Characteristics of Electroacupuncture Preconditioning and Treatment on Regulation of the Brain Transcriptome in Rats with Ischemic Stroke by Shuping Fu, Bufan Wu, Rou Peng, Houxi Xu, Xinyue Jing, Ling OuYang, Min Zhang, Tanqing Xu, Chang Chen, Shengfeng Lu

“…The present investigation delineated the neuroprotective potential of electroacupuncture (EA) administered pre-and post-stroke, with a focus on determining the commonalities and disparities between these two therapeutic approaches in ameliorating ischemic stroke-induced brain injury. …”
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Proteomic profiling reveals the potential mechanisms and regulatory targets of sirtuin 4 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s mouse model by Huidan Weng, Huidan Weng, Wenjing Song, Wenjing Song, Kangyue Fu, Yunqian Guan, Guoen Cai, Guoen Cai, En Huang, Xiaochun Chen, Xiaochun Chen, Haiqiang Zou, Qinyong Ye, Qinyong Ye

“…IntroductionParkinson’s disease (PD), as a common neurodegenerative disease, currently has no effective therapeutic approaches to delay or stop its progression. There is an urgent need to further define its pathogenesis and develop new therapeutic targets. …”
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CD24+CD44+CD54+EpCAM+ gastric cancer stem cells predict tumor progression and metastasis: clinical and experimental evidence by Angel A. Gómez-Gallegos, Lizbeth Ramírez-Vidal, Jared Becerril-Rico, Elizabeth Pérez-Islas, Zuly J. Hernandez-Peralta, Mariel E. Toledo-Guzmán, Alejandro García-Carrancá, Elizabeth Langley, Angélica Hernández-Guerrero, Fernando López-Casillas, Roberto Herrera-Goepfert, Luis F. Oñate-Ocaña, Elizabeth Ortiz-Sánchez

“…Overall, the extended CD24+CD44+CD54+EpCAM+ phenotype of GCSCs could support their isolation for the study of their stemness mechanisms, leading to the identification of better molecular targets for the development of both new therapeutic approaches such as oncoimmunotherapy and new diagnostic and clinical prognostic strategies for GC.…”
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Differential Pneumococcal Growth Features in Severe Invasive Disease Manifestations by Daan W. Arends, Wynand Alkema, Indri Hapsari Putri, Christa E. van der Gaast–de Jongh, Marc Eleveld, Jeroen D. Langereis, Quirijn de Mast, Jacques F. Meis, Marien I. de Jonge, Amelieke J. H. Cremers

“…Such knowledge could lead to more tailored vaccine targets or therapeutic approaches to reduce the million deaths that are caused by pneumococcal disease every year.…”
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Formulation and Characterization of Poly (Ethylene Glycol)-Coated Core-Shell Methionine Magnetic Nanoparticles as a Carrier for Naproxen Delivery: Growth Inhibition of Cancer Cells by Faten Eshrati Yeganeh, Amir Eshrati Yeganeh, Mohammad Yousefi, Bahareh Farasati Far, Iman Akbarzadeh, Dmitry Olegovich Bokov, Kaamran Raahemifar, Madjid Soltani

“…An efficient and selective drug delivery vehicle for cancer cells can remarkably improve therapeutic approaches. In this study, we focused on the synthesis and characterization of magnetic Ni_1−xCo_xFe₂O₄ nanoparticles (NPs) coated with two layers of methionine and polyethylene glycol to increase the loading capacity and lower toxicity to serve as an efficient drug carrier. …”
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A network medicine-based approach to explore the relationship between depression and inflammation by Xiaonan Hu, Huaxin Pang, Jia Liu, Yu Wang, Yifang Lou, Yufeng Zhao

“…The distance between them SAB < 0 implies that the pathogenesis of depression is likely to be related to the pathogenesis of its co-morbidities of depression and that potential therapeutic approaches may be derived from the disease treatment libraries of these co-morbidities. …”
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Sternum Metastases: From Case-Identifying Strategy to Multidisciplinary Management by Mara Carsote, Dana Terzea, Florina Vasilescu, Anca-Pati Cucu, Adrian Ciuche, Claudiu Nistor

