Safer and more efficient vital signs monitoring protocols to identify the deteriorating patients in the general hospital ward: an observational study by Jim Briggs, Ina Kostakis, Paul Meredith, Chiara Dall’ora, Julie Darbyshire, Stephen Gerry, Peter Griffiths, Jo Hope, Jeremy Jones, Caroline Kovacs, Rob Lawrence, David Prytherch, Peter Watkinson, Oliver Redfern

“…Current monitoring protocols (from NHS England) are based on expert opinion supported by little empirical evidence. …”
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Dergilerden Özetler by Ümit Ünüvar Atılmış, Taner Güven, Gökhan Ersoy

“…Applications in injury survival time and child abuse. Thogmartm JR, England D, Sıebert CF Jr. Am J Forensic Med Pathol. 2001;22(3):313-8. …”
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Impact of interventions to improve recovery of older adults following planned hospital admission on quality-of-life following discharge: linked-evidence synthesis by Debbie Kinsey, Samantha Febrey, Simon Briscoe, Dylan Kneale, Jo Thompson Coon, Daniele Carrieri, Christopher Lovegrove, John McGrath, Anthony Hemsley, GJ Melendez-Torres, Liz Shaw, Michael Nunns

“…Scientific summary Background The Office for National Statistics predicts that in England the proportion of people aged 65 years and over will increase from 18.2% to 20.7% of the total population between mid-2018 and mid-2028. …”
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Surgical versus non-surgical management of lateral compression type-1 pelvic fracture in adults 60 years and older: the L1FE RCT by Elizabeth Cook, Joanne Laycock, Dhanupriya Sivapathasuntharam, Camila Maturana, Catherine Hilton, Laura Doherty, Catherine Hewitt, Catriona McDaid, David Torgerson, Peter Bates

“…Site set-up Eleven sites in England and Wales were opened during the first phase of the internal pilot. …”
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A multicomponent intervention to reduce daily sitting time in office workers: the SMART Work & Life three-arm cluster RCT by Edwardson Charlotte L, Maylor Benjamin D, Biddle Stuart JH, Clemes Stacy A, Cox Edward, Davies Melanie J, Dunstan David W, Eborall Helen, Granat Malcolm H, Gray Laura J, Hadjiconstantinou Michelle, Healy Genevieve N, Jaicim Nishal Bhupendra, Lawton Sarah, Mandalia Panna, Munir Fehmidah, Richardson Gerry, Walker Simon, Yates Thomas, Clarke-Cornwell Alexandra M

“…Design A three-arm cluster randomised controlled trial. Setting Councils in England. Participants Office workers. Intervention SMART Work & Life is a multicomponent intervention that includes behaviour change strategies, delivered by workplace champions. …”
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Prehospital early warning scores for adults with suspected sepsis: the PHEWS observational cohort and decision-analytic modelling study by Steve Goodacre, Laura Sutton, Kate Ennis, Ben Thomas, Olivia Hawksworth, Khurram Iftikhar, Susan J Croft, Gordon Fuller, Simon Waterhouse, Daniel Hind, Matt Stevenson, Mike J Bradburn, Michael Smyth, Gavin D Perkins, Mark Millins, Andy Rosser, Jon Dickson, Matthew Wilson

“…Setting Two ambulance services and four acute hospitals in England. Participants Adults transported to hospital by emergency ambulance, excluding episodes with injury, mental health problems, cardiac arrest, direct transfer to specialist services, or no vital signs recorded. …”
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The implications of competing risks and direct treatment disutility in cardiovascular disease and osteoporotic fracture: risk prediction and cost effectiveness analysis by Bruce Guthrie, Gabriel Rogers, Shona Livingstone, Daniel R Morales, Peter Donnan, Sarah Davis, Ji Hee Youn, Rob Hainsworth, Alexander Thompson, Katherine Payne

“…General updates included rapid reviews to identify utility values and costs associated with CVD events, new regressions to predict baseline quality of life for people without CVD (based on Health Survey for England data) and type of first CVD event (based on data from objective 1), and inputs (costs, life expectancy) were updated to present-day values. …”
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Understanding the impact of psychosocial working conditions on workers’ health: we have come a long way, but are we there yet? by Ida EH Madsen, Reiner Rugulies

