The Asociación Mexicana de Gastroenterología consensus on the diagnosis and treatment of acute pancreatitis in children and adolescents by R. Vázquez-Frias, Y. Rivera-Suazo, A.K. Aguayo-Elorriaga, J.E. Alfaro-Bolaños, G.A. Argüello-Arévalo, J.F. Cadena-León, J.A. Chávez-Sáenz, A. Consuelo-Sánchez, E.V. Cruz-Romero, D. Espinosa-Saavedra, M.X. Espriu-Ramírez, J. Flores-Calderón, B. González-Ortiz, V. Hernández-Rosiles, K.R. Ignorosa-Arellano, C.M. Jaramillo-Esparza, F.R. Lozano-Hernández, A. Larrosa-Haro, U. Leal-Quiroga, J.A. Macias-Flores, B.A. Martínez-Leo, A. Martínez-Vázquez, N.M.J. Mendoza-Tavera, S. Pacheco-Sotelo, M. Reyes-Apodaca, C.A. Sánchez-Ramírez, C.A. Sifuentes-Vela, M. Sosa-Arce, F.E. Zárate-Mondragón

“…Different AP topics were addressed by 6 working groups, each of which reviewed the information and formulated statements considered pertinent for each module, on themes involving recommendations and points of debate, concerning diagnostic or therapeutic approaches. All the statements were presented and discussed. …”
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High PD-L1/IDO-2 and PD-L2/IDO-1 Co-Expression Levels Are Associated with Worse Overall Survival in Resected Non-Small Cell Lung Cancer Patients by Vienna Ludovini, Fortunato Bianconi, Annamaria Siggillino, Jacopo Vannucci, Sara Baglivo, Valeria Berti, Francesca Romana Tofanetti, Maria Sole Reda, Guido Bellezza, Martina Mandarano, Maria Laura Belladonna, Giulio Metro, Rita Chiari, Angelo Sidoni, Francesco Puma, Vincenzo Minotti, Fausto Roila

“…These features may have important implications for future immune-checkpoint therapeutic approaches.…”
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Consenso de la Asociación Mexicana de Gastroenterología sobre el diagnóstico y tratamiento de pancreatitis aguda en niñas, niños y adolescentes by R. Vázquez-Frias, Y. Rivera-Suazo, A.K. Aguayo-Elorriaga, J.E. Alfaro-Bolaños, G.A. Argüello-Arévalo, J.F. Cadena-León, J.A. Chávez-Sáenz, A. Consuelo-Sánchez, E.V. Cruz-Romero, D. Espinosa-Saavedra, M.X. Espriu-Ramírez, J. Flores-Calderón, B. González-Ortiz, V. Hernández-Rosiles, K.R. Ignorosa-Arellano, C.M. Jaramillo-Esparza, F.R. Lozano-Hernández, A. Larrosa-Haro, U. Leal-Quiroga, J.A. Macias-Flores, B.A. Martínez-Leo, A. Martínez-Vázquez, N.M.J. Mendoza-Tavera, S. Pacheco-Sotelo, M. Reyes-Apodaca, C.A. Sánchez-Ramírez, C.A. Sifuentes-Vela, M. Sosa-Arce, F.E. Zárate-Mondragón

“…Different AP topics were addressed by 6 working groups, each of which reviewed the information and formulated statements considered pertinent for each module, on themes involving recommendations and points of debate, concerning diagnostic or therapeutic approaches. All the statements were presented and discussed. …”
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The Real-World Data in Japanese Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib from a Nationwide Multicenter Study by Kaoru Tsuchiya, Masayuki Kurosaki, Azusa Sakamoto, Hiroyuki Marusawa, Yuji Kojima, Chitomi Hasebe, Hirotaka Arai, Kouji Joko, Masahiko Kondo, Keiji Tsuji, Tetsuro Sohda, Hiroyuki Kimura, Chikara Ogawa, Yasushi Uchida, Shuichi Wada, Haruhiko Kobashi, Koichiro Furuta, Masaya Shigeno, Atsunori Kusakabe, Takehiro Akahane, Ryoichi Narita, Hideo Yoshida, Akeri Mitsuda, Yasushi Ide, Tomomichi Matsushita, Namiki Izumi, on behalf of Japanese Red Cross Liver Study Group

