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12101
Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143/145
Published 2023-06-01“…This novel finding may lend support to the development of therapeutic approaches for IBD by manipulating the interaction between host genes, gut bacteria and its bioactive components.…”
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12102
Multiple myeloma with extramedullary plasmacytoma: pathogenesis and clinical case
Published 2022-11-01“…A comprehensive molecular genetic study of the extramedullary plasmacytoma’ substrate is necessary to understand the pathogenesis mechanisms and, on this basis, to develop differentiated therapeutic approaches.…”
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12103
A novel DNA damage repair-related gene signature predicting survival, immune infiltration and drug sensitivity in cervical cancer based on single cell sequencing
Published 2023-06-01“…BackgroundAberrant DNA damage repair (DDR) is one of the hallmarks of tumors, and therapeutic approaches targeting this feature are gaining increasing attention. …”
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12104
Deletion of CD36 exhibits limited impact on normal hematopoiesis and the leukemia microenvironment
Published 2023-05-01“…Altogether, considering the limited impact on normal hematopoiesis, therapeutic approaches to target CD36 in cancer are unlikely to result in toxicity to normal blood cells.…”
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12105
Insights into Microbiome and Metabolic Signatures of Children Undergoing Peanut Oral Immunotherapy
Published 2022-08-01“…A better understanding of the microbiome-related mechanisms underlying desensitization may allow development of smarter therapeutic approaches in the near future. Clinical implication: The oral microbiome composition is altered following successful peanut oral immunotherapy, with a significant increase in alpha diversity and the relative abundance of phylum Actinobacteria. …”
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12106
Triple-Negative Breast Cancer: Clinical Characteristics, Prognostic Features, and Long-Term Outcome: A Comparative Study
Published 2012-03-01“…Background: Because of the reported poor prognosis and absence of effective and specific therapeutic approaches, triple-negative breast cancer (TNBC) tumors have remained as an important area of investigations for clinicians and researchers. …”
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12107
Endothelial cell-derived extracellular vesicles impair the angiogenic response of coronary artery endothelial cells
Published 2022-07-01“…Acute treatments with inhibitors that prevent endogenous EV release immediately after an ischemic event may contribute to better efficacy of therapeutic approaches using functionalized exogenous EVs or other pro-angiogenic approaches.…”
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12108
Renal C4d is a potential biomarker of disease activity and severity in pediatric lupus nephritis patients
Published 2023-06-01“…These data suggest that renal C4d is a potential biomarker for disease activity and severity in pediatric LN patients, providing insights into the development of novel identification and therapeutic approaches for pediatric-onset SLE with LN.…”
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12109
SOLUBLE ADHESION MOLECULES IN CHILDREN WITH HEMOLYTIC UREMIC SYNDROME
Published 2018-12-01“…Understanding the role of complement dysregulation in aHUS pathogenesis has led to major changes in therapeutic approaches. Eculizumab (a humanized anti-C5 monoclonal antibody) inhibits the terminal complement pathway. …”
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12110
Interferência por RNA: uma nova alternativa para terapia nas doenças reumáticas RNA interference: a new alternative for rheumatic diseases therapy
Published 2010-12-01“…This review will present the basic principles of RNAi and discuss several aspects of RNAi-based therapeutic approaches, from in vitro tool design and target identification to in vivo pre-clinical drug delivery, and tests of autoimmune diseases in human cells and animal models. …”
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12111
Morphofunctional changes of microglia in adult and old Wistar rats
Published 2023-06-01“…Further research in this area will expand the understanding of the mechanisms of initiation and progression of neurodegeneration, which is necessary for the development of novel and effective therapeutic approaches to the treatment of AD.…”
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12112
Modern Anticoagulant Therapy for Atrial Fibrillation: Patient Adherence in Clinical Practice
Published 2022-03-01“…Assessment of adherence to anticoagulant therapy by doctors in two regional centers (Omsk and Ryazan) showed high prescribability of preventive antithrombotic therapy, which corresponds to modern therapeutic approaches. At the same time, patients demonstrated rather low levels of adherence to drug therapy, lifestyle modification, and medical support.…”
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12113
In a novel autoimmune and high-pressure glaucoma model a complex immune response is induced
Published 2024-03-01“…Hence, this new model mimics the pathomechanisms occurring in human glaucoma more accurately and could therefore be a helpful tool to find new therapeutic approaches for patients in the future.…”
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12114
Pyelonephritis in pregnancy: «traditional» drainage tactics and its results
Published 2020-04-01“…At the same time, a high percentage of the frequency of the preterm delivery threat, maintenance therapy on the stent (16.1%), recurrent attacks of pyelonephritis in drainage conditions (19.6%) during gestation, and also after stent removal in the postpartum period (5.7%), other variations of stent-associated symptoms and complications create the basis for reflection, the search for more optimal tactical and therapeutic approaches.…”
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12115
Ionizing Radiation Promotes Epithelial-Mesenchymal Transition Phenotype and Stem Cell Marker in The Lung adenocarcinoma: In Vitro and Bioinformatic Studiesc
Published 2022-09-01“…Objective: Ionizing radiation (IR) is one of the major therapeutic approaches in the non-small cell lung cancer (NSCLC);however, it can paradoxically result in cancer progression likely through promoting epithelial-mesenchymal transition(EMT) and the cancer stem cell phenotype. …”
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12116
Involvement of the Endocannabinoid System in the pathophysiology and therapeutics of movement disorders
Published 2022-10-01“…All of these processes are affected in movement disorders, coupled with this, the presence of functional cannabinoid receptors and ligands in the abovementioned regions, encourage the continuous searching for new compounds and therapeutic approaches aiming this system, to diminish, prevent, and treat the symptoms and causes of the movement disorders. …”
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12117
New Approach to Chronic Back Pain Treatment: A Case Control Study
Published 2022-12-01“…Conclusion: The results highlight how the treatment associated with ozone therapy and oral administration of alpha-lipoic acid + palmitoylethanolamide and myrrh can be considered a valid alternative to common therapeutic approaches in the treatment of chronic low back pain.…”
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12118
Characterization of immune checkpoints expression and lymphocyte densities of iranian breast cancer patients; the co-expression status and clinicopathological associates
Published 2023-06-01“…Abstract Background Breast malignancies are now the most common and deadliest type of neoplasms among women worldwide. Novel therapeutic approaches are needed to combat advanced stages of breast cancer. …”
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12119
Comprehensive circular RNA expression profile in radiation-treated HeLa cells and analysis of radioresistance-related circRNAs
Published 2018-06-01“…These findings may improve our understanding of the role of circRNAs in radioresistance in HeLa cells and allow the development of novel therapeutic approaches.…”
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12120
Simply adding oral nutritional supplementation to haemodialysis patients may not be enough: a real-life prospective interventional study
Published 2023-10-01“…Much effort has been invested in the improvement of nutritional status and amelioration of consequences through different therapeutic approaches, either intradialytic parenteral nutrition or more commonly oral nutritional supplementation. …”
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