Post‐inflammatory administration of N‐acetylcysteine reduces inflammation and alters receptor levels in a cellular model of Parkinson's disease by Zeynep Bengisu Kaya, Elif Karakoc, Pamela J. McLean, Esen Saka, Pergin Atilla

“…Further studies are needed to elucidate molecular mechanisms and pathways related to neuroinflammation in PD and to develop possible new therapeutic approaches to slow the clinical progression of PD.…”
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Common mental disorders in Gestalt therapy treatment: a multiple case study comparing patients with moderate and low integrated personality structures by Raphaela E. Kaisler, Raphaela E. Kaisler, Manfred Fede, Ulla Diltsch, Thomas Probst, Yvonne Schaffler

“…No change was reported in the level of personality functioning after 30 sessions in both groups.DiscussionThese results underscore the need for tailored therapeutic approaches based on the client's level of personality integration. …”
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Different mechanisms underlie compulsive alcohol self-administration in male and female rats by Sanne Toivainen, Li Xu, Francesco Gobbo, Andrea Della Valle, Andrea Coppola, Markus Heilig, Esi Domi

“…Abstract Background Sex is an important factor in the progression and treatment of alcohol addiction, and therapeutic approaches may have to be tailored to potential sex differences. …”
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Modulation of Negative Effects of Physiological Stress on Frozen-Thawed Semen with Nutrition of Organic Selenium in Ross 308 Rooster by N Kamrani, A Karimi, M Nazari, R Masoudi

“…A total of 24 broiler breeder roosters with the age of 28 weeks were used based on a completely randomized design with four therapeutic approaches (factorial 2×2) and six birds in each approach. …”
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Identification of potential biomarkers of vascular calcification using bioinformatics analysis and validation in vivo by Chuanzhen Chen, Yinteng Wu, Hai-lin Lu, Kai Liu, Xiao Qin

“…However, we know poorly about the molecular mechanisms and effective therapeutic approaches of VC. Methods The VC dataset, GSE146638, was downloaded from the Gene Expression Omnibus (GEO) database. …”
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Footprint of pancreas infiltrating and circulating immune cells throughout type 1 diabetes development by Ylke Bruggeman, Pieter-Jan Martens, Gabriele Sassi, Marijke Viaene, Clive H. Wasserfall, Chantal Mathieu, Conny Gysemans

“…An in-depth understanding of the dynamics and phenotype of the immune cells infiltrating the pancreas and the accompanying changes in their profiles in peripheral blood during T1D development is critical to generate novel preventive and therapeutic approaches, as well as to find biomarkers for the disease process.MethodsUsing multi-parameter flow cytometry, we explored the dynamic changes of immune cells infiltrating the pancreas and the pancreatic draining lymph nodes (PLN), compared to those in peripheral blood in female and male non-obese diabetic (NOD) mice during T1D progression.ResultsThe early stages of T1D development were characterized by an influx of innate dendritic cells and neutrophils in the pancreas. …”
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Nano-Chitosan/<i>Eucalyptus</i> Oil/Cellulose Acetate Nanofibers: Manufacturing, Antibacterial and Wound Healing Activities by Nagwa A. Elbhnsawi, Bassma H. Elwakil, Ahmed H. Hassanin, Nader Shehata, Salma Sameh Elshewemi, Mohamed Hagar, Zakia A. Olama

“…Accelerated wound healing in infected skin is still one of the areas where current therapeutic tactics fall short, which highlights the critical necessity for the exploration of new therapeutic approaches. The present study aimed to encapsulate <i>Eucalyptus</i> oil in a nano-drug carrier to enhance its antimicrobial activity. …”
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Bioassay-guided isolation of BACE1 inhibitors from Crataegus pinnatifida by Yajuan Zhou, Srijan Shrestha, Hyun Ah Jung, Jae Sue Choi

“…The findings of this study could be leveraged to develop novel therapeutic approaches for Alzheimer's disease.…”
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Adherence of Nontypeable Haemophilus influenzae to Cells and Substrates of the Airway Is Differentially Regulated by Individual ModA Phasevarions by Preeti Garai, John M. Atack, Brandon M. Wills, Michael P. Jennings, Lauren O. Bakaletz, Kenneth L. Brockman

“…NTHi adhesins are considered potential candidates for vaccines or other therapeutic approaches. The ModA phasevarions of NTHi play a role in the rapid adaptation of the pathogen to different environmental stress conditions. …”
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BRONCHOPULMONARY DYSLASIA OF NEWBORNS AND PROSPECTS OF CELL THERAPY IN UKRAINE AND WORLDWIDE by Illia V. Koshurba, Fedir V. Hladkykh, Yurii V. Koshurba

