Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation by Cláudia Caldeira, Carolina Cunha, Ana R. Vaz, Ana R. Vaz, Ana S. Falcão, Andreia Barateiro, Elsa Seixas, Adelaide Fernandes, Adelaide Fernandes, Dora Brites, Dora Brites

“…These findings help to improve our understanding on the heterogeneous responses that microglia can have along the progression of AD disease and imply that therapeutic approaches may differ from early to late stages.…”
Get full text

The Ephrin tyrosine kinase a3 (EphA3) is a novel mediator of RAGE-prompted motility of breast cancer cells by Marianna Talia, Francesca Cirillo, Asia Spinelli, Azzurra Zicarelli, Domenica Scordamaglia, Lucia Muglia, Salvatore De Rosis, Damiano Cosimo Rigiracciolo, Gianfranco Filippelli, Ida Daniela Perrotta, Mariano Davoli, Rosanna De Rosa, Rachele Macirella, Elvira Brunelli, Anna Maria Miglietta, Bruno Nardo, Daniela Tosoni, Salvatore Pece, Ernestina Marianna De Francesco, Antonino Belfiore, Marcello Maggiolini, Rosamaria Lappano

“…Overall, the current results may provide useful insights for more comprehensive therapeutic approaches in BC, particularly in obese and diabetic patients that are characterized by high RAGE levels.…”
Get full text

Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury by Sin-Yu Chen, Yi-Ling Chen, Po-Chen Li, Tai-Shan Cheng, Yeh-Shiu Chu, Yi-Shan Shen, Hsin-Tung Chen, Wei-Ni Tsai, Chien-Ling Huang, Martin Sieber, Yuan-Chieh Yeh, Hsiao-Sheng Liu, Chi-Ling Chiang, Chih-Hung Chang, Andrew S. Lee, Yen-Han Tseng, Ly James Lee, Hsiu-Jung Liao, Hon-Kan Yip, Chi-Ying F. Huang

“…These results provide potential avenues for developing innovative therapeutic approaches for more effective interventions in ALI.…”
Get full text

Long COVID Symptoms in Non-Hospitalised Patients: A Retrospective Study by Andreia M. Oliveira, Catarina Ferreira Coelho, Filipa Lourenço, Inês Campos Pinto, Joana Atabão, Raquel Cabrita, Rita Paraíso, Edgar Mesquita, Dyna Torrado, Pilar Marquez, Vanessa Z. Guerreiro

“…As the number of affected individuals continues to rise, it is crucial to find preventive, diagnostic, and therapeutic approaches. This study aims to describe different COVID-19 sequelae within a Primary Health Care population. …”
Get full text

A deep transcriptome meta-analysis reveals sex differences in multiple sclerosis by José Francisco Català-Senent, Zoraida Andreu, Marta R. Hidalgo, Irene Soler-Sáez, Francisco José Roig, Natalia Yanguas-Casás, Almudena Neva-Alejo, Adolfo López-Cerdán, María de la Iglesia-Vayá, Barbara E. Stranger, Francisco García-García

“…Here, we explore the role of sex in MS to identify molecular mechanisms underlying observed MS sex differences that may guide novel therapeutic approaches tailored for males or females. Methods: We performed a rigorous and systematic review of genome-wide transcriptome studies of MS that included patient sex data in the Gene Expression Omnibus and ArrayExpress databases following PRISMA statement guidelines. …”
Get full text

Protective effect and mechanism of baicalin on lung inflammatory injury in BALB/cJ mice induced by PM2.5 by Lili Deng, Mingyue Ma, Shuying Li, Lin Zhou, Sun Ye, Juan Wang, Qiaoqiao Yang, Chunling Xiao

“…However, presently there is a lack of effective preventive and therapeutic approaches for inflammatory lung injuries caused by PM2.5 exposure. …”
Get full text

Establishment and characterization of patient-derived xenograft of a rare pediatric anaplastic pleomorphic xanthoastrocytoma (PXA) bearing a CDC42SE2-BRAF fusion by Nur P. Damayanti, M. Reza Saadatzadeh, Erika Dobrota, Josue D. Ordaz, Barbara J. Bailey, Pankita H. Pandya, Khadijeh Bijangi-Vishehsaraei, Harlan E. Shannon, Anthony Alfonso, Kathy Coy, Melissa Trowbridge, Anthony L. Sinn, Zhong-Yin Zhang, Rosa I. Gallagher, Julia Wulfkuhle, Emanuel Petricoin, Angela M. Richardson, Mark S. Marshall, Alex Lion, Michael J. Ferguson, Karl E. Balsara, Karen E. Pollok

