Oligo-metastatic neoPlasms from the gastro-intestinal tract: iDentIfiCaTIon of cliNical and molecular drivers: the PREDICTION study by Alessandro Ottaiano, Antonella De Luca, Mariachiara Santorsola, Giosuè Scognamiglio, Annabella Di Mauro, Paolo Chiodini, Matilde Lambiase, Alessandra Sacco, Antonella Petrillo, Vincenza Granata, Roberta Fusco, Edoardo Mercadante, Nicola Martucci, Giuseppe De Luca, Antonello La Rocca, Egidio Celentano, Anna Crispo, Piergiacomo Di Gennaro, Fabiana Tatangelo, Gerardo Ferrara, Francesco Izzo, Andrea Belli, Renato Patrone, Paolo Delrio, Daniela Rega, Silvia De Franciscis, Paolo Muto, Vincenzo Ravo, Rossella Di Franco, Valentina Borzillo, Sara Santagata, Giuseppina Rea, Daniela Castaldo, Ugo Pace, Gianfranco De Feo, Stefania Scala, Guglielmo Nasti, Nicola Normanno

“…In this study, we present a protocol designed to prospectively identify OMD, with the aim of proposing novel therapeutic approaches and monitoring strategies. Methods The PREDICTION study is a monocentric, prospective, observational investigation. …”
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Maternal antibiotic administration during gestation can affect the memory and brain structure in mouse offspring by Dmytro Shepilov, Iryna Osadchenko, Tetiana Kovalenko, Chiaki Yamada, Chiaki Yamada, Anastasiia Chereshynska, Kateryna Smozhanyk, Galyna Ostrovska, Stanislav Groppa, Stanislav Groppa, Alexandru Movila, Alexandru Movila, Galyna Skibo

“…Maternal antibiotics administration (MAA) is among the widely used therapeutic approaches in pregnancy. Although published evidence demonstrates that infants exposed to antibiotics immediately after birth have altered recognition memory responses at one month of age, very little is known about in utero effects of antibiotics on the neuronal function and behavior of children after birth. …”
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Don't eat me/eat me signals as a novel strategy in cancer immunotherapy by Amirreza Khalaji, Fatereh Baharlouei Yancheshmeh, Fatemeh Farham, Arya Khorram, Shiva Sheshbolouki, Maryam Zokaei, Fatemeh Vatankhah, Mehdi Soleymani-Goloujeh

“…A potential solution lies in combination therapies targeting the ''eat me'' and ''Don't eat me'' signals in conjunction with other targeted therapeutic approaches. This innovative strategy holds promise as a novel avenue for the future treatment of cancer.…”
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NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma by Yizhi Zhan, Zhanqiao Zhang, Yuechen Liu, Yuan Fang, Yuwen Xie, Yilin Zheng, Guoxin Li, Li Liang, Yi Ding

“…Abstract Background Radiotherapy (RT) is one of the major therapeutic approaches to hepatocellular carcinoma (HCC). …”
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Molecular profiling of male breast cancer by multigene panel testing: Implications for precision oncology by Virginia Valentini, Valentina Silvestri, Agostino Bucalo, Giulia Conti, Mina Karimi, Linda Di Francesco, Giulia Pomati, Silvia Mezi, Bruna Cerbelli, Maria Gemma Pignataro, Arianna Nicolussi, Anna Coppa, Giulia D’Amati, Giuseppe Giannini, Giuseppe Giannini, Laura Ottini

“…IntroductionCompared with breast cancer (BC) in women, BC in men is a rare disease with genetic and molecular peculiarities. Therapeutic approaches for male BC (MBC) are currently extrapolated from the clinical management of female BC, although the disease does not exactly overlap in males and females. …”
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Whole exome sequencing and machine learning germline analysis of individuals presenting with extreme phenotypes of high and low risk of developing tobacco-associated lung adenocarc... by Ana Patiño-García, Elizabeth Guruceaga, Maria Pilar Andueza, Marimar Ocón, Jafait Junior Fodop Sokoudjou, Nicolás de Villalonga Zornoza, Gorka Alkorta-Aranburu, Ibon Tamayo Uria, Alfonso Gurpide, Carlos Camps, Eloísa Jantus-Lewintre, Maria Navamuel-Andueza, Miguel F. Sanmamed, Ignacio Melero, Mohamed Elgendy, Juan Pablo Fusco, Javier J. Zulueta, Juan P. de-Torres, Gorka Bastarrika, Luis Seijo, Ruben Pio, Luis M. Montuenga, Mikel Hernáez, Idoia Ochoa, Jose Luis Perez-Gracia

