Elly Kasim dan Perubahan Sosial: Analisis LIrik Lagu Minangkabau dalam Album Top Hits (1960-1970) by Novi Yulia

“…Penelitian ini menunjukkan perubahan masyarakat Minangkabau dan gambaran realitas sosial-budaya Minangkabau dalam empat isu utama yaitu rantau, nilai dan norma, revitalisasi budaya, dan perubahan sosial dalam lirik lagu yang dinyanyikan Elly Kasim dalam Album Top Hits 1960-1970. kata kunci Revitalisasi budaya, lirik lagu, transisi, transformasi, perubahan sosial …”
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Reaction of African stocks markets to disequilibrium episodes of the COVID-19 infection: Evidence from the top hit African countries by Suleiman O. Mamman, Jamilu Iliyasu, Aliyu Rafindadi Sanusi

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In silico exploration of phenolics as modulators of penicillin binding protein (PBP) 2× of Streptococcus pneumoniae by Jamiu Olaseni Aribisala, Nosipho Wendy S’thebe, Saheed Sabiu

“…These findings point to the possible benefits of the top-hit phenolics, and most especially silicristin, in the direct and synergistic treatment of infections caused by S. pneumoniae. …”
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Comparing PCR-generated artifacts of different polymerases for improved accuracy of DNA metabarcoding by Satoshi Nagai, Sirje Sildever, Noriko Nishi, Satoshi Tazawa, Leila Basti, Takanori Kobayashi, Yoshizumi Ishino

“…To compare the differences in PCR kits used for this experiment, we focused on the following seven parameters: 1) Quality, 2) Chimera, 3) Blast top hit accuracy, 4) Deletion, 5) Insertion, 6) Base substitution and 7) Amplification bias amongst species. …”
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Genome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) gene. by Karen Kapur, Toby Johnson, Noam D Beckmann, Joban Sehmi, Toshiko Tanaka, Zoltán Kutalik, Unnur Styrkarsdottir, Weihua Zhang, Diana Marek, Daniel F Gudbjartsson, Yuri Milaneschi, Hilma Holm, Angelo Diiorio, Dawn Waterworth, Yun Li, Andrew B Singleton, Unnur S Bjornsdottir, Gunnar Sigurdsson, Dena G Hernandez, Ranil Desilva, Paul Elliott, Gudmundur I Eyjolfsson, Jack M Guralnik, James Scott, Unnur Thorsteinsdottir, Stefania Bandinelli, John Chambers, Kari Stefansson, Gérard Waeber, Luigi Ferrucci, Jaspal S Kooner, Vincent Mooser, Peter Vollenweider, Jacques S Beckmann, Murielle Bochud, Sven Bergmann

“…This SNP had the strongest association in individuals of European descent, while for individuals of Indian Asian descent the top hit was rs17251221 (p = 1.1 x 10(-21)), a SNP in strong linkage disequilibrium with rs1801725. …”
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Targeting neurolysin in acute myeloid leukemia by Sara Mirali, Aaron D. Schimmer

“…We recently identified the mitochondrial peptidase, neurolysin (NLN), as a top hit in an acute myeloid leukemia (AML) viability screen. …”
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Computational study to discover potent phytochemical inhibitors against drug target, squalene synthase from Leishmania donovani by Padmika Madushanka Wadanambi, Uthpali Mannapperuma

“…In addition, study of pharmacophore modeling confirmed that top hit phytochemicals and the reported inhibitor (E5700) share common chemical features for their biochemical interaction with LdSQS. …”
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Development of New Thiophene-Containing Triaryl Pyrazoline Derivatives as PI3Kγ Inhibitors by Bing Yang, Bo Zhang, Qun Zhao, Jin Li, Yujun Shi

“…The anti-proliferation inhibitory activity and the enzymatic inhibition potency indicated consistent tendencies. The top hit <b>3s</b> could inhibit the phosphorylation of Akt by inhibiting PI3K through the PI3K-Akt-mTOR pathway. …”
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The molecular interplay of known phytochemicals as Culex pipiens and Rift Valley fever virus inhibitors through molecular docking by Nael Abutaha, Fahd A. AL-Mekhlafi, Mohamed A Wadaan, Ahmed Moustafa Rady, Almohannad A.A. Baabbad, Mohammed S. Al-Khalifa

“…Anabsinthin (-11.1 kcal/mol), zapoterin (-9.4 kcal/mol), porrigenin A (-9.4 kcal/mol), and 3-Acetyl-11-keto-beta-boswellic acid (AKBA) (-9.4 kcal/mol) were the top hit compounds for Cx. Pipiens. Similarly, the top hit compounds for RVFV were zapoterin, porrigenin A, anabsinthin, and yamogenin. …”
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Seven Golden Rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry by Fiehn Oliver, Kind Tobias

“…In each case, the correct formula was ranked as top hit when combining the seven rules with database queries.…”
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First genome-wide association study in an Australian aboriginal population provides insights into genetic risk factors for body mass index and type 2 diabetes. by Denise Anderson, Heather J Cordell, Michaela Fakiola, Richard W Francis, Genevieve Syn, Elizabeth S H Scaman, Elizabeth Davis, Simon J Miles, Toby McLeay, Sarra E Jamieson, Jenefer M Blackwell

