Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages by Kanglu Li, Guohua Yan, Hanji Huang, Mingjun Zheng, Ke Ma, Xiaofei Cui, Dejie Lu, Li Zheng, Bo Zhu, Jianwen Cheng, Jinmin Zhao

“…Currently, the therapeutic approaches for OA are very limited in clinical. …”
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Efficacy of Granulocyte Colony-Stimulating Factor in Acute on Chronic Liver Failure: A Systematic Review and Survival Meta-Analysis by Georgios Konstantis, Georgia Tsaousi, Chryssa Pourzitaki, Elisavet Kitsikidou, Dimitrios E. Magouliotis, Sebastian Wiener, Amos Cornelius Zeller, Katharina Willuweit, Hartmut H. Schmidt, Jassin Rashidi-Alavijeh

“…Background: Acute-on-chronic liver failure (ACLF) mostly occurs when there is an acute insult to the liver in patients with pre-existing liver disease, and it is characterized by a high mortality rate. Various therapeutic approaches have been used thus far, with orthotopic liver transplantation being the only definitive cure. …”
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YB-1 Is a Novel Target for the Inhibition of α-Adrenergic-Induced Hypertrophy by Jacqueline Heger, Stefan Partsch, Claudia Harjung, Zoltán V. Varga, Tamás Baranyai, Johannes Weiß, Lea Kremer, Fabian Locquet, Przemyslaw Leszek, Bence Ágg, Bettina Benczik, Péter Ferdinandy, Rainer Schulz, Gerhild Euler

“…Therefore, the transcription factor YB-1 is a pivotal signaling molecule, providing perspectives for therapeutic approaches.…”
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Pulmonary benign metastasizing leiomyoma in patients aged 45 years and younger: clinical features and novelty in treatment by Hao Su, Rong Fan, Hua Yang, Yan You, Lan Zhu, Fengzhi Feng

“…A wait-and-see strategy might be an option, but therapeutic approaches must be contemplated when complications or symptoms progress. …”
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Functional and neuromuscular changes induced via a low-cost, muscle-computer interface for telerehabilitation: A feasibility study in chronic stroke by Octavio Marin-Pardo, Miranda Rennie Donnelly, Coralie S. Phanord, Kira Wong, Jessica Pan, Sook-Lei Liew, Sook-Lei Liew, Sook-Lei Liew

“…Therefore, severely impaired people necessitate alternative therapeutic approaches. Measurement and feedback of electrical muscle activity via electromyography (EMG) have been previously implemented in the presence of minimal or no volitional movement to improve motor performance in people with stroke. …”
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A mixed methods systematic review of digital interventions to support the psychological health and well-being of people living with dermatological conditions by Rachael M. Hewitt, Rachael M. Hewitt, Matthew Ploszajski, Catherine Purcell, Rachael Pattinson, Bethan Jones, Georgina H. Wren, Olivia Hughes, Matthew J. Ridd, Andrew R. Thompson, Andrew R. Thompson, Chris Bundy

“…Nineteen interventions were condition-specific, 13 were delivered online, 16 involved an educational component, and 7 endorsed established, evidence-based therapeutic approaches. Improvements in knowledge, mood, quality of life, the therapeutic relationship, and reduced disease severity in the short to medium term, were reported, although there was substantial heterogeneity within the literature. …”
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The Prediction of miRNAs in SARS-CoV-2 Genomes: hsa-miR Databases Identify 7 Key miRs Linked to Host Responses and Virus Pathogenicity-Related KEGG Pathways Significant for Comorbi... by Elif Damla Arisan, Alwyn Dart, Guy H. Grant, Serdar Arisan, Songul Cuhadaroglu, Sigrun Lange, Pinar Uysal-Onganer

“…Based on our reported findings, miRNAs may constitute potential and effective therapeutic approaches in COVID-19 and its pathological consequences.…”
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Circulating biomarkers in familial cerebral cavernous malformationResearch in context by Francesca Lazzaroni, Jennifer M.T.A. Meessen, Ying Sun, Silvia Lanfranconi, Elisa Scola, Quintino Giorgio D'Alessandris, Laura Tassi, Maria Rita Carriero, Marco Castori, Silvia Marino, Adriana Blanda, Enrico B. Nicolis, Deborah Novelli, Roberta Calabrese, Nicolò M. Agnelli, Barbara Bottazzi, Roberto Leone, Selene Mazzola, Silvia Besana, Carlotta Catozzi, Luigi Nezi, Maria G. Lampugnani, Matteo Malinverno, Nastasja Grdseloff, Claudia J. Rödel, Behnam Rezai Jahromi, Niccolò Bolli, Francesco Passamonti, Peetra U. Magnusson, Salim Abdelilah-Seyfried, Elisabetta Dejana, Roberto Latini

