Integrated analysis of cell-specific gene expression in peripheral blood using ISG15 as a marker of rejection in kidney transplantation by Zijian Zhang, Zijian Zhang, Yan Qin, Yan Qin, Yicun Wang, Yicun Wang, Shuai Li, Shuai Li, Xiaopeng Hu, Xiaopeng Hu

“…The function of the novel gene ISG15 in monocytes was further confirmed by gene knockdown and lymphocyte-stimulated assay.ResultsThe bulk RNA-seq hardly predicted kidney transplant rejection accurately. Seven types of immune cells and transcriptomic characteristics were predicted from the gene expression data. …”
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The Sertoli Cell Complement Signature: A Suspected Mechanism in Xenograft Survival by Rachel L. Washburn, Dalia Martinez-Marin, Ksenija Korać, Tyler Sniegowski, Alexis R. Rodriguez, Beverly S. Chilton, Taylor Hibler, Kevin Pruitt, Yangzom D. Bhutia, Jannette M. Dufour

“…The complement system is an important component of transplant rejection. Sertoli cells, an immune regulatory testicular cell, survive long-term when transplanted across immunological barriers; thus, understanding the mechanisms behind this unique survival would be of great benefit to the transplantation field. …”
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Impact of genetic polymorphisms at the promoter area of IL-10 gene on tacrolimus level in Jordanian renal transplantation recipients by Khaleel Bara'ah, Yousef Al-Motassem, Al-Zoubi Mazhar Salim, Al-Ulemat Muhammad, Masadeh Ahmad A., Abuhaliema Ali, Al-Batayneh Khalid M., Al-Trad Bahaa

“…Background: Tacrolimus is a widely used immunosuppressant that prevents solid organ transplant rejection. The pharmacokinetics of Tacrolimus show considerable varia - bility. …”
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Tilting the Balance: Therapeutic Prospects of CD83 as a Checkpoint Molecule Controlling Resolution of Inflammation by Katrin Peckert-Maier, Dmytro Royzman, Pia Langguth, Anita Marosan, Astrid Strack, Atefeh Sadeghi Shermeh, Alexander Steinkasserer, Elisabeth Zinser, Andreas B. Wild

“…Chronic inflammatory diseases and transplant rejection represent major challenges for modern health care. …”
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The role of the NGAL biomarker in the assessment of early and prediction of late graft function in kidney transplantation from a living related donor by M. I. Kyrychenko

“…The incidence of acute kidney transplant rejection (AKTR), delay of graft function (DGF), primary non-function was recorded. …”
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Clinical adoptive regulatory T Cell therapy: State of the art, challenges, and prospective by Leila Amini, Leila Amini, Jaspal Kaeda, Enrico Fritsche, Andy Roemhild, Daniel Kaiser, Petra Reinke, Petra Reinke

“…A range of cell types with disparate immunoregulatory and regenerative properties are actively being investigated as potential therapeutic agents for specific transplant rejection, autoimmunity or injury-related indications. …”
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Indoleamine 2,3-Dioxygenase 1 (IDO1) in Kidney Transplantation: A Guardian against Rejection by Krzysztof Wiśnicki, Piotr Donizy, Agnieszka Hałoń, Patryk Wawrzonkowski, Dariusz Janczak, Magdalena Krajewska, Mirosław Banasik

“…These associations suggest that IDO1 may play a protective role in kidney transplant rejection. IDO1 modulation could offer novel therapeutic avenues to enhance graft survival. …”
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TGF-β Enhances Immunosuppression of Myeloid-Derived Suppressor Cells to Induce Transplant Immune Tolerance Through Affecting Arg-1 Expression by Peng Cao, Zejia Sun, Feilong Zhang, Jiandong Zhang, Xiang Zheng, Baozhong Yu, Yong Zhao, Wei Wang, Wei Wang

“…We intended to find an effective method that can produce MDSCs with significantly better efficiency and promote immune tolerance for transplant rejection through cell therapy. It has been reported that granulocyte and macrophage colony-stimulating factor (GM-CSF) could induce MDSCs in vitro to cause immunosuppression. …”
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Development of the in vivo flow cytometer by Novak, John P. (John Peter), 1957-

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Transiently Activated Human Regulatory T Cells Upregulate BCL-XL Expression and Acquire a Functional Advantage in vivo by Issa, F, Milward, K, Goto, R, Betts, G, Wood, K, Hester, J

“…-host disease and transplant rejection in experimental models, providing impetus for the use of Tregs as a cellular therapy in clinical transplantation. …”

The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties. by Bolt, S, Routledge, E, Lloyd, I, Chatenoud, L, Pope, H, Gorman, S, Clark, M, Waldmann, H

“…CD3 antibodies are proven immunosuppressants capable of reversing transplant rejection episodes. Their general application has been limited both by their immunogenicity and, in particular, by the "first-dose" cytokine-release syndrome experienced by patients after the initial administration of antibody. …”

Transcription factor NF-kB in the prognosis of outcomes for patients undergoing repeat keratoplasty by Komakh Y. A., Borzenok S. A., Radygina T. V., Kuptsova D. G., Petrichuk S. V.

