COMPARATIVE ANALYSIS OF DIFFERENT NEOADJUVANT CHEMOTHERAPY REGIMENS FOR TRIPLE-NEGATIVE BREAST CANCER by P. V. Krivorotko, E. K. Zhiltsova, L. P. Gigolaeva, Sh. M. Khadzhimatova, G. A. Dashyan, K. Yu. Zernov, E. S. Trufanova, А. S. Artemyeva, A. G. Kudaibergenova, V. F. Semiglazov

“…Due to the lack of efficiency of standard therapeutic approaches, it appears extremely important to search for new regimens of neoadjuvant polychemotherapy (NAPCT). …”
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Key Role of Obesity in Genitourinary Tumors with Emphasis on Urothelial and Prostate Cancers by Matteo Santoni, Alessia Cimadamore, Francesco Massari, Francesco Piva, Gaetano Aurilio, Angelo Martignetti, Marina Scarpelli, Vincenzo Di Nunno, Lidia Gatto, Nicola Battelli, Liang Cheng, Antonio Lopez-Beltran, Rodolfo Montironi

“…In an attempt to shed light on uncertain areas in such field, in the present review we illustrate the main molecular mechanisms linking obesity and cancer, focusing on the correlation between obesity and tumor risk, disease progression and response to chemo- and immunotherapy in patients with UC and the predictive/prognostic role of obesity in PCa patients treated with the currently available therapeutic approaches. <i>Methods</i>: We did a large-scale literature search on existing scientific websites focusing on keywords &#8220;obesity&#8221;, &#8220;body mass index (BMI)&#8221;, &#8220;urothelial cancer&#8221;, &#8220;prostate cancer&#8221;, &#8220;docetaxel&#8221;, &#8220;cabazitaxel&#8221;, &#8220;abiraterone acetate&#8221;, &#8220;enzalutamide&#8221;, and &#8220;radium223&#8221;. …”
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Targeting Store-Operated Calcium Entry Regulates the Inflammation-Induced Proliferation and Migration of Breast Cancer Cells by Mohammed Alqinyah, Abdullah S. Alhamed, Hajar O. Alnefaie, Mohammad M. Algahtani, Amira M. Badr, Abdullah M. Albogami, Mohamed Mohany, Yasseen A. Alassmrry, Adel F. Alghaith, Hussain N. Alhamami, Khalid Alhazzani, Ahmed Z. Alanazi, Omar Awad Alsaidan

“…Thus, we argue that the current study may provide novel targets for designing new therapeutic approaches for the treatment of breast cancer.…”
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Lysin (K)-specific demethylase 1 inhibition enhances proteasome inhibitor response and overcomes drug resistance in multiple myeloma by Cecilia Bandini, Elisabetta Mereu, Tina Paradzik, Maria Labrador, Monica Maccagno, Michela Cumerlato, Federico Oreglia, Lorenzo Prever, Veronica Manicardi, Elisa Taiana, Domenica Ronchetti, Mattia D’Agostino, Francesca Gay, Alessandra Larocca, Lenka Besse, Giorgio Roberto Merlo, Emilio Hirsch, Alessia Ciarrocchi, Giorgio Inghirami, Antonino Neri, Roberto Piva

“…Therefore, a major challenge is the development of novel therapeutic approaches to overcome drug resistance, improve patient outcomes, and broaden PIs applicability to other pathologies. …”
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Immunoproteomics enable broad identification of new Aspergillus fumigatus antigens in severe equine asthma by Maria-Christin Jentsch, Sabrina Lübke, Wieland Schrödl, Daniela Volke, Andor Krizsan, Ralf Hoffmann, Sarah Kaiser-Thom, Vinzenz Gerber, Eliane Marti, Bettina Wagner, Christiane L. Schnabel

“…Their identification can provide the basis for innovative diagnostics, prevention, or therapeutic approaches. Additionally, a more profound understanding of SEA and its potential underlying mechanisms can be established. …”
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Comparative efficacy and safety of ginkgo biloba related agents in patients with acute ischemic stroke: A Bayesian network meta-analysis of randomized controlled trials by Tingting Li, Qianhui Sun, Mingzhen Qin, Xiangyi Zheng, Boyuan Wang, Xuebin Zhang, Xiaolong Xie, Dawei Wei, Xinyi Shi, Hongrui Zhang, Qiuyang Jia, Chi Zhang, Ying Gao

