The Use of Tissue-on-Chip Technology to Focus the Search for Extracellular Vesicle miRNA Biomarkers in Thyroid Disease by Thomas Haigh, Hannah Beattie, Mark A. Wade, James England, Dmitriy Kuvshinov, Laszlo Karsai, John Greenman, Victoria Green

“…The current study uses an established method to maintain human thyroid tissue ex vivo on a tissue-on-chip device, allowing the collection, isolation and interrogation of the sEVs released directly from thyroid tissue. sEVs were analysed for differences in miRNA levels released from benign thyroid tissue, Graves’ disease tissue and papillary thyroid cancer (PTC), using miRNA sequencing and quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) to identify potential biomarkers of disease. …”
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The Prognostic Value of PERK in Cancer and Its Relationship With Immune Cell Infiltration by Peng Wang, Liying Han, Moxin Yu, Zhengyu Cao, Xiaoning Li, Yunxia Shao, Guoping Zhu

“…The TIMER database was used to investigate the correlation between PERK expression and tumor-infiltrating immune cells and analyze the relationship of PERK with marker genes of immune cells which were downloaded from the CellMarker database in BRCA, HNSC, and THCA.Results: PERK was differentially expressed in various cancers, such as breast cancer, liver cancer, lung cancer, gastric carcinoma, lymphoma, thyroid cancer, leukemia, and head and neck squamous cell carcinomas. …”
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The Combination of Sonographic Features and the Seven-Gene Panel May be Useful in the Management of Thyroid Nodules With Indeterminate Cytology by Marco Capezzone, Silvia Cantara, Andrea Di Santo, Alfonso Sagnella, Tania Pilli, Lucia Brilli, Cristina Ciuoli, Fabio Maino, Raffaella Forleo, Alessandra Cartocci, Maria Grazia Castagna

“…On the contrary, in TIR3B nodules both US risk stratification and seven-gene panel seem to be of little use, because the risk of thyroid cancer remains high regardless of US score and mutational status.…”
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Cutaneous lesions and other non-endocrine manifestations of Multiple Endocrine Neoplasia type 1 syndrome by Laura Pierotti, Elena Pardi, Elisa Dinoi, Paolo Piaggi, Simona Borsari, Simone Della Valentina, Chiara Sardella, Angela Michelucci, Maria Adelaide Caligo, Fausto Bogazzi, Claudio Marcocci, Claudio Marcocci, Filomena Cetani

“…Gastric leiomyoma was present in 1.1% of the patients and uterine leiomyoma in 14% of women. Thyroid cancer, breast cancer, lung cancer, basal cell carcinoma, melanoma, and colorectal cancer were present in 4.9%, 2.7%, 1.6%, 1.6%, 2.2%, and 0.5% of the whole series, respectively.ConclusionsWe found a significantly higher prevalence of angiofibromas and lipomas in F-MEN1 compared with S-MEN1 and in MEN1 mutation-positive compared to MEN1 mutation-negative patients. …”
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Pregnancy related cancer in Apulia. A population based linkage study by Ferdinando Murgia, Marco Marinaccio, Gennaro Cormio, Vera Loizzi, Rossana Cicinelli, Stefano Bettocchi, Ettore Cicinelli

“…Breast cancer was the most common cancer (37.7 cases per 100,000 pregnancies) and as a typical feature in our population thyroid cancers followed it by incidence (22.3 per 100,000 pregnancies). …”
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Consequences of parental preconceptional irradiation: Endocrine-metabolic pathology in offspring by S. F. Sosnina, P. O. Okatenko, M. E. Sokolnikov

“…Results: A significant predominance of thyroid diseases, particularly, iodine deficiencies, was detected at an earlier age among the offspring of Mayak Production Association workers compared to the control group; these cases were mostly related to low dose parental preconceptional exposure. Thyroid cancer was further detected in 0.16% (15/9321) of the studied cohort of the offspring of exposed parents with average manifestation age of 42.6. …”
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Preoperative risk stratification for patients with ≤ 1 cm papillary thyroid carcinomas based on preoperative blood inflammatory markers: construction of a dynamic predictive model... by Lingqian Zhao, Lingqian Zhao, Tao Hu, Tao Hu, Yuan Cai, Yuan Cai, Tianhan Zhou, Wenhao Zhang, Fan Wu, Yu Zhang, Dingcun Luo, Dingcun Luo

