Slit Guidance Ligand 3 (SLIT3) Loaded in Hydrogel Microparticles Enhances the Tendon-Bone Healing through Promotion of Type-H Vessel Formation: An Experimental Study in Mice by Jianting Li, Guanfu Wu, Changhao Xu, Zhining Cai, Jiali Ji, Ziyi Yu, Jing Zhang, Jiali Wang

“…Type H vessels have been recently found to closely modulate bone formation via regulation of the osteo-angiogenic crosstalk, so the strategies favoring type H vessel formation may be promising therapeutic approaches for improved graft osteointegration. …”
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New Cases and Mutations in <i>SEC23B</i> Gene Causing Congenital Dyserythropoietic Anemia Type II by Melina Mara Musri, Veronica Venturi, Xènia Ferrer-Cortès, Lídia Romero-Cortadellas, Gonzalo Hernández, Pilar Leoz, María Pilar Ricard Andrés, Marta Morado, María del Carmen Fernández Valle, David Beneitez Pastor, Ana Ortuño Cabrero, Maite Moreno Gamiz, Leonor Senent Peris, Amanda Isabel Perez-Valencia, Santiago Pérez-Montero, Cristian Tornador, Mayka Sánchez

“…In this work, we summarize a comprehensive spectrum of <i>SEC23B</i> variants, describe nine new CDA II cases accounting for six previously unreported variants, and discuss innovative therapeutic approaches for CDA II.…”
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Novel bispecific nanobody mitigates experimental intestinal inflammation in mice by targeting TNF‐α and IL‐23p19 bioactivities by Jiewen Wang, Guangbo Kang, Huiying Lu, Ario deMarco, Haibin Yuan, Zelin Feng, Mengxue Gao, Xiaoli Wang, Huahong Wang, Xiaolan Zhang, Yuli Wang, Miao Zhang, Ping Wang, Yuanhang Feng, Zhanju Liu, Xiaocang Cao, He Huang

“…Abstract Background Inflammatory bowel diseases (IBDs) pose significant challenges in terms of treatment non‐response, necessitating the development of novel therapeutic approaches. Although biological medicines that target TNF‐α (tumour necrosis factor‐α) have shown clinical success in some IBD patients, a substantial proportion still fails to respond. …”
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Genistein effect on cognition in prodromal Alzheimer’s disease patients. The GENIAL clinical trial by José Viña, Joaquín Escudero, Miquel Baquero, Mónica Cebrián, Juan Antonio Carbonell-Asíns, José Enrique Muñoz, Encarnación Satorres, Juan Carlos Meléndez, José Ferrer-Rebolleda, Mª del Puig Cózar-Santiago, Jose Manuel Santabárbara-Gómez, Mariona Jové, Reinald Pamplona, Francisco José Tarazona-Santabalbina, Consuelo Borrás

“…Thus, long-term therapeutic approaches, with safe, minimally invasive, and yet effective substances are recommended. …”
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Ethnoveterinary Practices and Ethnobotanical Knowledge on Plants Used against Cattle Diseases among Two Communities in South Africa by Mompati Vincent Chakale, John Awungnjia Asong, Madeleen Struwig, Mulunda Mwanza, Adeyemi Oladapo Aremu

“…Ethnoveterinary practices and ethnobotanical knowledge serve as potential therapeutic approaches used to manage and prevent cattle diseases within poor communities in developing nations. …”
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Chronic Inflammation: Synergistic Interactions of Recruiting Macrophages (TAMs) and Eosinophils (Eos) with Host Mast Cells (MCs) and Tumorigenesis in CALTs. M-CSF, Suitable Biomark... by Mahin Khatami

“…Systematic monitoring of interactions between resident and recruited cells should provide key information not only about early events in loss of immune surveillance, but it would help making informed decisions for balancing the inherent tumoricidal (Yin) and tumorigenic (Yang) properties of immune system and effective preventive and therapeutic approaches and accurate risk assessment toward improvement of public health.…”
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Functional differences in human aortic valve interstitial cells from patients with varying calcific aortic valve disease by Robin Tuscher, Alex Khang, Toni M. West, Chiara Camillo, Giovanni Ferrari, Michael S. Sacks

“…Current treatment for CAVD remains surgical replacement with its continued durability problems, as there are no pharmaceutical therapies or other alternative treatments available. Before such therapeutic approaches can be developed, a deeper understanding of CAVD disease mechanisms is clearly required. …”
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The Experience of the Crisis Clinic at the Scientific and Practical Center for Mental Health of Children and Adolescents named after G.E. Sukhareva by Pyotr V. Bezmenov, Anna Ya. Basova, Roman V. Deych, Yulia V. Severina

“…In addition to medication, comprehensive psychotherapeutic assistance is recommended. The leading therapeutic approaches are cognitive-behavioral, including DBT, and family therapy, with the efforts of therapists concentrated on alleviating post-traumatic stress, depression, and behavioral problems, as well as resolving intrafamily conflicts. …”
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Evolutionarily stable gene clusters shed light on the common grounds of pathogenicity in the Acinetobacter calcoaceticus-baumannii complex by Bardya Djahanschiri, Gisela Di Venanzio, Jesus S. Distel, Jennifer Breisch, Marius Alfred Dieckmann, Alexander Goesmann, Beate Averhoff, Stephan Göttig, Gottfried Wilharm, Mario F. Feldman, Ingo Ebersberger