“…GI+WM and GDLM+WM stand out for the comprehensive therapeutic efficacy of patients with stroke through comparisons among various therapeutic approaches. Moreover, SXN+WM, GK+WM and GDLM+WM might be among the most effective in improving the functional efficacy outcome, while GI+WM might be among the least effective. …”
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T-Cell Infiltration and Clonality May Identify Distinct Survival Groups in Colorectal Cancer: Development and Validation of a Prognostic Model Based on The Cancer Genome Atlas (TCG... by Luca G. Campana, Wasat Mansoor, James Hill, Christian Macutkiewicz, Finlay Curran, David Donnelly, Ben Hornung, Peter Charleston, Robert Bristow, Graham M. Lord, Sara Valpione

“…We identified a subset of CRCs with “very high” TIL/Tc infiltration, poor prognosis and distinct genetic and immunologic features, which may benefit from alternative therapeutic approaches. These results need validation in prospective patient cohorts.…”
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Four Togolese plant species exhibiting cytotoxicity and antitumor activities lightning polytherapy approach in cancer treatment by P. Kola, S.N. Manjula, K. Metowogo, S.V. Madhunapantula, K. Eklu-Gadegbeku

“…Background: Cancer is leading to premature deaths across the globe. Therapeutic approaches are still being developed to enhance the survival of cancer patients. …”
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DEVELOPMENT OF MURINE STEM CELLS WITH CONDITIONAL KNOCKOUT OF HUMANIZED SNCA GENE by E. A. Patrakhanov, V. M. Pokrovsky, A. Yu. Karagodina, A. M. Krayushkina, N. S. Zhunusov, A. V. Deykin, M. V. Korokin, M. V. Pokrovsky, O. B. Altukhova

“…The results obtained are fundamentally important not only for understanding the development of the pathological process in α-synucleinopathies, but which is more important, for the development of new therapeutic approaches that will stop the extension of the human α-synuclein aggregation pathology throughout the nervous system, and the validation of these approaches in preclinical trials.Conclusion. …”
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Novel insights into the pharmacological modulation of human periodontal ligament stem cells by the amino-bisphosphonate Alendronate by Anna Di Vito, Emanuela Chiarella, Jessica Sovereto, Jessica Bria, Ida Daniela Perrotta, Alessandro Salatino, Francesco Baudi, Alessandro Sacco, Alessandro Antonelli, Flavia Biamonte, Tullio Barni, Amerigo Giudice

“…Our findings indicated that the effects of ALN on hPDLSCs behavior are dose-dependent and suggest a role for oxidative stress in ALN-induced cell death that may lead to novel therapeutic approaches for ONJ.…”
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Pathogenesis and Current Treatment Strategies of Hepatocellular Carcinoma by Deniz Tümen, Philipp Heumann, Karsten Gülow, Cagla-Nur Demirci, Lidia-Sabina Cosma, Martina Müller, Arne Kandulski

“…Furthermore, we discuss novel precautional and pre-therapeutic approaches including therapeutic vaccination, adoptive cell transfer, locoregional therapy enhancement, and non-coding RNA-based therapy as promising treatment options. …”
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Vascular Analysis of Type 1, 2, and 3 Macular Neovascularization in Age-Related Macular Degeneration Using Swept-Source Optical Coherence Tomography Angiography Shows New Insights... by Henrik Faatz, Kai Rothaus, Martin Ziegler, Marius Book, Britta Heimes-Bussmann, Daniel Pauleikhoff, Albrecht Lommatzsch

“…Background: The clinical appearance of macular neovascularization (MNV) in age-related macular degeneration (nAMD) varies widely, but so far, this has had no relevance in terms of therapeutic approaches or prognosis. Therefore, our purpose was to investigate if and which differences exist in the vascular architecture of MNV and to quantify them. …”
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Náuseas e vômitos no pós-operatório: uma revisão do "pequeno-grande" problema Náuseas y vómitos en el posoperatorio: una revisión del "pequeño-grande" problema Postoperative nausea... by Neusa Lages, Cristina Fonseca, Aida Neves, Nuno Landeiro, Fernando José Abelha

