Responsiveness to immune checkpoint inhibitors versus other systemic therapies in RET-aberrant malignancies by Jessica Lee, Vivek Subbiah, Shuang Liu, Jason Roszik, David Hong, Funda Meric-Bernstam, John Heymach, Ramona Dadu, Kenneth Hess, Le Huang, Aparna Hegde, Alexander Y Andreev-Drakhlin, Maria Cabanillas, Mimi I Hu, Naifa L Busaidy, Steven I Sherman, Elizabeth G Grubbs, Siraj M Ali, Yasir Y Elamin, George R Simon, George R Blumenschein, Jr, Vassiliki A Papadimitrakopoulou

“…ICI therapy and a diagnosis other than medullary thyroid cancer (MTC) were independent risk factors for treatment discontinuation.Conclusion Our study supports the prioritisation of non-ICI over ICI therapy in patients with RET+ tumours.…”
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Knockdown of Thymidine Kinase 1 Suppresses Cell Proliferation, Invasion, Migration, and Epithelial–Mesenchymal Transition in Thyroid Carcinoma Cells by Chang Liu, Chang Liu, Jian Wang, Li Zhao, Hui He, Pan Zhao, Zheng Peng, Feiyuan Liu, Juan Chen, Weiqing Wu, Guangsuo Wang, Fajin Dong

“…The present study aimed to determine the role TK1 in the progression of thyroid cancer and to explore the underlying molecular mechanisms. …”
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The Specifically Androgen-Regulated Gene (SARG) Promotes Papillary Thyroid Carcinoma (PTC) Lymphatic Metastasis Through Vascular Endothelial Growth Factor C (VEGF-C) and VEGF Recep... by Shuai-Jun Xu, Shuai-Jun Xu, Bin Jin, Wei-Jun Zhao, Xue-Xian Chen, Xue-Xian Chen, Ying-Ying Tong, Ying-Ying Tong, Xiao-Fei Ding, Ying-Yuan Chen, Dong-Hao Wang, Zhi-Ming Wang, Bing-Qing Dai, Sai Chen, Yong Liang, Guang Chen, Su-Jiao Pan, Ling-Long Xu

“…The papillary thyroid carcinoma (PTC) metastasizes through lymphatic spread, but the follicular thyroid cancer (FTC) metastasis occurs by following hematogenous spread. …”
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Diagnostic performance of next-generation sequencing and genetic profiling in thyroid nodules from a single center in China by Min Ren, Qianlan Yao, Longlong Bao, Zhiting Wang, Ran Wei, Qianming Bai, Bo Ping, Cai Chang, Yu Wang, Xiaoyan Zhou, Xiaoli Zhu

“…Objective: The data regarding the mutation landscape in Chinese patients with thyroid cancer are limited. The diagnostic performance of thyroid nodul es by fine-needle aspiration (FNA) cytology needs optimization, especially in indeterminate nodules. …”
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LRP-1-dependent control of calpain expression and activity: A new mechanism regulating thyroid carcinoma cell adhesion by Benoit Langlois, Benoit Langlois, Julie Martin, Julie Martin, Christophe Schneider, Christophe Schneider, Cathy Hachet, Cathy Hachet, Christine Terryn, Damien Rioult, Laurent Martiny, Laurent Martiny, Louis Théret, Louis Théret, Stéphanie Salesse, Stéphanie Salesse, Stéphane Dedieu, Stéphane Dedieu

“…In conclusion, we identified an additional and innovative intracellular mechanism which demonstrates LRP-1 pro-motile action in thyroid cancer cells. LRP-1 ability to specifically control calpain-2 expression and activity highlights a novel facet of its de-adhesion receptor status.…”
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Prediction model of cervical lymph node metastasis based on clinicopathological characteristics of papillary thyroid carcinoma: a dual-center retrospective study by Wenji Liu, Wenji Liu, Die Zhang, Die Zhang, Hui Jiang, Hui Jiang, Jie Peng, Jie Peng, Fei Xu, Fei Xu, Hongxin Shu, Hongxin Shu, Zijian Su, Zijian Su, Tao Yi, Yunxia Lv

