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Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation
Published 2017-08-01“…These findings help to improve our understanding on the heterogeneous responses that microglia can have along the progression of AD disease and imply that therapeutic approaches may differ from early to late stages.…”
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12342
The Ephrin tyrosine kinase a3 (EphA3) is a novel mediator of RAGE-prompted motility of breast cancer cells
Published 2023-07-01“…Overall, the current results may provide useful insights for more comprehensive therapeutic approaches in BC, particularly in obese and diabetic patients that are characterized by high RAGE levels.…”
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12343
Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury
Published 2024-03-01“…These results provide potential avenues for developing innovative therapeutic approaches for more effective interventions in ALI.…”
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12344
Long COVID Symptoms in Non-Hospitalised Patients: A Retrospective Study
Published 2023-08-01“…As the number of affected individuals continues to rise, it is crucial to find preventive, diagnostic, and therapeutic approaches. This study aims to describe different COVID-19 sequelae within a Primary Health Care population. …”
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12345
A deep transcriptome meta-analysis reveals sex differences in multiple sclerosis
Published 2023-06-01“…Here, we explore the role of sex in MS to identify molecular mechanisms underlying observed MS sex differences that may guide novel therapeutic approaches tailored for males or females. Methods: We performed a rigorous and systematic review of genome-wide transcriptome studies of MS that included patient sex data in the Gene Expression Omnibus and ArrayExpress databases following PRISMA statement guidelines. …”
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12346
Protective effect and mechanism of baicalin on lung inflammatory injury in BALB/cJ mice induced by PM2.5
Published 2022-12-01“…However, presently there is a lack of effective preventive and therapeutic approaches for inflammatory lung injuries caused by PM2.5 exposure. …”
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12347
Establishment and characterization of patient-derived xenograft of a rare pediatric anaplastic pleomorphic xanthoastrocytoma (PXA) bearing a CDC42SE2-BRAF fusion
Published 2023-06-01“…Therefore, development of relevant preclinical models to investigate molecular underpinnings of disease and to guide novel therapeutic approaches are of interest. Here, for the first time we established, and characterized a patient-derived xenograft (PDX) from a leptomeningeal spread of a patient with recurrent APXA bearing a novel CDC42SE2-BRAF fusion. …”
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12348
The circadian clock remains intact, but with dampened hormonal output in heart failureResearch in context
Published 2023-05-01“…This emphasises the importance of taking timing into account in research and therapy for HF, setting the stage for another dimension of diagnostic, prognostic and therapeutic approaches. Funding: Hartstichting.…”
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12349
Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity
Published 2023-11-01“…The important task of discovering upstream regulators of stemness that are amenable for targeting in PDAC is essential for the advancement of more potent therapeutic approaches. In this study, we sought to elucidate the function of the nuclear receptor subfamily 5, group A, member 2 (NR5A2) in the context of pancreatic CSCs. …”
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12350
CK1BP Reduces α-Synuclein Oligomerization and Aggregation Independent of Serine 129 Phosphorylation
Published 2021-10-01“…Accordingly, CK1BP represents a promising target for the rational design of therapeutic approaches to cease or at least delay the progression of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">α</mi></semantics></math></inline-formula>-synucleinopathies.…”
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12351
2010 Use it but still lose it: Exploring age-related changes in skeletal stem cell location and activation in response to physical stimulation
Published 2018-06-01“…DISCUSSION/SIGNIFICANCE OF IMPACT: Mechanical loading presents an inexpensive treatment for increasing bone mass and bone strength, but may be insufficient to prevent or reverse age-related bone loss due to reduced numbers of osteogenic progenitors in the periosteum. Therapeutic approaches targeting the osteogenic capacity of periosteal cells will be required to address declining mechanoresponsiveness with age.…”
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12352
Clinical and Pharmacotherapeutic Profile of Patients with Type 2 Diabetes Mellitus Admitted to a Hospital Emergency Department
Published 2023-01-01“…Type 2 diabetes mellitus (T2DM) is closely associated with other pathologies, which may require complex therapeutic approaches. We aim to characterize the clinical and pharmacological profile of T2DM patients admitted to an emergency department. …”
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12353
Anti-inflammation is an important way that Qingre-Huazhuo-Jiangsuan recipe treats acute gouty arthritis
Published 2023-10-01“…These findings provide new therapeutic approaches and ideas for the clinical treatment of AGA.…”
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12354
Abstract 032: Ovine Models for Cerebral Venous Catheter Access: A Single Center Experience
Published 2023-11-01“…Introduction Large animal models are utilized for preclinical neuroendovascular research, and aid in the characterization and de‐risking of novel therapeutic approaches. To date, only a single prior study has been published providing a detailed account of an ovine model (Corriedale sheep) for cerebral venous access. …”
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12355
METTL1 promotes neuroblastoma development through m7G tRNA modification and selective oncogenic gene translation
Published 2022-09-01“…Conclusion This study revealed the critical role and mechanism of METTL1-mediated tRNA m7G modification in regulating NBL progression, providing new insights for developing therapeutic approaches for NBL patients.…”
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12356
A Comparative Study of the Triglycerides/HDL Ratio and Pseudocholinesterase Levels in Patients with Bladder Cancer
Published 2022-02-01“…The TG/HDL ratio and PChE levels as well as their combined use could help physicians to assess/confirm the presence of this very common cancer, where early detection is important to ensure the best therapeutical approach.…”
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12357
The mediating role of emotional expressiveness in the relationship between Hexaco personality traits with internet betrayal in students
Published 2023-01-01“…Also, action should be taken to develop therapeutic approaches and psychological interventions in the counseling centers of the police command for the health of families. …”
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12358
Point-of-care optical biosensor platforms for stroke diagnostics with blood-based biomarkers
Published 2020“…The ‘time is brain’ rational is a major limitation in therapeutic approaches, due to the association of time delays with worsen outcome in patients. …”
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Thesis-Doctor of Philosophy -
12359
Amyloid fibril formation kinetics of low-pH denatured bovine PI3K-SH3 monitored by three different NMR techniques
Published 2023-11-01“…A detailed understanding of the underlying molecular mechanisms is mandatory for developing innovative therapeutic approaches. The bovine PI3K-SH3 domain has been a model system for aggregation and fibril formation.Methods: We monitored the fibril formation kinetics of low pH-denatured recombinantly expressed [U-13C, 15N] labeled bovine PI3K-SH3 by a combination of solution NMR, high-resolution magic angle spinning (HR-MAS) NMR and solid-state NMR spectra. …”
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12360
Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1
Published 2022-01-01“…This has implications for understanding disease mechanisms (GPX3 acts in the same pathway as SOD1, a well-established ALS-associated gene) and identifying new therapeutic approaches. Few previous examples of in-depth investigations of risk loci in ALS exist and a similar approach could be applied to investigate future expected GWAS findings.…”
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