“…The studies (n = 14) may be classified into one of three groups: studies addressing the incidence of bone metastases (including sternum) amid different primary cancers, such as prostate cancer (N = 122 with bone metastases, 83% of them with chest wall metastases), head and neck cancers (N = 3620, 0.8% with bone metastases, and 10.34% of this subgroup with sternum involvement); and glioblastoma (N = 92 with bone metastases, 37% of them with non-vertebral metastases, including the sternum); assessment cohorts, including breast cancer (N = 410; accuracy and sensitivity of PET/CT vs. bone scintigraphy is superior with concern to sternum spreading) and bone metastases of unknown origin (N = 83, including a subgroup with sternum metastases; some features of PET/CT help the differentiation with multiple myeloma); and cohorts with various therapeutic approaches, such as palliative arterial embolization (N = 10), thymic neuroendocrine neoplasia (1/5 detected with sternum metastases), survival rates for sternum metastases vs. non-sternum chest wall involvement (N = 87), oligo-metastatic (sternal) breast cancer (3 studies, N = 16 for all of them), oligo-metastatic head and neck cancer (N = 81), conformal radiotherapy (N = 24,215, including an analysis on sternum spreading), and EBRT followed by MR-HIFU (N = 6). …”
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3204 Renin-Angiotensin System Inhibitors Do Not Improve Survival in Fibrillin-1 Hypomorphic Mice with Established Aortic Aneurysm by Mary Burchett Sheppard, Jeff Zheying Chen, Debra L. Rateri, Jessica J. Moorleghen, Mackenzie Weiland, Alan Daugherty

“…Additional studies for understanding the mechanism underlying this sexual dimorphism have the potential to elucidate new therapeutic approaches for aortic disease.…”
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Association between triglyceride glucose index (TyG) and psychotic symptoms in patients with first-episode drug-naïve major depressive disorder by Junjun Liu, Junjun Liu, Junjun Liu, Yangchun Wang, Wei Mu, Yang Liu, Ruixiang Tong, Zhaomin Lu, Hsinsung Yuan, Fengnan Jia, Xiaobin Zhang, Zhe Li, Wanqiu Yang, Xiangdong Du, Xiangdong Du, Xiangyang Zhang

“…Particularly, a considerable 142% rise in the probability of experiencing psychotic symptoms was found with each incremental elevation in the TyG index.ConclusionsUnderstanding the non-linear link between the TyG index and the risk of psychotic symptoms in Chinese patients with FEDN MDD highlights the potential for targeted therapeutic approaches. By acknowledging the threshold effect observed, there is an opportunity to mitigate risk factors associated with IR-related psychiatric comorbidities through tailored interventions. …”
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Key Trace Elements Zinc and Magnesium Levels Decline After Fracture in a Rat Model by Jonathan R. Lopez MBS, David Ahn BA, Mark Fisher BS, Dhruv Mendiratta BS, Isabel Herzog BA, Ruey Horng Chee BS, Carter Levine, Ariel A. Docuyanan, Alexis Dompor MBS, Brian Moriarty, Jason M. Daniels, Glen Nie, David Paglia PhD, Joseph Benevenia MD, Sheldon S. Lin MD, James P. O’Connor PhD

“…These observations may offer insight into potential therapeutic approaches utilizing zinc and magnesium for fracture healing in the future.…”
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Multimodal treatment strategies for colorectal liver metastases by Dominique Lisa Birrer, Christoph Tschuor, Cäcilia S. Reiner, Ralph Fritsch, Thomas Pfammatter, Helena Garcia Schüler, Matea Pavic, Michelle De Oliveira, Henrik Petrowsky, Philip Dutkowski, Christian E. Oberkofler, Pierre-Alain Clavien