“…This article aimed at reviewing physiological mechanisms, risk factors and therapeutic approaches available to manage PONV. CONTENTS: Several strategies to manage PONV are suggested in this article, but stress is given to guidelines published by Gan in 2003. …”
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ENHANCING FOLLICULAR LYMPHOMA DIAGNOSIS WITH THE AID OF MEDTEST: AN INNOVATIVE CLINICAL TOOL by KAM Martins, FHB Souza, LR Augusto, RB Magalhães, LAA Rodrigues, EBA Menezes, PR Souza, RW Savio, SS Leal, MAAD Reis

“…Patients with FL may be symptomatic or asymptomatic, and upon detection of suspicious nodules, an excisional lymph node biopsy is requested, providing a confirmatory diagnosis of the patient's health condition. Therapeutic approaches vary according to FL staging. For Grade I FL, watchful waiting is initially recommended, without any antineoplastic chemotherapy unless symptoms, tumor mass increase, or extranodal involvement occur. …”
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Extracellular Enzymatic Activity of Candida Species Isolated from Patients with Head and Neck Cancer Undergoing Radiation Therapy and Its Correlation with Mucositis: A Cross-Sectio... by Neethu Babu, Chitralekha Saikumar, Jomon Raphael Chalissery, Harish Kumar

“…Additionally, this knowledge aids in the development of new antifungal drugs that target these enzymes, thereby enhancing therapeutic approaches. Understanding the extracellular enzymatic activity of Candida species is crucial for the development of new anticandidial drugs targeting these enzymes. …”
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Integrated analysis of lncRNA/circRNA–miRNA–mRNA in the proliferative phase of liver regeneration in mice with liver fibrosis by Qian Wang, Zhangtao Long, Fengfeng Zhu, Huajian Li, Zhiqiang Xiang, Hao Liang, Yachen Wu, Xiaoming Dai, Zhu Zhu

“…The findings provide insights into molecular mechanisms that may be useful in developing new therapeutic approaches to ameliorate diseases that are characterized by liver fibrosis, which would be beneficial for the prevention of liver failure and treatment of liver cancer.…”
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Pleiotropic immunomodulating effects of peptide Arginyl-alpha-Aspartyl-Lysyl-Valyl-Tyrosyl-Arginine on various subsets of neutrophilic granulocytes and their phenotype in patients... by V. N. Gorodin, V. A. Matushkina, V. N. Chapurina, A. I. Menyailo, S. V. Kovaleva, E. I. Dydyshko

“…The key role of neutrophilic granulocytes (NG) in the pathogenesis of COVID-19 makes them new targets for therapeutic approaches and of influencing the course and outcome of the disease, restoring changes in the phenotype and functions of NG. …”
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PIEZO1 ACTIVATION INCREASES NEUTROPHIL ADHESIVE PROPERTIES IN SICKLE CELL ANEMIA by FC Leonardo, PL Brito, S Egée, E Nader, P Connes, STO Saad, FF Costa, N Conran

“…This study highlights the significance of Piezo1 in the pathophysiology of SCA and could offer new insights for therapeutic approaches for treating this condition.…”
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24-h bronchodilation and inspiratory capacity improvements with glycopyrrolate/formoterol fumarate via co-suspension delivery technology in COPD by Colin Reisner, Gregory Gottschlich, Faisal Fakih, Andras Koser, James Krainson, Luis Delacruz, Samir Arora, Gregory Feldman, Krishna Pudi, Shahid Siddiqui, Chad Orevillo, Andrea Maes, Earl St. Rose, Ubaldo Martin

“…Abstract Background Symptoms of chronic obstructive pulmonary disease may vary throughout the day and it is important that therapeutic approaches provide 24-h symptom control. We report the results of two phase IIIb crossover studies, PT003011 and PT003012, investigating the 24-h lung function profile of GFF MDI (glycopyrrolate/formoterol fumarate 18/9.6 μg delivered using innovative co-suspension delivery technology) administered twice daily. …”
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Cognitive behavioral therapy for the treatment of PTSD by Ioannis Syros

“…Background: A variety of therapeutic approaches have been implemented to treat post-traumatic stress symptoms and concomitant difficulties. …”
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