Medication use and comorbidities in an increasingly younger osteoarthritis population: an 18-year retrospective open-cohort study by Jerry Hall, Brian J Piper, Haiyan Sun, Edward Casey, Jove Graham, Tonia Novosat, Joseph A Boscarino, Melissa S Kern, Vanessa A Hayduk, Craig Beck, Rebecca L Robinson, Patricia Dorling, Eric Wright

“…Patients had low comorbidity overall, but anxiety, depression and gastro-oesophageal reflux disease showed the largest increases in prevalence. Opioid use (tramadol and non-tramadol) showed peaks followed by declines, while most other medications increased slightly in use or remained steady.Conclusions We observe increasing OA prevalence and a greater proportion of younger patients over time. …”
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A buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72 h in mouse femoral fracture models by Angelique Wolter, Christian H. Bucher, Sebastian Kurmies, Viktoria Schreiner, Frank Konietschke, Katharina Hohlbaum, Robert Klopfleisch, Max Löhning, Christa Thöne-Reineke, Frank Buttgereit, Jörg Huwyler, Paulin Jirkof, Anna E. Rapp, Annemarie Lang

“…The BUP-Depot provided effective analgesia for 72 h, comparable to the effectiveness of Tramadol in the drinking water. Fracture healing outcome was not different between analgesic regimes. …”
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The evaluation of the efficacy of etofenamate spray in postoperative cesarean pain: Randomized, double-blind, placebo-controlled trial by Kübra Bakİ Erİn, Recep Erİn, Safia Omar Sahal, Seyfi Kartal, Deniz Kulaksiz

“…If analgesia was insufficient, tramadol (Contramal®) 50 mg IV doses were added and recorded. …”
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Comparison of Efficacy of Erector Spinae Plane Block with Paravertebral Block for Postoperative Analgesia in Patients Undergoing Breast Cancer Surgery by Arjun Singh, Nidhi Agrawal, Udismita Baruah, Surabhi Sandill

“…Both the groups were comparable in terms of fentanyl requirement and total 24 hours tramadol requirement Other parameters like postoperative nausea vomiting, effect on hemodynamic and overall patient satisfaction were also comparable between the two groups. …”
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A prospective, randomized clinical study for evaluation of pregabalin for post-operative analgesia in infraumbilical surgeries by Mona Bhalavi, Kishore Uikey, Seema Bhalavi, Sonali Tripathi

“…In Group P, rescue analgesic Inj. Tramadol was given after 12.33±3.47 h as compared to 3.47±8.19 h in Group D (P<0.0001) with total need of 133.56±49.27 mg and 210.73±63.35 mg over 24 h in patients of Groups P and D, respectively (P<0.0001). …”
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Opioid prescription patterns in the province of Las Palmas, Canary Islands, Spain (2016–2020): differences between urban and rural areas by Alexis Oliva, Patricia González de Chavez, Sandra Dévora, Susana Abdala

“…The dispensation level of strong opioids varied between islands, from 56.41% for Fuerteventura vs. 17.61% for Gran Canaria, although these values remained stable. Tramadol with acetaminophen and Tramadol in monotherapy were the most consumed forms of the weak opioids, whereas Buprenorphine was the most used strong opioid followed by Fentanyl, although demand for it varied between islands, the transdermal formulations were the most frequent pharmaceutical preparation.Conclusion: The differences in prescription opioid use are most likely explained by the opioid prescribing practices in each island, whereas factors such urbanicity level, population age, population density and status socioeconomic does not help to explain the differences in prescription opioid use across rural and urban areas.…”
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Estudio prospectivo comparativo del manejo de la analgesia preventiva en pacientes sometidos a artroplastia total de rodilla primaria by Fernando Adrián Lopreite, Santiago Iglesias, Daniel Veloz Serrano, Alfredo Montero Vinces, Hernán del Sel

“…El grupo A recibió analgesia preoperatoria con una combinación de etoricoxib, tramadol y paracetamol, por vía oral, 2 horas antes de la cirugía. …”
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Twelfth thoracic vertebra erector spinae plane block for postoperative analgesia and early recovery after lumbar spine surgery in elderly patients: a single-blind randomized contro... by Aijia Zhang, Jiaxin Chen, Xiaoyun Zhang, Tao Jiang, Dongmei Li, Xuemin Cai, Haixu Wang, Wengang Ding

“…The ESPB group had less intraoperative remifentanil use (P < 0.001), and less tramadol use within 72 h postoperatively (P < 0.001). …”
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Single dose dipyrone for acute postoperative pain. by Edwards, J, Meseguer, F, Faura, C, Moore, R, McQuay, H, Derry, S

“…There was no difference in participants experiencing at least 50% pain relief with 2.5 g intravenous dipyrone and 100 mg intravenous tramadol (70% vs 65%; two studies, 200 participants). …”

Single dose dipyrone for acute postoperative pain. by Edwards, J, Meseguer, F, Faura, C, Moore, R, McQuay, H, Derry, S