“…In recent years, effective therapeutic approaches have revolutionised liver surgery and new strategies have enabled the conversion of primarily non-resectable metastatic disease for resection. …”
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IDIOPATHIC LOBULAR PANNICULITIS IN RHEUMATOLOGY PRACTICE: THE AUTHORS’ OWN DATA by O. N. Egorova, B. S. Belov, S. I. Glukhova, S. G. Radenska-Lopovok

“…The literature contains almost no data on the diagnostic value of laboratory studies and therapeutic approaches, which served as the basis for this investigation. …”
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Eosinophilic esophagitis – Where are we today? by Cristina Targa Ferreira, Mario Cesar Vieira, Glenn T. Furuta, Fernando Celso Lopes Fernandes de Barros, Mirna Chehade

“…Objective: The objective of this review is to provide an overview of the practical diagnostic and therapeutic approaches to eosinophilic esophagitis and to increase the visibility of the disease among pediatricians. …”
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Passive and active strategies for transdermal drug delivery with nanotechnology and temporal pressure by Lio, Daniel Chin Shiuan

“…Especially for delivery of genetic therapy, nanotechnology can facilitate the transdermal delivery of various therapeutic approaches. On the other hand, temporal pressure serves as an attractive alternative to hypodermic injection, achieving effective transdermal delivery similar to microneedles.…”
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Molecular characterization of a novel pyocin and its immunity protein in pseudomonas aeruginosa by Bahareh Haji Rasouliha

“…The findings in this study, including the relationship between PVD-biosynthesis genes and mvaU regulatory gene, and the affirmation of S5 and S5I role, provide valuable insights in understanding virulence gene of P. aeruginosa and further expanding therapeutic approaches that can be taken against pathogenicity and antibiotic resistance properties of this bacterium.…”
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An in-vitro evaluation of C-di-GMP mediated biofilm dispersal as a potential strategy to restore antimicrobial efficacy by Roizman, Dan

“…The need for novel therapeutic approaches to prevent and/or eradicate microbial infections is urgent. …”
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The molecular pharmacology and modulation of the proton-activated chloride channel PAC by Pearson, CL

“…In summary, this project reveals new cellular mechanisms that underpin the physiological response to extracellular acidity, and suggests new therapeutic approaches for pharmacological modulation of these mechanisms. …”

Cockle shell-derived nano carrier for Ara-C in the treatment of acute myeloid leukaemia by Ghaji, Mustafa Saddam

“…Leukemia is a cancerous disease of bone marrow and blood in which acute form progresses more rapidly than the chronic form. The major therapeutic approaches of different cancer types are limited to conventional chemotherapy such as (Ara-C) which suffers less specific, high toxicity and short half-life, multidrug resistance and selectivity, narrow therapeutic index and significant increases in high dose distribution to healthy cells or tissues. …”
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Effects of disrupting insulin-like growth factor-1 receptor (IGF-1R) signal transduction pathways with inhibitors of IGF-1R, EGFR, PI3K, MEK, and MTOR in breast cancer cell lines by Ayub, Ayunadirah

“…Targeting these kinases and their pathways are promising therapeutic approaches compared to disruption of IGF-1R alone. …”
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Analysis of genetic polymorphism as risk factor of diabetes nephropathy among type 2 diabetic patients of a tertiary hospital by Yahya, Mohd Jokha

“…Genetic analysis of the polymorphism and susceptibility provides best apprehension on the pathogenesis elevating to innovative therapeutic approaches in patient management. The aim of this study was to determine the association of Carnosinase (CNDP1-D18S880 and rs2346061), Endothelial nitric oxide synthase (NOS3-rs1799983), Engulfment and cell mortality (ELMO1-rs74130), Manganese superoxide dismutase (MnSOD-rs4880) Methylene tetrahydrofolate reductase (MTHFR-rs1801133), Monocyte Chemoattractant protein-1 (CCL2-rs3917887), Chemokine receptor 5 (CCR5- rs1799987), Matrix Metalloproteinase-9 protein (MMP9-rs17576) and Interleukin-8 (IL8-rs4073) polymorphism to T2DM nephropathy among Malaysian. …”
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