“…In addition, a preoperative risk stratification predictive model was constructed and validated.MethodsClinical and pathologic data, as well as preoperative blood specimens, were collected from patients who underwent initial thyroid cancer surgery at the Hangzhou First People’s Hospital, from January 2014 to January 2023. …”
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Strain Elastography as a Valuable Diagnosis Tool in Intermediate Cytology (Bethesda III) Thyroid Nodules by Dana Stoian, Florin Borcan, Izabella Petre, Ioana Mozos, Flore Varcus, Viviana Ivan, Andreea Cioca, Adrian Apostol, Cristina Adriana Dehelean

“…The combined conventional ultrasound and elastography identified thyroid cancer in cases with intermediate cytology with a sensitivity of 89.5% with a specificity of 50%. …”
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Performance of multigene testing in cytologically indeterminate thyroid nodules and molecular risk stratification by Yuanyuan Zhou, Xinping Wu, Yuzhi Zhang, Zhiqiang Li, Xia Ge, Hao Chen, Yuan Mao, Wenbo Ding

“…Objective Thyroid cancer is the third most prevalent cancer among females. …”
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Second Cancers in Classical Hodgkin Lymphoma and Diffuse Large B-Cell Lymphoma: A Systematic Review by the Fondazione Italiana Linfomi by Luca Nassi, Vitaliana De Sanctis, Giacomo Loseto, Chiara Gerardi, Eleonora Allocati, Sabino Ciavarella, Carla Minoia, Attilio Guarini, Alessia Bari

“…Moreover, the authors discuss additional papers, to guide the early diagnosis of lung, colorectal, skin, and thyroid cancer in patients at risk due to family history, drug or RT exposure, or unhealthy lifestyles. …”
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Circ_0058124 Aggravates the Progression of Papillary Thyroid Carcinoma by Activating LMO4 Expression via Targeting miR-370-3p by Liu L, Yan C, Tao S, Wang H

“…Lei Liu,1 Chaohui Yan,1 Shudong Tao,1 Hailing Wang2 1Department of Otorhinolaryngology & Head and Neck Surgery, Tianjin Third Central Hospital, Tianjin, People’s Republic of China; 2Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People’s Republic of ChinaCorrespondence: Hailing WangDepartment of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, North Ring Lake West Road, Heyuan District, Tianjin 300060, People’s Republic of ChinaTel/Fax +86 022– 23340123Email mimohg@163.comBackground: Thyroid cancer is the most common malignant tumor in the endocrine system. …”
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Goitre-A Clinical Image by Aman Chhabra, Vaishali Kuchewar, Twinkle Joshi

“…They form an entity known as simple nodular goitre when dysregulation, thyroiditis, autoimmune thyroid disease, and thyroid cancer are absent [1]. This is regularly observed in nations without a public health initiative to prevent iodine deficiency [2].The case is relevant as it signifies a rare clinical condition which in future causes systemic complications. …”
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Selenium and thyroid diseases by Fei Wang, Fei Wang, Chunyu Li, Chunyu Li, Shaoxin Li, Shaoxin Li, Lili Cui, Lili Cui, Junyu Zhao, Junyu Zhao, Lin Liao, Lin Liao

“…Selenium supplementation in Hashimoto’s thyroiditis was associated with the decreased levels of anti-thyroid peroxidase antibody and improved thyroid ultrasound structure. In thyroid cancer, various selenium supplements have shown variable anticancer activity. …”
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An Easy Guide for Voice Evaluation in the Clinic by Filipina T. Cevallos-Schnabel