“…The patients with bone metastasis would be candidates for new therapeutic approaches.…”
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PARP1 IS DIFFERENTIALLY EXPRESSED IN BCR-ABL P190+ ALL PATIENT SAMPLES AND TARGETING PARP INHIBITION INDUCES CELL DEATH COMPARABLE TO THAT OF TYROSINE-KINASE GOLDEN STANDARD IN PRE... by CB Machado, WAS Ferreira, FMCP Pessoa, FAR Mell-Júnior, AD Seabra, RM Ribeiro, MO Morae-Filho, MEA Moraes, LEB Souza, CFA Moreir-Nunes

“…Objective: BCR-ABL1 p190 translocation represents a worse prognosis for acute lymphoblastic leukemia (ALL) patients, and development of new therapeutic approaches is of utmost importance to the oncologic routine. …”
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PREDICTIVE FACTORS AND CLINICAL AND PARACLINICAL FEATURES OF URINARY TRACT DYSFUNCTION IN PRETERM INFANTS by Ю. Годованець, А. Фрунза

“…The research themes included: a research project on ‘Improvement of Prognostic, Diagnostic, and Therapeutic Approaches to Perinatal Pathology in Newborns and Infants, Optimization of Followup and Rehabilitation Schemes’ (State registration number 0115U002768, duration from 01.2015 to 12.2019); and a research project on ‘Chronobiological and Adaptive Aspects, as well as Features of Vegetative Regulation in Pathological Conditions in Children of Diff erent Age Groups’ (State registration number 0122U002245, duration from 01.2020 to 12.2024). …”
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Cellular responses against DNA damaged by platinum anticancer drugs by Jung, Yongwon, 1977-

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Investigating isocitrate dehydrogenase mutations in cancer using new metabolomics methods by Walsby-Tickle, J

“…Consequently, there is a need for better diagnostic and therapeutic approaches. Small molecule inhibitors, which are specific to isocitrate dehydrogenase mutations and reduce the abundance of 2 hydroxyglutarate, have been developed; however, resistance to treatment has since been reported, including the manifestation of second site mutations. …”

Influência de características gerais na qualidade de vida de pacientes com doença pulmonar obstrutiva crônica Influence of general clinical parameters on the quality of life of chr... by Victor Zuniga Dourado, Letícia Cláudia de Oliveira Antunes, Lídia Raquel de Carvalho, Irma Godoy

“…CONCLUSIONS: The BMI and 6MWT were shown to have an influence on quality of life in the COPD patients studied. Therefore, therapeutic approaches to improving the quality of life of COPD patients should take these indices into consideration.…”
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Cirurgia vídeo-assistida para a ablação da fibrilação atrial isolada por radiofrequência bipolar Cirugía videoasistida para ablación de fibrilación atrial aislada por radiofrecuenc... by Alexandre Siciliano Colafranceschi, Andrey José de Oliveira Monteiro, Eduardo Souza Leal Botelho, Leonardo Secchin Canale, Arnaldo Rabischoffsky, Ieda Prata Costa, Fernando Eugênio dos Santos Cruz Filho, Roberto Luiz Menssing da Silva Sá, Ana Luiza Boechat, Luis Alberto Oliveira Dallan

“…<br>BACKGROUND: The prevalence of atrial fibrillation, expenses with the healthcare system and the associated high morbidity and mortality have justified the search for new therapeutic approaches. OBJECTIVE: To evaluate the reproducibility of the surgical technique, its safety and the initial outcome of the video-assisted surgery for the isolated atrial fibrillation ablation with bipolar radiofrequency. …”
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Neurogenetics and Epigenetics of Loneliness by Bowirrat A, Elman I, Dennen CA, Gondré-Lewis MC, Cadet JL, Khalsa J, Baron D, Soni D, Gold MS, McLaughlin TJ, Bagchi D, Braverman ER, Ceccanti M, Thanos PK, Modestino EJ, Sunder K, Jafari N, Zeine F, Badgaiyan RD, Barh D, Makale M, Murphy KT, Blum K

“…Identification of the individual contributions by various (epi)genetic factors presents opportunities for the creation of innovative preventive, diagnostic, and therapeutic approaches for individuals who cope with persistent feelings of loneliness. …”
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Hemograma de cães envenenados experimentalmente com Bothrops alternatus após diferentes tratamentos. by D. O. Jacome, M. M. Melo, M. M. B. Santos, K. M. Ferreira, R. M. Sabaini

