CCR5 as a Coreceptor for Human Immunodeficiency Virus and Simian Immunodeficiency Viruses: A Prototypic Love-Hate Affair by Anna J. Jasinska, Anna J. Jasinska, Anna J. Jasinska, Ivona Pandrea, Ivona Pandrea, Cristian Apetrei, Cristian Apetrei

“…These natural strategies against SIV/HIV-1 infection, involving control of CCR5 function, inspired therapeutic approaches against HIV-1 disease, employing CCR5 coreceptor blocking as well as gene editing and silencing of CCR5. …”
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Clinical pharmacology: Developmental path, regulations, education, practical management: Generally and in Serbia by Kastratović Dragana A., Marković Srđan Z., Slobodan Janković M.

“…Topic: Clinical pharmacology is a medical discipline created in the middle of the 20th century, it implies the most effective application of medicine, and it could be said that it is the culmination of all therapeutic approaches in medicine, or simply in the preservation of human health. …”
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Comparison of antiviral effect of camel lactoferrin peptide (CLF36) and new generation drugs against hepatitis C virus by Marjan Azghandi, Mojtaba Tahmoorespur, Mohammad Hadi Sekhavati

“…One of these new therapeutic approaches is the use of recombinant proteins, which have no side effects for the patient and at the same time are cheap and available.Materials and methodsTo conduct this study, the three-dimensional structures of virus proteases (NS2, NS3, NS4A, NS5A and NS5B) and recombinant peptide CLF36, were obtained. …”
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A Web-Based Positive Psychological Intervention to Improve Blood Pressure Control in Spanish-Speaking Hispanic/Latino Adults With Uncontrolled Hypertension: Protocol and Design for... by Hernandez, Rosalba, Cohn, Michael, Hernandez, Alison, Daviglus, Martha, Martinez, Lizet, Martinez, Angela, Martinez, Itzel, Durazo-Arvizu, Ramon, Moskowitz, Judith

“…Hispanic/Latino people in the United States have high cardiovascular disease risk and poorly controlled blood pressure (BP) compared with their peers of European ancestry, and they represent a population in need of new and innovative therapeutic approaches. As such, a focused intervention to boost psychological well-being holds promise as a novel therapeutic target for hypertension in Hispanic/Latino adults; to date, however, no research has explored whether a causal link is evident. …”
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Effects of Yoga on Blood Glucose and Lipid Profile of Type 2 Diabetes Patients Without Complications: A Systematic Review and Meta-Analysis by Shanshan Chen, Shilin Deng, Yang Liu, Tiantian Yin

“…Although it has been empirically established that physical activity is a promising therapeutical approach to the prevention and management of T2DM, the effectiveness of yoga on T2DM has not yet reached an agreement across studies and also needs an updated synthetic examination.PurposeThe purpose of this study was to examine the effect of yoga training on diabetes-related indicators compared with usual care.MethodsThe review protocol of this study has been registered in the PROSPERO with a registration number CRD42021267868. …”
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Examining the Effectiveness of Web-Based Interventions to Enhance Resilience in Health Care Professionals: Systematic Review by Catherine Henshall, Edoardo Ostinelli, Jade Harvey, Zoe Davey, Bemigho Aghanenu, Andrea Cipriani, Mary-Jane Attenburrow

“…Interventions included various web-based formats and therapeutic approaches over variable time frames. One randomized controlled trial directly measured resilience, whereas the remaining 3 used proxy measures to measure psychological concepts linked to resilience. …”
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Effectiveness of outpatient and community treatments for people with a diagnosis of ‘personality disorder’: systematic review and meta-analysis by Panos Katakis, Merle Schlief, Phoebe Barnett, Luke Sheridan Rains, Sarah Rowe, Steve Pilling, Sonia Johnson

“…Conclusions People with a ‘personality disorder’ diagnosis benefited from psychological and psychosocial interventions delivered in community or outpatient settings, with all therapeutic approaches showing similar effectiveness. Mental health services should provide people with CEN with specialised treatments in accordance with the availability and the patients’ preferences.…”
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Modeling COVID-19 disease processes by remote elicitation of causal Bayesian networks from medical experts by Steven Mascaro, Yue Wu, Owen Woodberry, Erik P. Nyberg, Ross Pearson, Jessica A. Ramsay, Ariel O. Mace, David A. Foley, Thomas L. Snelling, Ann E. Nicholson, COVID BN Advisory Group

“…Better understanding is needed for predicting their progression, targeting therapeutic approaches, and improving patient outcomes. While many mathematical causal models describe COVID-19 epidemiology, none have described its pathophysiology. …”
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The superior cervical ganglion is involved in chronic chemoreflex sensitization during recovery from acute lung injury by Kajal Kamra, Kajal Kamra, Nikolay Karpuk, Irving H. Zucker, Harold D. Schultz, Han-Jun Wang, Han-Jun Wang

“…Further understanding of the underlying mechanism will provide important information for the long-term goal of developing novel targeted therapeutic approaches to pulmonary diseases to improve clinical outcomes.…”
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Traumatized German soldiers with moral injury – value-based cognitive-behavioral group therapy to treat war-related shame by Caroline Diekmann, Caroline Diekmann, Leonie Issels, Christina Alliger-Horn, Heinrich Rau, Christian Fischer, Thomas Thiel, Gerd Willmund, Peter Zimmermann

