Engineering persistent interleukin-2 for cancer immunotherapy by Gai, Shuning

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Development of CRISPR-Cas genome and epigenome engineering tools towards retinal degenerations by Kantor, A

“…The engineering of the clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) nuclease system has revolutionized the field of molecular biology and generated excitement for the potential of novel therapeutic approaches to treat retinal diseases. Here, I explore the development of CRISPR-Cas9 tools and their therapeutic adaptation towards the treatment of retinal disease.…”

'Hepitopes': A Database of HLA Class I Epitopes in Hepatitis B Virus (HBV) by Matthews, P

“…For these reasons, increased clinical and scientific scrutiny is being applied to develop new therapeutic approaches with an ultimate goal of achieving cure. …”

Slower calcium handling balances faster cross-bridge cycling in human MYBPC3 HCM by Pioner, JM, Vitale, G, Steczina, S, Langione, M, Margara, F, Santini, L, Giardini, F, Lazzeri, E, Piroddi, N, Scellini, B, Palandri, C, Schuldt, M, Spinelli, V, Girolami, F, Mazzarotto, F, van der Velden, J, Cerbai, E, Tesi, C, Olivotto, I, Bueno-Orovio, A, Sacconi, L, Coppini, R, Ferrantini, C, Regnier, M, Poggesi, C

“…Compensatory electrophysiological changes (eg, reduced potassium channel expression) appear to preserve twitch contraction parameters, but may expose patients to greater arrhythmic propensity and disease progression. Therapeutic approaches correcting the primary sarcomeric defects may prevent secondary cardiomyocyte remodeling.…”

Design and synthesis of sulfur-containing butylated hydroxytoluene: antioxidant potency and selective anticancer agent by Ahmad, Mohd H., Abd Rahman, Noorsaadah, Kadir, Farkaad Abdul, Al-Ani, Lina Adnan, Hashim, Najihah Mohd, Yehye, Wageeh Abdulhadi

“…This work efficiently sets the ground for eminent sulfur-containing phenols developed based on a well-known standard antioxidant BHT, with features superior to common drawbacks faced in cancer therapeutic approaches, in addition to the great potential holding as selective and biocompatible agent for cancer applications.…”

Gut Microbial Succession Patterns and Metabolic Profiling during Pregnancy and Lactation in a Goat Model by Ke Zhang, Gongwei Liu, Yujiang Wu, Ting Zhang, Mengmeng Guo, Yu Lei, Xi Cao, Langda Suo, Daniel Brugger, Xiaolong Wang, Yuxin Yang, Yulin Chen

“…These findings are key for guiding targeted microbial therapeutic approaches to modulate microbiomes in gestating and lactating mammals.…”
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Deciphering the role of NETosis-related signatures in the prognosis and immunotherapy of soft-tissue sarcoma using machine learning by Lin Qi, Lin Qi, Fangyue Chen, Lu Wang, Lu Wang, Zhimin Yang, Zhimin Yang, Zhimin Yang, Wenchao Zhang, Wenchao Zhang, Zhihong Li, Zhihong Li

“…The results of our study highlight the critical role NRGs play in tumor biology and the potential for personalized therapeutic approaches through the application of the NETosis score model in STS patients.…”
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Evaluation of the HBV liver reservoir with fine needle aspirates by Barbara Testoni, Armando Andres Roca Suarez, Arianna Battisti, Marie-Laure Plissonnier, Marintha Heil, Thierry Fontanges, François Villeret, Yasmina Chouik, Massimo Levrero, Upkar Gill, Patrick Kennedy, Fabien Zoulim

“…Background & Aims: Finite duration of treatment associated with HBsAg loss is the current goal for improved therapeutic approaches against chronic HBV infection, as it indicates elimination or durable inactivation of intrahepatic covalently closed circular DNA (cccDNA). …”
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Small airways morphological alterations associated with functional impairment in lymphangioleiomyomatosis by Lígia Pelosi Mendonça, Natalia de Souza Xavier Costa, Ellen Caroline Toledo do Nascimento, Martina Rodrigues de Oliveira, Carlos Roberto Ribeiro de Carvalho, Bruno Guedes Baldi, Marisa Dolhnikoff

