Low Pre-Transplant Caveolin-1 Serum Concentrations Are Associated with Acute Cellular Tubulointerstitial Rejection in Kidney Transplantation by Florian Emmerich, Stefan Zschiedrich, Christine Reichenbach-Braun, Caner Süsal, Susana Minguet, Marie-Christin Pauly, Maximilian Seidl

“…Acute and chronic transplant rejections due to alloreactivity are essential contributors to graft loss. …”
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Lymphatic Reconstruction in Kidney Allograft Aggravates Chronic Rejection by Promoting Alloantigen Presentation by Jinwen Lin, Ying Chen, Huijuan Zhu, Kai Cheng, Huiping Wang, Xianping Yu, Mengmeng Tang, Jianghua Chen

“…These results reveal a rebuilt pathway for alloantigen trafficking and lymphocytes activation, providing strategies to alleviate chronic transplantation rejection.…”
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Glomerular Macrophages in Human Auto- and Allo-Immune Nephritis by Solange Moll, Andrea Angeletti, Leonardo Scapozza, Andrea Cavalli, Gian Marco Ghiggeri, Marco Prunotto

“…Literature on the glomerular macrophage role in human crescentic glomerulonephritis and renal transplantation rejection with glomerulitis, is sparse. Evidence from preclinical models indicates that macrophages profoundly modulate disease progression, both in terms of number—where depletion has resulted in a reduced glomerular lesion—and sub-phenotype—M1 being more profoundly detrimental than M2. …”
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Allele frequencies of the human platelet antigen-1 in the Egyptian population by Han Kyudong, Salem Abdel, Batzer Mark A

“…Human platelet antigen (HPA) systems are associated with alloimmunization and organ transplantation rejection as well as the development of cardiovascular disease. …”
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<i>Botryllus schlosseri</i> as a Unique Colonial Chordate Model for the Study and Modulation of Innate Immune Activity by Oron Goldstein, Edna Ayerim Mandujano-Tinoco, Tom Levy, Shani Talice, Tal Raveh, Orly Gershoni-Yahalom, Ayelet Voskoboynik, Benyamin Rosental

“…While most transplantation rejections occur due to the adaptive immune response, the proinflammatory response of innate immunity is necessary for the activation of adaptive immunity. …”
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Nanomedicine and nanoparticle-based delivery systems in plastic and reconstructive surgery by Jea Giezl N. Solidum, Jeremy A. Ceriales, Erika P. Ong, Eric David B. Ornos, Ruth Joy L. Relador, Elgin Paul B. Quebral, Jose Florencio F. Lapeña, Ourlad Alzeus G. Tantengco, Ka Yiu Lee

“…Cell surface-targeted, controlled-release, and inorganic nanoparticle formulations with inherent biological properties have enabled enhanced wound healing, tumor visualization/imaging, tissue viability, and decreased infection, and graft/transplantation rejection through immunosuppression. Conclusions Nanomedicine is also now being applied with electronics, theranostics, and advanced bioengineering technologies. …”
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Long Time Complications of Renal Transplantation by Seyed Abbas Tabatabaei, Seyed Mozafar Hashemi, Mahmood Zandi

“…Methods: In a cross sectional study long time complications of kidney transplantation such as infection, cardial and renal were studied .This retrospective study reviewed patient population in terms of age, sex, etiology of transplantation reject, using corticosteroid drugs and survival time for new kidney. …”
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Extracellular Vesicles in Type 1 Diabetes: A Versatile Tool by Caitlin N. Suire, Mangesh D. Hade

“…Extracellular vesicles (EVs) are lipid-bound nanoparticles that contain diverse content from their cell of origin and can be used as a biomarker for both the onset of diabetes and transplantation rejection. Furthermore, vesicles can be loaded with therapeutic cargo and delivered in conjunction with a transplant to increase cell survival and long-term outcomes. …”
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The Danish Nephrology Registry by Heaf J

“…Registered complications include peritonitis in peritoneal dialysis patients, causes of peritoneal dialysis technique failure, and transplant rejections. Fifteen biochemical variables are registered, mainly describing anemia control, mineral and bone disease, nutritional and uremia status. …”
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Treg Enhancing Therapies to Treat Autoimmune Diseases by Peter J. Eggenhuizen, Boaz H. Ng, Joshua D. Ooi

“…Regulatory T cells (Tregs) are a small yet critical subset of CD4+ T cells, which have the role of maintaining immune homeostasis by, for example, regulating self-tolerance, tumor immunity, anti-microbial resistance, allergy and transplantation rejection. The suppressive mechanisms by which Tregs function are varied and pleiotropic. …”
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Visual Rehabilitation in Patients With Corneal Blindness Using Keratoprosthesis by Saeed Rahmani, Mohammad Ali Javadi, Kiana Hassanpour, Farid Karimian

