A Retrospective Exploratory Analysis for Serum Extracellular Vesicles Reveals APRIL (TNFSF13), CXCL13, and VEGF-A as Prognostic Biomarkers for Neoadjuvant Chemotherapy in Triple-Ne... by Hae Hyun Jung, Ji-Yeon Kim, Eun Yoon Cho, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Yeon Hee Park, Jin Seok Ahn, Young-Hyuck Im

“…It is important to identify patients who are most likely to have poor survival outcomes to identify candidates for more aggressive therapeutic approaches after NAC. Many studies have demonstrated that cytokines and growth factors packaged into extracellular vesicles (EVs) have an essential role in tumor progression and drug resistance. …”
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Circadian gene ARNTL initiates circGUCY1A2 transcription to suppress non-small cell lung cancer progression via miR-200c-3p/PTEN signaling by Deze Zhao, Yeping Dong, Minghao Duan, Dan He, Qun Xie, Wei Peng, Weifang Cui, Junjie Jiang, Yuanda Cheng, Heng Zhang, Faqing Tang, Chunfang Zhang, Yang Gao, Chaojun Duan

“…Conclusions This study is an original demonstration that ARNTL can inhibit the development of lung adenocarcinoma through the circGUCY1A2/miR-200c-3p/PTEN axis, and this finding provides potential targets and therapeutic approaches for the treatment of lung adenocarcinoma.…”
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Abstinence from Escalation of Cocaine Intake Changes the microRNA Landscape in the Cortico-Accumbal Pathway by Vidhya Kumaresan, Yolpanhchana Lim, Poorva Juneja, Allison E. Tipton, Giordano de Guglielmo, Lieselot L. G. Carrette, Marsida Kallupi, Lisa Maturin, Ying Liu, Olivier George, Huiping Zhang

“…Our findings highlight the impact of acute and protracted abstinence from escalated cocaine intake on miRNA expression in the cortico-accumbal pathway, a key circuit in addiction, and suggest developing novel biomarkers and therapeutic approaches to prevent relapse by targeting abstinence-associated miRNAs and their regulated mRNAs.…”
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The Profiling of 179 miRNA Expression in Serum from Limb Girdle Muscular Dystrophy Patients and Healthy Controls by Francesca Magri, Laura Napoli, Michela Ripolone, Patrizia Ciscato, Maurizio Moggio, Stefania Corti, Giacomo Pietro Comi, Monica Sciacco, Simona Zanotti

“…Over the last few years there has been an increasing interest in the use of non-invasive circulating biomarkers to monitor disease progression and to evaluate the efficacy of therapeutic approaches. Our aim was to identify the miRNA signature with potential value for LGMD patient screening and stratification. …”
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Hemidesmus indicus (L.) R. Br. ex Schult as natural bioactive products: An evidence-based review focused on inflammation related cancer prevention potential by Saikat Sena, Johannes Van Staden, Vijay Kumar, Azamal Husen

“…Due to this theoretical basis, the inflammatory response to cancer has emerged as the center of attention for novel preventive and therapeutic approaches. To reduce inflammation, immunomodulatory medications are often used in cancer therapy. …”
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A novel cuproptosis-related subtypes and gene signature associates with immunophenotype and predicts prognosis accurately in neuroblastoma by Xiao-Mao Tian, Xiao-Mao Tian, Xiao-Mao Tian, Bin Xiang, Bin Xiang, Bin Xiang, Yi-Hang Yu, Yi-Hang Yu, Yi-Hang Yu, Qi Li, Qi Li, Qi Li, Zhao-Xia Zhang, Zhao-Xia Zhang, Zhao-Xia Zhang, Chenghao Zhanghuang, Chenghao Zhanghuang, Li-Ming Jin, Li-Ming Jin, Li-Ming Jin, Jin-Kui Wang, Jin-Kui Wang, Jin-Kui Wang, Tao Mi, Tao Mi, Tao Mi, Mei-Lin Chen, Mei-Lin Chen, Mei-Lin Chen, Feng Liu, Feng Liu, Feng Liu, Guang-Hui Wei, Guang-Hui Wei, Guang-Hui Wei