“…Causes, coping and consequences of stress at work - Wiley series on studies in occupational stress. Chichester, England: John Wiley & Sons; 1988. p. 375-411. 27. …”
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Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials by Cathrine Axfors, Perrine Janiaud, Andreas M. Schmitt, Janneke van’t Hooft, Emily R. Smith, Noah A. Haber, Akin Abayomi, Manal Abduljalil, Abdulkarim Abdulrahman, Yeny Acosta-Ampudia, Manuela Aguilar-Guisado, Farah Al-Beidh, Marissa M. Alejandria, Rachelle N. Alfonso, Mohammad Ali, Manaf AlQahtani, Alaa AlZamrooni, Juan-Manuel Anaya, Mark Angelo C. Ang, Ismael F. Aomar, Luis E. Argumanis, Alexander Averyanov, Vladimir P. Baklaushev, Olga Balionis, Thomas Benfield, Scott Berry, Nadia Birocco, Lynn B. Bonifacio, Asha C. Bowen, Abbie Bown, Carlos Cabello-Gutierrez, Bernardo Camacho, Adrian Camacho-Ortiz, Sally Campbell-Lee, Damon H. Cao, Ana Cardesa, Jose M. Carnate, German Jr. J. Castillo, Rossana Cavallo, Fazle R. Chowdhury, Forhad U. H. Chowdhury, Giovannino Ciccone, Antonella Cingolani, Fresthel Monica M. Climacosa, Veerle Compernolle, Carlo Francisco N. Cortez, Abel Costa Neto, Sergio D’Antico, James Daly, Franca Danielle, Joshua S. Davis, Francesco Giuseppe De Rosa, Justin T. Denholm, Claudia M. Denkinger, Daniel Desmecht, Juan C. Díaz-Coronado, Juan A. Díaz Ponce-Medrano, Anne-Françoise Donneau, Teresita E. Dumagay, Susanna Dunachie, Cecile C. Dungog, Olufemi Erinoso, Ivy Mae S. Escasa, Lise J. Estcourt, Amy Evans, Agnes L. M. Evasan, Christian J. Fareli, Veronica Fernandez-Sanchez, Claudia Galassi, Juan E. Gallo, Patricia J. Garcia, Patricia L. Garcia, Jesus A. Garcia, Mutien Garigliany, Elvira Garza-Gonzalez, Deonne Thaddeus V. Gauiran, Paula A. Gaviria García, Jose-Antonio Giron-Gonzalez, David Gómez-Almaguer, Anthony C. Gordon, André Gothot, Jeser Santiago Grass Guaqueta, Cameron Green, David Grimaldi, Naomi E. Hammond, Heli Harvala, Francisco M. Heralde, Jesica Herrick, Alisa M. Higgins, Thomas E. Hills, Jennifer Hines, Karin Holm, Ashraful Hoque, Eric Hoste, Jose M. Ignacio, Alexander V. Ivanov, Maike Janssen, Jeffrey H. Jennings, Vivekanand Jha, Ruby Anne N. King, Jens Kjeldsen-Kragh, Paul Klenerman, Aditya Kotecha, Fiorella Krapp, Luciana Labanca, Emma Laing, Mona Landin-Olsson, Pierre-François Laterre, Lyn-Li Lim, Jodor Lim, Oskar Ljungquist, Jorge M. Llaca-Díaz, Concepción López-Robles, Salvador López-Cárdenas, Ileana Lopez-Plaza, Josephine Anne C. Lucero, Maria Lundgren, Juan Macías, Sandy C. Maganito, Anna Flor G. Malundo, Rubén D. Manrique, Paola M. Manzini, Miguel Marcos, Ignacio Marquez, Francisco Javier Martínez-Marcos, Ana M. Mata, Colin J. McArthur, Zoe K. McQuilten, Bryan J. McVerry, David K. Menon, Geert Meyfroidt, Ma. Angelina L. Mirasol, Benoît Misset, James S. Molton, Alric V. Mondragon, Diana M. Monsalve, Parastoo Moradi Choghakabodi, Susan C. Morpeth, Paul R. Mouncey, Michel Moutschen, Carsten Müller-Tidow, Erin Murphy, Tome Najdovski, Alistair D. Nichol, Henrik Nielsen, Richard M. Novak, Matthew V. N. O’Sullivan, Julian Olalla, Akin Osibogun, Bodunrin Osikomaiya, Salvador Oyonarte, Juan M. Pardo-Oviedo, Mahesh C. Patel, David L. Paterson, Carlos A. Peña-Perez, Angel A. Perez-Calatayud, Eduardo Pérez-Alba, Anastasia Perkina, Naomi Perry, Mandana Pouladzadeh, Inmaculada Poyato, David J. Price, Anne Kristine H. Quero, Md. M. Rahman, Md. S. Rahman, Mayur Ramesh, Carolina Ramírez-Santana, Magnus Rasmussen, Megan A. Rees, Eduardo Rego, Jason A. Roberts, David J. Roberts, Yhojan Rodríguez, Jesús Rodríguez-Baño, Benjamin A. Rogers, Manuel Rojas, Alberto Romero, Kathryn M. Rowan, Fabio Saccona, Mehdi Safdarian, Maria Clariza M. Santos, Joe Sasadeusz, Gitana Scozzari, Manu Shankar-Hari, Gorav Sharma, Thomas Snelling, Alonso Soto, Pedrito Y. Tagayuna, Amy Tang, Geneva Tatem, Luciana Teofili, Steven Y. C. Tong, Alexis F. Turgeon, Januario D. Veloso, Balasubramanian Venkatesh, Yanet Ventura-Enriquez, Steve A. Webb, Lothar Wiese, Christian Wikén, Erica M. Wood, Gaukhar M. Yusubalieva, Kai Zacharowski, Ryan Zarychanski, Nina Khanna, David Moher, Steven N. Goodman, John P. A. Ioannidis, Lars G. Hemkens