“…BackgroundThe overall prevalence of papillary thyroid carcinoma (PTC) patients is expanding along with an ongoing increase in thyroid cancer incidence. Patients with PTC who have lymph node metastases have a poor prognosis and a high death rate. …”
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Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease by Alexander T. Williams, Jing Chen, Kayesha Coley, Chiara Batini, Abril Izquierdo, Richard Packer, Erik Abner, Stavroula Kanoni, David J. Shepherd, Robert C. Free, Edward J. Hollox, Nigel J. Brunskill, Ioanna Ntalla, Nicola Reeve, Christopher E. Brightling, Laura Venn, Emma Adams, Catherine Bee, Susan E. Wallace, Manish Pareek, Anna L. Hansell, Tõnu Esko, Estonian Biobank Research Team, Daniel Stow, Benjamin M. Jacobs, David A. van Heel, Genes & Health Research Team, William Hennah, Balasubramanya S. Rao, Frank Dudbridge, Louise V. Wain, Nick Shrine, Martin D. Tobin, Catherine John

“…In Europeans, the TSH polygenic score is associated with thyroid disease, including thyroid cancer and age-of-onset of hypothyroidism and hyperthyroidism. …”
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Whole-Body MRI Surveillance—Baseline Findings in the Swedish Multicentre Hereditary <i>TP53</i>-Related Cancer Syndrome Study (SWEP53) by Meis Omran, Emma Tham, Yvonne Brandberg, Håkan Ahlström, Claudia Lundgren, Ylva Paulsson-Karlsson, Ekaterina Kuchinskaya, Gustav Silander, Anna Rosén, Fredrik Persson, Henrik Leonhardt, Marie Stenmark-Askmalm, Johanna Berg, Danielle van Westen, Svetlana Bajalica-Lagercrantz, Lennart Blomqvist, on behalf of the Swedish Clinical TP53 Study Group (SweClinTP53)

“…In total, 42 showed a normal scan, while 19 (31%) needed further workup, of whom three individuals (3/19 = 16%) were diagnosed with asymptomatic malignant tumours (thyroid cancer, disseminated upper GI cancer, and liver metastasis from a previous breast cancer). …”
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Tyr Phosphatase-Mediated P-ERK Inhibition Suppresses Senescence in EIA + v-raf Transformed Cells, Which, Paradoxically, Are Apoptosis-Protected in a MEK-Dependent Manner by Stefania De Vitis, Antonella Sonia Treglia, Luca Ulianich, Stefano Turco, Giuseppe Terrazzano, Angela Lombardi, Claudia Miele, Corrado Garbi, Francesco Beguinot, Bruno Di Jeso

“…High tyrosine phosphatase activity and evasion from senescence were confirmed in an anaplastic thyroid cancer cell line. Therefore, besides EIA, EIA + raf cells suppress senescence through a new mechanism, namely, phosphatase-mediated P-ERK1/2 inhibition, but, paradoxically, retain the oncogenic effects of the Raf-ERK pathway. …”
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Evaluation of SNA001, a Novel Recombinant Human Thyroid Stimulating Hormone Injection, in Patients With Differentiated Thyroid Carcinoma by Yushen Gu, Hongrong Xu, Yanling Yang, Yan Xiu, Pengcheng Hu, Min Liu, Xiangqing Wang, Jun Song, Yan Di, Jian Wang, Xiaoxia Zhang, Tao Xu, Xuening Li, Hongcheng Shi

“…To assess the safety, tolerance, pharmacokinetic and pharmacodynamic properties of SNA001, the two-period (SNA001 period and THW period), dose-ascending study in well-differentiated thyroid cancer (DTC) patients was designed. Three doses (0.45 mg, 0.9 mg, and 1.35 mg) of SNA001 were intramuscularly injected, twice in the SNA001 period to stimulate iodine-131 uptake and thyroglobulin (Tg) release. 24 h after the last dose of SNA001, iodine-131 (111–185 MBq) was administrated, followed by whole-body scan (WBS) 48 h later. …”
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Low Expression of the Polycomb Protein RING1 Predicts Poor Prognosis in Human Breast Cancer by Song Gao, Si-Yu Wang, Si-Yu Wang, Xing-Da Zhang, Xing-Da Zhang, Hao Wu, Hao Wu, Hao Wu, Hao Wu, Da Pang, Da Pang, Da Pang, Da Pang

“…However, its expression level was decreased in COAD (Colon Cancer), KICH (Kidney Chromophobe), KIRP (kidney papillary cell carcinoma), THCA (Thyroid Cancer), and BRCA (Breast carcinoma). RING1 low expression is an unfavorable prognostic factor in many cancer patients, especially in breast cancer patients. …”
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Comparative N-Glycoproteomics Analysis of Clinical Samples Via Different Mass Spectrometry Dissociation Methods by Wenjuan Zeng, Shanshan Zheng, Tao Su, Jiahan Cheng, Yonghong Mao, Yi Zhong, Yueqiu Liu, Jianhai Chen, Wanjun Zhao, Tianhai Lin, Fang Liu, Guisen Li, Hao Yang, Yong Zhang

