Single cell and bulk RNA expression analyses identify enhanced hexosamine biosynthetic pathway and O-GlcNAcylation in acute myeloid leukemia blasts and stem cells by Robert Schauner, Robert Schauner, Jordan Cress, Changjin Hong, David Wald, David Wald, David Wald, Parameswaran Ramakrishnan, Parameswaran Ramakrishnan, Parameswaran Ramakrishnan

“…It also blocked cell cycle progression suggesting a link between enhanced O-GlcNAcylation and NF-κB activation in AML cell survival and proliferation.DiscussionOur study suggests the HBP may prove a potential target, alone or in combination with other therapeutic approaches, to impact both AML blasts and stem cells. …”
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Is dexamethasone-induced muscle atrophy an alternative model for naturally aged sarcopenia model? by Belle Yu-Hsuan Wang, Allen Wei-Ting Hsiao, Nicodemus Wong, Yi-Fan Chen, Chien-Wei Lee, Wayne Yuk Wai Lee

“…Although many studies have used different sarcopenia animal models for exploring the underlying mechanism and therapeutic approaches for sarcopenia, limited study has provided evidence of the relevance of these animal models. …”
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Dynamics of heart rate variability in rats with streptozotocin-induced diabetes by Maria P. Morozova, Svetlana A. Gavrilova, Evgeniy V. Ivanov, Anna M. Gorbacheva, Ekaterina M. Rzhavina, Aleksey K. Erdyakov, Zera N. Dzhemilova, Ekaterina V. Artemova, Alla Y. Tokmakova, Vladimir B. Koshelev, Gagik R. Galstyan

“…Correction of vascular disorders is effectively treated by modern therapeutic approaches, but the damage of nervous system has been studied insufficiently. …”
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Revealing the impact of TOX3 on osteoarthritis: insights from bioinformatics by Zhengyan Wang, Shuang Ding, Chunyan Zhang, Hongsheng Zhan, Yunfei Li, Jing Yan, Yuyan Jia, Xukai Wang, Ying Wang

“…The study establishes a basis for comprehending the intricate correlation between characteristic genes and Osteoarthritis, as well as for the formulation of individualized therapeutic approaches.…”
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Sepsis-Associated Acute Kidney Injury: Where Are We Now? by Dimitris Kounatidis, Natalia G. Vallianou, Sotiria Psallida, Fotis Panagopoulos, Evangelia Margellou, Dimitrios Tsilingiris, Irene Karampela, Theodora Stratigou, Maria Dalamaga

“…In addition, potential novel diagnostic and prognostic biomarkers as well as therapeutic approaches are discussed. A plethora of mechanisms are implicated in the pathogenesis of SA-AKI, including inflammation and metabolic reprogramming during sepsis; various types of cell death such as apoptosis, necroptosis, pyroptosis and ferroptosis; autophagy and efferocytosis; and hemodynamic changes (macrovascular and microvascular dysfunction). …”
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mHealth Intervention for Improving Pain, Quality of Life, and Functional Disability in Patients With Chronic Pain: Systematic Review by Marta Moreno-Ligero, Jose A Moral-Munoz, Alejandro Salazar, Inmaculada Failde

“…The eligibility criteria were RCTs of adults (≥18 years old) with CP, intervened with mHealth systems based on mobile apps for monitoring pain and health-related outcomes, for pain and behavioral self-management, and for performing therapeutic approaches, compared to conventional treatments (physical, occupational, and psychological therapies; usual medical care; and education) or nonintervention, reporting pain intensity, QoL, and functional disability. …”
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Race-specific coregulatory and transcriptomic profiles associated with DNA methylation and androgen receptor in prostate cancer by Swathi Ramakrishnan, Eduardo Cortes-Gomez, Sarah R. Athans, Kristopher M. Attwood, Spencer R. Rosario, Se Jin Kim, Donald E. Mager, Emily G. Isenhart, Qiang Hu, Jianmin Wang, Anna Woloszynska

“…Further investigation into these identified pathways may lead to the development of personalized therapeutic approaches to improve outcomes for prostate cancer patients across different racial backgrounds.…”
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Interpersonal trauma: psychodynamic psychotherapy and neurobiology by Helen Lazaratou

“…The study of interpersonal trauma offers a good example of how different approaches, biological and psychodynamic, may come closer and possibly be unified into a single model, which could result in more effective therapeutic approaches.…”
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Carbonic Anhydrase Inhibition as a Target for Antibiotic Synergy in Enterococci by Gayatri Shankar Chilambi, Yu-Hao Wang, Nathan R. Wallace, Chetachukwu Obiwuma, Kirsten M. Evans, Yanhong Li, Menna-Allah W. Shalaby, Daniel P. Flaherty, Ryan K. Shields, Yohei Doi, Daria Van Tyne

“…IMPORTANCE Enterococcal infections can be difficult to treat, and new therapeutic approaches are needed. In studying an E. faecalis clinical strain from an infected patient, we found that the bacteria were rendered hypersusceptible to aminoglycoside antibiotics through a mutation that disrupted the α-CA. …”
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MRI for risk stratification of muscle invasion by upper tract urothelial carcinoma: a feasibility study by Emanuele Messina, Flavia Proietti, Ludovica Laschena, Rocco Simone Flammia, Martina Pecoraro, Stefano Cipollari, Giuseppe Simone, Carlo Catalano, Costantino Leonardo, Valeria Panebianco

