The ability of natural tolerance to be applied to allogeneic tissue: determinants and limits by Razavy Haide, Perez-Diez Ainhoa, Chan William FN, Anderson Colin C

“…<p>Abstract</p> <p>Background</p> <p>Transplant rejection has been considered to occur primarily because donor antigens are not present during the development of the recipient's immune system to induce tolerance. …”
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CD200:CD200R Interactions and Their Importance in Immunoregulation by Katarzyna Kotwica-Mojzych, Barbara Jodłowska-Jędrych, Mariusz Mojzych

“…The molecule CD200, described many years ago as a naturally occurring immunomodulatory agent, capable of regulating inflammation and transplant rejection, has attracted additional interest over the past years with the realization that it may also serve as an important marker for progressive malignancy. …”
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Implantable Immunosuppressant Delivery to Prevent Rejection in Transplantation by Madonna Rica Anggelia, Ren-Wen Huang, Hui-Yun Cheng, Chih-Hung Lin, Cheng-Hung Lin

“…Collectively, this review will help relevant readers understand the different approaches to prevent transplant rejection in a new era of therapeutic agent delivery.…”
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Degeneration of Bioprosthetic Heart Valves: Update 2020 by Alexander E. Kostyunin, Arseniy E. Yuzhalin, Maria A. Rezvova, Evgeniy A. Ovcharenko, Tatiana V. Glushkova, Anton G. Kutikhin

“…Recent studies implicate the host immune response as a major modality of SVD pathogenesis, manifested by a combination of processes phenocopying the long‐term transplant rejection, atherosclerosis, and calcification of native aortic valves. …”
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Polyelectrolyte Coating of Ferumoxytol Differentially Impacts the Labeling of Inflammatory and Steady-State Dendritic Cell Subtypes by Nehar Celikkin, John E. Wong, Martin Zenke, Thomas Hieronymus

“…Functionally distinct DC subsets exist, either under steady-state or inflammatory conditions, which are explored for the specific treatment of various diseases, such as cancer, autoimmunity, and transplant rejection. Here, the impact of the PE coating of ferumoxytol for uptake into both inflammatory and steady-state DCs and the cellular responses to MNP labeling is addressed. …”
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Therapeutic Antibodies in Cancer Treatment in the UK by Khadiga Eltarhoni, Faddy Kamel, Katrina Ihebunezie, Pasha Nisar, Mikhail Soloviev

“…Oncology, autoimmune diseases and to a smaller degree the prophylaxis of organ transplant rejection are their main application areas. As of the date of this review, 37 monoclonal antibody products are approved for use in cancer treatments in the United Kingdom. …”
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The Reasons for Refusing Kidney Transplantation Among Iranian Patients Undergoing Peritoneal Dialysis by Fateme Biabani, Gholamhossein Mahmudirad, Hadi Hassankhani, Azad Rahmani

“…According to patients, kidney transplantation is a long-term procedure that causes financial stress and physical and social problems and there is a risk of transplant rejection. On the other hand, patients were accustomed to performing PD and considered it a part of their life. …”
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Ocular surface complications following biological therapy for cancer by Kevin Sheng-Kai Ma, Kevin Sheng-Kai Ma, Kevin Sheng-Kai Ma, Ping-Feng Tsai, Tina Yi-Jin Hsieh, Tina Yi-Jin Hsieh, James Chodosh

“…Dry eye, Stevens-Johnson syndrome, and corneal transplant rejection have all been reported following the use of immune checkpoint inhibitors. …”
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SODIUM REABSORPTION ESTIMATION FOR EVALUATION OF FUNCTIONAL STATE OF TRANSPLANTED KIDNEY by I. E. Borodoulin, I. A. Pronchenko, I. P. Ermakova

“…In the group of recipients with chronic transplant rejection a free member of regression equation was significantly higher, than in health volunteers (р &lt; 0,01). …”
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The challenges of managing psychiatric disorders in children with kidney transplant and end-stage renal disease: A case report by O. Fodor, A.-M. Ciubotariu, I. Mihailescu

“…Moreover, his medical history includes CRS (congenital renal disease), kidney transplant at the age of 2 followed with transplant rejection in 2019. Currently he is under haemodialysis and multiple drug prescriptions associated with his severe medical condition which interferes with the psychotropic treatment. …”
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Non-invasive Biomarkers of Acute Rejection in Kidney Transplantation: Novel Targets and Strategies by Michael Eikmans, Els M. Gielis, Kristien J. Ledeganck, Jianxin Yang, Daniel Abramowicz, Frans F. J. Claas