“…Therefore, development of relevant preclinical models to investigate molecular underpinnings of disease and to guide novel therapeutic approaches are of interest. Here, for the first time we established, and characterized a patient-derived xenograft (PDX) from a leptomeningeal spread of a patient with recurrent APXA bearing a novel CDC42SE2-BRAF fusion. …”
Get full text

The circadian clock remains intact, but with dampened hormonal output in heart failureResearch in context by Sandra Crnko, Markella I. Printezi, Peter-Paul M. Zwetsloot, Laurynas Leiteris, Andrew I. Lumley, Lu Zhang, Isabelle Ernens, Tijn P.J. Jansen, Lilian Homsma, Dries Feyen, Martijn van Faassen, Bastiaan C. du Pré, Carlo A.J.M. Gaillard, Hans Kemperman, Marish I.F.J. Oerlemans, Pieter A.F.M. Doevendans, Anne M. May, Nicolaas P.A. Zuithoff, Joost P.G. Sluijter, Yvan Devaux, Linda W. van Laake

“…This emphasises the importance of taking timing into account in research and therapy for HF, setting the stage for another dimension of diagnostic, prognostic and therapeutic approaches. Funding: Hartstichting.…”
Get full text

Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity by Quan Zheng, Jiajia Tang, Alexandra Aicher, Tony Bou Kheir, Berina Sabanovic, Preeta Ananthanarayanan, Chiara Reina, Minchun Chen, Jian-Min Gu, Bin He, Sonia Alcala, Diana Behrens, Rita T. Lawlo, Aldo Scarpa, Manuel Hidalgo, Bruno Sainz, Patricia Sancho, Christopher Heeschen

“…The important task of discovering upstream regulators of stemness that are amenable for targeting in PDAC is essential for the advancement of more potent therapeutic approaches. In this study, we sought to elucidate the function of the nuclear receptor subfamily 5, group A, member 2 (NR5A2) in the context of pancreatic CSCs. …”
Get full text

CK1BP Reduces α-Synuclein Oligomerization and Aggregation Independent of Serine 129 Phosphorylation by Lea Elsholz, Yasmine Wasser, Patrick Ziegler, Pardes Habib, Aaron Voigt

“…Accordingly, CK1BP represents a promising target for the rational design of therapeutic approaches to cease or at least delay the progression of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">α</mi></semantics></math></inline-formula>-synucleinopathies.…”
Get full text

2010 Use it but still lose it: Exploring age-related changes in skeletal stem cell location and activation in response to physical stimulation by Pamela C. Zuckerman, Chao Liu, Alesha B. Castillo

“…DISCUSSION/SIGNIFICANCE OF IMPACT: Mechanical loading presents an inexpensive treatment for increasing bone mass and bone strength, but may be insufficient to prevent or reverse age-related bone loss due to reduced numbers of osteogenic progenitors in the periosteum. Therapeutic approaches targeting the osteogenic capacity of periosteal cells will be required to address declining mechanoresponsiveness with age.…”
Get full text

Clinical and Pharmacotherapeutic Profile of Patients with Type 2 Diabetes Mellitus Admitted to a Hospital Emergency Department by António Cabral Lopes, Olga Lourenço, Fátima Roque, Manuel Morgado

“…Type 2 diabetes mellitus (T2DM) is closely associated with other pathologies, which may require complex therapeutic approaches. We aim to characterize the clinical and pharmacological profile of T2DM patients admitted to an emergency department. …”
Get full text

Anti-inflammation is an important way that Qingre-Huazhuo-Jiangsuan recipe treats acute gouty arthritis by Yazhuo Wang, Yang Xu, Jingrui Tan, Jiaxue Ye, Weizhen Cui, Jie Hou, Peiyu Liu, Jianwei Li, Shiyuan Wang, Qingyang Zhao

“…These findings provide new therapeutic approaches and ideas for the clinical treatment of AGA.…”
Get full text