“…However, CT does not allow distinguishing ureter wall layers, making impossible to assess muscle invasion, a factor contributing to differentiate high- from low-risk UTUCs, which require different therapeutic approaches. We investigated the feasibility of MRI assessment of UTUC muscle invasion. …”
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Uso de cobertura com prata no tratamento de úlcera de marjolin: estudo de caso by Janislei Soares Dantas, Glenda Agra, Jacqueline Barbosa da Silva, Débora Thaíse Freires de Brito, Marta Miriam Lopes Costa, Thiago Lins da Costa Almeida

“…Method: This is a case study of a patient with Marjolin’s ulcer, followed from preoperative to wound healing, focusing on medical and nursing therapeutic approaches in a specialized service. Results: Patient follow-up was performed by the Nursing team of a Skin Commission and scheduled consultations with vascular surgeon, dermatologist and oncologist, biopsy was performed; soon after the diagnostic confirmation, the patient underwent surgery to remove the tumor, in the postoperative period, therapeutic interventions were initiated for the treatment of the lesion. …”
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ER Stress in COVID-19 and Parkinson’s Disease: In Vitro and In Silico Evidences by Zahara L. Chaudhry, Mahmoud Gamal, Ingrid Ferhati, Mohamad Warda, Bushra Y. Ahmed

“…Furthermore, our results using the ER stress inhibitor and caspase specific inhibitors provided cellular protection suggesting that the use of specific inhibitors can provide effective therapeutic approaches for the treatment of COVID-19 and PD.…”
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Aloe Extracts Inhibit Skin Inflammatory Responses by Regulating NF-κB, ERK, and JNK Signaling Pathways in an LPS-Induced RAW264.7 Macrophages Model by Wang F, Liu J, An Q, Wang Y, Yang Y, Huo T, Yang S, Ju R, Quan Q

“…While current pharmacological treatments are reported to have cytotoxicity and various side effects, herbal medicines with few side effects and low cytotoxicity are considered as alternative therapeutic approaches.Methods: In order to investigate anti-inflammatory effects and mechanisms of ALOE, the potential cytotoxicity of A. vera extracts (ALOE) was determined in vitro at first. …”
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Kaixin Jieyu Granule attenuates neuroinflammation-induced depressive-like behavior through TLR4/PI3K/AKT/FOXO1 pathway: a study of network pharmacology and experimental validation by Manman Xu, Wujianwen Zhai, Ying Zhang, Juhua Pan, Jie Li, Shijing Huang

“…The study’s findings reveal novel mechanisms underlying the anti-depressant effects of KJG, presenting promising avenues for the development of targeted therapeutic approaches for depression.…”
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Treatment of Secondary Aortoenteric Fistulas Following AORTIC Aneurysm Repair in a Tertiary Reference Center by Kyriakos Oikonomou, Karin Pfister, Piotr M. Kasprzak, Wilma Schierling, Thomas Betz, Georgios Sachsamanis

“…Objectives: To present our experience with various therapeutic approaches for the treatment of secondary aortoenteric fistulas following open and endovascular aortic aneurysm repair. …”
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Testing the Efficacy of a Scalable Telephone-Delivered Guided Imagery Tobacco Cessation Treatment: Protocol for a Randomized Clinical Trial by Judith S Gordon, Julie S Armin, Peter Giacobbi Jr, Chiu-Hsieh Hsu, Kari Marano, Christine E Sheffer

“…New, effective therapeutic approaches are needed to meet the preferences of people who want to stop smoking. …”
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Up-Regulation of miR-9-5p Inhibits Hypoxia-Ischemia Brain Damage Through the DDIT4-Mediated Autophagy Pathways in Neonatal Mice by Gai C, Xing X, Song Y, Zhao Y, Jiang Z, Cheng Y, Xiao Y, Wang Z

“…Despite intensive research and many therapeutic approaches, there are limited neuroprotective strategies against HI insults. …”
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Effect of anti-adhesion agents on cytokine profile in an experimental model of postoperative intra-abdominal adhesions by F.T. Akhmedov, H.B. Isayev, S.V. Guliyeva

“…Many attempts have been made to prevent peritoneal adhesions using anti-adhesion agents, barriers and other therapeutic approaches, but their efficacy has not been widely accepted. …”
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What is changing in the treatment of acute coronary syndrome in the Russian Federation? by S. A. Boytsov, B. G. Alekyan, R. M. Shakhnovich, V. I. Ganyukov

“…The purpose of the publication is to demonstrate the trend in therapeutic approaches to the management of patients with ACS in 2020-2022. in Russia and analysis of their effectiveness. …”
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<i>lmo4a</i> Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway by Le Sun, Lu Ping, Ruzhen Gao, Bo Zhang, Xiaowei Chen

“…Further research is needed to distinguish the relationships between <i>lmo4</i> and the Bmp pathway, which may lead to diagnostic and therapeutic approaches towards human inner ear malformation.…”
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