Efficacy of hearing aid treatment on sound perception and residual hearing preservation in patients with tinnitus and coexisting hearing loss: study protocol for a randomized contr... by Peifan Li, Dongmei Tang, Yongzhen Wu, Yanbo Yin, Shan Sun

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Study protocol for ACTIVE study: safety and feasibility evaluation of external ventricular drainage with ACTIVE fluid exchange in intraventricular hemorrhage—a phase 2, multi-cente... by Mette Haldrup, Niwar Mohamad, Mads Rasmussen, Line Thorup, Stig Dyrskog, Claus Ziegler Simonsen, Rares Miscov, Carsten Reidies Bjarkam, Mads Grønhøj, Frantz Rom Poulsen, Anders Rosendal Korshøj

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Designs for adding a treatment arm to an ongoing clinical trial by Maxine Bennett, Adrian P. Mander

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Impact of pharmacist educational intervention on disease knowledge, rehabilitation and medication adherence, treatment-induced direct cost, health-related quality of life and satis... by Atta Abbas Naqvi, Mohamed Azmi Hassali, Syed Baqir Shyum Naqvi, Muhammad Tariq Aftab

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The effect of an educational program for pregnant women to prevent allergic diseases in infants: study protocol for a randomized controlled trial by Rie Nakamura, Nao Ishiguro, Eiji Naru, Yukiko Ishitsuka, Masato Nakade, Yoko Nezu

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Streamlining regulation of clinical trials – update on the Academy of Medical Sciences review and government’s response by Ford Gary A

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Correction to: Xanthohumol microbiome and signature in healthy adults (the XMaS trial): a phase I triple-masked, placebo-controlled clinical trial by Ryan Bradley, Blake O. Langley, Jennifer J. Ryan, John Phipps, Douglas A. Hanes, Emily Stack, Janet K. Jansson, Thomas O. Metz, Jan Frederik Stevens

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Bayesian adaptive designs for multi-arm trials: an orthopaedic case study by Elizabeth G. Ryan, Sarah E. Lamb, Esther Williamson, Simon Gates

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The effects of probiotic Saccharomyces boulardii on the mental health, quality of life, fatigue, pain, and indices of inflammation and oxidative stress in patients with multiple sc... by Dawood Aghamohammadi, Hormoz Ayromlou, Neda Dolatkhah, Fatemeh Jahanjoo, Seyed Kazem Shakouri

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Tonsillectomy versus tonsillotomy for recurrent acute tonsillitis in children and adults (TOTO): study protocol for a randomized non-inferiority trial by Orlando Guntinas-Lichius, Katharina Geißler, Thomas Asendorf, Ralf Tostmann, Jan Löhler

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Effects of a chronotype-adapted diet on weight loss, cardiometabolic health, and gut microbiota: study protocol for a randomized controlled trial by Monica Dinu, Sofia Lotti, Giuditta Pagliai, Antonia Napoletano, Marta Tristan Asensi, Ilaria Giangrandi, Rossella Marcucci, Amedeo Amedei, Barbara Colombini, Francesco Sofi

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Efficacy of acupuncture and its influence on the emotional network in adult insomnia patients: protocol for a randomized controlled clinical trial by Tongfei Jiang, Qi Zhang, Fang Yuan, Fan Zhang, Jing Guo

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The effects of centralised and specialised combined pharmacological and psychological intervention compared with decentralised and non-specialised treatment in the early course of... by Gluud Christian, Dam Henrik, Christensen Ellen, Hansen Hanne, Kessing Lars, Wetterslev Jørn

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Anonymous online cognitive behavioral therapy for sleep disorders in shift workers—a study protocol for a randomized controlled trial by Lukas Retzer, Monika Feil, Richard Reindl, Kneginja Richter, Robert Lehmann, Mark Stemmler, Elmar Graessel

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Acupuncture, or non-directive counselling versus usual care for the treatment of depression: a pilot study by MacPherson Hugh, Schroer Sylvia

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Strengthening primary care for diabetes and hypertension in Eswatini: study protocol for a nationwide cluster-randomized controlled trial by Michaela Theilmann, Ntombifuthi Ginindza, John Myeni, Sijabulile Dlamini, Bongekile Thobekile Cindzi, Dumezweni Dlamini, Thobile L. Dlamini, Maike Greve, Harsh Vivek Harkare, Mbuso Hleta, Philile Khumalo, Lutz M. Kolbe, Simon Lewin, Lisa-Rufaro Marowa, Sakhile Masuku, Dumsile Mavuso, Marjan Molemans, Nyasatu Ntshalintshali, Nomathemba Nxumalo, Brianna Osetinsky, Christopher Pell, Ria Reis, Fortunate Shabalala, Bongumusa R. Simelane, Lisa Stehr, Fabrizio Tediosi, Frank van Leth, Jan-Walter De Neve, Till Bärnighausen, Pascal Geldsetzer

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The efficacy and safety of deucravacitinib compared to methotrexate, in patients with vulvar lichen planus who have failed topical therapy with potent corticosteroids: a study prot... by Marlene Wijaya, Gayle Fischer, Rebecca Bronwyn Saunderson

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Vestibular prognosis in idiopathic sudden sensorineural hearing loss with vestibular dysfunction treated with oral or intratympanic glucocorticoids: a protocol for randomized contr... by Weiming Hao, Liping Zhao, Huiqian Yu, Huawei Li

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Generalisability of trials of home blood pressure monitoring; a comparison of two UK primary care trials by Kerry Sally M, Markus Hugh S, Khong Teck K, Oakeshott Pippa

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Effects of remote ischemic conditioning on conditioned pain modulation and cardiac autonomic modulation in women with knee osteoarthritis: placebo-controlled randomized clinical tr... by Taíse Mendes Biral, Allysiê Priscilla de Souza Cavina, Eduardo Pizzo Junior, Carlos Alberto Toledo Teixeira Filho, Franciele Marques Vanderlei

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