Abstract 032: Ovine Models for Cerebral Venous Catheter Access: A Single Center Experience by José M Morales, Naoki Kaneko, Gary R Duckwiler

“…Introduction Large animal models are utilized for preclinical neuroendovascular research, and aid in the characterization and de‐risking of novel therapeutic approaches. To date, only a single prior study has been published providing a detailed account of an ovine model (Corriedale sheep) for cerebral venous access. …”
Get full text

METTL1 promotes neuroblastoma development through m7G tRNA modification and selective oncogenic gene translation by Ying Huang, Jieyi Ma, Cuiyun Yang, Paijia Wei, Minghui Yang, Hui Han, Hua Dong Chen, Tianfang Yue, Shu Xiao, Xuanyu Chen, Zuoqing Li, Yanlai Tang, Jiesi Luo, Shuibin Lin, Libin Huang

“…Conclusion This study revealed the critical role and mechanism of METTL1-mediated tRNA m7G modification in regulating NBL progression, providing new insights for developing therapeutic approaches for NBL patients.…”
Get full text

A Comparative Study of the Triglycerides/HDL Ratio and Pseudocholinesterase Levels in Patients with Bladder Cancer by Felice Crocetto, Savio Domenico Pandolfo, Achille Aveta, Raffaele Martino, Francesco Trama, Vincenzo Francesco Caputo, Biagio Barone, Marco Abate, Enrico Sicignano, Simone Cilio, Gianluca Russo, Matteo Massanova, Concetta Di Vito, Ciro Imbimbo, Giovanni Tarantino

“…The TG/HDL ratio and PChE levels as well as their combined use could help physicians to assess/confirm the presence of this very common cancer, where early detection is important to ensure the best therapeutical approach.…”
Get full text

The mediating role of emotional expressiveness in the relationship between Hexaco personality traits with internet betrayal in students by Solmaz Rasulzadeh Nemini, Jamal Sadeghi

“…Also, action should be taken to develop therapeutic approaches and psychological interventions in the counseling centers of the police command for the health of families. …”
Get full text

Point-of-care optical biosensor platforms for stroke diagnostics with blood-based biomarkers by Harpaz, Dorin

“…The ‘time is brain’ rational is a major limitation in therapeutic approaches, due to the association of time delays with worsen outcome in patients. …”
Get full text

Amyloid fibril formation kinetics of low-pH denatured bovine PI3K-SH3 monitored by three different NMR techniques by Luis Gardon, Luis Gardon, Nina Becker, Nina Becker, Nick Rähse, Christoph Hölbling, Athina Apostolidis, Celina M. Schulz, Kevin Bochinsky, Lothar Gremer, Lothar Gremer, Henrike Heise, Henrike Heise, Nils-Alexander Lakomek, Nils-Alexander Lakomek

“…A detailed understanding of the underlying molecular mechanisms is mandatory for developing innovative therapeutic approaches. The bovine PI3K-SH3 domain has been a model system for aggregation and fibril formation.Methods: We monitored the fibril formation kinetics of low pH-denatured recombinantly expressed [U-13C, 15N] labeled bovine PI3K-SH3 by a combination of solution NMR, high-resolution magic angle spinning (HR-MAS) NMR and solid-state NMR spectra. …”
Get full text

Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1 by Restuadi Restuadi, Frederik J. Steyn, Edor Kabashi, Shyuan T. Ngo, Fei-Fei Cheng, Marta F. Nabais, Mike J. Thompson, Ting Qi, Yang Wu, Anjali K. Henders, Leanne Wallace, Chris R. Bye, Bradley J. Turner, Laura Ziser, Susan Mathers, Pamela A. McCombe, Merrilee Needham, David Schultz, Matthew C. Kiernan, Wouter van Rheenen, Leonard H. van den Berg, Jan H. Veldink, Roel Ophoff, Alexander Gusev, Noah Zaitlen, Allan F. McRae, Robert D. Henderson, Naomi R. Wray, Jean Giacomotto, Fleur C. Garton

“…This has implications for understanding disease mechanisms (GPX3 acts in the same pathway as SOD1, a well-established ALS-associated gene) and identifying new therapeutic approaches. Few previous examples of in-depth investigations of risk loci in ALS exist and a similar approach could be applied to investigate future expected GWAS findings.…”
Get full text