“…The limited possibilities of BPD pharmacotherapy prompted the search for new therapeutic approaches. One of the alternatives is biological therapy based on mesenchymal stem cells (MSCs), secretome of MSCs, cryopreserved tissue extracts, etc. …”
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Sugiol Masters Apoptotic Precision to Halt Gastric Cancer Cell Proliferation by Tahani Bakhsh, Samah Sulaiman Abuzahrah, Safa H. Qahl, Mohamed A. Akela, Irfan A. Rather

“…In combination with interventions that regulate cell cycle progression and mitigate the DNA damage response, the efficacy of these therapeutic approaches can be further enhanced. The findings from our study highlight the antiproliferative and apoptotic potential of sugiol against human gastric cancer cells (SNU-5). …”
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Selected Lectures of the Meeting “Rare diseases: diagnostic pathways and new therapies”, including the session on the Life MILCH project and the session titled “They will be famous... by --- Various Authors

“…DIAGNOSIS AND THERAPEUTIC APPROACHES TO SPINA BIFIDA: A COMPREHENSIVE REVIEW • G. …”
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Functional balance training in people with Parkinson’s disease: a protocol of balanceHOME randomized control trial with crossover by Sara Monleón Guinot, Constanza San Martín Valenzuela, Constanza San Martín Valenzuela, Constanza San Martín Valenzuela, Vivina Aranda Asensi, Concepción de Salazar Antón, Manuel Villanueva Navarro, Jose M. Tomás

“…This still-to-be-finished study will open the possibility of new strategies according to changes in post-pandemic therapeutic approaches.…”
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Autophagy-Modulated Biomaterial: A Robust Weapon for Modulating the Wound Environment to Promote Skin Wound Healing by Zhang J, Li L, Yu J, Zhang F, Shi J, LI M, Liu J, Li H, Gao J, Wu Y

“…Moreover, this can lay the foundation for the development of more effective therapeutic approaches and novel biomaterials for clinical applications.Keywords: wound healing, autophagy, biomaterial, antibacterial effects, inflammatory response, oxidative stress…”
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A six-month prospective, randomised, double-blinded, placebo-controlled, crossover, dietary trial design to investigate the potential of psychobiotics on seizure semiology and como... by Teresa Schmidt, Sebastian Meller, Nina Meyerhoff, Friederike Twele, Brian Zanghi, Holger Andreas Volk

“…The microbiome-gut-brain axis may serve as a new target for the development of innovative multimodal therapeutic approaches to overcome current shortcomings in epilepsy management. …”
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Study of risk factors for the osteoporosis development in rheumatoid arthritis in real clinical practice by E. V. Papichev, Yu. R. Akhverdyan, Yu. V. Polyakova, L. E. Sivordova, B. V. Zavodovskii

“…Its development is associated with the mechanisms underlying in the progression of autoimmune inflammatory diseases and therapeutic approaches used for them. The study of risk factors for osteoporosis can contribute to the clarification of its pathogenesis components, as well as the development of new methods for prevention, diagnosis and treatment of this condition.Aim. …”
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Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity by Dorival Mendes Rodrigues-Junior, Cristiano Raminelli, Haifa Hassanie, Gustavo Henrique Goulart Trossini, Givago Prado Perecim, Laia Caja, Aristidis Moustakas, André Luiz Vettore

“…Abstract Glioblastoma (GBM) is the most aggressive and common primary malignant brain tumor with limited available therapeutic approaches. Despite improvements in therapeutic options for GBM patients, efforts to develop new successful strategies remain as major unmet medical needs. …”
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Histone modification enhances the effectiveness of IL-13 receptor targeted immunotoxin in murine models of human pancreatic cancer by Puri Raj K, Joshi Bharat H, Fujisawa Toshio

“…HDAC inhibition provides a novel opportunity in designing combinatorial therapeutic approaches not only in combination with IL-13-PE but with other immunotoxins for therapy of pancreatic cancer and other cancers.…”
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Comparing Effectiveness of Acceptance and Commitment Therapy (ACT), Emotion-Focused Therapy (EFT) and Combining ACT & EFT in the Spiritual Well-being of Couples Referring to Counse... by Masoumeh Nemati, Farideh Dokaneheeifard, Masoumeh Behboodi

“…Background and Objective: Finding effective therapeutic approaches to improving the spirituality of individuals, especially couples, is very helpful in reconciling their differences, enhancing their intimacy and preventing family problems. …”
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Genome-Wide Profiling of H3K56 Acetylation and Transcription Factor Binding Sites in Human Adipocytes by Lo, Kinyui Alice, Bauchmann, Mary K., Baumann, Amy P., Donahue, Christopher J., Thiede, Mark A., Hayes, Lisa S., Des Etages, Shelley Ann G., Fraenkel, Ernest

“…The regulation of transcription in adipocytes is particularly important, as it is a target for several therapeutic approaches. Transcriptional outcomes are influenced by both histone modifications and transcription factor binding. …”
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