Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143/145 by Henry Wade, Kaichao Pan, Qihua Duan, Szczepan Kaluzny, Ekta Pandey, Linda Fatumoju, Viswanathan Saraswathi, Rongxue Wu, Edward N. Harris, Qiaozhu Su

“…This novel finding may lend support to the development of therapeutic approaches for IBD by manipulating the interaction between host genes, gut bacteria and its bioactive components.…”
Get full text

Multiple myeloma with extramedullary plasmacytoma: pathogenesis and clinical case by M. V. Firsova, N. V. Risinskaya, M. V. Solovev, T. N. Obukhova, M. A. Kislitsyna, E. E. Nikulina, I. A. Yakutik, T. V. Abramova, A. B. Sudarikov, A. M. Kovrigina, L. P. Mendeleeva

“…A comprehensive molecular genetic study of the extramedullary plasmacytoma’ substrate is necessary to understand the pathogenesis mechanisms and, on this basis, to develop differentiated therapeutic approaches.…”
Get full text

A novel DNA damage repair-related gene signature predicting survival, immune infiltration and drug sensitivity in cervical cancer based on single cell sequencing by Xiaoqing Xiang, Jiawen Kang, Jingwen Jiang, Yaning Zhang, Yong Zhang, Lesai Li, Xiaoning Peng

“…BackgroundAberrant DNA damage repair (DDR) is one of the hallmarks of tumors, and therapeutic approaches targeting this feature are gaining increasing attention. …”
Get full text

Deletion of CD36 exhibits limited impact on normal hematopoiesis and the leukemia microenvironment by Yiting Meng, Mateusz Pospiech, Atham Ali, Ritu Chandwani, Mary Vergel, Sandra Onyemaechi, George Yaghmour, Rong Lu, Houda Alachkar

“…Altogether, considering the limited impact on normal hematopoiesis, therapeutic approaches to target CD36 in cancer are unlikely to result in toxicity to normal blood cells.…”
Get full text

Insights into Microbiome and Metabolic Signatures of Children Undergoing Peanut Oral Immunotherapy by Andrea C. Blackman, Santosh Thapa, Alamelu Venkatachalam, Thomas D. Horvath, Jessica K. Runge, Sigmund J. Haidacher, Kathleen M. Hoch, Anthony M. Haag, Ruth Ann Luna, Aikaterini Anagnostou

“…A better understanding of the microbiome-related mechanisms underlying desensitization may allow development of smarter therapeutic approaches in the near future. Clinical implication: The oral microbiome composition is altered following successful peanut oral immunotherapy, with a significant increase in alpha diversity and the relative abundance of phylum Actinobacteria. …”
Get full text

Triple-Negative Breast Cancer: Clinical Characteristics, Prognostic Features, and Long-Term Outcome: A Comparative Study by Leila Rahmani, Ali Shahriari Ahmadi, Ali Basi, Tahere Zarouk Ahimahalle

“…Background: Because of the reported poor prognosis and absence of effective and specific therapeutic approaches, triple-negative breast cancer (TNBC) tumors have remained as an important area of investigations for clinicians and researchers. …”
Get full text

Endothelial cell-derived extracellular vesicles impair the angiogenic response of coronary artery endothelial cells by Nigeste Carter, Allison H. Mathiesen, Noel Miller, Michael Brown, Ruben M. L. Colunga Biancatelli, John D. Catravas, John D. Catravas, Anca D. Dobrian

“…Acute treatments with inhibitors that prevent endogenous EV release immediately after an ischemic event may contribute to better efficacy of therapeutic approaches using functionalized exogenous EVs or other pro-angiogenic approaches.…”
Get full text

Renal C4d is a potential biomarker of disease activity and severity in pediatric lupus nephritis patients by Xueyao Wang, Shaojie Fu, Jinyu Yu, Daru Tang, Hao Wu, Zhonggao Xu

“…These data suggest that renal C4d is a potential biomarker for disease activity and severity in pediatric LN patients, providing insights into the development of novel identification and therapeutic approaches for pediatric-onset SLE with LN.…”
Get full text

SOLUBLE ADHESION MOLECULES IN CHILDREN WITH HEMOLYTIC UREMIC SYNDROME by T. E. Pankratenko, O. V. Moskalets, T. Yu. Abaseeva

“…Understanding the role of complement dysregulation in aHUS pathogenesis has led to major changes in therapeutic approaches. Eculizumab (a humanized anti-C5 monoclonal antibody) inhibits the terminal complement pathway. …”
Get full text

Interferência por RNA: uma nova alternativa para terapia nas doenças reumáticas RNA interference: a new alternative for rheumatic diseases therapy by Natália Regine de França, Danilo Mesquita Júnior, Amanda Bandeira Lima, Fernando Vianna Cabral Pucci, Luís Eduardo Coelho Andrade, Neusa Pereira Silva

“…This review will present the basic principles of RNAi and discuss several aspects of RNAi-based therapeutic approaches, from in vitro tool design and target identification to in vivo pre-clinical drug delivery, and tests of autoimmune diseases in human cells and animal models. …”
Get full text