“…Our strategy may allow the identification of high-risk subjects and the development of new therapeutic approaches. Funding: See a detailed list of funding bodies in the Acknowledgements section at the end of the manuscript.…”
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Identification and functional interpretation of miRNAs affected by rare CNVs in CAKUT by Kristina Mitrovic, Ivan Zivotic, Ivana Kolic, Ana Djordjevic, Jelena Zakula, Jelena Filipovic Trickovic, Maja Zivkovic, Aleksandra Stankovic, Ivan Jovanovic

“…Understanding the potential of CNV-affected miRNAs to participate in CAKUT as genetic drivers represent a crucial implication for the development of novel therapeutic approaches.…”
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Precision Medicine Management of Chronic Lymphocytic Leukemia by Riccardo Moia, Andrea Patriarca, Mattia Schipani, Valentina Ferri, Chiara Favini, Sruthi Sagiraju, Wael Al Essa, Gianluca Gaidano

“…Some patients may never require treatment, whereas others relapse early after front line therapeutic approaches. Recent whole genome and whole exome sequencing studies have allowed a better understanding of CLL pathogenesis and the identification of genetic lesions with potential clinical relevance. …”
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Engineering recombinant replication-competent bluetongue viruses expressing reporter genes for in vitro and non-invasive in vivo studies by Sergio Utrilla-Trigo, Luis Jiménez-Cabello, Alejandro Marín-López, Miguel Illescas-Amo, Germán Andrés, Eva Calvo-Pinilla, Gema Lorenzo, Piet A. van Rijn, Javier Ortego, Aitor Nogales

“…In addition, we have investigated the in vivo replication and dissemination of BTV in IFNAR (−/−) mice using BTV/NLuc and non-invasive in vivo imaging systems.IMPORTANCEThe use of replication-competent viruses that encode a traceable fluorescent or luciferase reporter protein has significantly contributed to the in vitro and in vivo study of viral infections and the development of novel therapeutic approaches. In this work, we have generated rBTV that express fluorescent or luminescence proteins to track BTV infection both in vitro and in vivo. …”
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Concatenation of molecular docking and molecular simulation of BACE-1, γ-secretase targeted ligands: in pursuit of Alzheimer’s treatment by Nasimudeen R. Jabir, Md. Tabish Rehman, Khadeejah Alsolami, Shazi Shakil, Torki A. Zughaibi, Raed F. Alserihi, Mohd. Shahnawaz Khan, Mohamed F. AlAjmi, Shams Tabrez

“…Hence, multi-targeted therapeutic approaches are gaining attention in pharmacological developments.Aims As an extension of our earlier reports, we have performed docking and molecular dynamic (MD) simulation studies for the same 13 potential ligands against beta-site APP cleaving enzyme 1 (BACE-1) and γ-secretase as a therapeutic target for AD. …”
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Transcriptome Analysis Reveals Hub Genes Regulating Autophagy in Patients With Severe COVID-19 by Jinfeng Huang, Jinfeng Huang, Yimeng Wang, Yawen Zha, Xin Zeng, Wenxing Li, Meijuan Zhou, Meijuan Zhou

“…This study might facilitate a more profound knowledge of the biological characteristics and progression of COVID-19 and the development of novel therapeutic approaches to achieve a breakthrough in the current COVID-19 pandemic.…”
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Apigenin inhibits angiogenesis in retinal microvascular endothelial cells through regulating of the miR-140-5p/HDAC3-mediated PTEN/PI3K/AKT pathway by Chaojun Fu, Jun Peng, Yanjun Ling, Hongqing Zhao, Yongwang Zhao, Xiuli Zhang, Min Ai, Qinghua Peng, Yuhui Qin

“…Our study may contribute to the development of novel therapeutic approaches and identification of potential targets for the treatment of DR.…”
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Exploring prognostic microbiota markers in patients with endometrial carcinoma: Intratumoral insights by Jie Liu, Yi Qu, Yang-Yang Li, Ya-Lan Xu, Yi-Fang Yan, Hao Qin

“…Significantly, our study's expansive sample analysis from the TCGA-UCEC cohort, employing linear discriminant analysis effect size methodology, not only validates but also enhances our understanding of the microbiota's role in endometrial cancer, paving the way for novel diagnostic and therapeutic approaches in its management.…”
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Role of mitochondria-bound HK2 in rheumatoid arthritis fibroblast-like synoviocytes by Alyssa Torres, Sarah Kang, Christopher B. Mahony, Martha Cedeño, Patricia G. Oliveira, Marta Fernandez-Bustamante, Samuel Kemble, Teresina Laragione, Percio S. Gulko, Adam P. Croft, Elsa Sanchez-Lopez, Shigeki Miyamoto, Monica Guma