“…NB exhibited genetic, morphologic, and clinical heterogeneity, which limited the efficacy of available therapeutic approaches. Recently, a new term ‘cuproptosis’ has been used to denote a unique biological process triggered by the action of copper. …”
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Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects by Roohi Mohi-ud-din, Apporva Chawla, Pooja Sharma, Prince Ahad Mir, Faheem Hyder Potoo, Željko Reiner, Ivan Reiner, Dilek Arslan Ateşşahin, Javad Sharifi-Rad, Reyaz Hassan Mir, Daniela Calina

“…These findings suggest the potential of these repurposed drugs as effective therapeutic approaches in cancer treatment. Repurposing approved non-oncology drugs provides a promising strategy for addressing the urgent need for effective and accessible cancer treatments. …”
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PDK1 Inhibitor BX795 Improves Cisplatin and Radio-Efficacy in Oral Squamous Cell Carcinoma by Downregulating the PDK1/CD47/Akt-Mediated Glycolysis Signaling Pathway by Shin Pai, Vijesh Kumar Yadav, Kuang-Tai Kuo, Narpati Wesa Pikatan, Chun-Shu Lin, Ming-Hsien Chien, Wei-Hwa Lee, Michael Hsiao, Shao-Chih Chiu, Chi-Tai Yeh, Jo-Ting Tsai

“…Molecular targeting is one of the new therapeutic approaches to target cancer. Among a plethora of targetable signaling molecules, PDK1 is currently rising as a potential target for cancer therapy. …”
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Genome-Based Multi-Antigenic Epitopes Vaccine Construct Designing against <i>Staphylococcus hominis</i> Using Reverse Vaccinology and Biophysical Approaches by Mahreen Nawaz, Asad Ullah, Alhanouf I. Al-Harbi, Mahboob Ul Haq, Alaa R. Hameed, Sajjad Ahmad, Aamir Aziz, Khadija Raziq, Saifullah Khan, Muhammad Irfan, Riaz Muhammad

“…This prompted the need to explore novel therapeutic approaches as an alternative to antibiotics. The current study aimed to develop a broad-spectrum, multi-epitope vaccine to control bacterial infections and reduce the burden on healthcare systems. …”
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Effective connectivity differences in motor network during passive movement of paretic and non-paretic ankles in subacute stroke patients by Marianna Nagy, Csaba Aranyi, Gábor Opposits, Tamás Papp, Levente Lánczi, Ervin Berényi, Csilla Vér, László Csiba, Péter Katona, Tamás Spisák, Miklós Emri

“…Background A better understanding of the neural changes associated with paresis in stroke patients could have important implications for therapeutic approaches. Dynamic Causal Modeling (DCM) for functional magnetic resonance imaging (fMRI) is commonly used for analyzing effective connectivity patterns of brain networks due to its significant property of modeling neural states behind fMRI signals. …”
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One Third of Malignant Pleural Mesothelioma Shows High Immunohistochemical Expression of MSLN or CXCR4 Which Indicates Potent Candidates for Endo-Radiotherapy by Thomas Hager, Sabrina Borchert, Michael Wessolly, Alexander Mathilakathu, Elena Mairinger, Jens Kollmeier, Thomas Mairinger, Balazs Hegedus, Kristina Greimelmaier, Jeremias Wohlschlaeger, Ken Herrmann, Fabian Dominik Mairinger

“…Malignant pleural mesothelioma (MPM) is a mainly asbestos-related tumour associated with a very poor prognosis. Therapeutic approaches include multimodal therapy and chemotherapeutics, with cisplatin being the drug of choice, but response rates of only up to 14% indicate very poor outcomes. …”
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Two-dimensional-Ti3C2 magnetic nanocomposite for targeted cancer chemotherapy by Mahdieh Darroudi, Mahdieh Darroudi, Mahdieh Darroudi, Seyedeh Elnaz Nazari, Maryam Karimzadeh, Fereshteh Asgharzadeh, Nima Khalili-Tanha, Seyyedeh Zahra Asghari, Sara Ranjbari, Fatemeh Babaei, Majid Rezayi, Majid Rezayi, Majid Rezayi, Majid Khazaei, Majid Khazaei

