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12061
A Retrospective Exploratory Analysis for Serum Extracellular Vesicles Reveals APRIL (TNFSF13), CXCL13, and VEGF-A as Prognostic Biomarkers for Neoadjuvant Chemotherapy in Triple-Ne...
Published 2023-10-01“…It is important to identify patients who are most likely to have poor survival outcomes to identify candidates for more aggressive therapeutic approaches after NAC. Many studies have demonstrated that cytokines and growth factors packaged into extracellular vesicles (EVs) have an essential role in tumor progression and drug resistance. …”
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12062
Circadian gene ARNTL initiates circGUCY1A2 transcription to suppress non-small cell lung cancer progression via miR-200c-3p/PTEN signaling
Published 2023-09-01“…Conclusions This study is an original demonstration that ARNTL can inhibit the development of lung adenocarcinoma through the circGUCY1A2/miR-200c-3p/PTEN axis, and this finding provides potential targets and therapeutic approaches for the treatment of lung adenocarcinoma.…”
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12063
Abstinence from Escalation of Cocaine Intake Changes the microRNA Landscape in the Cortico-Accumbal Pathway
Published 2023-05-01“…Our findings highlight the impact of acute and protracted abstinence from escalated cocaine intake on miRNA expression in the cortico-accumbal pathway, a key circuit in addiction, and suggest developing novel biomarkers and therapeutic approaches to prevent relapse by targeting abstinence-associated miRNAs and their regulated mRNAs.…”
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12064
The Profiling of 179 miRNA Expression in Serum from Limb Girdle Muscular Dystrophy Patients and Healthy Controls
Published 2023-12-01“…Over the last few years there has been an increasing interest in the use of non-invasive circulating biomarkers to monitor disease progression and to evaluate the efficacy of therapeutic approaches. Our aim was to identify the miRNA signature with potential value for LGMD patient screening and stratification. …”
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12065
Hemidesmus indicus (L.) R. Br. ex Schult as natural bioactive products: An evidence-based review focused on inflammation related cancer prevention potential
Published 2023-01-01“…Due to this theoretical basis, the inflammatory response to cancer has emerged as the center of attention for novel preventive and therapeutic approaches. To reduce inflammation, immunomodulatory medications are often used in cancer therapy. …”
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12066
A novel cuproptosis-related subtypes and gene signature associates with immunophenotype and predicts prognosis accurately in neuroblastoma
Published 2022-09-01“…NB exhibited genetic, morphologic, and clinical heterogeneity, which limited the efficacy of available therapeutic approaches. Recently, a new term ‘cuproptosis’ has been used to denote a unique biological process triggered by the action of copper. …”
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12067
Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects
Published 2023-09-01“…These findings suggest the potential of these repurposed drugs as effective therapeutic approaches in cancer treatment. Repurposing approved non-oncology drugs provides a promising strategy for addressing the urgent need for effective and accessible cancer treatments. …”
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12068
PDK1 Inhibitor BX795 Improves Cisplatin and Radio-Efficacy in Oral Squamous Cell Carcinoma by Downregulating the PDK1/CD47/Akt-Mediated Glycolysis Signaling Pathway
Published 2021-10-01“…Molecular targeting is one of the new therapeutic approaches to target cancer. Among a plethora of targetable signaling molecules, PDK1 is currently rising as a potential target for cancer therapy. …”
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12069
Genome-Based Multi-Antigenic Epitopes Vaccine Construct Designing against <i>Staphylococcus hominis</i> Using Reverse Vaccinology and Biophysical Approaches
Published 2022-10-01“…This prompted the need to explore novel therapeutic approaches as an alternative to antibiotics. The current study aimed to develop a broad-spectrum, multi-epitope vaccine to control bacterial infections and reduce the burden on healthcare systems. …”
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12070
Effective connectivity differences in motor network during passive movement of paretic and non-paretic ankles in subacute stroke patients