“…Results Out of more than 1000 articles in the field of the artificial cornea, about 70 related articles were selected and reviewed.Conclusion Generally, keratoprosthesis is used for patients for whom corneal transplantation is not possible or the risk of corneal transplantation rejection is high. The patient’s current condition and the outcome of the patient’s anterior and posterior segment examinations, previous treatments and surgeries, and the medications used should be considered. …”
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Transplant Candidates of 70+ Years Have Superior Survival If Receiving Pre-Emptively a Living Donor Kidney by Michiel G. H. Betjes, Marcia M. L. Kho, Joke Roodnat, Annelies E. de Weerd

“…Primary non-function (38%) and rejection (43%) were the major causes of graft loss in the first year after DDK transplantation. Rejection-related graft loss was 4.6% during follow-up. …”
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Increased serum level of soluble interleukin-2 receptor is associated with a worse response of metastatic clear cell renal cell carcinoma to interferon alpha and sequential VEGF-ta... by Akinori Nukui, Akinori Masuda, Hideyuki Abe, Kyoko Arai, Ken-Ichiro Yoshida, Takao Kamai

“…Soluble interleukin-2 receptor (sIL-2R) has a role in T cell activation and may be important for immune regulation in various conditions, including infections, transplantation rejection, autoimmune inflammatory states, and cancer. …”
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In vitro and in vivo Evidence on Intra-tumor Injection of Allogeneic Serum for Immunotherapy in a Mouse Model of Colon Cancer by Erfan Basirat, Danial Dehghan, Ardeshir Abbasi, Nafiseh Pakravan

“… It is believed that preformed antibodies are responsible for blood transfusion reactions and transplant rejections. In order to remove a tumor, the tissue must be rejected. …”
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The Flow Cytometric Analysis of Peripheral Blood Lymphocytes and Expression of HLA II Molecules in Lymphocyte During Acute Rejection After Renal Transplantation by Guo J, Qin C, Li X, Zhuang X

“…The mRNA and protein expressions of HLA II molecules of peripheral blood B lymphocytes in the control group were significantly higher that these in the test group.Conclusion: The proportion of peripheral blood T lymphocytes, B lymphocytes, CD4CD8 double positive T cells, and the expression of HLA II molecules of peripheral blood lymphocytes can all indicate the occurrence of acute renal transplantation rejection, which were exceedingly useful to clinicians in judging the acute rejection of renal transplantation in the early stages.Keywords: acute rejection, HLA II molecules, kidney transplantation, peripheral blood lymphocytes, flow cytometric analysis…”
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Induction of liver transplant immune tolerance in an outbred rat strain model using tacrolimus by Min-Jung Park, Hyun Sik Na, Young-Shin Joo, Keun-Hyung Cho, Se-Young Kim, Jeong Won Choi, Jin-Ah Baek, Jong Young Choi, Young Kyoung You, Mi-La Cho

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PRO – AND ANTI-INFLAMMATORY CYTOKINES ARE EARLY MARKERS OF ACUTE REJECTION OF THE TRANSPLANTED KIDNEY by T. V. FEDORENKO, N. V. KOLESNIKOVA, E. F. FILIPPOV

“…Meanwhile, the determination of a number of blood cytokines before kidney transplantation allows predicting post-transplantation rejection. In particular, certain criteria favorable course of the period after kidney transplantation by absence of HLA antibodies in patients with chronic renal failure can be considered as the initial (within 6 hours of transplantation) low levels of IL1β, IL6, IL17а. …”
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Gene expression profile of human T cells following a single stimulation of peripheral blood mononuclear cells with anti-CD3 antibodies by Isabel Garcia Sousa, Kelly Cristina Rodrigues Simi, Manuela Maragno do Almo, Maryani Andressa Gomes Bezerra, Gero Doose, Tainá Raiol, Peter F. Stadler, Steve Hoffmann, Andréa Queiroz Maranhão, Marcelo Macedo Brigido

“…Abstract Background Anti-CD3 immunotherapy was initially approved for clinical use for renal transplantation rejection prevention. Subsequently, new generations of anti-CD3 antibodies have entered clinical trials for a broader spectrum of therapeutic applications, including cancer and autoimmune diseases. …”
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High-throughput screening identification of novel immunomodulatory combinations for the generation of tolerogenic dendritic cells by Sihan Jia, Jeremiah Kim, Aaron Palmer Esser-Kahn, Peter Deak

“…IntroductionTolerogenic Dendritic Cells (tolDCs) have an exceptional promise as a potential therapy for autoimmune disease and transplantation rejection. TolDCs are a unique phenotype of antigen presenting cells (APCs) that can influence naïve T cells into antigen specific T regulatory cells (Tregs), which can re-establish tolerance against auto/allo-antigens in the long term. …”
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Molecular Assessment of C4d-Positive Renal Transplant Biopsies Without Evidence of Rejection by Katherine M. Dominy, Michelle Willicombe, Tariq Al Johani, Hannah Beckwith, Dawn Goodall, Paul Brookes, H. Terence Cook, Tom Cairns, Adam McLean, Candice Roufosse

“…Keywords: antibody mediated rejection, C4d, kidney, molecular, transplant rejection…”
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