“…Introduction: Cervical cancer is the leading cause of cancer-related death in women, so novel therapeutic approaches are needed to improve the effectiveness of current therapies or extend their activity. …”
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Analysis of risk factors for acute pancreatitis complicated with pancreatic sinistral portal hypertension and construction of predictive model by Xin Zhao, Xin Zhao, Tian-Yang Mao, Tian-Yang Mao, Kang-Yi Jiang, Kang-Yi Jiang, Qing-Yun Xie, Qing-Yun Xie, Jie Yang, Jie Yang, Bo Du, Bo Du, Zhi-Xu Wang, Zhi-Xu Wang, Jin-Qiang Fu, Jin-Qiang Fu, Feng-Wei Gao, Ze-Hua Lei, Ze-Hua Lei

“…The predictive model developed for AP complicated with PSPH may serve toward developing preventive and therapeutic approaches for PSPH.…”
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Morpho-Constitutional Classification of Urinary Stones as Prospective Approach for the Management of Human Pathological Biomineralization: New Insights from Southern Italy by Francesco Izzo, Alessio Langella, Chiara Germinario, Celestino Grifa, Ettore Varricchio, Maria Chiara Di Meo, Luigi Salzano, Giuseppe Lotrecchiano, Mariano Mercurio

“…Occurrence of lower percentages of phosphate (i.e., brushite [CaHPO₄·2(H₂O)] and carbonated apatite [Ca₁₀(PO₄CO₃)₆(OH)₈]) and mixed stones (such as, for example, a mixture of ammonium urate [NH₄C₅H₃N₄O₃] and calcium oxalates) indicates specific etiopathogenetic mechanisms, suggesting proper therapeutical approaches.…”
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Pathological complete remission in ALK-positive lung cancer patient after multiple lines of conversion therapy by Dan Que, Hongbo Zou, Bijing Mao, Huan Zhang, Wei Liang, Qin Liu, Leiyu Ke, Lijie Guo, Qichao Xie

“…IntroductionTraditional therapeutic approaches for the treatment of advanced non-small-cell lung cancer (NSCLC) are based on chemotherapy. …”
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Phenotype and Function of Activated Natural Killer Cells From Patients With Prostate Cancer: Patient-Dependent Responses to Priming and IL-2 Activation by Simon P. Hood, Gemma A. Foulds, Heather Imrie, Stephen Reeder, Stéphanie E. B. McArdle, Masood Khan, Alan Graham Pockley

“…However, our findings also indicate that patients will need to be stratified according to their potential responsiveness to individual therapeutic approaches.…”
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The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3 by Tomotake Kanai, Naoki Kondo, Masayasu Okada, Hiroshige Sano, Go Okumura, Yasufumi Kijima, Akira Ogose, Hiroyuki Kawashima, Naoto Endo

“…We hypothesized that elucidating this relationship would lead to novel therapeutic approaches to RA treatment and management. Methods We investigated the effect of administering a low dose (1000 μM or less) of an antioxidant (NAC) to human rheumatoid fibroblast-like synoviocytes (MH7A cells). …”
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Circulating tissue inhibitor of metalloproteinases 1 (TIMP-1) at COVID-19 onset predicts severity status by Stefano Brusa, Daniela Terracciano, Dario Bruzzese, Mariano Fiorenza, Lucia Stanziola, Biagio Pinchera, Valeria Valente, Ivan Gentile, Antonio Cittadini, Ilaria Mormile, Mauro Mormile, Giuseppe Portella

“…Interestingly, our results prompted that serum TIMP-1 level may potentially be used to select the patients for therapeutic approaches targeting matrix metalloproteases pathway.…”
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Development and validation of a nomogram for the risk prediction of malignant cerebral edema after acute large hemispheric infarction involving the anterior circulation by Wei Xie, Xiaoming Ma, Geman Xu, Geman Xu, Yumei Wang, Wendie Huang, Meng Liu, Shiying Sheng, Jie Yuan, Jie Yuan, Jing Wang, Jing Wang

“…This model can serve as a precise and practical tool for clinical decision-making in patients with LHI who may require aggressive therapeutic approaches.…”
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Targeting HDACs in Pancreatic Neuroendocrine Tumor Models by Rosa Lynn Schmitz, Julia Weissbach, Jan Kleilein, Jessica Bell, Stefan Hüttelmaier, Fabrice Viol, Till Clauditz, Patricia Grabowski, Helmut Laumen, Jonas Rosendahl, Patrick Michl, Jörg Schrader, Sebastian Krug

“…In addition to surgical resection, several therapeutic approaches, including biotherapy, targeted therapy or chemotherapy are applicable. …”
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