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Total ankle replacement versus ankle arthrodesis for patients aged 50–85 years with end-stage ankle osteoarthritis: the TARVA RCT by Goldberg Andrew J, Chowdhury Kashfia, Bordea Ekaterina, Blackstone James, Brooking Deirdre, Deane Elizabeth L, Hauptmannova Iva, Cooke Paul, Cumbers Marion, Skene Simon S, Doré Caroline J

“…The TARs implanted in England, Wales, Northern Ireland, the Isle of Man and Guernsey are captured on the National Joint Registry, which has revision surgery as its end point. …”
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The Care Home Independent Pharmacist Prescriber Study (CHIPPS): development and implementation of an RCT to estimate safety, effectiveness and cost-effectiveness by David Wright, Richard Holland, David Phillip Alldred, Christine Bond, Carmel Hughes, Garry Barton, Fiona Poland, Lee Shepstone, Antony Arthur, Linda Birt, Jeanette Blacklock, Annie Blyth, Stamatina Cheilari, Amrit Daffu-O’Reilly, Lindsay Dalgarno, James Desborough, Joanna Ford, Kelly Grant, Janet Gray, Christine Handford, Bronwen Harry, Helen Hill, Jacqueline Inch, Phyo Kyaw Myint, Nigel Norris, Maureen Spargo, Vivienne Maskrey, David Turner, Laura Watts, Arnold Zermansky

“…Methods The study sites were located in Northern Ireland (one site), Scotland (one site) and England (two sites). Ethical approval was received for each work package (WP). …”
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Frenotomy with breastfeeding support versus breastfeeding support alone for infants with tongue-tie and breastfeeding difficulties: the FROSTTIE RCT by Knight Marian, Ramakrishnan Rema, Ratushnyak Svetlana, Rivero-Arias Oliver, Bell Jennifer, Bowler Ursula, Buchanan Phyll, Carter Claire, Cole Christina, Hewer Oliver, Hurd Madeleine, King Andy, Juszczak Ed, Linsell Louise, Long Anna-May, Mottram Linda, Murray David, Oddie Sam, Quigley Maria, Stalker Victoria, Stanbury Kayleigh, Welsh Richard, Hardy Pollyanna

“…Methods Study design The FROSTTIE trial was a multicentre, RCT conducted in 12 infant feeding services in England. Participants Inclusion criteria Any infant aged <10 weeks referred (by parent or other breastfeeding support service) to an infant feeding service with breastfeeding difficulties and judged to have tongue-tie, whose parent has given informed consent for participation. …”
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Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease: the ALL-HEART RCT and economic evaluation by Isla S Mackenzie, Christopher J Hawkey, Ian Ford, Nicola Greenlaw, Filippo Pigazzani, Amy Rogers, Allan D Struthers, Alan G Begg, Li Wei, Anthony J Avery, Jaspal S Taggar, Andrew Walker, Suzanne L Duce, Rebecca J Barr, Jennifer S Dumbleton, Evelien D Rooke, Jonathan N Townend, Lewis D Ritchie, Thomas M MacDonald