“…Background: Obtaining a clear graft after repeat keratoplasty is still a challenging task for corneal transplant surgeons. Corneal transplant rejection rate is significantly increased in repeat keratoplasty compared with first keratoplasty. …”
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Serological Responses after a Fourth Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis by Yameng Mu, Hongxiao Wu, Zhouling Jiang, Kehang Liu, Xiaoyu Xue, Wei Zhang, Zhihai Chen

“…Safety data were reported in three studies, demonstrating that adverse effects following the fourth dose were generally mild, and patients with these adverse effects did not require hospitalization. No transplant rejection or serious adverse events were observed. …”
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Anti‐thymocyte globulin‐mediated immunosenescent alterations of T cells in kidney transplant patients by Ga Hye Lee, Jee Youn Lee, Jiyeon Jang, Yeon Jun Kang, Seung Ah Choi, Hyeon Chang Kim, Sungha Park, Myoung Soo Kim, Won‐Woo Lee

“…The immunosuppressant anti‐thymocyte globulin (ATG) has been applied for induction therapy to reduce the risk of acute transplant rejection for patients at high immunological risk. …”
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Allosteric inhibition of the T cell receptor by a designed membrane ligand by Yujie Ye, Shumpei Morita, Justin J Chang, Patrick M Buckley, Kiera B Wilhelm, Daniel DiMaio, Jay T Groves, Francisco N Barrera

“…The TCR inhibition achieved by PITCR might be useful to treat inflammatory and autoimmune diseases and to prevent organ transplant rejection, as in these conditions aberrant activation of TCR contributes to disease.…”
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Specific immunosuppressive role of nanodrugs targeting calcineurin in innate myeloid cells by Miriam Colombo, Laura Marongiu, Francesca Mingozzi, Roberta Marzi, Clara Cigni, Fabio Alessandro Facchini, Rany Rotem, Mihai Valache, Giulia Stucchi, Giuseppe Rocca, Laura Gornati, Maria Antonietta Rizzuto, Lucia Salvioni, Ivan Zanoni, Alessandro Gori, Davide Prosperi, Francesca Granucci

“…Summary: Calcineurin (CN) inhibitors currently used to avoid transplant rejection block the activation of adaptive immune responses but also prevent the development of tolerance toward the graft, by directly inhibiting T cells. …”
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The association between genetic variants at 3’-UTR and 5’-URR of HLA-G gene and the clinical outcomes of patients with leukemia receiving hematopoietic stem cell transplantation... by Ding-Ping Chen, Ding-Ping Chen, Po-Nan Wang, Ai-Ling Hour, Wei-Tzu Lin, Fang-Ping Hsu, Wei-Ting Wang, Ching-Ping Tseng, Ching-Ping Tseng, Ching-Ping Tseng

“…HLA-G gene plays an important role in immune tolerance, assisting immune escape of tumor cells, and decrease of transplant rejection. In this study, we explored the association of genetic variants at the 3’-untranslated region (3’-UTR) and 5’-upstream regulatory region (5’-URR) of HLA-G gene with the adverse outcomes of patients with leukemia receiving HSCT. …”
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10-YEAR HEART TRANSPLANTATION EXPERIENCE IN NOVOSIBIRSK by A. M. Chernyavskiy, D. V. Doronin, A. V. Fomichev, D. E. Osipov, V. A. Shmyrev, A. M. Karaskov

“…The death causes in the long-term period were acute transplant rejection in 4 cases (40%), coronary artery disease of the transplanted heart in 3 cases (30%), Kaposi’s sarcoma in 1 case (10%), lung cancer in 1 case (10%), and viral pneumonia in 1 case (10%).Conclusion. …”
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Preventative effect of TSPO ligands on mixed antibody-mediated rejection through a Mitochondria-mediated metabolic disorder by Yannan Zhang, Jiannan He, Zhe Yang, Haofeng Zheng, Haoxiang Deng, Zihuan Luo, Qipeng Sun, Qiquan Sun

“…This model was treated with the TSPO ligands, FGIN1-27 or Ro5-4864, to investigate the role of ligands in preventing transplant rejection and DSAs production in vivo. As TSPO was the mitochondrial membrane transporters, we then investigated the TSPO ligands effect on mitochondrial-related metabolic ability of B cells as well as expression of downstream proteins. …”
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Allosteric inhibition of the T cell receptor by a designed membrane ligand by Ye, Yujie, Morita, Shumpei, Chang, Justin J., Buckley, Patrick M., Wilhelm, Kiera B., DiMaio, Daniel, Groves, Jay T., Barrera, Francisco N.

“…The TCR inhibition achieved by PITCR might be useful to treat inflammatory and autoimmune diseases and to prevent organ transplant rejection, as in these conditions aberrant activation of TCR contributes to disease.…”
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