“…Interpretation: Overall, our study identifies a set of biochemical parameters to predict CCM progression, suggesting biological interpretations and potential therapeutic approaches to CCM disease. Funding: Italian Medicines Agency, Associazione Italiana per la Ricerca sul Cancro (AIRC), ERC, Leducq Transatlantic Network of Excellence, Swedish Research Council.…”
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Napabucasin plus nab-paclitaxel with gemcitabine versus nab-paclitaxel with gemcitabine in previously untreated metastatic pancreatic adenocarcinoma: an adaptive multicentre, rando... by Tanios Bekaii-Saab, Takuji Okusaka, David Goldstein, Do-Youn Oh, Makoto Ueno, Tatsuya Ioka, Weijia Fang, Eric C. Anderson, Marcus S. Noel, Michele Reni, Hye Jin Choi, Jonathan S. Goldberg, Sang Cheul Oh, Chung-Pin Li, Josep Tabernero, Jian Li, Emma Foos, Cindy Oh, Eric Van Cutsem

“…Our data reinforce the value of nab-paclitaxel plus gemcitabine as a platform for novel therapeutics approaches in mPDAC. Funding: The Sumitomo Pharma Oncology, Inc.…”
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Targeted degradation of ⍺-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology by Jihoon Lee, Ki Woon Sung, Eun-Jin Bae, Dabin Yoon, Dasarang Kim, Jin Saem Lee, Da-ha Park, Daniel Youngjae Park, Su Ran Mun, Soon Chul Kwon, Hye Yeon Kim, Joo-Ok Min, Seung-Jae Lee, Young Ho Suh, Yong Tae Kwon

“…Although extensive efforts were undertaken to develop therapeutic approaches to delay the symptoms of PD, untreated α-synuclein (α-syn) aggregates cause cellular toxicity and stimulate further disease progression. …”
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Radiation therapy induces immunosenescence mediated by p90RSK by Masaki Imanishi, Haizi Cheng, Sivareddy Kotla, Anita Deswal, Nhat-Tu Le, Eduardo Chini, Kyung Ae Ko, Venkata S. K. Samanthapudi, Ling-Ling Lee, Joerg Herrmann, Xiaolei Xu, Cielito Reyes-Gibby, Sai-Ching J. Yeung, Keri L. Schadler, Syed Wamique Yusuf, Zhongxing Liao, Roza Nurieva, El-ad David Amir, Jared K. Burks, Nicolas L. Palaskas, John P. Cooke, Steven H. Lin, Michihiro Kobayashi, Momoko Yoshimoto, Jun-ichi Abe

“…A complete understanding of the mechanisms by which RT induces CVD could lead to specific preventive, therapeutic approaches. It is becoming evident that both genotoxic chemotherapy agents and radiation induce mitochondrial dysfunction and cellular senescence. …”
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Human Wharton’s Jelly Mesenchymal Stem Cells Secretome Inhibits Human SARS-CoV-2 and Avian Infectious Bronchitis Coronaviruses by Mohamed A. A. Hussein, Hosni A. M. Hussein, Ali A. Thabet, Karim M. Selim, Mervat A. Dawood, Ahmed M. El-Adly, Ahmed A. Wardany, Ali Sobhy, Sameh Magdeldin, Aya Osama, Ali M. Anwar, Mohammed Abdel-Wahab, Hussam Askar, Elsayed K. Bakhiet, Serageldeen Sultan, Amgad A. Ezzat, Usama Abdel Raouf, Magdy M. Afifi

“…These findings indicate that hWJ-MSC-S could be utilized in future pre-clinical and clinical studies to develop effective therapeutic approaches against human COVID-19 and avian IB respiratory diseases.…”
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Feasibility, safety and effectiveness of prednisolone and vitamin B1, B6, and B12 in patients with post-COVID-19-syndrome (PreVitaCOV) – protocol of a randomised, double-blind, pla... by Caroline Tengelmann, Stefanie Joos, Yvonne Kaußner, Uwe Malzahn, Laura Lunden, Andreas Klug, Karl Georg Häusler, Catharina Escales, Walter Maetzler, Klemens Hügen, Oliver Zolk, Peter U. Heuschmann, Christian Förster, Hanna Kaduszkiewicz, Ildikó Gágyor

“…Discussion The PreVitaCOV trial may contribute to the understanding of therapeutic approaches in PC19S in a primary care context. …”
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Steatosis drives monocyte-derived macrophage accumulation in human metabolic dysfunction-associated fatty liver disease by Mandy M. Chan, Sabine Daemen, Joseph W. Beals, Marina Terekhova, Bin Q. Yang, Christina F. Fu, Li He, Arick C. Park, Gordon I. Smith, Babak Razani, Kathleen Byrnes, Wandy L. Beatty, Shaina R. Eckhouse, J. Christopher Eagon, Daniel Ferguson, Brian N. Finck, Samuel Klein, Maxim N. Artyomov, Joel D. Schilling