“…A voice problem becoming worse and permanent could be a growing polyp or cyst, vocal fold paralysis in laryngeal cancer or thyroid cancer.  A long lecture triggering the hoarseness and rest relieving it may suggest soft nodules, or Reinke’s edema due to vocal fold trauma of voice abuse and misuse.   …”
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Cancer incidence in Canada: trends and projections (1983-2032) by Lin Xie, Robert Semenciw, Les Mery

“…For females, breast, lung, colorectal and uterine cancers figure as the top 4 most common incident cancers in both periods. However, thyroid cancer will overtake non-Hodgkin lymphoma as the fifth most common cancer by 2028-2032. …”
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Overexpressed ZC3H13 suppresses papillary thyroid carcinoma growth through m6A modification-mediated IQGAP1 degradation by Rong Xie, Wanzhi Chen, Yunxia Lv, Debin Xu, Da Huang, Tao Zhou, Shuyong Zhang, Chengfeng Xiong, Jichun Yu

“…Then, ZC3H13 overexpression/knockout thyroid cancer cells were constructed by lentivirus transfection, and the effects of overexpression of ZC3H13 on the proliferation, migration and invasion of PTC cells were detected by CCK8 and transwell experiments. …”
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Cancer survival analysis on population-based cancer registry data in Zhejiang Province, China (2018–2019) by Huizhang Li, Youqing Wang, Weiwei Gong, Chen Zhu, Le Wang, Yaoyao Chen, Lingbin Du, Xiangdong Cheng

“…The top five cancers with top age-standardized 5-year RS were thyroid cancer (96.0%), breast cancer (84.3%), testicular cancer (79.9%), prostate cancer (77.2%), and bladder cancer (70.6%), and the five cancers with the lowest age-standardized 5-year RS were pancreatic cancer (6.0%), liver cancer (15.6%), gallbladder cancer (17.1%), esophageal cancer (22.7%), and leukemia (31.0%). …”
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Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies by Georgios Boutzios, Eleni Koukoulioti, Andreas V. Goules, Ioannis Kalliakmanis, Ilias Giovannopoulos, Panayiotis Vlachoyiannopoulos, Haralampos M. Moutsopoulos, Haralampos M. Moutsopoulos, Athanasios G. Tzioufas

“…In the subgroup of patients with additional autoimmune diseases (n = 140), younger age and positive APCA were independently associated with the presence of organ-specific autoimmunity (OR 0.954, 95% CI 0.927–0.982 and OR 3.100, 95% CI 1.256–7.652, respectively). Papillary thyroid cancer (PTC) occurred in 3.5% of patients (26/29 women). …”
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Silicon-photomultiplier-based PET/CT reduces the minimum detectable activity of iodine-124 by David Kersting, Walter Jentzen, Pedro Fragoso Costa, Miriam Sraieb, Patrick Sandach, Lale Umutlu, Maurizio Conti, Fadi Zarrad, Christoph Rischpler, Wolfgang Peter Fendler, Ken Herrmann, Manuel Weber

“…Abstract The radioiodine isotope pair 124I/131I is used in a theranostic approach for patient-specific treatment of differentiated thyroid cancer. Lesion detectability is notably higher for 124I PET (positron emission tomography) than for 131I gamma camera imaging but can be limited for small and low uptake lesions. …”
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Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodie... by Ivan Blažeković, Matija Romić, Marija Bosak Butković, Ines Šiško Markoš, Vedrana Gladić Nenadić, Valentina Vidranski, Petra Petranović Ovčariček, Dražena Krilić, Tea Varjačić, Josip Staničić, Roko Granić, Marija Punda, Ivan Mihaljević, Tomislav Jukić, Maja Franceschi

“…The worldwide incidence of differentiated thyroid cancer (DTC) has increased in recent decades, likely due to frequent use of cervical ultrasonography (US) and US-guided fine needle aspiration biopsy (FNA)., US is performed during follow-up after thyroidectomy, and US-guided FNA with cytology is used if suspicious cervical lymph nodes (LN ) or thyroid bed masses are detected. …”
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