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12161
Oligo-metastatic neoPlasms from the gastro-intestinal tract: iDentIfiCaTIon of cliNical and molecular drivers: the PREDICTION study
Published 2023-10-01“…In this study, we present a protocol designed to prospectively identify OMD, with the aim of proposing novel therapeutic approaches and monitoring strategies. Methods The PREDICTION study is a monocentric, prospective, observational investigation. …”
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12162
Maternal antibiotic administration during gestation can affect the memory and brain structure in mouse offspring
Published 2023-05-01“…Maternal antibiotics administration (MAA) is among the widely used therapeutic approaches in pregnancy. Although published evidence demonstrates that infants exposed to antibiotics immediately after birth have altered recognition memory responses at one month of age, very little is known about in utero effects of antibiotics on the neuronal function and behavior of children after birth. …”
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12163
Don't eat me/eat me signals as a novel strategy in cancer immunotherapy
Published 2023-10-01“…A potential solution lies in combination therapies targeting the ''eat me'' and ''Don't eat me'' signals in conjunction with other targeted therapeutic approaches. This innovative strategy holds promise as a novel avenue for the future treatment of cancer.…”
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12164
NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma
Published 2022-10-01“…Abstract Background Radiotherapy (RT) is one of the major therapeutic approaches to hepatocellular carcinoma (HCC). …”
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12165
Molecular profiling of male breast cancer by multigene panel testing: Implications for precision oncology
Published 2023-01-01“…IntroductionCompared with breast cancer (BC) in women, BC in men is a rare disease with genetic and molecular peculiarities. Therapeutic approaches for male BC (MBC) are currently extrapolated from the clinical management of female BC, although the disease does not exactly overlap in males and females. …”
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12166
Whole exome sequencing and machine learning germline analysis of individuals presenting with extreme phenotypes of high and low risk of developing tobacco-associated lung adenocarc...
Published 2024-04-01“…Our strategy may allow the identification of high-risk subjects and the development of new therapeutic approaches. Funding: See a detailed list of funding bodies in the Acknowledgements section at the end of the manuscript.…”
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12167
Identification and functional interpretation of miRNAs affected by rare CNVs in CAKUT
Published 2022-10-01“…Understanding the potential of CNV-affected miRNAs to participate in CAKUT as genetic drivers represent a crucial implication for the development of novel therapeutic approaches.…”
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12168
Precision Medicine Management of Chronic Lymphocytic Leukemia
Published 2020-03-01“…Some patients may never require treatment, whereas others relapse early after front line therapeutic approaches. Recent whole genome and whole exome sequencing studies have allowed a better understanding of CLL pathogenesis and the identification of genetic lesions with potential clinical relevance. …”
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12169
Engineering recombinant replication-competent bluetongue viruses expressing reporter genes for in vitro and non-invasive in vivo studies
Published 2024-03-01“…In addition, we have investigated the in vivo replication and dissemination of BTV in IFNAR (−/−) mice using BTV/NLuc and non-invasive in vivo imaging systems.IMPORTANCEThe use of replication-competent viruses that encode a traceable fluorescent or luciferase reporter protein has significantly contributed to the in vitro and in vivo study of viral infections and the development of novel therapeutic approaches. In this work, we have generated rBTV that express fluorescent or luminescence proteins to track BTV infection both in vitro and in vivo. …”
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12170
Concatenation of molecular docking and molecular simulation of BACE-1, γ-secretase targeted ligands: in pursuit of Alzheimer’s treatment
Published 2021-01-01“…Hence, multi-targeted therapeutic approaches are gaining attention in pharmacological developments.Aims As an extension of our earlier reports, we have performed docking and molecular dynamic (MD) simulation studies for the same 13 potential ligands against beta-site APP cleaving enzyme 1 (BACE-1) and γ-secretase as a therapeutic target for AD. …”
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12171
Transcriptome Analysis Reveals Hub Genes Regulating Autophagy in Patients With Severe COVID-19
Published 2022-07-01“…This study might facilitate a more profound knowledge of the biological characteristics and progression of COVID-19 and the development of novel therapeutic approaches to achieve a breakthrough in the current COVID-19 pandemic.…”
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12172
Apigenin inhibits angiogenesis in retinal microvascular endothelial cells through regulating of the miR-140-5p/HDAC3-mediated PTEN/PI3K/AKT pathway
Published 2023-07-01“…Our study may contribute to the development of novel therapeutic approaches and identification of potential targets for the treatment of DR.…”
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12173
Exploring prognostic microbiota markers in patients with endometrial carcinoma: Intratumoral insights
Published 2024-03-01“…Significantly, our study's expansive sample analysis from the TCGA-UCEC cohort, employing linear discriminant analysis effect size methodology, not only validates but also enhances our understanding of the microbiota's role in endometrial cancer, paving the way for novel diagnostic and therapeutic approaches in its management.…”
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12174
Role of mitochondria-bound HK2 in rheumatoid arthritis fibroblast-like synoviocytes
Published 2023-07-01“…In murine models, MJ treatment significantly decreased arthritis severity, whereas HK2FL was able to induce synovial hypertrophy as opposed to HK2ΔN.ConclusionOur results suggest that mitochondrial HK2 regulates the aggressive phenotype of RA FLS. New therapeutic approaches to dissociate HK2 from mitochondria offer a safer approach than global glycolysis inhibition.…”
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12175
Gut microbiota composition in COVID-19 hospitalized patients with mild or severe symptoms
Published 2022-12-01“…Our data show that patients affected by SARS-CoV-2 with mild or severe symptoms display different gut microbiota profiles which can be exploited as potential prognostic biomarkers paving also the way to new integrative therapeutic approaches.…”
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12176
GENERALIZED TONIC-CLONIC SEIZURES : CLASSIFICATION, ELECTRO-CLINICAL CHARACTERISTICS, AND EFFICACY OF ANTIEPILEPTIC THERAPY
Published 2017-11-01“…The variety of GTCS- associated syndromes, and the significant differences in the prognosis and the therapeutic approaches, necessitate using the full range of diagnostic measures.…”
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12177
Multi-omics reveal microbial determinants impacting the treatment outcome of antidepressants in major depressive disorder
Published 2023-08-01“…By shedding light on the interplay between these factors, this research contributes to our broader understanding of the complex mechanisms underlying the treatment of MDD and opens new avenues for optimizing therapeutic approaches. Video Abstract…”
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12178
Non-Motor Symptoms of Parkinson’s Disease and Their Impact on Quality of Life in a Cohort of Moroccan Patients
Published 2018-04-01“…Understanding the pathophysiology of these NMSs should be placed at the forefront in order to develop new therapeutic approaches by improving the QoL of PD patients.…”
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12179
Histopathological and Molecular Profiling of Clear Cell Sarcoma and Correlation with Response to Crizotinib: An Exploratory Study Related to EORTC 90101 “CREATE” Trial
Published 2021-12-01“…Our work describes the molecular heterogeneity in CCSA and provides further insight into the biology of this ultra-rare malignancy, which may potentially lead to better therapeutic approaches for CCSA.…”
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12180
High-Throughput Drug Library Screening in Primary <i>KMT2A</i>-Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling
Published 2022-03-01“…Implementing novel therapeutic approaches for these patients is a slow-paced and costly process. …”
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