“…There was no difference in participants experiencing at least 50% pain relief with 2.5 g intravenous dipyrone and 100 mg intravenous tramadol (70% vs 65%; two studies, 200 participants). …”

Lumbar neuropathic pain of lower limbs treated by spinal infusion of ziconotide a case – report by Luca Quadrino

“…Initial treatment with tramadol gave poor results and a new protocol with hydromorphone – pregabalin was started. …”
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Screen-Printed Voltammetric Sensors—Tools for Environmental Water Monitoring of Painkillers by Katarzyna Tyszczuk-Rotko, Jędrzej Kozak, Bożena Czech

“…This article focuses on applying screen-printed voltammetric sensors for the voltammetric determination of painkillers residues, including non-steroidal anti-inflammatory drugs, paracetamol, and tramadol in environmental water samples. The main advantages of these electrodes are simplicity, reliability, portability, small instrumental setups comprising the three electrodes, and modest cost. …”
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Use of hyperbaric oxygen therapy to treat glans penis necrosis after prostatic artery embolization by Kelly Johnson-Arbor, David Field

“…Within days, he experienced tissue necrosis involving the glans penis. Treatment with tramadol, tadalafil, topical lidocaine, and hyperbaric oxygenation was initiated, and the necrosis resolved after fifteen days. …”
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Drugs of choice, drugs of change: Egyptian consumption habits since the 1920s by Robins, P

“…It will further ask how this composition has changed and why, giving special focus to the relatively new mass, opioid drug, Tramadol.…”

Opioids in geriatric units in 14 Belgian hospitals: prevalence, dosage and associated factors by Wim Henri Janssens, Nele J. Van Den Noortgate, Veerle Mouton, Peter Desmet, Katrien Van Puyvelde, Elke Steen, Caroline Maere, Katlijn Van Mulders, Eva De Raes, Julien Dekoninck, Celine Kympers, Bart Werbrouck, Jozefien Delaere, Ruth D. Piers

“…To achieve this, a multiple binary logistic regression model was fitted for opioid use, and a multiple linear regression model for opioid dose.Results: Opioids were used in 24.4% of 784 patients, of which 57.9% was treated with tramadol, 13.2% with oxycodone or morphine and 28.9% with transdermal buprenorphine or fentanyl. …”
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PREVALÊNCIA DE INTERAÇÕES MEDICAMENTOSAS ENVOLVENDO MEDICAMENTOS DE ALTA VIGILÂNCIA: ESTUDO TRANSVERSAL by Ana Laura Biral Cortes, Zenith Rosa Silvino, Fernanda Barbosa Moreira Santos, Juliana Aguiar Carvalho Pereira, Graziela Silva Tavares

“…Os principais MAVs nas IMP foram: insulina regular, midazolam, fentanil e tramadol. Dos 112 tipos de IMP identificados, algumas foram recorrentes; a saber: tramadol e ondansetrona, fentanil e midazolam, midazolam e omeprazol, insulina regular e hidrocortisona, bem como insulina regular e noradrenalina. …”
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Efficacy and safety of parecoxib and flurbiprofen axetil for perioperative analgesia in children: a network meta-analysis by Xi Chen, Xi Chen, Pan Chen, Xiao Chen, Min Huang, Kejing Tang, Qiuyi He

“…Compared with children who received tramadol treatment, both the children who received flurbiprofen axetil or parecoxib had lower pain scores at 8 h postoperatively. …”
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Optimization of an Enhanced Recovery After Surgery protocol for opioid-free pain management following robotic thoracic surgeryCentral MessagePerspectives by Karishma Kodia, MD, Ahmed Alnajar, MD, Joanne Szewczyk, MD, Joy Stephens-McDonnough, MsN, Nestor R. Villamizar, MD, Dao M. Nguyen, MD, MSc, FRCSC, FACS

“…Protocol optimization included replacing saline diluent with 0.25% bupivacaine and switching tramadol to as needed, keeping other aspects unchanged. …”
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Clinical case discussion: treating severe pain syndrome with strong opioids in combination with nsaids in a cancer patient by R. R. Sarmanaeva, G. R. Abuzarova

“…Most often, physicians encounter difficulties when transfer patients from tramadol to more potent tertiary preparations of WHO Analgesic Ladder. …”
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Co-prescribing of opioids and benzodiazepines/Z-drugs associated with all-cause mortality—A population-based longitudinal study in primary care with weak opioids most commonly pres... by Kristjan Linnet, Heidrun Sjofn Thorsteinsdottir, Johann Agust Sigurdsson, Johann Agust Sigurdsson, Emil Larus Sigurdsson, Emil Larus Sigurdsson, Larus Steinthor Gudmundsson

“…This increase in mortality was not observed among patients on &lt;1000 DDDs of benzodiazepines/Z-drugs.Conclusion: The study supports evidence suggesting that mortality increases in a dose-dependent manner in patients co-prescribed benzodiazepines/Z-drugs and weak opioids (codeine, tramadol). An association between the number of chronic conditions and a rise in mortality was found. …”
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