Morphofunctional changes of microglia in adult and old Wistar rats by A. V. Sentyabreva, E. A. Melnikova, E. A. Miroshnichenko, I. S. Tsvetkov, A. M. Kosyreva

“…Further research in this area will expand the understanding of the mechanisms of initiation and progression of neurodegeneration, which is necessary for the development of novel and effective therapeutic approaches to the treatment of AD.…”
Get full text

Modern Anticoagulant Therapy for Atrial Fibrillation: Patient Adherence in Clinical Practice by Yu. P. Skirdenko, N. A. Nikolaev, K. G. Pereverzeva, A. Yu. Timakova, A. S. Galus, S. S. Yakushin

“…Assessment of adherence to anticoagulant therapy by doctors in two regional centers (Omsk and Ryazan) showed high prescribability of preventive antithrombotic therapy, which corresponds to modern therapeutic approaches. At the same time, patients demonstrated rather low levels of adherence to drug therapy, lifestyle modification, and medical support.…”
Get full text

In a novel autoimmune and high-pressure glaucoma model a complex immune response is induced by Sabrina Reinehr, Julien Wulf, Janine Theile, Kim K. Schulte, Marcus Peters, Rudolf Fuchshofer, H. Burkhard Dick, Stephanie C. Joachim

“…Hence, this new model mimics the pathomechanisms occurring in human glaucoma more accurately and could therefore be a helpful tool to find new therapeutic approaches for patients in the future.…”
Get full text

Pyelonephritis in pregnancy: «traditional» drainage tactics and its results by V. V. Levchenko, P. P. Morgun, A. V. Voldokhin, A. Y. Abu Trabi, A. S. Maslovsky

“…At the same time, a high percentage of the frequency of the preterm delivery threat, maintenance therapy on the stent (16.1%), recurrent attacks of pyelonephritis in drainage conditions (19.6%) during gestation, and also after stent removal in the postpartum period (5.7%), other variations of stent-associated symptoms and complications create the basis for reflection, the search for more optimal tactical and therapeutic approaches.…”
Get full text

Ionizing Radiation Promotes Epithelial-Mesenchymal Transition Phenotype and Stem Cell Marker in The Lung adenocarcinoma: In Vitro and Bioinformatic Studiesc by Mehdi Raei, Mahdi Bagheri, Safieh Aghaabdollahian, Masoud Ghorbani, Afshin Sadeghi

“…Objective: Ionizing radiation (IR) is one of the major therapeutic approaches in the non-small cell lung cancer (NSCLC);however, it can paradoxically result in cancer progression likely through promoting epithelial-mesenchymal transition(EMT) and the cancer stem cell phenotype. …”
Get full text

Involvement of the Endocannabinoid System in the pathophysiology and therapeutics of movement disorders by A.R. Tejeda-Martínez, J.M. Viveros-Paredes, M.E. Flores-Soto

“…All of these processes are affected in movement disorders, coupled with this, the presence of functional cannabinoid receptors and ligands in the abovementioned regions, encourage the continuous searching for new compounds and therapeutic approaches aiming this system, to diminish, prevent, and treat the symptoms and causes of the movement disorders. …”
Get full text

New Approach to Chronic Back Pain Treatment: A Case Control Study by Matteo Bonetti, Dorina Lauritano, Gian Maria Ottaviani, Alessandro Fontana, Michele Frigerio, Alessio Zambello, Luigi Della Gatta, Mario Muto, Francesco Carinci

“…Conclusion: The results highlight how the treatment associated with ozone therapy and oral administration of alpha-lipoic acid + palmitoylethanolamide and myrrh can be considered a valid alternative to common therapeutic approaches in the treatment of chronic low back pain.…”
Get full text

Characterization of immune checkpoints expression and lymphocyte densities of iranian breast cancer patients; the co-expression status and clinicopathological associates by Mohammadhossein Pournabee, Mahsa Keshavarz-Fathi, Pooyesh Esmaeili, Pouya Mahdavi Sharif, Fatemeh Nili, Behnaz Jahanbin

“…Abstract Background Breast malignancies are now the most common and deadliest type of neoplasms among women worldwide. Novel therapeutic approaches are needed to combat advanced stages of breast cancer. …”
Get full text

Comprehensive circular RNA expression profile in radiation-treated HeLa cells and analysis of radioresistance-related circRNAs by Duo Yu, Yunfeng Li, Zhihui Ming, Hongyong Wang, Zhuo Dong, Ling Qiu, Tiejun Wang

“…These findings may improve our understanding of the role of circRNAs in radioresistance in HeLa cells and allow the development of novel therapeutic approaches.…”
Get full text

Simply adding oral nutritional supplementation to haemodialysis patients may not be enough: a real-life prospective interventional study by Andreja Ocepek, Robert Ekart, Robert Ekart, Petra Povalej Bržan, Petra Povalej Bržan, Sebastjan Bevc, Sebastjan Bevc

“…Much effort has been invested in the improvement of nutritional status and amelioration of consequences through different therapeutic approaches, either intradialytic parenteral nutrition or more commonly oral nutritional supplementation. …”
Get full text