“…These findings are important as they establish a translational link between mouse and human models of disease, which is important for the development and testing of new therapeutic approaches for MAFLD.…”
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Origin and Dynamics of Mycobacterium tuberculosis Subpopulations That Predictably Generate Drug Tolerance and Resistance by Jees Sebastian, Anooja Thomas, Carly Levine, Riju Shrestha, Shawn Levy, Hassan Safi, Sri Ram Pentakota, Pradeep Kumar, David Alland

“…Their identification provides opportunities to test genetic and therapeutic approaches that may result in shorter and more effective TB treatments.…”
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Akkermansia muciniphila and Parabacteroides distasonis synergistically protect from colitis by promoting ILC3 in the gut by Joana Gaifem, Ana Mendes-Frias, Mathis Wolter, Alex Steimle, Maria Jose Garzón, Carles Ubeda, Clarisse Nobre, Abigail González, Salomé S. Pinho, Cristina Cunha, Agostinho Carvalho, António Gil Castro, Mahesh S. Desai, Fernando Rodrigues, Ricardo Silvestre

“…Our study highlights the beneficial role of gut bacteria in dictating intestinal homeostasis, which is an important step toward employing microbiome-driven therapeutic approaches for IBD clinical management.IMPORTANCEThe contribution of the gut microbiome to the balance between homeostasis and inflammation is widely known. …”
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Multicenter registry and test bed for extended outpatient hemodynamic monitoring: the hemodynamic frontiers in heart failure (HF2) initiative by J. Thomas Heywood, Kartik Munshi, Timothy Jordan, Evan Muse, Marat Fudim, Andrew J. Sauer, Margaret McDermott, Hirak Shah, Arvind Bhimaraj, Rola Khedraki, Monique R. Robinson, Patrick McCann, Elizabeth Volz, Ashrith Guha, Orvar Jonsson, Kunjan A. Bhatt, Mosi K. Bennett, Terrie Ann Benjamin, Maya Guglin, Jacob Abraham

“…Average baseline hemodynamics at device implant are right atrial pressure (RAP) of 11 mmHg, pulmonary artery systolic pressure (PASP) of 47 mmHg, pulmonary artery diastolic pressure (PADP) 21 mmHg, mean pulmonary artery pressure (mPAP) of 20 mmHg, pulmonary capillary wedge pressure (PCWP) of 19 mmHg, cardiac output (CO) of 5.3 L/min, and cardiac index (CI) of 2.5 L/min/m2.ConclusionA real-world registry of patients implanted with a PAP sensor enables long-term evaluation of hemodynamic and clinic outcomes in highly-phenotyped ambulatory HF patients, and creates a unique opportunity to validate and test novel diagnostic and therapeutic approaches to HF.…”
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The Sialic Acid-Dependent Nematocyst Discharge Process in Relation to Its Physical-Chemical Properties Is a Role Model for Nanomedical Diagnostic and Therapeutic Tools by Ruiyan Zhang, Li Jin, Ning Zhang, Athanasios K. Petridis, Thomas Eckert, Georgios Scheiner-Bobis, Martin Bergmann, Axel Scheidig, Roland Schauer, Mingdi Yan, Samurdhi A. Wijesundera, Bengt Nordén, Barun K. Chatterjee, Hans-Christian Siebert

“…Since a number of tumor-cells, especially brain-tumor cells such as neuroblastoma tissues carry the polysaccharide chain polySia in similar concentration as fish eggs or fish skin, it makes sense to use these findings for new diagnostic and therapeutic approaches in the field of nanomedicine. Therefore, the nematocyst discharge process can be considered as a bionic blue-print for future nanomedical devices in cancer diagnostics and therapies. …”
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Impact of LDLR polymorphisms on lipid levels and atorvastatin’s efficacy in a northern Chinese adult Han cohort with dyslipidemia by Hong-Liang Zhao, Yang You, Yan Tian, Luyan Wang, Yongqiang An, Guoqiang Zhang, Chang Shu, Mingxin Yu, Yihua Zhu, Qian Li, Yanwei Zhang, Ningling Sun, Songnian Hu, Gang Liu

“…Furthermore, this investigation advocates for the integration of genetic testing into the management of dyslipidemia, paving the way for customized therapeutic approaches that could significantly improve patient care. …”
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<i>Astragalus polysaccharide</i> (PG2) Ameliorates Cancer Symptom Clusters, as well as Improves Quality of Life in Patients with Metastatic Disease, through Modulation of the Infla... by Wen-Chien Huang, Kuang-Tai Kuo, Oluwaseun Adebayo Bamodu, Yen-Kuang Lin, Chun-Hua Wang, Kang-Yun Lee, Liang-Shun Wang, Chi-Tai Yeh, Jo-Ting Tsai

“…This necessitates novel therapeutic approaches with enhanced efficacy, minimal or no treatment-related adverse effects, and improved QoL in patients with cancer, especially those with metastatic/advance stage disease. …”
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