“…Three thousand four hundred and sixty-four (60.5%) participants were recruited in England and 2257 (39.5%) participants in Scotland. …”
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The evolution of metastatic upper tract urothelial carcinoma through genomic-transcriptomic and single-cell protein markers analysis by Kentaro Ohara, André Figueiredo Rendeiro, Bhavneet Bhinder, Kenneth Wha Eng, Hiranmayi Ravichandran, Duy Nguyen, David Pisapia, Aram Vosoughi, Evan Fernandez, Kyrillus S. Shohdy, Jyothi Manohar, Shaham Beg, David Wilkes, Brian D. Robinson, Francesca Khani, Rohan Bareja, Scott T. Tagawa, Madhu M. Ouseph, Andrea Sboner, Olivier Elemento, Bishoy M. Faltas, Juan Miguel Mosquera

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Patient derived organoids to model rare prostate cancer phenotypes by Loredana Puca, Rohan Bareja, Davide Prandi, Reid Shaw, Matteo Benelli, Wouter R. Karthaus, Judy Hess, Michael Sigouros, Adam Donoghue, Myriam Kossai, Dong Gao, Joanna Cyrta, Verena Sailer, Aram Vosoughi, Chantal Pauli, Yelena Churakova, Cynthia Cheung, Lesa Dayal Deonarine, Terra J. McNary, Rachele Rosati, Scott T. Tagawa, David M. Nanus, Juan Miguel Mosquera, Charles L. Sawyers, Yu Chen, Giorgio Inghirami, Rema A. Rao, Carla Grandori, Olivier Elemento, Andrea Sboner, Francesca Demichelis, Mark A. Rubin, Himisha Beltran

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Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia by Mayumi Sugita, David C. Wilkes, Rohan Bareja, Kenneth W. Eng, Sarah Nataraj, Reyna A. Jimenez-Flores, LunBiao Yan, Jeanne Pauline De Leon, Jaclyn A. Croyle, Justin Kaner, Swathi Merugu, Sahil Sharma, Theresa Y. MacDonald, Zohal Noorzad, Palak Panchal, Danielle Pancirer, Shuhua Cheng, Jenny Z. Xiang, Luke Olson, Koen Van Besien, David S. Rickman, Susan Mathew, Wayne Tam, Mark A. Rubin, Himisha Beltran, Andrea Sboner, Duane C. Hassane, Gabriela Chiosis, Olivier Elemento, Gail J. Roboz, Juan Miguel Mosquera, Monica L. Guzman

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Integration of whole-exome and anchored PCR-based next generation sequencing significantly increases detection of actionable alterations in precision oncology by Shaham Beg, Rohan Bareja, Kentaro Ohara, Kenneth Wha Eng, David C. Wilkes, David J. Pisapia, Wael Al Zoughbi, Sarah Kudman, Wei Zhang, Rema Rao, Jyothi Manohar, Troy Kane, Michael Sigouros, Jenny Zhaoying Xiang, Francesca Khani, Brian D. Robinson, Bishoy M. Faltas, Cora N. Sternberg, Andrea Sboner, Himisha Beltran, Olivier Elemento, Juan Miguel Mosquera

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Adjunctive Medication Management and Contingency Management to enhance adherence to acamprosate for alcohol dependence: the ADAM trial RCT by Kim Donoghue, Sadie Boniface, Eileen Brobbin, Sarah Byford, Rachel Coleman, Simon Coulton, Edward Day, Ranjita Dhital, Anum Farid, Laura Hermann, Amy Jordan, Andreas Kimergård, Maria-Leoni Koutsou, Anne Lingford-Hughes, John Marsden, Joanne Neale, Aimee O’Neill, Thomas Phillips, James Shearer, Julia Sinclair, Joanna Smith, John Strang, John Weinman, Cate Whittlesea, Kideshini Widyaratna, Colin Drummond

“…Setting Specialist alcohol treatment services in five regions of England (South East London, Central and North West London, Wessex, Yorkshire and Humber and West Midlands). …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…“Allocating Organs to Cognitively Impaired Patients,” New England Journal of Medicine 376, no. 4 (2017): 299-301. …”
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Marketing madness by Anne Zimmerman

“…[xxiv]For a list of all 27 amicus briefs filed see https://www.scotusblog.com/case-files/cases/sorrell-v-ims-health-inc/ For example, in support of the Vermont law, the AARP, New England Journal of Medicine, the Electronic Privacy Information Center, the Vermont Medical Society, Berkeley Media Studies, Public Health Law and Policy filed amicus curiae briefs. …”
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