“…The intact N-glycopeptides of distinct samples, namely, plasma from prostate cancer (PCa) patients, urine from immunoglobulin A nephropathy (IgAN) patients, human hepatocarcinoma cell line (HepG2), and thyroid tissues from thyroid cancer (TC) patients were analyzed by these methods. …”
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Contrast-enhanced ultrasound combined targeted microbubbles for diagnosis of highly aggressive papillary thyroid carcinoma by Jiaojiao Ma, Jiaojiao Ma, Yuan Wang, Xuehua Xi, Jiajia Tang, Jiajia Tang, Linping Wang, Linping Wang, Liangkai Wang, Liangkai Wang, Di Wang, Xiaolong Liang, Bo Zhang, Bo Zhang, Bo Zhang

“…BackgroundAccurate diagnosis of highly aggressive papillary thyroid cancer (PTC) may greatly help avoid overdiagnosis and overtreatment of PTC. …”
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Carcinoma papilífero da tireoide associado à tireoidite de Hashimoto: frequência e aspectos histopatológicos Papillary thyroid carcinoma associated to Hashimoto's thyroiditis: freq... by Denise Cruz Camboim, Vivina Marta Simões da Motta Figueirôa, Daisy Nunes de Oliveira Lima, Paula Abreu-e-Lima, Maria do Carmo Carvalho de Abreu-e-Lima

“…<br>INTRODUCTION: Papillary carcinoma is the most common type of thyroid cancer and Hashimoto's thyroiditis is the most frequent cause of hypothyroidism in areas where iodine levels are adequate. …”
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Cardiovascular Toxicities Secondary to Biotherapy and Molecular Targeted Therapies in Neuroendocrine Neoplasms: A Systematic Review and Meta-Analysis of Randomized Placebo-Controll... by Charalampos Aktypis, Maria-Eleni Spei, Maria Yavropoulou, Göran Wallin, Anna Koumarianou, Gregory Kaltsas, Eva Kassi, Kosmas Daskalakis

“…Placebo-controlled randomized clinical trials (RCTs) in patients with metastatic NENs, including medullary thyroid cancer (MTC) were included. A total of 3695 articles and 122 clinical trials registered in clinicaltrials.gov were screened. …”
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Avaliação de novas tecnologias PET/CT medicina nuclear. by Maria Rosário Giraldes

“…The use of PET in cancer treatment must be done only in the cancer of mama; cáncer colorectal; cancer of esofagus; cancer of head and neck; lung cancer; linfoma; melanoma; and Solitary Pulmonary Nodules; cancer of thyroid; cancer cervical . Those types of cancer are 46,7 % of total cancer mortality. …”
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Identification of Osteosarcoma Metastasis-Associated Gene Biomarkers and Potentially Targeted Drugs Based on Bioinformatic and Experimental Analysis [Retraction] by Cao MD, Song YC, Yang ZM, Wang DW, Lin YM, Lu HD

“…Identification of immune-related lncRNAs to improve the prognosis prediction for patients with papillary thyroid cancer. Biosci Rep. 2021;41(2): BSR20204086. doi: https://doi.org/10.1042/BSR20204086, respectively. …”
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P82 by S. Shevchenko, L, Mostovich, G. Logacheva, S. Svyatchenko, L. Gulyaeva

“…Papillary thyroid cancer (PTC) is the most common malignancy of the endocrine system. …”
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Feasibility of active surveillance in patients with clinically T1b papillary thyroid carcinoma ≤1.5 cm in preoperative ultrasonography: MASTER study by Sang-Hyeon Ju, Yong Bae Ji, Minchul Song, Joung Youl Lim, Da Beom Heo, Min-Gyu Kim, Jae Won Chang, Ho-Ryun Won, Yea Eun Kang, Eu Jeong Ku, Mijin Kim, Eun Kyung Lee, June Young Choi, Hyeong Won Yu, Young Joo Park, Jun-Ho Choe, Bon Seok Koo

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Case report: Tisagenlecleucel for treatment of relapsed B- acute lymphoblastic leukemia in a patient with CHEK2 mutation by Abraham Ipe, Anne Angiolillo, Anne Angiolillo, David Jacobsohn, David Jacobsohn, Jinjun Cheng, Jinjun Cheng, Miriam Bornhorst, Miriam Bornhorst, Joyce Turner, Joyce Turner, Anant Vatsayan, Anant Vatsayan

“…Extended family history also revealed a diagnosis of anaplastic thyroid cancer in maternal uncle at the age of 44 years. …”
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