“…This study provides further evidence that therapeutic approaches – through fostering a reconciliatory, compassionate, and forgiving approach toward oneself and others – target the underlying mechanisms of moral injury. …”
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Cross-sectional, hospital-based analysis of headache types using ICHD-3 criteria in the Middle East, Asia, and Africa: the Head-MENAA study by H. Genc, B. Baykan, H. Bolay, D. Uluduz, I. Unal-Cevik, N. Kissani, O. Luvsannorov, M. Togha, A. A. Ozdemir, A. Ozge, on behalf of Head-MENAA study group

“…Bearing in mind that the distribution of headache subtypes in neurology clinics (NC) is essential for planning appropriate diagnostic and therapeutic approaches, the primary goals of this multi-centric study are to carry out inter-regional comparisons by using current diagnostic criteria with evaluations of neurologists to delineate headache burden. …”
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Host genetic factors in susceptibility to malaria and tuberculosis by Ruwende, C, Ruwende, Cyril

“…By offering insight into the pathophysiology of diseases, genetic studies provide options for new therapeutic approaches to major health problems. The results of case-control studies of genetic factors associated with disease outcomes in malaria and tuberculosis in an African setting are presented in this thesis.…”

Common signatures of differential microRNA expression in Parkinson’s and Alzheimer’s disease brains by Dobricic, V, Schilling, M, Farkas, I, Gveric, DO, Ohlei, O, Schulz, J, Middleton, L, Gentleman, SM, Parkkinen, L, Bertram, L, Lill, CM

“…Intriguingly, based on publicly available high-throughput sequencing of RNA isolated by cross-linking immunoprecipitation data, hsa-miR-132 may interact with&nbsp;<em>SNCA</em>&nbsp;messenger RNA in the human brain, possibly pinpointing novel therapeutic approaches in fighting Parkinson&rsquo;s disease.…”

Redox sensor and effector functions of tetrahydrobiopterin and the mitochondria in molecular models of cardiovascular disease by Bailey, J

“…This highlights the need to explore the wider roles of BH₄ signalling to allow alternate therapeutic approaches. Thus the aims of this thesis were to identify novel pathways modulated by BH₄, both independent from and via NO signalling.…”

Genetic and molecular basis of myeloid neoplasms at single cell resolution by Rodriguez Meira, A

“…Ultimately, this analysis could potentially guide the development of new therapeutic approaches to specifically target disease propagating cells.…”

Increasing awareness and perception of heart failure in Europe and improving care--rationale and design of the SHAPE Study. by Remme, W, Boccanelli, A, Cline, C, Cohen-Solal, A, Dietz, R, Hobbs, R, Keukelaar, K, Sendon, J, Macarie, C, McMurray, J, Rauch, B, Ruzyllo, W, Zannad, F

“…CONCLUSION: This first part of the SHAPE study will provide important information about the level of knowledge and understanding of heart failure of the general public, as well as the perception of the relevance of heart failure and appropriate diagnostic and therapeutic approaches by both the primary care physician and the medical specialist. …”

The role of two-pore channels 2 (TPC2) in melanoma tumourigenesis and metastasis by Hanbashi, AA

“…Therefore, the identification of novel therapeutic approaches continues to be a crucial task. Understanding the pathophysiological role of potential drug targets for this disease enables the discovery of new therapeutic strategies. …”

Life and counselling experiences of elderly Malay residents in Rumah Seri Kenangan, Cheras, Malaysia by Rahimi, Mohd Khairul Anuar

“…It is hoped that further research could be done on counselling the elderly by using other therapeutic approaches and on other ethnic group.…”
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MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma by Consuelo Pitolli, Alberto Marini, Marika Guerra, Marco Pieraccioli, Veronica Marabitti, Fernando Palluzzi, Luciano Giacò, Gianpiero Tamburrini, Francesco Cecconi, Francesca Nazio, Claudio Sette, Vittoria Pagliarini

“…Conclusions Our study demonstrates that CDK12/13 activity represents an exploitable vulnerability in MYC-high Group 3 MB and may pave the ground for new therapeutic approaches for this high-risk brain tumor.…”
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The weekend effect on the provision of Emergency Surgery before and during the COVID-19 pandemic: case–control analysis of a retrospective multicentre database by Giovanni D. Tebala, Marika S. Milani, Roberto Cirocchi, Mark Bignell, Giles Bond-Smith, Christopher Lewis, Vanni Agnoletti, Marco Catarci, Salomone Di Saverio, Gianluigi Luridiana, Fausto Catena, Marco Scatizzi, Pierluigi Marini, the CovidICE-International Collaborative

“…Abstract Introduction The concept of “weekend effect”, that is, substandard healthcare during weekends, has never been fully demonstrated, and the different outcomes of emergency surgical patients admitted during weekends may be due to different conditions at admission and/or different therapeutic approaches. Aim of this international audit was to identify any change of pattern of emergency surgical admissions and treatments during weekends. …”
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