“…Understanding the morphological changes in the airways that may occur early in the disease can help us understand the pathophysiology of disease progression and understand the rationale for possible therapeutic approaches, such as the use of bronchodilators. …”
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Peptidyl tRNA Hydrolase Is Required for Robust Prolyl-tRNA Turnover in Mycobacterium tuberculosis by Francesca G. Tomasi, Jessica T. P. Schweber, Satoshi Kimura, Junhao Zhu, Laura A. T. Cleghorn, Susan H. Davis, Simon R. Green, Matthew K. Waldor, Eric J. Rubin

“…Collectively, our findings reveal the potency of Cu-tRNAseq for profiling peptidyl tRNAs and suggest that targeting Pth would open new therapeutic approaches for TB. IMPORTANCE Peptidyl tRNA hydrolase (Pth) is an enzyme that cuts unfinished peptides off tRNA that has been prematurely released from a stalled ribosome. …”
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The Outcome of Surgical Treatment for the Neuropathic Diabetic Foot Lesions—A Single-Center Study by Florin Bobirca, Catalin Gabriel Smarandache, Anca Bobirca, Cristina Alexandru, Dan Dumitrescu, Anca Pantea Stoian, Cristina Bica, Lacramioara Aurelia Brinduse, Anca Musetescu, Daniela-Elena Gheoca-Mutu, Sebastian Isac, Ioan Ancuta

“…Admission anemia and diabetic nephropathy were predictive of a major therapeutical approach, with <i>p</i> = 0.011, OR = 2.975, 95% CI (1.244–8.116) and <i>p</i> = 0.001, OR = 3.565, 95% CI (1.623–7.832), respectively. …”
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A muscle‐specific MuRF1‐E2 network requires stabilization of MuRF1‐E2 complexes by telethonin, a newly identified substrate by Cécile Polge, Stéphanie Cabantous, Christiane Deval, Agnès Claustre, Antoine Hauvette, Catherine Bouchenot, Julien Aniort, Daniel Béchet, Lydie Combaret, Didier Attaix, Daniel Taillandier

“…Conclusions We report here the first MuRF1‐E2s network, which may prove valuable for deciphering the precise mechanisms involved in the atrophying muscle programme and for proposing new therapeutical approaches.…”
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Identification of the cuproptosis-related hub genes and therapeutic agents for sarcopenia by Yingqian Zhu, Yingqian Zhu, Xin Chen, Xin Chen, Shasha Geng, Shasha Geng, Qingqing Li, Qingqing Li, Yang Li, Yang Li, Huixiao Yuan, Huixiao Yuan, Hua Jiang, Hua Jiang

“…These outcomes provide new insights for better understanding of sarcopenia and innovative therapeutic approaches.…”
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Bazi Bushen ameliorates age-related energy metabolism dysregulation by targeting the IL-17/TNF inflammatory pathway associated with SASP by Xiaogang Shen, Mengnan Li, Yawen Li, Yuning Jiang, Kunxu Niu, Shixiong Zhang, Xuan Lu, Runtao Zhang, Zhiqin Zhao, Liangxing Zhou, Zhifang Guo, Siwei Wang, Cong Wei, Liping Chang, Yunlong Hou, Yiling Wu

“…This study presents novel clinical therapeutic approaches for the prevention and treatment of age-related metabolic diseases.…”
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Explicit and Implicit Own's Body and Space Perception in Painful Musculoskeletal Disorders and Rheumatic Diseases: A Systematic Scoping Review by Antonello Viceconti, Eleonora Maria Camerone, Deborah Luzzi, Debora Pentassuglia, Matteo Pardini, Matteo Pardini, Diego Ristori, Giacomo Rossettini, Alberto Gallace, Alberto Gallace, Matthew R. Longo, Marco Testa