“…Palavras-chave: Hemograma, Bothrops, cão SUMMARY: The aim of this study was to evaluate hemograms of dogs experimentally envenomed with Bothrops alternatus following different therapeutic approaches (specific anti-venom serum, flunixin meglumine and aqueous extract of Curcuma longa). …”
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Alice Parfitt - Thesis submitted in partial fulfilment of the degree of Doctor of Clinical Psychology (DClinPsych) by Parfitt, A

“…</p> <p><b>Discussion:</b> Recommendations for psychological support in LCCs are suggested. Therapeutic approaches focused on (i) adjusting to CKD (such as Cognitive Behavioural Therapy and Acceptance and Commitment Therapy), (ii) symptom reduction (e.g. pain-management or mindfulness-based interventions) and (iii) systemic-focused interventions may be particularly helpful.…”

Selected Lectures of the 18th International Workshop on Neonatology and Pediatrics; Cagliari (Italy); October 19-22, 2022 by --- Various Authors

“…PREECLAMPSIA, FETAL INTRAUTERINE GROWTH RESTRICTION AND MATERNAL CARDIOVASCULAR ADAPTATION: A KEY TO FIND A NEW THERAPEUTICAL APPROACH • H. Valensise, D. Farsetti, F. Pometti, B. …”
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Патогенетические механизмы фибрилляции предсердий и формирования предсердного фиброза = Pathogenic mechanisms of atrial fibrillation and atrial fibrosis formation... by A. I. Gozhenko, N. R. Bayazitov, E. M. Levchenko, V. V. Goriachyi, A. V. Goriachyi

“…This paper reviews the current understanding of how atrial fibrosis creates a substrate for AF, summarizes available data on the mechanisms of fibrosis and its distribution, and highlights the therapeutic approaches aimed at reducing the structural remodeling to prevent AF. …”
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Fibrose pulmonar idiopática: apresentação clínica, evolução e fatores de prognóstico basais numa coorte portuguesa by F. Soares Pires, P. Caetano Mota, N. Melo, D. Costa, J.M. Jesus, R. Cunha, S. Guimarães, C. Souto-Moura, A. Morais

“…These results could mean different physiopathologic pathways, which could implicate different therapeutic approaches. Palavras-chave: Fibrose pulmonar idiopática, Sobrevivência, Prognóstico, Keywords: Idiopathic Pulmonary Fibrosis, Survival, Prognosis…”
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Psychosocial interventions for self-harm in adults. by Hawton, K, Witt, K, Taylor Salisbury, T, Arensman, E, Gunnell, D, Hazell, P, Townsend, E, van Heeringen, K

“…Casemanagement and remote contact interventions did not appear to have any benefits in terms of reducing repetition of SH. Other therapeutic approaches weremostly evaluated in single trials ofmoderate to very low quality such that the evidence relating to these interventions is inconclusive.…”

Artificial Intelligence and Healthcare by Harish Rangareddy, Shashidhar Kurpad Nagaraj

“…For healthcare applications, the machine learning allows phenotyping of individuals’ health facilitating targeted diagnostic or therapeutic approaches to diseases. AI with natural language processing can be applied for clinical data to extract information from free text such as clinical observations or health journals and converting into standard clinical terminologies. …”
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COVID-19 associated mucormycosis – a recent challenge by Vitorino Modesto dos Santos, Lister Arruda Modesto dos Santos, Taciana Arruda Modesto Sugai

“…Surgery plus antimycotic agent (61%), antimycotic therapy alone (28%), and surgery alone (11%) were the therapeutic approaches. All neonatal patients underwent a surgical procedure; posaconazole (30%) and isavuconazole (11%) effectively treated these patients.5 The authors commented on low immunity during the COVID-19 pandemic favoring the high prevalence of mucormycosis in India and the difficulties of early diagnosis and treatment.5 Divakar6 reviewed data about mucormycosis in general and the cases associated with the two waves of COVID-19 infections in India.6 The estimated mortality rate of mucormycosis (50%) may be over 90% if untreated; Rhizopus arrhizus was the most common agent of human mucormycosis described in Indian patients, followed by Apophysomyces variabilis, R. microsporus, and R. homothallicus.6 Mucormycosis among COVID-19 patients, including the mortality rate, are increasing in India and some of the neighboring countries such as Bangladesh, Nepal, and Pakistan.6 Because of species-specific differences, there are therapeutic challenges in India, with only three potentially efficient drugs (amphotericin B, posaconazole, and isavuconazole). …”
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