyltransferase (ChAT) gene, an ACh-synthesizing enzyme, HMO6.NEP human microglial cells encoding the neprilysin (NEP) gene, an Aβ-degrading enzyme, and HMO6.SRA cells encoding the scavenger receptor A (SRA) gene, an Aβ-uptaking receptor. …”
Get full text

Prognostic factors associated with early recurrence following liver resection for colorectal liver metastases: a systematic review and meta-analysis by Yuan Tian, Yaoqun Wang, Ningyuan Wen, Shaofeng Wang, Bei Li, Geng Liu

“…Additionally, it is essential to undertake well-designed prospective investigations to examine additional prognostic factors and develop salvage therapeutic approaches for ER of CRLM.…”
Get full text

Triple-Negative Breast Cancer: Clinical Characteristics, Prognostic Features, and Long-Term Outcome: A Comparative Study by Tahere Zarouk Ahimahalle, Ali Basi, Ali Shahriari Ahmadi, Leila Rahmani

“…Background: Because of the reported poor prognosis and absence of effective and specific therapeutic approaches, triple-negative breast cancer (TNBC) tumors have remained as an important area of investigations for clinicians and researchers. …”
Get full text