“…Nevertheless, genes/pathways in common with other ethnicities were identified despite the arrival of Aboriginal people in Australia >45,000 years ago. The top hit (rs10868204 Pgenotyped = 1.50x10-6; rs11140653 Pimputed_1000G = 2.90x10-7) for BMI lies 5' of NTRK2, the type 2 neurotrophic tyrosine kinase receptor for brain-derived neurotrophic factor (BDNF) that regulates energy balance downstream of melanocortin-4 receptor (MC4R). …”
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47 Cross-ancestry GWAS meta-analysis of keloids discovers novel susceptibility loci in diverse populations by Catherine Anne Greene, Gabrielle Hampton, Gail P. Jarvik, Bahram Namjou-Khales, Atlas Khan, Yuan Luo, Todd L. Edwards, Digna R. Velez Edwards, Jacklyn N. Hellwege

“…Keloid heritability estimates from LDSC were 6%, 21%, and 34% for European, East Asian, and African ancestry, respectively. The top hit (P = 1.7e-77) in the cross-ancestry analysis was at a replicated variant (rs10863683) located downstream of LINC01705. …”
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Quantitative and qualitative proteome characteristics extracted from in-depth integrated genomics and proteomics analysis. by Low, T, van Heesch, S, van den Toorn, H, Giansanti, P, Cristobal, A, Toonen, P, Schafer, S, Hübner, N, van Breukelen, B, Mohammed, S, Cuppen, E, Heck, A, Guryev, V

“…Our multilevel analysis identified a genomic variant in the promoter of the most differentially expressed gene Cyp17a1, a previously reported top hit in genome-wide association studies for human hypertension, as a potential contributor to the hypertension phenotype in SHR rats. …”

Genome-wide association study reveals a polymorphism in the podocyte receptor RANK for the decline of renal function in coronary patients. by Andreas Leiherer, Axel Muendlein, Philipp Rein, Christoph H Saely, Elena Kinz, Alexander Vonbank, Peter Fraunberger, Heinz Drexel

“…We revealed a suggestive association with 3 polymorphisms, surpassing genome-wide significance (p = 4.0 e-7). The top hit rs17069906 (p = 5.6 e-10) is located within the genomic region of RANK, recently demonstrated to be an important player in the adaptive recovery response in podocytes and suggested as a promising therapeutic target in glomerular diseases.…”
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Quantitative and qualitative proteome characteristics extracted from in-depth integrated genomics and proteomics analysis by Low, T, vanHeesch, S, vandenToorn, H, Giansanti, P, Cristobal, A, Toonen, P, Schafer, S, Hübner, N, vanBreukelen, B, Mohammed, S, Cuppen, E, Heck, A, Guryev, V

“…Our multilevel analysis identified a genomic variant in the promoter of the most differentially expressed gene Cyp17a1, a previously reported top hit in genome-wide association studies for human hypertension, as a potential contributor to the hypertension phenotype in SHR rats. …”

Machine learning for predicting lifespan-extending chemical compounds by Barardo, D, Newby, D, Thornton, D, Ghafourian, T, Pedro de Magalhães, J, Freitas, A

“…We applied our best model to predict compounds which are more likely to increase C. elegans’ lifespan in the DGIdb database, where the effect of the compounds on an organism’s lifespan is unknown. The top hit compounds can be broadly divided into four groups: compounds affecting mitochondria, compounds for cancer treatment, anti-inflammatories, and compounds for gonadotropin-releasing hormone therapies.…”

In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor–microenvironment interactions by Su, P, Liu, Y, Chen, T, Xue, Y, Zeng, Y, Zhu, G, Chen, S, Teng, M, Ci, X, Guo, M, He, MY, Hao, J, Chu, V, Xu, W, Wang, S, Mehdipour, P, Xu, X, Marhon, SA, Soares, F, Pham, N, Wu, BX, Her, PH, Feng, S, Alshamlan, N

“…By comparing targeted CRISPR–Cas9 screens in a two-dimensional culture with xenografts derived from the same cell line, we identified MEN1 as the top hit that confers differential dropout effects in vitro and in vivo. …”

Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation by Maria Fomicheva, Ian G Macara

“…Using this powerful assay, we performed a genome-wide CRISPR/Cas9 knockout screen, selecting for cells that proliferate normally at low density but continue to divide at high density. Unexpectedly, one top hit was Traf3, a negative regulator of NF-κB signaling that has never previously been linked to density-dependent proliferation. …”
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The PRMT5/WDR77 complex restricts hepatitis E virus replication. by Xiaohui Ju, Yanying Yu, Wenlin Ren, Lin Dong, Xianbin Meng, Haiteng Deng, Yuchen Nan, Qiang Ding

“…Of note, the protein arginine methyltransferase 5 (PRMT5)/WDR77 complex was identified in both cell culture models as the top hit. Furthermore, we demonstrated that PRMT5 and WDR77 can specifically inhibit HEV replication, but not other viruses such as HCV or SARS-CoV-2, and this inhibition is conserved among different HEV strains and genotypes. …”
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De Novo Transcriptome Analysis of Allium cepa L. (Onion) Bulb to Identify Allergens and Epitopes. by Hemalatha Rajkumar, Ramesh Kumar Ramagoni, Vijayendra Chary Anchoju, Raju Naik Vankudavath, Arshi Uz Zaman Syed

“…Of the categorized genes, 61.2% showed metabolic functions followed by cellular components such as binding, cellular processes; catalytic activity and cell part. With BLASTx top hit analysis, a total of 2,511 homologous allergenic sequences were found, which had 37-100% similarity with 46 different types of allergens existing in the database. …”
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