“…Here, we provide an overview of the current status on research of biomarkers of acute kidney transplant rejection in blood and urine. We specifically discuss relatively novel research strategies in biomarker research, including transcriptomics and proteomics, and elaborate on donor-derived cell-free DNA as a potential biomarker.…”
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Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin. by Cursiefen, C, Schlötzer-Schrehardt, U, Küchle, M, Sorokin, L, Breiteneder-Geleff, S, Alitalo, K, Jackson, D

“…METHODS: Human corneas exhibiting neovascularization secondary to keratitis, transplant rejection, trauma, and limbal insufficiency (n = 21) were assessed for lymphatic vessel content by conventional transmission electron microscopy and by immunostaining and immunoelectron microscopy with antibodies specific for the lymphatic endothelial markers, lymphatic vessel endothelial hyaluronan receptor (LYVE-1) and the 38-kDa integral membrane glycoprotein podoplanin. …”

Anti-CD4-mediated selection of Treg in vitro - in vitro suppression does not predict in vivo capacity to prevent graft rejection. by Oliveira, V, Sawitzki, B, Chapman, S, Appelt, C, Gebuhr, I, Wieckiewicz, J, Long, E, Wood, K

“…Regulatory T cells (Treg) have been shown to play a role in the prevention of autoimmune diseases and transplant rejection. Based on an established protocol known to generate alloantigen reactive Treg in vivo, we have developed a strategy for the in vitro selection of Treg. …”

Characterising the immune response to combined skin and solid organ transplants by Stark, H

“…Finally in Chapter 6 a human transgenic mouse model is used to explore the role of Langerhans cell related pathways in skin transplant rejection.</p> <p>This is the first study to characterise both the systemic and local immune response in a combined skin and solid organ transplant, offering unique insights into the dynamic changes in immune phenotype post-transplantation and during rejection. …”

Prospects of the Use of Cell Therapy to Induce Immune Tolerance by Zhenkun Wang, Xiaolong Liu, Xiaolong Liu, Fenglin Cao, Joseph A. Bellanti, Jin Zhou, Song Guo Zheng

“…Conditions in which abnormal or excessive immune responses exist, such as autoimmune diseases (ADs), graft-versus-host disease, transplant rejection, and hypersensitivity reactions, are serious hazards to human health and well-being. …”
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Anti-CD45RC antibody immunotherapy prevents and treats experimental autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy syndrome by Marine Besnard, Céline Sérazin, Jason Ossart, Anne Moreau, Nadège Vimond, Léa Flippe, Hanna Sein, Grace A. Smith, Stefania Pittaluga, Elise M.N. Ferré, Claire Usal, Ignacio Anegon, Annamari Ranki, Michail S. Lionakis, Pärt Peterson, Carole Guillonneau

“…Targeted monoclonal antibody (mAb) therapies show great promise for the treatment of transplant rejection and autoimmune diseases by inducing more specific immunomodulatory effects than broadly immunosuppressive drugs routinely used. …”
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A Safety and Tolerability Study of Thin Film Freeze-Dried Tacrolimus for Local Pulmonary Drug Delivery in Human Subjects by Sawittree Sahakijpijarn, Moeezullah Beg, Stephanie M. Levine, Jay I. Peters, Robert O. Williams

“…Previous studies reported that inhaled TAC combined with 50% <i>w/w</i> lactose (LAC) was safe and effective for the treatment of lung transplant rejection in rodent models. In this study, we aimed to investigate the safety and tolerability of TFF TAC-LAC in human subjects. …”
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FIRST EXPERIENCE WITH HEART TRANSPLANTATION IN KRASNODAR REGION by K. O. Barbukhatti, E. D. Kosmacheva, N. V. Kizhvatova, E. V. Gordeeva, E. D. Aleksandrova, L. K. Kruberg, O. A. Pozdnyakova, C. A. Raff, I. I. Yakuba, V. A. Porkhanov

“…Causes of death were septic complications, thromboembolia of the pulmonary artery, severe pancreatonecrosis, and transplant rejection due to non-compliance with immunosuppression therapy, heart rhythm disturbances. …”
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Kidney Transplantation and Diagnostic Imaging: The Early Days and Future Advancements of Transplant Surgery by Stan Benjamens, Cyril Moers, Riemer H.J.A. Slart, Robert A. Pol

“…In the years thereafter, kidney transplantation and diagnostic imaging followed a synergistic path for their development, with key discoveries in transplant rejection pathways, immunosuppressive therapies, and the integration of diagnostic imaging in transplant programs. …”
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THE LEVEL OF DENDRITIC CELLS IN KIDNEY TRANSPLANT RECIPIENTS IN THE EARLY POSTOPERATIVE PERIOD by Zybleva S. V., Zyblev S. L.

“…The patients were divided into groups: PGF – those with satisfactory primary graft function, PGD – those with primary graft dysfunction, TR – those with transplant rejection in the postoperative period. The comparison group (CG) consisted of healthy volunteers. …”
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