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12021
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12022
Development of CRISPR-Cas genome and epigenome engineering tools towards retinal degenerations
Published 2022“…The engineering of the clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) nuclease system has revolutionized the field of molecular biology and generated excitement for the potential of novel therapeutic approaches to treat retinal diseases. Here, I explore the development of CRISPR-Cas9 tools and their therapeutic adaptation towards the treatment of retinal disease.…”
Thesis -
12023
'Hepitopes': A Database of HLA Class I Epitopes in Hepatitis B Virus (HBV)
Published 2016“…For these reasons, increased clinical and scientific scrutiny is being applied to develop new therapeutic approaches with an ultimate goal of achieving cure. …”
Dataset -
12024
Slower calcium handling balances faster cross-bridge cycling in human MYBPC3 HCM
Published 2023“…Compensatory electrophysiological changes (eg, reduced potassium channel expression) appear to preserve twitch contraction parameters, but may expose patients to greater arrhythmic propensity and disease progression. Therapeutic approaches correcting the primary sarcomeric defects may prevent secondary cardiomyocyte remodeling.…”
Journal article -
12025
Design and synthesis of sulfur-containing butylated hydroxytoluene: antioxidant potency and selective anticancer agent
Published 2019“…This work efficiently sets the ground for eminent sulfur-containing phenols developed based on a well-known standard antioxidant BHT, with features superior to common drawbacks faced in cancer therapeutic approaches, in addition to the great potential holding as selective and biocompatible agent for cancer applications.…”
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12026
Gut Microbial Succession Patterns and Metabolic Profiling during Pregnancy and Lactation in a Goat Model
Published 2023-02-01“…These findings are key for guiding targeted microbial therapeutic approaches to modulate microbiomes in gestating and lactating mammals.…”
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12027
Deciphering the role of NETosis-related signatures in the prognosis and immunotherapy of soft-tissue sarcoma using machine learning
Published 2023-06-01“…The results of our study highlight the critical role NRGs play in tumor biology and the potential for personalized therapeutic approaches through the application of the NETosis score model in STS patients.…”
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12028
Evaluation of the HBV liver reservoir with fine needle aspirates
Published 2023-10-01“…Background & Aims: Finite duration of treatment associated with HBsAg loss is the current goal for improved therapeutic approaches against chronic HBV infection, as it indicates elimination or durable inactivation of intrahepatic covalently closed circular DNA (cccDNA). …”
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12029
Small airways morphological alterations associated with functional impairment in lymphangioleiomyomatosis
Published 2024-01-01“…Understanding the morphological changes in the airways that may occur early in the disease can help us understand the pathophysiology of disease progression and understand the rationale for possible therapeutic approaches, such as the use of bronchodilators. …”
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12030
Peptidyl tRNA Hydrolase Is Required for Robust Prolyl-tRNA Turnover in Mycobacterium tuberculosis
Published 2023-02-01“…Collectively, our findings reveal the potency of Cu-tRNAseq for profiling peptidyl tRNAs and suggest that targeting Pth would open new therapeutic approaches for TB. IMPORTANCE Peptidyl tRNA hydrolase (Pth) is an enzyme that cuts unfinished peptides off tRNA that has been prematurely released from a stalled ribosome. …”
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12031
The Outcome of Surgical Treatment for the Neuropathic Diabetic Foot Lesions—A Single-Center Study
Published 2022-07-01“…Admission anemia and diabetic nephropathy were predictive of a major therapeutical approach, with <i>p</i> = 0.011, OR = 2.975, 95% CI (1.244–8.116) and <i>p</i> = 0.001, OR = 3.565, 95% CI (1.623–7.832), respectively. …”
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12032
A muscle‐specific MuRF1‐E2 network requires stabilization of MuRF1‐E2 complexes by telethonin, a newly identified substrate
Published 2018-02-01“…Conclusions We report here the first MuRF1‐E2s network, which may prove valuable for deciphering the precise mechanisms involved in the atrophying muscle programme and for proposing new therapeutical approaches.…”
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12033
Identification of the cuproptosis-related hub genes and therapeutic agents for sarcopenia
Published 2023-03-01“…These outcomes provide new insights for better understanding of sarcopenia and innovative therapeutic approaches.…”
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12034
Bazi Bushen ameliorates age-related energy metabolism dysregulation by targeting the IL-17/TNF inflammatory pathway associated with SASP
Published 2024-04-01“…This study presents novel clinical therapeutic approaches for the prevention and treatment of age-related metabolic diseases.…”
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12035
Explicit and Implicit Own's Body and Space Perception in Painful Musculoskeletal Disorders and Rheumatic Diseases: A Systematic Scoping Review
Published 2020-04-01“…Almost half of the intervention studies (42%) provided therapeutic approaches combining more than one perceptual task, or sensory-motor tasks together with perceptual strategies, thus it was difficult to estimate the relative effectiveness of each single therapeutic component.Conclusions: To our knowledge, this is the first attempt to systematically map and summarize this research area in the field of musculoskeletal disorders and rheumatic diseases. …”
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12036
Polypodium leucotomos targets multiple aspects of oral carcinogenesis and it is a potential antitumor phytotherapy against tongue cancer growth
Published 2023-01-01“…These malignancies exhibit rapid progression, poor prognosis, and often mutilating therapeutical approaches. The determination of a prophylactic and/or therapeutic antitumor role of the polyphenolic extract Polypodium leucotomos(PL) would be relevant in developing new tools for prevention and treatment.Methods: We aimed to determine the antitumor effect of PL by treating OSCC cell lines with PL metabolites and evaluating its action during OSCC progression in vivo.Results: PL treatment successfully impaired cell cycling and proliferation, migration, and invasion, enhanced apoptosis, and modulated macrophage polarization associated with the tumoral immune-inflammatory response of tongue cancer cell lines (TSCC). …”
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12037
5-Azacytidine Downregulates the Proliferation and Migration of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Targeting miR-139-5p/ROCK2 Pathway
Published 2022-03-01“…Background: For hepatocellular carcinoma (HCC), effective therapeutic approaches are lacking. As aberrant gene methylation is a major contributor to HCC development, demethylating drugs such as 5-azacytidine (5-Aza) have been proposed. …”
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12038
Three weeks of exercise therapy altered brain functional connectivity in fibromyalgia inpatients
Published 2023-08-01“…Therefore, new therapeutic approaches are awaited. Recently, exercise therapy has been gathering much attention as a promising treatment for FM. …”
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12039
Advances in Mass Spectrometry-Based Blood Metabolomics Profiling for Non-Cancer Diseases: A Comprehensive Review
Published 2024-01-01“…By analyzing blood samples, researchers gain valuable insights into the metabolic perturbations associated with these diseases, potentially leading to the identification of novel biomarkers and the development of personalized therapeutic approaches. Furthermore, we provide a comprehensive overview of various mass spectrometry approaches utilized in blood metabolomics research, including GC-MS, LC-MS, and others discussing their advantages and limitations. …”
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12040
Pro-Fibrotic Phenotype in a Patient with Segmental Stiff Skin Syndrome via TGF-β Signaling Overactivation
Published 2020-07-01“…Our results for the first time reported that aberrant TGF-β signaling may drive the pathogenesis of segmental SSS and might open the way to novel therapeutic approaches.…”
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Article