“…Acinetobacter baumannii, a nosocomial pathogen ranked top by the World Health Organization in the list of bacteria for which novel therapeutic approaches are needed, is a prime example. Here, we have carved out the genetic make-up that distinguishes A. baumannii and its pathogenic next relatives from other and mostly apathogenic Acinetobacter species. …”
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Delivering synaptic protein mRNAs via extracellular vesicles ameliorates cognitive impairment in a mouse model of Alzheimer’s disease by Huimin Cai, Yana Pang, Ziye Ren, Xiaofeng Fu, Longfei Jia

“…Delivery of synaptic protein mRNAs via EVs stands as a promising effective precision treatment strategy for AD, which significantly advances the current understanding of therapeutic approaches for the disease.…”
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Distinctive Prognostic Value and Cellular Functions of Osteopontin Splice Variants in Human Gastric Cancer by Chengcheng Hao, Yuxin Cui, Jane Lane, Shuqin Jia, Jiafu Ji, Wen G. Jiang

“…Focusing on specific OPN isoforms could be a novel direction for developing diagnostic and therapeutic approaches in gastric cancer.…”
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Evaluation and Application of a Customizable Wireless Platform: A Body Sensor Network for Unobtrusive Gait Analysis in Everyday Life by Markus Lueken, Leo Mueller, Michel G. Decker, Cornelius Bollheimer, Steffen Leonhardt, Chuong Ngo

“…Body sensor networks (BSNs) represent an important research tool for exploring novel diagnostic or therapeutic approaches. They allow for integrating different measurement techniques into body-worn sensors organized in a network structure. …”
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Monocarboxylate Transporter-2 Expression Restricts Tumor Growth in a Murine Model of Lung Cancer: A Multi-Omic Analysis by Abdelnaby Khalyfa, Zhuanhong Qiao, Murugesan Raju, Chi-Ren Shyu, Lyndon Coghill, Aaron Ericsson, David Gozal

“…These findings provide initial opportunities for potential delineation of oncometabolic immunomodulatory therapeutic approaches.…”
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Development of alternative herbals remedy for gastric cancer based on transcriptomic analysis of immune infiltration and ferroptosis by Mingyue Li, Jie Tao, Rui Qian, Feng Jiang, Yinzhi Song, Zhicong Zeng, Changlong Cai

“…Subsequently, the effect of resveratrol and magnolol was experimentally verified.Conclusion: Herbal medicines such as S. liguliobae, Rhizoma Coptidis, Rhizoma P. cuspidati and herbal ingredients such as resveratrol, curcumin, salvianolic acid b may provide research directions and alternative therapeutic approaches for immunomodulation of TME and ferroptosis of tumour cells in gastric cancer.…”
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Association of triglyceride-glucose index trajectory and frailty in urban older residents: evidence from the 10-year follow-up in a cohort study by Yin Yuan, Simiao Chen, Chunjin Lin, Xiaoming Huang, Siyang Lin, Feng Huang, Pengli Zhu

“…The trajectories of the TyG index can help to identify older individuals at a higher risk of frailty who deserve primitive preventive and therapeutic approaches.…”
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Concepções de enfermeiras sobre o prolongamento artificial da vida [Nurses’ view on artificial extension of life] by Carina Marinho Picanço, Dora Sadigursky

“…Conclusions show nurses believe there should be limits to therapeutic approaches and they consider artificial prolongation of life to be a source for patient’s suffering. …”
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SYNOPSIS AND PROSPECTS OF AUTOIMMUNOLOGY DEVELOPMENT WORLDWIDE (AFTER THE MATERIALS OF THE 11th INTERNATIONAL CONGRESS IN LISBON, MAY 16-20, 2018). PROCEEDING I: FIRST ACADEMY OF A... by E. A. Korneva, A. V. Petyaeva, T. V. Fedotkina, L. P. Churilov, Y. Shoenfeld

“…The questions of antibody production and B lymphocyte functions are considered taking into account recently discovered mechanisms of intracellular penetration of immunoglobulins and details of affinity maturation of lymphoid clones. The new therapeutic approaches in the treatment of autoimmune diseases associated with influences on B and T lymphocytes are described. …”
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Design of Virtual Reality Exergames for Upper Limb Stroke Rehabilitation Following Iterative Design Methods: Usability Study by Julian Felipe Villada Castillo, Maria Fernanda Montoya Vega, John Edison Muñoz Cardona, David Lopez, Leonardo Quiñones, Oscar Alberto Henao Gallo, Jose Fernando Lopez

“…This iterative approach enhances game design and markedly boosts user satisfaction, suggesting exergames have promising potential as adjunctive elements in traditional therapeutic approaches.…”
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The association between albumin levels and survival in patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis by Deniz Can Guven, Taha Koray Sahin, Enes Erul, Alessandro Rizzo, Angela Dalia Ricci, Sercan Aksoy, Suayib Yalcin

“…Further research is needed to delineate the role of albumin levels in patients treated with ICIs in the adjuvant setting, as well as the possible benefit of therapeutic approaches to improve hypoalbuminemia.…”
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Human stem cell derived beta-like cells engineered to present PD-L1 improve transplant survival in NOD mice carrying human HLA class I by Jorge Santini-González, Roberto Castro-Gutierrez, Matthew W. Becker, Chad Rancourt, Holger A. Russ, Edward A. Phelps

“…There is a critical need for therapeutic approaches that combine renewable sources of replacement beta cells with localized immunomodulation to counter recurrence of autoimmunity in type 1 diabetes (T1D). …”
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