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Trpm8 Expression in Human and Mouse Castration Resistant Prostate Adenocarcinoma Paves the Way for the Preclinical Development of TRPM8-Based Targeted Therapies
Published 2022-01-01“…Our data demonstrate that D-3263 substantially enhances the pro-apoptotic activity of enzalutamide and docetaxel in TRAMP-C1 e TRAMP-C2 PCa cell lines. To conclude, this study provides the basis for pre-clinical in vivo testing of TRPM8 targeting as a novel strategy to implement the efficacy of standard-of-care treatments for advanced PCa.…”
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Shipping Management Simulation Game for Teaching and Learning in Higher Education: A Quasi-Experimental Study
Published 2019-11-01“…Further analysis indicated that there were differences in students’ achievement for the tramp services and liner services content. This improvement has boosted their confidence in making decision in solving problem related to the tramp services and liner services knowledge. …”
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86
The β-Secretase 1 Enzyme as a Novel Therapeutic Target for Prostate Cancer
Published 2023-12-01“…Additionally, the downstream product of BACE1 activity, i.e., Aβ1-42 expression, was also observed in these PCa tissues by IHC as well as by PET imaging in TRAMP mice. Furthermore, BACE1 gene expression and activity was confirmed in several established PCa cell lines (LNCaP, C4-2B-enzalutamide sensitive [S], C4-2B-enzalutamide resistant [R], 22Rv1-S, 22Rv1-R, PC3, DU145, and TRAMP-C1) by real-time PCR and fluorometric assay, respectively. …”
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87
Repertoire enhancement with adoptively transferred female lymphocytes controls the growth of pre-implanted murine prostate cancer.
Published 2012-01-01“…We identify in female CD4 T cells stimulated with TRAMP-C2 a dominant MHC II-restricted response to the Y-chromosome antigen DBY. …”
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MINDIN Exerts Protumorigenic Actions on Primary Prostate Tumors via Downregulation of the Scaffold Protein NHERF-1
Published 2021-01-01“…Upregulation of MINDIN and downregulation of NHERF-1 expression were observed both in human prostate cancer samples and in the TRAMP-C1 model. MINDIN silencing restored NHERF-1 expression to control levels in the mouse model. …”
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Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor angiogenesis in vivo
Published 2009“…To investigate the role of VDR in calcitriol effects on tumor vasculature, we established TRAMP-2 tumors subcutaneously into either VDR wild-type (WT) or knockout (KO) mice. …”
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Nexrutine® preserves muscle mass similar to exercise in prostate cancer mouse model
Published 2019-08-01“…Nexrutine® and exercise were equally able to protect TRAMP mice against PCa‐induced muscle loss (P = 0.04). …”
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91
Argentine ant, Linepithema humile (Mayr) (Insecta: Hymenoptera: Formicidae)
Published 2021-09-01“…Linepithema humile has been designated as a tramp ant species, meaning that it has an incredible ability to spread and establish in new areas and is difficult to control. …”
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Donald Trump's phenomenon; an analysis of the Celebritization of Politicians in the age of mediatization of politics
Published 2021-10-01“…This was a major reason of the success of Trump in the US presidential election. Therefore today, Tramp is mentioned as a celebrity politician or political superstar. …”
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Transforming the prostatic tumor microenvironment with oncolytic virotherapy
Published 2018-07-01“…Treatment of mice with bulky TRAMP-C2 tumors using oncolytic STEAP immunotherapy induced an overt delay in tumor progression, marked intratumoral lymphocytic infiltration with an active transcriptional profile and up-regulation of MHC class I. …”
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Iron supplementation enhances RSL3-induced ferroptosis to treat naïve and prevent castration-resistant prostate cancer
Published 2023-03-01“…Exploiting in vitro and in vivo human and murine PCa models and the multistage transgenic TRAMP model of PCa we show that RSL3 induces ferroptosis in PCa cells and demonstrate for the first time that iron supplementation significantly increases the effect of RSL3 triggering lipid peroxidation, enhanced intracellular stress and leading to cancer cell death. …”
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Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer
Published 2023-03-01“…Here, we demonstrate that two multi-target natural products, cannabidiol (CBD) and cannabigerol (CBG), suppress HRPC development in the TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model by reprogramming metabolic and oncogenic signaling. …”
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Discourse Analysis of Hassan Rouhani and Donald Trump Speeches at the General Assembly of the United Nations with PDAM Method
Published 2019-04-01“…In this paper, using content analysis methods and analyzing discourse, the text of the speeches of Hassan Rouhani and Donald Tramp at the general assembly of 2017 will be examined in quantitative and qualitative terms and discussed in the context of CMM as one of the ideas of the field of between Cultural communication. …”
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Activation of tolerogenic dendritic cells in the tumor draining lymph CD8+ T cells engineered to express CD40 ligand
Published 2012“…The antitumor CD8[supersript +] T cell response was further enhanced if TRAMP mice were also immunized with a tumor-specific Ag. …”
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Mort als aiguamolls : quan el plom de la caça es converteix en un verí
Published 2008-06-01“…Els milers de milions de perdigons de plom que s’usen cada any per caçar són petites trampes letals per als ocells que accidentalment els ingereixen. …”
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Towards a sustainable and resilient fleet management
Published 2017“…This work can be extended in the future to study the disruption management in tramp services, and to deal the positioning and loading sequence of cargos.…”
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Investigating radiotherapy response in a novel syngeneic model of prostate cancer
Published 2020“…Compared to the commonly used TRAMP C1 model, generated with SV40 large T-antigen, DVL3 tumours are immunologically cold, with a lower proportion of CD8+ T-cells, and high proportion of immunosuppressive myeloid derived suppressor cells (MDSCs), thus resembling high-risk PCa. …”
Journal article