Published 2020-05-01“…Background A better understanding of the neural changes associated with paresis in stroke patients could have important implications for therapeutic approaches. Dynamic Causal Modeling (DCM) for functional magnetic resonance imaging (fMRI) is commonly used for analyzing effective connectivity patterns of brain networks due to its significant property of modeling neural states behind fMRI signals. …”
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12071
One Third of Malignant Pleural Mesothelioma Shows High Immunohistochemical Expression of MSLN or CXCR4 Which Indicates Potent Candidates for Endo-Radiotherapy
Published 2023-03-01“…Malignant pleural mesothelioma (MPM) is a mainly asbestos-related tumour associated with a very poor prognosis. Therapeutic approaches include multimodal therapy and chemotherapeutics, with cisplatin being the drug of choice, but response rates of only up to 14% indicate very poor outcomes. …”
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12072
Two-dimensional-Ti3C2 magnetic nanocomposite for targeted cancer chemotherapy
Published 2023-01-01“…Introduction: Cervical cancer is the leading cause of cancer-related death in women, so novel therapeutic approaches are needed to improve the effectiveness of current therapies or extend their activity. …”
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12073
Analysis of risk factors for acute pancreatitis complicated with pancreatic sinistral portal hypertension and construction of predictive model
Published 2024-01-01“…The predictive model developed for AP complicated with PSPH may serve toward developing preventive and therapeutic approaches for PSPH.…”
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12074
Morpho-Constitutional Classification of Urinary Stones as Prospective Approach for the Management of Human Pathological Biomineralization: New Insights from Southern Italy
Published 2022-11-01“…Occurrence of lower percentages of phosphate (i.e., brushite [CaHPO<sub>4</sub>·2(H<sub>2</sub>O)] and carbonated apatite [Ca<sub>10</sub>(PO<sub>4</sub>CO<sub>3</sub>)<sub>6</sub>(OH)<sub>8</sub>]) and mixed stones (such as, for example, a mixture of ammonium urate [NH<sub>4</sub>C<sub>5</sub>H<sub>3</sub>N<sub>4</sub>O<sub>3</sub>] and calcium oxalates) indicates specific etiopathogenetic mechanisms, suggesting proper therapeutical approaches.…”
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12075
Pathological complete remission in ALK-positive lung cancer patient after multiple lines of conversion therapy
Published 2022-11-01“…IntroductionTraditional therapeutic approaches for the treatment of advanced non-small-cell lung cancer (NSCLC) are based on chemotherapy. …”
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12076
Phenotype and Function of Activated Natural Killer Cells From Patients With Prostate Cancer: Patient-Dependent Responses to Priming and IL-2 Activation
Published 2019-01-01“…However, our findings also indicate that patients will need to be stratified according to their potential responsiveness to individual therapeutic approaches.…”
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12077
The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3
Published 2020-03-01“…We hypothesized that elucidating this relationship would lead to novel therapeutic approaches to RA treatment and management. Methods We investigated the effect of administering a low dose (1000 μM or less) of an antioxidant (NAC) to human rheumatoid fibroblast-like synoviocytes (MH7A cells). …”
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12078
Circulating tissue inhibitor of metalloproteinases 1 (TIMP-1) at COVID-19 onset predicts severity status
Published 2022-11-01“…Interestingly, our results prompted that serum TIMP-1 level may potentially be used to select the patients for therapeutic approaches targeting matrix metalloproteases pathway.…”
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12079
Development and validation of a nomogram for the risk prediction of malignant cerebral edema after acute large hemispheric infarction involving the anterior circulation
Published 2023-09-01“…This model can serve as a precise and practical tool for clinical decision-making in patients with LHI who may require aggressive therapeutic approaches.…”
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12080
Targeting HDACs in Pancreatic Neuroendocrine Tumor Models
Published 2021-06-01“…In addition to surgical resection, several therapeutic approaches, including biotherapy, targeted therapy or chemotherapy are applicable. …”
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