“…Almost half of the intervention studies (42%) provided therapeutic approaches combining more than one perceptual task, or sensory-motor tasks together with perceptual strategies, thus it was difficult to estimate the relative effectiveness of each single therapeutic component.Conclusions: To our knowledge, this is the first attempt to systematically map and summarize this research area in the field of musculoskeletal disorders and rheumatic diseases. …”
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Polypodium leucotomos targets multiple aspects of oral carcinogenesis and it is a potential antitumor phytotherapy against tongue cancer growth by Pammela A. Lacerda, Luan C. Oenning, Guilherme Cuoghi Bellato, Lucilene Lopes-Santos, Natalícia de Jesus Antunes, Bruno Augusto Linhares Almeida Mariz, Gabriela Teixeira, Rafael Vasconcelos, Gustavo Ferreira Simões, Ivani Aparecida de Souza, Ivani Aparecida de Souza, Clóvis Antônio Lopes Pinto, Clóvis Antônio Lopes Pinto, Tuula Salo, Ricardo D. Coletta, Ricardo D. Coletta, Taize M. Augusto, Taize M. Augusto, Taize M. Augusto, Carine Ervolino de Oliveira, Carine Ervolino de Oliveira, Nilva K. Cervigne, Nilva K. Cervigne, Nilva K. Cervigne

“…These malignancies exhibit rapid progression, poor prognosis, and often mutilating therapeutical approaches. The determination of a prophylactic and/or therapeutic antitumor role of the polyphenolic extract Polypodium leucotomos(PL) would be relevant in developing new tools for prevention and treatment.Methods: We aimed to determine the antitumor effect of PL by treating OSCC cell lines with PL metabolites and evaluating its action during OSCC progression in vivo.Results: PL treatment successfully impaired cell cycling and proliferation, migration, and invasion, enhanced apoptosis, and modulated macrophage polarization associated with the tumoral immune-inflammatory response of tongue cancer cell lines (TSCC). …”
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5-Azacytidine Downregulates the Proliferation and Migration of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Targeting miR-139-5p/ROCK2 Pathway by Federica Tonon, Maja Cemazar, Urska Kamensek, Cristina Zennaro, Gabriele Pozzato, Sergio Caserta, Flora Ascione, Mario Grassi, Stefano Guido, Cinzia Ferrari, Laura Cansolino, Francesco Trotta, Biljana Grcar Kuzmanov, Giancarlo Forte, Fabiana Martino, Francesca Perrone, Riccardo Bomben, Valter Gattei, Nicola Elvassore, Erminio Murano, Nhung Hai Truong, Michael Olson, Rossella Farra, Gabriele Grassi, Barbara Dapas

“…Background: For hepatocellular carcinoma (HCC), effective therapeutic approaches are lacking. As aberrant gene methylation is a major contributor to HCC development, demethylating drugs such as 5-azacytidine (5-Aza) have been proposed. …”
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Three weeks of exercise therapy altered brain functional connectivity in fibromyalgia inpatients by Shigeyuki Kan, Nobuko Fujita, Masahiko Shibata, Kenji Miki, Masao Yukioka, Emiko Senba

“…Therefore, new therapeutic approaches are awaited. Recently, exercise therapy has been gathering much attention as a promising treatment for FM. …”
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Advances in Mass Spectrometry-Based Blood Metabolomics Profiling for Non-Cancer Diseases: A Comprehensive Review by Ekaterina Demicheva, Vladislav Dordiuk, Fernando Polanco Espino, Konstantin Ushenin, Saied Aboushanab, Vadim Shevyrin, Aleksey Buhler, Elena Mukhlynina, Olga Solovyova, Irina Danilova, Elena Kovaleva

“…By analyzing blood samples, researchers gain valuable insights into the metabolic perturbations associated with these diseases, potentially leading to the identification of novel biomarkers and the development of personalized therapeutic approaches. Furthermore, we provide a comprehensive overview of various mass spectrometry approaches utilized in blood metabolomics research, including GC-MS, LC-MS, and others discussing their advantages and limitations. …”
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Pro-Fibrotic Phenotype in a Patient with Segmental Stiff Skin Syndrome via TGF-β Signaling Overactivation by Carmela Fusco, Grazia Nardella, Bartolomeo Augello, Francesca Boccafoschi, Orazio Palumbo, Luca Fusaro, Angelantonio Notarangelo, Raffaela Barbano, Paola Parrella, Giuseppina Annicchiarico, Carmela De Meco, Lucia Micale, Paolo Graziano, Marco Castori

“…Our results for the first time reported that aberrant TGF-β signaling may drive the pathogenesis of segmental SSS and might open the way to novel therapeutic approaches.…”
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