“…In murine models, MJ treatment significantly decreased arthritis severity, whereas HK2FL was able to induce synovial hypertrophy as opposed to HK2ΔN.ConclusionOur results suggest that mitochondrial HK2 regulates the aggressive phenotype of RA FLS. New therapeutic approaches to dissociate HK2 from mitochondria offer a safer approach than global glycolysis inhibition.…”
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Gut microbiota composition in COVID-19 hospitalized patients with mild or severe symptoms by Antonio Mazzarelli, Maria Letizia Giancola, Andrea Fontana, Pierluca Piselli, Elena Binda, Nadia Trivieri, Gandino Mencarelli, Luisa Marchioni, Antonella Vulcano, Chiara De Giuli, Concetta Panebianco, Annacandida Villani, Massimiliano Copetti, Francesco Perri, Carla Fontana, Emanuele Nicastri, Valerio Pazienza

“…Our data show that patients affected by SARS-CoV-2 with mild or severe symptoms display different gut microbiota profiles which can be exploited as potential prognostic biomarkers paving also the way to new integrative therapeutic approaches.…”
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GENERALIZED TONIC-CLONIC SEIZURES : CLASSIFICATION, ELECTRO-CLINICAL CHARACTERISTICS, AND EFFICACY OF ANTIEPILEPTIC THERAPY by M. B. Mironov, N. V. Chebanenko, S. G. Burd, T. M. Krasilshikova, M. N. Sarzhina, M. M. Gunchenko, G. G. Avakyan, Yu. V. Rubleva, T. T. Batysheva, G. N. Avakyan

“…The variety of GTCS- associated syndromes, and the significant differences in the prognosis and the therapeutic approaches, necessitate using the full range of diagnostic measures.…”
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Multi-omics reveal microbial determinants impacting the treatment outcome of antidepressants in major depressive disorder by Yaping Wang, Jingjing Zhou, Junbin Ye, Zuoli Sun, Yi He, Yingxin Zhao, Siyu Ren, Guofu Zhang, Min Liu, Peng Zheng, Gang Wang, Jian Yang

“…By shedding light on the interplay between these factors, this research contributes to our broader understanding of the complex mechanisms underlying the treatment of MDD and opens new avenues for optimizing therapeutic approaches. Video Abstract…”
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Non-Motor Symptoms of Parkinson’s Disease and Their Impact on Quality of Life in a Cohort of Moroccan Patients by Houyam Tibar, Houyam Tibar, Houyam Tibar, Houyam Tibar, Khalil El Bayad, Ahmed Bouhouche, Ahmed Bouhouche, El Hachmia Ait Ben Haddou, El Hachmia Ait Ben Haddou, Ali Benomar, Ali Benomar, Mohamed Yahyaoui, Mohamed Yahyaoui, Abdelhamid Benazzouz, Abdelhamid Benazzouz, Wafa Regragui, Wafa Regragui

“…Understanding the pathophysiology of these NMSs should be placed at the forefront in order to develop new therapeutic approaches by improving the QoL of PD patients.…”
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Histopathological and Molecular Profiling of Clear Cell Sarcoma and Correlation with Response to Crizotinib: An Exploratory Study Related to EORTC 90101 “CREATE” Trial by Che-Jui Lee, Elodie Modave, Bram Boeckx, Silvia Stacchiotti, Piotr Rutkowski, Jean-Yves Blay, Maria Debiec-Rychter, Raf Sciot, Diether Lambrechts, Agnieszka Wozniak, Patrick Schöffski

“…Our work describes the molecular heterogeneity in CCSA and provides further insight into the biology of this ultra-rare malignancy, which may potentially lead to better therapeutic approaches for CCSA.…”
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High-Throughput Drug Library Screening in Primary <i>KMT2A</i>-Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling by Priscilla Wander, Susan T. C. J. M. Arentsen-Peters, Kirsten S. Vrenken, Sandra Mimoso Pinhanҫos, Bianca Koopmans, M. Emmy M. Dolman, Luke Jones, Patricia Garrido Castro, Pauline Schneider, Mark Kerstjens, Jan J. Molenaar, Rob Pieters, Christian Michel Zwaan, Ronald W. Stam

“…Implementing novel therapeutic approaches for these patients is a slow-paced and costly process. …”
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